Slashdot Mirror


New Treatment From Australia For All Cancers

New submitter FirephoxRising writes "A new, protein-based treatment from the University of NSW breaks down cancers by destroying their internal protein structures. The approach has been tried before but always resulted in too much damage to muscles and the heart. The new approach allows the new class of drug to attack tumors without damaging normal cells. Professor Peter Gunning said, 'Our drug causes the structure of the cancer cell to collapse — and it happens relatively quickly.'"

26 of 217 comments (clear)

  1. Yay! by Anonymous Coward · · Score: 5, Funny

    Another daily cure for cancer.

    1. Re:Yay! by i+kan+reed · · Score: 5, Informative

      Yeah, and the headline even contradicts the poorly written news article(which is already far too removed from the research to be safe). It specifically was engineered to treat one kind of cancer, they think it will effects on a similar cancer, and have a little hope for "many others". That's a far-cry from "curing all cancers".

    2. Re:Yay! by MightyMartian · · Score: 4, Insightful

      Yes, it only goes to prove my axiom "The only thing worse than science journalism are /. summaries."

      --
      The world's burning. Moped Jesus spotted on I50. Details at 11.
    3. Re:Yay! by ColdWetDog · · Score: 5, Informative

      Surprisingly, the full text is available without registering or going through a paywall. Must be a leak into a different universe or something.

      Just scanned it quickly - all cells have a cytoskelaton, a framework that allows a cell to maintain a three dimensional shape. Cytoskeletons are controlled, in part, because of a class of proteins called tropomyosins. These proteins are turned over quite rapidly in cancer cells yielding the hypothesis that targeting those molecules could selectively kill cancerous cells. Unfortunately, the chemicals that have been used previously also targeted non cancer cells and caused a lot of systemic toxicity (they cured the cancer, but unfortunately, the patient died).

      The new compound, TR100 (sounds like a toy truck), specifically targets a type of tropomyosin presumably found only in cancer cells. Leaves normal cells alone.

      IF this remains true in testing and IF the compound doesn't have other, unintended and typically deleterious effects it MIGHT be a good drug. Grandstanding by the PR idiots notwithstanding.

      The road to Big Pharma Hell is paved with effective in vitro cures for cancer.

      --
      Faster! Faster! Faster would be better!
    4. Re:Yay! by reverseengineer · · Score: 4, Informative

      There is reason to think that a drug like this would be broadly effective against different kinds of cancer. TR100 disrupts the actin cytoskeleton vital to all cells, and specifically disrupts its formation by targeting an isoform of the protein tropomyosin. Isoforms are different structures for the the same protein- every cell needs tropomyosin to regulate their actin filaments, but cancer cells preferentially use a certain structure of tropomyosin. Compounds with anti-actin activity have been looked at for a long time as anticancer compounds, but the known ones have been nonspecific. TR100 also has the advantage of being a relatively simple small molecule instead of a complicated biomolecule, which could make its development as a commercial drug much easier.

      It is however, still (potentially) just a new chemotherapy agent, one of many out there. From what has been observed from other chemo agents, just because a compound targets a basic cellular function doesn't mean a cancer can't develop resistance. The taxanes and the Vinca alkaloids arrest mitosis (by targeting microtubules), and are excellent, widely used drugs, but are not the The Cure for Cancer. I'd imagine this compound to be along those lines- another weapon in the oncology arsenal, but not a magic bullet.

      --
      "FDA staff reviewers expressed concern about the number of patients who were left out of the study because they died."
    5. Re:Yay! by interkin3tic · · Score: 4, Insightful
      The article points out that some combinations of tropomyosins are needed in the embryo, but are dispensable afterward. You needed this particular combination of tropomyosins targeted before birth, but your heart doesn't need it now. Cancer cells often revert back to a more primordial state mimicking development. So the strategy seems to be targeting that since only the cancer should be using it.

