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Gene Variant Can Cause Nattering Nabobs of Negativity

Freshly Exhumed writes "Researchers from the University of British Columbia, Cornell University and Toronto's Centre for Addiction and Mental Health report in the journal Psychological Science [abstract; press release] that a gene variant can cause individuals to perceive the negative side of every situation. UBC Prof. Rebecca Todd said the ADRA2b deletion variant influences not only emotional memory, which was previously known, but also amplifies a person's real-time perception of events, for better or for worse. 'Some individuals are predisposed to see the world more darkly than others,' Todd said. 'What we found is that a previously known genetic variation causes some individuals to perceive the world more vividly than others and, particularly, negative aspects of the world.'"

171 comments

  1. Ignore your problems. by Anonymous Coward · · Score: 1

    They'll go away.

    1. Re:Ignore your problems. by icebike · · Score: 5, Insightful

      They'll go away.

      Exactly, realists are the coal mine canaries of society: "but also amplifies a person's real-time perception of events".
      Maybe instead of calling people who point out negative aspect of grandiose plans Debbie Downers, and nabobs of negatively, it would make more sense to realize that when there are a significant number of people saying "hold on there", that just possibly society is getting ahead of itself and rushing head long down yet another repetitive boondoggle that has failed before.

      --
      Sig Battery depleted. Reverting to safe mode.
    2. Re:Ignore your problems. by Anonymous Coward · · Score: 0

      They'll go away.

      Exactly, realists are the coal mine canaries of society: "but also amplifies a person's real-time perception of events".
      Maybe instead of calling people who point out negative aspect of grandiose plans Debbie Downers, and nabobs of negatively, it would make more sense to realize that when there are a significant number of people saying "hold on there", that just possibly society is getting ahead of itself and rushing head long down yet another repetitive boondoggle that has failed before.

      Yup, what exactly is *wrong* with perceiving the bad as well as the good?
      Sounds pretty well rounded to me.

    3. Re:Ignore your problems. by lxs · · Score: 1

      Ah the depressive-realist school of thought. Better known as the no-fun-at-parties crowd. Once I learned to accept the repetitive boondoggles are inherent in the human condition, most of the depression went away. For a troupe of furless chimps, we're doing alright.

    4. Re:Ignore your problems. by ThisIsSaei2561 · · Score: 1

      Way to trivialize depression as an issue of perspective, cured with a single, simple change.

      If we just accept that things are terrible, and be happy about it, we will be happy about it. Genius.

    5. Re:Ignore your problems. by Anonymous Coward · · Score: 0

      I must have multiple copies of that .

    6. Re:Ignore your problems. by Swave+An+deBwoner · · Score: 1

      Bobby? Bobby McFerrin? Is that really you?

    7. Re:Ignore your problems. by Samantha+Wright · · Score: 1

      Just so we're clear—you're misusing "realist" there. There is a (somewhat disproven) psychological theory called depressive realism that argues that a certain amount of negativity compensates for wishful thinking, but to take it as a generic label is to presume correctness. You might be better off saying "cynic" or "sceptic."

      The general philosophical term "realist" is just an antonym of solipsist; i.e. someone who believes the world exists (although there's also an artistic term called "realism" which is about producing authentic depictions.)

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    8. Re:Ignore your problems. by Jeremi · · Score: 3, Insightful

      Depression is a mental disorder caused by a chemical imbalance in the brain, and should not be trivialized.

      A negative outlook, on the other hand, is a habit, and like any bad habit, it can be recognized as such and changed.

      Mental health issues aside, there are people out there who make themselves unhappy to no good purpose, e.g. by having unrealistic expectations. For those people, an attitude adjustment is a good idea, as it will make them both happier and more successful.

      --


      I don't care if it's 90,000 hectares. That lake was not my doing.
    9. Re:Ignore your problems. by lxs · · Score: 4, Insightful

      I'm sorry if that post came over as flippant, because depression is a problem I do take seriously. At least it got your attention.

      First off, the judgment of terrible is yours, not mine. I merely stated that it's a bloody miracle that a bunch of monkeys has figured out farming, poetry and mathematics and that we shouldn't be too hard on ourselves for not being perfect rational creatures living in Star Trek Utopia.

      Secondly, making happiness a habit does work in practice, and has done for centuries. Buddhism and Stoicism have long traditions in this kind of thought. There is that line from Hamlet: There is nothing good or bad but thinking makes it so.

      This isn't a quick and single simple change, it takes years of practice and you'll have frequent relapses into hopelessness, but it does start with a simple change of perspective.
      Act depressed and you'll feel depressed. Act happy and eventually you'll be happy.

    10. Re:Ignore your problems. by theshowmecanuck · · Score: 1

      He/she is obviously a 'glass is half empty' kind of person, reading negativity into everything. On the bright said, the study said this could be a survival trait.

      --
      -- I ignore anonymous replies to my comments and postings.
    11. Re:Ignore your problems. by Nephandus · · Score: 5, Insightful

      Circular argument and intentional selection bias. "Success" there requires constant redefinition to fit whatever the fuck happens. It's both a no true Scotsman fallacy and changing the goalposts. When the "positive" wacko misses something, he pulls a doublethink and redefines his supposed values such that his altered goals arbitrarily fit whatever he happen to hit, so he "succeeded" to hit his completely redefined target. Being unhappy because you're not mindfucked into wanting whatever garbage you're stuck with isn't "no good purpose". Just because your values are lies your constantly rewrite to fit arbitrary conditions doesn't make everyone else's values as utterly meaningless as yours are. Some of us actually value what we value. Shocking, I know...