      The specific combination will not be important to all cancers, but it's possible that the STRATEGY of targeting individual tropomyosin combinations might be broadly applicable. They used the structure of the tropomyosins in question to identify drugs that would block it specifically. That could be used in other combinations. You get a sample of the tumor, find it's using combination X and Y. Y is used by the heart and is no good for targeting, but X is, so you attack that. Another cancer, combo AB and Y might be upregulated, so you look into A or B. One would likely also use it in combination with other chemotherapy. If Y combo, is the only one the cancer is using, and again that one is needed for the heart, you might give a low dose of that with a lowered dose of taxol, which targets all dividing cells. That one-two punch will have two sets of side effects to worry about, but if you give low doses of both, you might target the cancer more effectively with reduced side effects.

      I'm not a clinical doctor, so maybe that's not the idea, just that more tools are better, and the strategy is what seems to be a bigger story.

      The road to Big Pharma Hell is paved with effective in vitro cures for cancer

      It's also the road to better basic research tools. You can't jump from the stone age to the space age obviously. If this were the stone age, I might want to develop a better chisel. If people funding (?) research back in the stone age were the same people that are funding biomedical research today, I probably would suggest that a better chisel would be better able to cut metal for the rocket engine. I'd know in reality, it would just make it easier to carve stones to make a house, but if I don't promise big, the research money will go to some guy rubbing sticks together suggesting it was a novel source of combustion energy for reaching that big bright thing in the night sky.

      I won't say it in my grant applications, but I doubt we have the technology to cure cancer at this point. That doesn't mean my research won't be essential to the eventual cure for cancer, nor does it mean that cancer research is wasted.

  2. Exciting Times by Somebody+Is+Using+My · · Score: 5, Interesting

    Whether this new cure is a true breakthrough or not, it is really exciting to live in a time where things such as CURING CANCER are possible (even living on the verge of such a time is breathtaking). The places science and technology are taking us are out of a science-fiction novel. We might not have flying cars or jetpacks (except we /do/!), but we truly are living "in the future". A thousand years ago what we take for granted would have seemed magic or even godlike. And who knows what tomorrow will hold for us - a cure for death, perhaps?

    Even knowing that no such advance comes without its unforeseen darkside, it is still enough to give me a childlike glee and hope again.

    1. Re:Exciting Times by h4rr4r · · Score: 3, Insightful

      Such a claim requires some serious proof.

      Unless you mean our current means of food production enable people to live long enough to get these diseases.

    2. Re:Exciting Times by i+kan+reed · · Score: 5, Interesting

      Well, one of the dark sides is that our agrochemical food causes many of these cancers in the first place.

      He said lacking any justification at all for his statement.

      People die of cancer everywhere, and everywhen, it's not unique to "our" food. It's not magically caused by "chemicals". There are carcinogens present in modern society, but the primary causes of cancer aren't your damn food.

    3. Re:Exciting Times by omnichad · · Score: 4, Informative

      A cure for death would wreak unbelievable chaos on the world.

    4. Re:Exciting Times by quantumghost · · Score: 5, Informative

      Whether this new cure is a true breakthrough or not, it is really exciting to live in a time where things such as CURING CANCER are possible (even living on the verge of such a time is breathtaking).

      Actually, most cancers are curable. I can cut out most tumors....the problem is getting to them early enough. Solid tumors are mostly responsive to surgery first, chemotherapy and, for some cancers, radiotherapy are best left to "mop up" residual cells be it tumor-in-situ or micrometastases or out metastatic disease, now there are a few exceptions - especially the "liquid tumors" or hematologic malignancies.

      What I'd really like to see is better screening for cancers - the only universal truth about cancers is that the earlier they are caught, the better the response to treatment. Catch a cancerous growth early before is has spread locally and we can cut it out and you'll likely be cured. When it has a chance to invade locally and especially distally, I can't perform a simple operation to remove it - I have to take out more tissue and sometimes in different places or other organs...sometimes the tumor burden is so great that an operation won't make a difference. This is where chemo can also be used. But responses to chemo are almost universally poorer than surgery. And please bear in mind, most people use "cancer" like its a single entity. It is not. There are a multitude of cancerous transformations for each cell line in the body, each with its own peculiarities.

      Don't get me wrong, any improvement in chemotherapy will increase survivor hood of cancer, but I doubt that this will do much to change the initial treatment of most cancers.