      --
      "A soft answer turneth away wrath. Once wrath is looking the other way, shoot it in the head."
    12. Re:Ignore your problems. by nospam007 · · Score: 1

      "A negative outlook, on the other hand, is a habit, and like any bad habit, it can be recognized as such and changed."

      The article says exactly otherwise, it's genetic, willpower is about as effective there as if you wanted to change the size of your dick.
      So nothing you do can change the demotivators at work who continue to depress everybody around them with their bleak view of the world.
      Unless a DNA-test is developed so that you can hire only happy people.

    13. Re:Ignore your problems. by Nephandus · · Score: 1

      It's not PC, entertaining to the soft-headed escapist majority (those are related...), and doesn't line snake-oil salesmen like Seligman's pockets.

      --
      "A soft answer turneth away wrath. Once wrath is looking the other way, shoot it in the head."
    14. Re:Ignore your problems. by Anonymous Coward · · Score: 1

      Sounds an awful alot like this

      "Stress is the resulting syndrom coming from the surpression of the brain's natural desire to choak the living shit out of idiots"

    15. Re:Ignore your problems. by Anonymous Coward · · Score: 0

      The general philosophical term "realist" is just an antonym of solipsist; i.e. someone who believes the world exists

      It is a bit more subtle than that.

      Philosophical realism means that "universals" (forms/ideas in Plato's sense, or abstract notions) exist.

      It means that we (for example) discover mathematical truths, rather than invent them.

      A realist is never a solipsist, but one does not necessarily have to be a realist to not be a solipsist.

    16. Re:Ignore your problems. by Anonymous Coward · · Score: 2, Interesting

      Actually willpower, nutrition, physical activity, etc. may change gene expression to turn it on and off. DNA is not a static structure.
      For instance, go search for: gene expression dna meditation

      THAT is reality, not the fiction that DNA is interpreted one and only one way, and there's nothing we can do about it.
      A little knowledge is dangerous.

    17. Re:Ignore your problems. by Anonymous Coward · · Score: 0

      Dykman et al. argue that, although depressive people make more accurate judgments about having no control in situations where in fact they have no control, they also believe they have no control when in fact they do; and so their perceptions are not more accurate overall.[20]

      Essentially it's like flipping a coin and always calling Tails. You're going to be right 50% of the time. If you only look at the Tails results and see what they guessed they'll appear to be right 100% of the time. You need to look at the overall picture to see how (in)accurate they really are.

    18. Re:Ignore your problems. by Anonymous Coward · · Score: 1

      Actually, the size of one's dick is quite variable, both in its erect and flaccid state, depending on one's mental state.

    19. Re:Ignore your problems. by Anonymous Coward · · Score: 1

      The "chemical imbalance" thing is only one of many multiple signs of depression. It's not the "cause" of depression.
      Our brain changes its chemistry all the time in different states, and in the depressed state there are certain chemical patterns, but do not mistake the chemical state of the brain with its causes.

      All emotions map to some chemical consequences in the brain. For positive ones, when we rejoice, love, or laugh, you get endorphins releases. You will be able to monitor a state of increased endorphins levels in happy people, but that's a consequence of happiness, not a cause.

    20. Re:Ignore your problems. by Anonymous Coward · · Score: 0

      Yeah the headline could have also said:

      Allowing yourself to become engrossed in worldly items, disables you from counting the bodies.

      Anyone that tells me that I'm a Debbie downer always gets told the same thing, "Show me the good news". Of course I'm getting through life with minimum amounts of money, after all I'm a minimalist. I'm only happy when I get to spend my time living, rather than paying bills. I went to a wedding last night that probably cost around $350,000. All of those people seemed really happy with the way things are going. I was looking at the flower arrangements at each table (maybe there were 200 tables), and guessed that each table had $500 worth of flowers.

      I think that rather than looking at DNA, they could look at how much money folks have. Poor people have a way of cringing when the rich are shitting on them. And looking out into the world, it looks like a lot of rich people overlook the bad things in the world, to keep their feeling of peace.

      Ironically, the wedding was held by the owners of a company that assesses damages for insurance companies, ha!

    21. Re:Ignore your problems. by Samantha+Wright · · Score: 1

      No, it's not that narrow; materialist realism, for example, can exist entirely without supporting any notions considered idealist. (And I guess the other AC is right about solipsism.) The point is that it's just believing something is real, it's not about having a tempered perspective.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    22. Re:Ignore your problems. by Man+On+Pink+Corner · · Score: 1

      After all, reality has a well-known negative bias.

    23. Re:Ignore your problems. by Will.Woodhull · · Score: 1

      There is probably an evolutionary benefit to the dour outlook in some cultures.

      The young Viking who looks at a longboat with eyes that see the possibility of the sail tearing loose, or cordage breaking, or a half-rotted stave giving way is much more likely to have more children than his same age cousin, who sees a pretty ship that will take him to wonderfully rich and interesting places. This negativity is reflected in the Asatrurar myths and stories, which generally have unpleasant endings.

      But in other parts of the world individuals did not have to deal with the same kinds of technological risks on a daily basis. Floods and famines happen, but while devastating those did not present the same kind of daily individual risks that drive evolution. If the plow breaks, then most likely it can be fixed before anyone dies of hunger.

      An interesting hypothesis is that this dark gene will be found to be more common among peoples whose ancestors' daily lives depended on keeping the technology in good repair. Such as Scandinavians, the Inuit and other Arctic Circle peoples, South Pacific groups that depended on fishing boats, the Mongolian tribes that need high tech clothing and shelters to make it from day to day, etc. A pessimistic outlook has a lot of survival value for peoples who are relying on technology to keep them alive.

      It should be noted in passing that persons with this dark gene are likely to write software that has fewer bugs and does a better job at handling corner cases. However in this profession the genetics of nerd behavior are also at play so the probability of any procreative activity is very low.

      --
      Will
    24. Re:Ignore your problems. by Will.Woodhull · · Score: 2

      Depression is a chemical imbalance in the brain caused by a disorder in mentation, and should not be trivialized.

      FTFY.

      Drugs are not the answer. As a group, the "antidepressive" drugs cause more problems than they help, and do not cure anything, but merely hide some of the symptoms. This group also contains some of the worst truly addictive drugs available by prescription or illegally. They are over-prescribed, because it is so much easier to pop a pill than to deal with the depression itself.

      --
      Will
    25. Re:Ignore your problems. by Anonymous Coward · · Score: 0

      Pessimists are not realists. Pessimists are, by definition, people who have a distorted view of reality where bad things take on greater importance just because it's bad. Optimists and pessimists distort reality in the same way, just in opposite directions. If you have to choose, there is abundant evidence that optimists get better objective results than pessimists, in addition to leading happier lives. Realists suffer from the delusion that they have an unbiased view of the world, which isn't actually possible. You decide what is important - the facts never make that decision for you. You can focus on bad things or good things. There is no fact of the matter about which one is correct. Pessimist versus optimist is not facts versus fantasy, it's a free choice about what you choose to focus on. The optimists are ahead by getting better objective results, but there is nothing fundamentally wrong about either stance - neither stance is more out of touch with reality than the other.

    26. Re:Ignore your problems. by DrLang21 · · Score: 1

      There's nothing wrong with seeing the bad and the good. There is something wrong with consistently overblowing the bad and ignoring the good.

      --
      I see the glass as full with a FoS of 2.
    27. Re:Ignore your problems. by dlingman · · Score: 1

      Your glass is half empty? Let me top that up for you... You've already finished 1/2 your drink - why would you be sad?

    28. Re:Ignore your problems. by theshowmecanuck · · Score: 1

      Me? I just think the glass is too big. Get me a smaller glass and it will be full.

      --
      -- I ignore anonymous replies to my comments and postings.
    29. Re:Ignore your problems. by Anonymous Coward · · Score: 0

      I find your ideas intriguing, but I don't want to subscribe to your newsletter.

    30. Re:Ignore your problems. by hazah · · Score: 1

      Already you are wrong. You will NOT be right 50% of the time. You will have a 50% chance of being right on every coin toss! For instance, what if you flip the coin ONLY ONE TIME? Will you get 50% heads and 50% tails, or, more likely, will you get 100% of one or the other?

  2. first by Anonymous Coward · · Score: 1, Interesting

    beta.slashdot.org = vomit

    1. Re:first by AdamStarks · · Score: 1

      On the bright side, at least one of your statements is true!

  3. Theres a gene for everything now by AvderTheTerrible · · Score: 0

    A gene that makes me see things negatively? This explains SO MUCH. Please tell me they are working on a way to toggle it off. Just once I'd like to not instinctively see the negative in everything.

    1. Re:Theres a gene for everything now by Anonymous Coward · · Score: 1

      The article says that it is believed that nearly half of caucasians have the gene (and, I guess, express it), so nothing terribly new.

      The experiment apparently only shows that those with the gene remember "negative" words better than those who don't, when both are showed a combination of positive, neutral and negative words. So hardly seems like worth-shattering material.

    2. Re:Theres a gene for everything now by Samantha+Wright · · Score: 4, Interesting

      Not a gene—just a mutation. Perplexingly, there is a drug that blocks the receptor in question, but it's for treating sexual dysfunction. Possibly a goldmine for witty remarks.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    3. Re:Theres a gene for everything now by Anonymous Coward · · Score: 1

      Ahh, so all this research is just another marketing gimmick, disguised as science, to sell more drugs.

      There I go again, looking at the dark side of everything.

      Maybe this gene is supposed to help us find the truth since the truth is so often negative. What we need now are a bunch of happy pills to make us all optimistic and naive little sheep.

    4. Re:Theres a gene for everything now by Samantha+Wright · · Score: 4, Interesting

      Well, no, obviously not; even at the most pessimistic extreme, you'd have to convince a lot of cynics just like yourself that thinking negatively is necessarily a bad thing and that they should shell out biggish bucks to fix it. That's not exactly going to happen, now is it? :)

      Realistically, the utility of understanding this gene variant and producing pharmaceutical remedies is in helping people with clinical depression break down barriers—people so cynical and miserable that they can't function normally. Yohimbine is currently prescribed to people already on antidepressants, though, so I would tend to guess it either doesn't address the effects of the mutation, or fixing it doesn't affect much once you're already on an SSRI.