    5. Re:Exciting Times by JanneM · · Score: 5, Informative

      Mostly I agree wholeheartedly. A close relative has survived colon cancer (one of the most survivable cancers today), in no small part because it was diagnosed and removed in time.

      But, it seems that screening has some pretty tough limits. You have some cancers such as glioblastoma that seem to still be pretty much uniformly fatal no matter how early you find them. And breast cancer seems to be less promising for screening than it seemed at first; the aggressive type seems to be liable to have metastised almost no matter how early it is detected, while the other types are fairly unlikely to do so, even with late detection.

      This seems to partly explain why breast cancer survival hasn't budged nearly as much as expected with the advent of wide-spread screening.

      Screeining _is_ important. Surgery is the main means of cancer cure. And both have improved hugely over time. But for all that, cancers still collectively comprise the second most common cause of death, behind cardiovascular issues. And arguably a much more difficult and prolongued death for most sufferers. I'd say any improvement in treatment is both urgent and welcome.

      --
      Trust the Computer. The Computer is your friend.
    6. Re:Exciting Times by kevkingofthesea · · Score: 5, Insightful

      Assuming there's been an increase in cancer incidence in recent history (not saying there's been one, I just don't feel like looking it up), I'd conjecture that it's primarily due to our greatly increased average lifespan, not any ill effects of whatever foods or chemicals we might have added to our daily diets.

    7. Re:Exciting Times by RobinH · · Score: 3, Informative

      There is the tiny problem that chemotherapy damages your brain. There is, at the very least, a measurable and significant decline in IQ when tested before and after chemotherapy. Google for effect on iq from chemo to see some information.

      --
      "I have never let my schooling interfere with my education." - Mark Twain
    8. Re:Exciting Times by lisaparratt · · Score: 3, Insightful

      THEY'RE FLUORIDATING OUR AVGAS!
      dsjghsdbfgbfgngvbnbvnyjghmjghdmjhmhj

  3. Oblig by war4peace · · Score: 4, Insightful

    TV Personality: And how many people have you treated so far?
    Dr. Alice Krippin: Well, we've had ten thousand and nine clinical trials in humans so far.
    TV Personality: And how many are cancer-free?
    Dr. Alice Krippin: Ten thousand and nine.
    TV Personality: So you have actually cured cancer.
    Dr. Alice Krippin: Yes, yes... yes, we have.
    [cuts to post-apocalyptic New York three years later]

    --
    ...gis sdrawkcab (usually not responding to ACs; don't bother posting as AC)
  4. Re:Even if this does pan out... by Anonymous Coward · · Score: 4, Funny

    Yeah, you're right, curing cancer sucks. This is the worst day ever. :(((

  5. Re:SCIENCE! by iggymanz · · Score: 3, Interesting

    if we have a global nuclear war, does that mean science won?

  6. for certain animals by iggymanz · · Score: 3, Informative

    this has never been tried on a human being and won't be until at least 2015

    many cures for cancer have worked very well in animals over the past three decades

  7. Re:SCIENCE! by rubycodez · · Score: 5, Informative

    that actually was a quote of Vishnu in the Hindu scriptures Bhagavad-Gita.

  8. Call me cynical by grasshoppa · · Score: 4, Funny

    But all I think they've cured is the need for research funding for a year or two.

    --
    Mod me down with all of your hatred and your journey towards the dark side will be complete!
  9. a cure for a self inflicted plague by nimbius · · Score: 4, Insightful

    the CDC routinely releases statistics and studies that conclude people who eat healthy and exercise regularly experience dramatically lower cancer rates. of course cancer is a terrible disease for anyone it afflicts but rarifying its manifestation should be of greater realistic priority than a panacea. if you're pining for a silver bullet you might want to give running shoes, fresh fruit and vegetables a shot. Drink a little less, and for christ sake if you're still smoking, quit.

    --
    Good people go to bed earlier.
  10. Re:SCIENCE! by FreeUser · · Score: 4, Insightful

    if we have a global nuclear war, does that mean science won?

    No. In all liklihood, it will mean religious fanatics in either America, some other region, or both, got their hands on nukes and decided to usher in whatever their version of post-apacalyptic "our religion now rules on Earth as it does in Heaven" millennium. By the time they realize what fools they were, we as a species have joined the other 99% of species in extinction.