      That all being said, I do agree with you that cynicism can have its advantages—I have an ongoing hypothesis that childhood isolation and depression encourage the development of independent reasoning skills and hence improve intelligence, although it's a bit untestable still. I was inclined to proposition earlier that perhaps this allele has a meaningful relationship with the development of Western civilization, but that line of inquest gets very Social-Darwinist-sounding very quickly, and isn't exactly a great conversation piece. The reason for this is that as many as 50% of Caucasians are believed to have this allele (much more than other populations), so either it's completely meaningless in the long term and just happened by chance, or it conferred some relevant advantage.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    5. Re:Theres a gene for everything now by Anonymous Coward · · Score: 0

      Meehl, Paul E. (1967). "Theory-Testing in Psychology and Physics: A Methodological Paradox". Philosophy of Science 34 (2): 103–115.

    6. Re:Theres a gene for everything now by sumdumass · · Score: 1

      Ha.. I can see that working. If I concentrated in all the negative I could see in my sexual partners I likely would have problems performing too.

      How much do you wanna bet that this will be the new ADHD type illness that schools rush to have children treated for. I can see it now, a school without goth.. and a lot more promiscuous kids.

    7. Re:Theres a gene for everything now by Anonymous Coward · · Score: 0

      Possibly a goldmine for witty remarks.

      I've been hard at work trying to come up with one, but, really, what's the point?

    8. Re:Theres a gene for everything now by Samantha+Wright · · Score: 1

      Actually, sexual dysfunction is usually about seeing negatives in oneself, not one's partners.

      Personally, I'd like to believe that parents would be too cynical to prescribe anti-cynicism drugs to their kids, but that logic might be a little too convenient to be reality.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    9. Re:Theres a gene for everything now by Anonymous Coward · · Score: 0

      a school without goth.. and a lot more promiscuous kids.

      Sounds like paradise to me.

    10. Re:Theres a gene for everything now by FireFury03 · · Score: 1

      Not a gene—just a mutation. Perplexingly, there is a drug that blocks the receptor in question, but it's for treating sexual dysfunction. Possibly a goldmine for witty remarks.

      Interestingly, selective serotinin reuptake inhibitors (antidepressants) are already used to treat premature ejaculation. As you can imagine, that particular side effect is annoying to people who just want it to fix their depression.

    11. Re:Theres a gene for everything now by Anonymous Coward · · Score: 0

      Search online for: gene expression dna meditation

      Meditation is just one of gazillion ways, but I'd actually recommend yoga as a path, not as a gym practice though.

    12. Re:Theres a gene for everything now by Anonymous Coward · · Score: 0

      What is the point of personal responsibility if everything is genetic and deterministic? Why have a judiciary? Why have civilization? Whither Holocene? This is why responsibility is ASSIGNED and not assumed.

      Now it is time for the Fucking Psychopath® to inject a Judeo-Christian worldview into this cesspool of [space + time + matter + energy + chance] forum to make those whose walls are plastered with plaques to waste mod points.

    13. Re:Theres a gene for everything now by Anonymous Coward · · Score: 0

      Be careful now, before you know it you'll have karma issues for expressing politically incorrect concepts like creation, fall, redemption and consummation.

      Remember, we are all divine expressed in fragments and what the blue-eyed hyper-Abrahamic bigots call SIN is nothing but a tool of oppressing those expressing dominant traits.

    14. Re:Theres a gene for everything now by Anonymous Coward · · Score: 0

      66 That all being said, I do agree with you that cynicism can have its advantages—I have an ongoing hypothesis that childhood isolation and depression encourage the development of independent reasoning skills and hence improve intelligence, although it's a bit untestable still. I was inclined to proposition earlier that perhaps this allele has a meaningful relationship with the development of Western civilization, but that line of inquest gets very Social-Darwinist-sounding very quickly, and isn't exactly a great conversation piece. The reason for this is that as many as 50% of Caucasians are believed to have this allele (much more than other populations), so either it's completely meaningless in the long term and just happened by chance, or it conferred some relevant advantage. 99

      Has anyone come up with a more sublime expression of racism?

    15. Re:Theres a gene for everything now by russotto · · Score: 1

      Well, no, obviously not; even at the most pessimistic extreme, you'd have to convince a lot of cynics just like yourself that thinking negatively is necessarily a bad thing and that they should shell out biggish bucks to fix it.

      Of course not. Cynicism is what you get after optimism smacks into the shoals of reality for the Nth time, provided you have this gene variant. If you have the other gene variant, you remain positive no matter how often your optimism fails.

    16. Re:Theres a gene for everything now by oji-sama · · Score: 1

      Based on some people I know, I would say that if you have this gene variant you remain negative no matter how often your pessimism fails. But perhaps I'm just being negative. ^.^

      --
      It is what it is.
    17. Re:Theres a gene for everything now by russotto · · Score: 1

      Based on some people I know, I would say that if you have this gene variant you remain negative no matter how often your pessimism fails.

      Pessimism's typical failure is that the worst-case failure mode you imagined wasn't bad enough. Of course THAT makes you remain negative.

      On the rare occasions when things turn out better than you expected, it's never long before the reduced pessimism engendered by that event causes you to get bit in the butt again. After THAT happens more than a few times, THEN you become insensitive to success.

    18. Re:Theres a gene for everything now by Samantha+Wright · · Score: 1

      And yet Yohimbine is prescribed when SSRIs cause sexual dysfunction. It seems a lot of drugs cause random sex drive side effects; Ritalin can either increase or decrease libido, too.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    19. Re:Theres a gene for everything now by FireFury03 · · Score: 1

      And yet Yohimbine is prescribed when SSRIs cause sexual dysfunction. It seems a lot of drugs cause random sex drive side effects; Ritalin can either increase or decrease libido, too.

      Notably if you read the side effects list of a lot of drugs, the listed side effects often include the thing they are supposed to treat (my favorite is antidepressants listing "depression, anxiety and suicide" as a side effect).

    20. Re:Theres a gene for everything now by Samantha+Wright · · Score: 2

      The modern anthropological view is that it doesn't matter. The success of one population does not invalidate the history of another, just like with environmental conservationism. The fundamental problem with scientific racism is that being the pinnacle of evolution is impossible; leading civilization today is no guarantee you'll be leading it tomorrow—and not the only way to live a happy life anyway. It is perhaps no surprise that a lot of Americans in particular, poisoned by centuries of pressure to conform to the stereotype of the omnipotent entrepreneur, have trouble grasping this.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    21. Re:Theres a gene for everything now by Samantha+Wright · · Score: 2

      Welcome to the wild world of pharmacogenomics. Brain drugs depend on such subtle and variable parts of our genomes that they have a very high chance of backfiring. Antidepressants are particularly awful at this, which is extra-horrific because they take months of side-effects before they actually do the job. Thus there's a lot of money in personalized medicine—a quick test can potentially prevent a toxic reaction or putting a depressive person through years of agony as the therapist tries increasingly expensive antidepressants.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    22. Re:Theres a gene for everything now by Samantha+Wright · · Score: 1

      ADRA2b is probably much more subtle in its effect than that, although we don't have hard numbers for everyday discouragements.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    23. Re:Theres a gene for everything now by TapeCutter · · Score: 1

      Zoloft + alcohol = a fucked up, suicidal personality. I've seen 5 families wrecked over the last 10yrs, 2 ended up in jail. I've also seen Zoloft help people but none of those were drinkers. Alcohol lowers inhibition, Zoloft lowers anxiety. You need some anxiety to tell yourself that what your doing is potentially wrong/dangerous, you need some inhibitions to stop you from compulsively acting out every thought. A good doctor knows all this and will train his patients to self-monitor their anxiety levels while on the drug, sadly far too many try to make it "go away" with a script.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    24. Re:Theres a gene for everything now by TapeCutter · · Score: 1

      This is why responsibility is ASSIGNED and not assumed.

      Personal responsibility: The act of ASSIGNING responsibility to one's self. Now it is time for you to inject a thesaurus into your bookshelf.

      BTW: The "deterministic" universe at our scale is built on a foundation of perfect randomness, "reality" is a probability curve that in practice can only be calculated by watching it happen. The subtle paradox about perfect randomness is that perfect randomness has a predictable behaviour. Mind predictably emerges from matter like cyclones predictably emerge from tropical seas, they are both specific patterns in matter that survive for fleeting moments and then dissipate. There is no point to it, you are free to impose your own meaning, if you have one.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
  4. What about the gene by Anonymous Coward · · Score: 0

    that causes individuals to always post 'Correlation != Causation" in response to stories about research studies?

    BTW the whole thing sucks.

  5. At first blush... by Quinn_Inuit · · Score: 1

    It might be tempting to say that everyone would be better off if they had this gene expressed in moderation, but I don't think it's quite so simple. Civilizations are no more than breaths in the life of our species, and we have no reason to believe living conditions in ten thousand years will be much like they are now. An appropriate expression of this gene for our current situation might be inappropriate later, so I recommend against removing this variation from our species. Like the variations preserved in the last wild wheat that still lives in forgotten corners of Ethiopia, strange copies or expressions of this gene might be vital against some threat we can't even conceive today.

    --

    Stop learning! Only you can prevent esoterrorism.
    1. Re:At first blush... by Samantha+Wright · · Score: 2

      You mean gene variant, not gene. if you lost ADRA2B, you would die. All healthy humans have more or less the same genes.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    2. Re:At first blush... by Ambassador+Kosh · · Score: 4, Interesting

      I like identifying this stuff, quantifying it and maybe even finding temporary ways to control how it works. However I would not recommend actually permanently changing it.

      It is strange because some of this research I don't really want reported to the general public because they don't have the scientific understanding for it but they are willing to leap to an idea and demand it be done. There are some genes that seem likely to be tied to male homosexuality however those same genes are also tied to female fertility. I have seen some people talking about how we should "cure" homosexuals by fixing that gene. What I worry about is that a group could get enough power to try and actually do that. The problem is that we could also end up sterilizing people treated which could be catastrophically bad.

      I just see so many people as misusing research to further their own ideological ends. We need to do this research, we need to understand why stuff happens. We need to know why as a mother has more male children epigenetic markers get set on further male children to change gene expression. There is a LOT we can learn from that. I just don't want to see that research abused. I wish we could get rid of this idiotic idea of XX=female, XY = male. Gender and sex are NOT even close to that simple.