    Regardless, it will mean the baser side of human nature won, and happened to use a scientificly derived tool as it defeated our better natures, and our species.

    --
    The Future of Human Evolution: Autonomy
  11. What is this stuff? by rs79 · · Score: 5, Interesting

    I wonder if it's real or some really horrid chemical they can't quite get safe enough to use without dissolving your veins. That's the problem with that "discovery" in Sask. that cured cancer in rats. That's because rats can't scream as their veins dissolve.

    Put on your thinking caps, why has cance shot up since 1900? What changed?

    In 2007 or so, a Cytochrome B enzyme was found - CYP1B1 that only occurs in cancer cells. Fresh off the end of a successful prostate cancer drug, the first one with a new paradigm - something other than "kill ALL of the cells and pray" (See: http://www.sfgate.com/cgi-bin/article.cgi?f=%2Fc%2Fa%2F2012%2F06%2F02%2FMNI11ORI84.DTL) that exploited CYP17, Potter then set out to make a more generalized one based on the nearly universal CYP1B1. He designed the molecule then set about to make it and while looking for precursors noticed the exact same molecule occurs in fruit, made in response to mold.

    So they tried it, and it worked. Every time. It gets converted in cells with CYP1B1 to picotaneol which is fatal to cancer cells but not regular cells. If you google "Salvestrol case studies" you'll find three clinical trials where cancer was reversed in every case. It's not patentable...

    So, the current hypothesis is, since we began spraying anti-fungals, there's no mold so the plant doesn't make this chemical in response to mold, so non-organic fruit contains only 10% of what unsprayed fruit has. And it's a very bitter chemical and we breed bitterness out...

    Cancerous cells can be found in any animal at any time, the body takes care of them. The problem arises when it can't, and we find Gene P53 is deactivated in those people. This reactivates it; once the body has the correct raw materials it gets down to work.

    It's always better to help the body do what it does naturally and has for millions of years compared to some synthetic noxious substance. If nothing else understand that with a chemical that's already in the body all the time, the body knows what to do with it. With man-made drugs there are always side effects in every case as the body has no idea what to do with the molecules it doesn't recognize and they latch on to places they shouldn't and hellooo side effects.

    There are 30,000 deaths a year from these side effects.

    This chemical is found in tangerines and prune plums, strawberries, asparagus and so on. Tangerines have the most. Which raises an interesting question. Do areas that grow a lot of tangerines have a lower cancer rate. That would be Morocco.

    It's not on the list of per capita cancer rates WHO keeps, that's quoted in Wiki. That list ranges from South Africa as the lowest (about 250) to Denmark with the highest at 387 or something. Note also that poor countries have less, developed countries have more... poor people grow their own food and can't afford chemicals.

    But, if you poke around on the Moroccan government website long enough, you find their per-capita cancer rate: 100. Less than half the lowest stat WHO has for any country. And besides having all the tangerines, they pretty much invented chain smoking there. But still: 100.

    So, if these guys are using this mechanism and trying to make a patent end run, bad. If it's something else, some noxious chemical, it's equally worthless. If however they have a new agent that also uses the pro-drug paradigm Potter found, then that would be good.

    But there's a reason they don't give any details on this compound and I'd really like to know what it is.

    --
    Need Mercedes parts ?
    1. Re:What is this stuff? by semi-extrinsic · · Score: 4, Insightful

      I'm not arguing with the articles you posted, but the argument "India/Morocco/Nepal has less cancer, so we must be doing something to cause cancer" has a significant weakness: many people in those countries die before they have the time to get cancer.

      --
      for i in `facebook friends "=bday" 2>/dev/null | cut -d " " -f 3-`; do facebook wallpost $i "Happy birthday!"; done
    2. Re:What is this stuff? by Samrobb · · Score: 4, Funny

      Wouldn't it be ironic if the cure for cancer was bruised moldy tomatoes?

      Ridiculous. Next you'll be claiming that moldy bread is a cure for bacterial infections.

      --
      "Great men are not always wise: neither do the aged understand judgement." Job 32:9