      --
      Computer modeling for biotech drug manufacturing is HARD! :)
    3. Re:At first blush... by Quinn_Inuit · · Score: 1

      Good point. Thanks for the correction.

      --

      Stop learning! Only you can prevent esoterrorism.
    4. Re:At first blush... by muridae · · Score: 4, Informative

      I wish we could get rid of this idiotic idea of XX=female, XY = male. Gender and sex are NOT even close to that simple.

      It would be nice if people could understand that. Or at least understand that XY genotypes can be born expressing a female phenotype, and vice versa; but getting the general populace to believe anything that goes against what they were taught in school is very tough to do. "If it's that complicated, why don't they teach that?" I've actually heard that, as if a high school advance placement A&P or an on level biology course could get through all of that in less than one term. Sure, it makes Punnett squares easy to understand and relate to personal knowledge, but it's so far from right that it needs to just be tossed out of high school classes completely. "23X0, XXY, XYY, AIS, Turner's Syndrome, and lots of other combinations just make teaching simple 2 gene human expression too difficult. There are so many possible mutations of the genes involved, too many ways for multiple genes to combine like discussed about Down's Syndrome, and too many external genes that also influence human sex and gender (and expression of both and sexuality as well) for it to ever be discussed in the simplified manner needed at the high school level."

      Unfortunately, even spelling it out in mostly small words like that doesn't often work. Even getting them to understand that X and Y were picked not because of the shape of the chromosome, which all look like an X during mitosis, but because they were common 'unknowns' in math. When biologists need a new set, they continued with W and Z. "Wiki doesn't say that," results in my face meeting the nearest wall repeatedly, because a facepalm just isn't a strong enough reaction.

    5. Re:At first blush... by Anonymous Coward · · Score: 0

      I wish we could get rid of this idiotic idea of XX=female, XY = male. Gender and sex are NOT even close to that simple.

      Right. There are upwards of 0.2% of people who don't follow that pattern. The (supposedly) technically savvy group at /. can't consistently distinguish "they're" from "their" or "lose" from "loose," and you want the general populace to embrace exceptions that happen like Pick-3 winners? Science helps us understand the world, in large part by simplifying it so ordinary mortals can follow it. Or did you think that Hook's Law describes the actual mechanics of springs?

      I'd suggest a better course would be for rare disease/disorder researchers to get some perspective on the scale of their topic.

    6. Re:At first blush... by Velex · · Score: 1

      Which genes are related to female bisexuality? Can we start a selective breeding campaign?

      Fine, I troll, I troll! I see the point you're making. I wish more people would think this stuff through more thoroughly. There has to be a reason why pessimism and homosexuality don't breed themselves out.

      --
      Join the Slashcott! Stay away entirely Feb 10 thru Feb 17! Close all tabs to prevent autorefresh!
    7. Re:At first blush... by Anonymous Coward · · Score: 0

      Yeah, my first thought was, "Great, now they're going to start looking for a 'cure'." People will start talking about how positivity helps us lead happier and more productive lives, but really that's just what stupid happy productive people tell themselves to make themselves feel better.

      Pessimism and negativity and being unhappy make you feel bad, but that doesn't mean that they don't have their uses. Society needs to have critics who sit back and complain.

    8. Re:At first blush... by PattyMc · · Score: 2

      I agree we have to be on the look out for Unintended Consequences. What if we cured bipolar disorder, alcoholism and depression and the milder forms of autism? Would the only art we made be ala Sleeper - Rod McKuen and Walter Keane? I was diagnosed as BPII over 50 years ago. I always drew and painted and my pieces were quite good, an outlet. Ever since menopause and early retirement (stressful job in advertising) I have been sane and have not done one damn thing artistically. Maybe if people could slip in an out or just keep the good parts but I fear a total cure via gene manipulation or whatever tech applies in the future will make us Eloi.

  6. Here come the internet attention whores by Mr.+Freeman · · Score: 4, Insightful

    This is going to be the newest thing that every special little snowflake on the internet self-diagnoses with in order to get some attention. It's the next OCD.

    --
    -1 disagree is not a modifier for a reason. -1 troll, flaimbait, redundant, overrated are NOT acceptable substitutes.
    1. Re:Here come the internet attention whores by Black+Parrot · · Score: 4, Funny

      I had it first!

      --
      Sheesh, evil *and* a jerk. -- Jade
    2. Re:Here come the internet attention whores by Samantha+Wright · · Score: 1

      From TFA:

      [...] it is believed more than half of Caucasians have ADRA2b [...]

      So, y'know. You might have it. The noted effects are minor, but highly certain (p < 0.001 on ANOVA).

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    3. Re:Here come the internet attention whores by ArsonSmith · · Score: 1

      I see what you did there.

      --
      Paying taxes to buy civilization is like paying a hooker to buy love.
    4. Re:Here come the internet attention whores by obtuse · · Score: 1

      And your attitude demonstrates what a special snowflake you think that you are. Troll.

      --
      Assembly is the reverse of disassembly.
    5. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      A p value is the probability of getting a result given the null hypothesis is true. You have just interpreted it as the probability the alternative hypothesis is true, which is the fallacy of transposing the conditional.

    6. Re:Here come the internet attention whores by NoNonAlphaCharsHere · · Score: 1

      Sounds like an effete corps of impudent snobs who characterize themselves as intellectuals.

    7. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      I had it second! Now the rest of you, just follow the line unless you feel too special for that which you obviously do and then something terrible happens, again.

    8. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      So you're saying they did the wrong research, they should really identify the attention-whore gene and be done with it.

    9. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      I had it first!

      THIS IS RIDICULOUS BECAUSE I HAD IT FIRST! I was diagnosed even before they discovered this mutation! I've been suffering my whole life with Nattering Nabobs of Negativity. Now I know I am predisposed to being a jerk. Finally someone understands my disability. I hope the government can support me so I don't have to work. Now get off my lawn!

    10. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      Like your post does? Negativity, check. Internet attention whoring blog post, check.

    11. Re:Here come the internet attention whores by muridae · · Score: 1

      You must know a lot about those.

    12. Re:Here come the internet attention whores by Samantha+Wright · · Score: 1

      I find your level of pedantry staggering, and probably better-utilized in professional arenas where it has an actual impact of changing something. What are you trying to actually say? That you have no faith in their ability to control for confounding variables, and that I'm a bad person for believing they did?

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    13. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      You obviously didn't. My christian name is ADRA2b.

    14. Re:Here come the internet attention whores by NoNonAlphaCharsHere · · Score: 1

      Whoosh.


      On a related note, anybody else having flashbacks from the old Mrs. Agnew's Diary column?

    15. Re:Here come the internet attention whores by muridae · · Score: 1

      not at all, just playing my post so you could continue further if you wanted. Sometimes a good gag just needs a straight man to continue, guess your's didn't. Would a gay one have been better?

      And no, most of the Lampoon stuff was from before my time. The little I've found and read were not enough to cause flashbacks. Now, if I had only been on proper 70's medication, maybe the flashbacks would be more vivid.

    16. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      I had it first!

      Patient Zero identified. We've gotta take him out for the good of the species.

    17. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      I find your level of pedantry staggering

      That's rich, coming from someone who argues about the difference between having a gene for X and having a gene *variant* for X.

    18. Re:Here come the internet attention whores by AmiMoJo · · Score: 1

      When a new problem like this is discovered there are is always a large number of diagnosis that then tail off over time, simply because before it was known people could not be diagnosed with it.

      I expect this will happen to me a couple of times in my life. I have Reiter's Syndrome, which is basically a name given to a bunch of symptoms that are vaguely auto-immune related but very poorly understood. One day someone will figure out the root cause and I'll get a new diagnosis, and hopefully treatment.

      Similar I also suffer from Chronic Fatigue, a relatively new problem in that it didn't used to be well recognised or accepted. Again, what causes it is not well understood but there is some research being done, and eventually people with it will get a new diagnosis.

      When these new diagnoses come in I expect there will be similar comments to yours - look at all the medically illiterate idiots claiming to have it. Well, before you judge them consider that many of them might have been diagnosed by a real doctor and now have some real hope of treatment.

      --
      const int one = 65536; (Silvermoon, Texture.cs)
      SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
    19. Re:Here come the internet attention whores by Samantha+Wright · · Score: 1

      That's simply a lack of education on your part—genes are whole programs that define a mutation, and gene variants are a polite way of referring to very common mutations found in those programs. Popular science writing is profoundly inaccurate when it conflates the two, since humans generally have very few differences in what genes they actually possess.

      On the other hand, when I say a study's rejection of the null hypothesis shows strong support for the alternative hypothesis, that simply means I have confidence there are no plausible alternative hypotheses that might better explain the dataset. No abuses of terminology are made and nothing inaccurate has been said. If you would like to present evidence that their controls were inadequate, by all means do so; otherwise you're attacking the validity of their research without basis.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    20. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      Your misinterpretation of a p value is similarly due to lack of education. It is not pedantry to point it out. The last 50 or so years of science is messed up due to people misunderstanding p values because they underly so many decisions made and conclusions drawn. Then once some claim makes it into the literature and gets established based off this the publication bias keeps it going for decades. Honestly who knows what is true coming out of science these days.

      Good science:
      Have theory that predicts specific outcomes. If specific outcomes are not observed then adjust theory. Very unlikely a bad theory will be consistent with precise data or easily adjusted.
      P-value science:
      Have theory that predicts either positive or negative effect, use p value to tell you the chance there is exactly 0 effect. There is a 50% a priori chance some confound will cause your results to be consistent with the theory. The only thing that matters is sample size and precision of measurement which are both functions of how much money and effort you spend. Rich get richer phenomenon ensues.

    21. Re:Here come the internet attention whores by Samantha+Wright · · Score: 1

      Forgive me, but I can't see any practical implications of your reasoning that aren't merely a question of whether or not the controls used were adequate, which I already brought up. Specific outcomes can't be predicted until a complete underlying model has been built, which is impossible until well after an initial statistical survey has been conducted even in relatively simple single-gene cases. With something as complicated as the whole human brain, which is by far the most complex scientific endeavour we have ever undertaken as a civilization, carefully-controlled studies are a valuable tool in helping us get pointed in the right direction.

      The unfortunate economic consequences are somewhat mitigated through consortia of smaller institutions and the existence of merit-based grants. Keep in mind grants have been around forever, and have always functioned to make science funding more egalitarian; unequal distribution of wealth is not exactly a new problem.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    22. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      A p value (as normally used) only tells you the probability of getting the result given the effect exactly equals 0 and the various assumptions of the stats test are true. The effect is never exactly zero (and if it was there will always be some confound not 100% controlled for) and the assumptions are always false to some extent, therefore calculating a pvalue is a highly misleading and only gets in the way of researchers analyzing their data and designing better experiments that would lead to us building an underlying model in the future.

      The practical implication is to stop with the averages, stop with the pvalues, plot the data, and independently replicate experiments so that we can see the distributions and compare them.

    23. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      Fuck you. It's like being born with armor against swindlers and infra-vision that paints a tainted glow around corruption. Now hire me.

    24. Re:Here come the internet attention whores by Samantha+Wright · · Score: 1

      Compare them how? Sorry, but I think you just made an argument for a paired Student's t-test. That doesn't get away from your p-value phobia at all.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    25. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      Compare by looking at the shape of the distribution to see if it is consistent and reliable results. The t test looks only at averages. Look I don't care if people like to compare averages, but if this prevents them from showing me the distribution of results and replicating studies because "its been done before" then they are preventing scientific progress. Something is preventing researchers from doing that, I am attributing it to misinterpreting p values.

      I will tell you as someone who has tried to come up with a "underlying theory", that studies only reporting averages and direction of effects are totally worthless, depend more on who performed the study than anything else, and will get ignored by those who wish to come up with underlying theories. Yes this is 99% of what has been published in the last 20 years in biology and medicine.

    26. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      Please try out this:
      http://www.stat.duke.edu/~berger/applet2/pvalue.html

      James Berger is also a name to know.

    27. Re:Here come the internet attention whores by Samantha+Wright · · Score: 1

      What you're describing is a paired difference test. The paired t-test that I suggested is an example of such. It's a little fancier than just comparing averages; in fact, all t-tests also compare variance.

      I can't believe I have to spell it out for you, but paired tests are not possible when studying the effects of a gene in a population. You can't just mutate targeted genes in people and expect results; we don't have the technology, and even if we did, it would be profoundly unethical to use in a double-blind trial. All that leaves you with are the statistical properties of the distribution, which is invariably mound-shaped and a little lumpy. There's not much to look at that isn't described by the variance and the mean.

      Even if you did have a way to force people to use a super-powerful method for comparing the exact shapes of two distributions, such as the Kolmogorov-Smirnov test, which does indeed return an exact value, the most important result would still be the confidence metric that results from the test.

      And as I understand it, it's generally best practice when discovering the underlying mechanism for something to cite all of the studies that either support or conflict with your conclusions, and then explain why the conflicting studies are wrong. Otherwise people will just shake their heads at you and say there's a ton of evidence that you're wrong.

      --
      Bio questions? Ask me to start a Q&A journal. Computer analogies available for most topics!
    28. Re:Here come the internet attention whores by Anonymous Coward · · Score: 0

      I am not talking about using any significance tests. They all share the same problem of giving misleading and unreliable results as described multiple times in this thread. Please stop.

      1) Do a study once. Make a plot of the individual results so all can see the shape and location of the distribution
      2) Replicate the study in an independent lab. Make a plot of the individual results so all can see the shape and location of the distribution.

      3) Compare the two distribution locations and shapes using your mind and considering possible sources of systemic bias. If you would like to use a statistical test to help you good, if not that is fine to. Relying solely on the stats test is bad.
      4) Judge whether the results have been replicated and can be deemed reliable enough to incorporate into an underlying theory.

  7. Of course by Anonymous Coward · · Score: 0

    I've probably got about five of those.

  8. Well by Anonymous Coward · · Score: 0

    This sucks

  9. And this is a problem how? by Anonymous Coward · · Score: 0

    I wouldn't want a professor that's all positive about the subject their teaching about, better a negative teacher with perspective than an airhead that can only smile and wink...

    This is called evolution, and why it's relevant to average people is beyond me "unless you want to modify people into become yes-men"

    1. Re:And this is a problem how? by Anonymous Coward · · Score: 0

      and BTW, the world would suck if everyone had perfect genes.

    2. Re:And this is a problem how? by Hal_Porter · · Score: 1

      Nonsense. People would dress well in Hugo Boss uniforms and ze trains would run on time.

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
  10. At least lets look at the bright side by Anonymous Coward · · Score: 0

    Great, there is no bright side.

  11. Pessimism by Anonymous Coward · · Score: 0

    is not a disease to be cured.

    1. Re:Pessimism by hoboroadie · · Score: 1

      I get a lot of crap for my comments. I always thought it was Socratic analysis, but I've noticed it does seem instinctual.

      --
      They feared that it could be used to suppress protest or support unpopular rule.
  12. BS by Anonymous Coward · · Score: 0

    This is just all made up crap from the right.

    Why can't they leave things alone?

    The left is always making shit up like this!

  13. Researchers now searching for by Anonymous Coward · · Score: 0

    gene which causes unquestioning blind obedience to the idiots in charge.

    1. Re:Researchers now searching for by Anonymous Coward · · Score: 0

      gene which causes unquestioning blind obedience to the idiots in charge.

      That gene has already been found.

      The name of the gene is : Br+Cr1, which is an abbreviated version of "bread and circuses 1".

    2. Re:Researchers now searching for by muridae · · Score: 2

      If you are going to troll in a biology thread, at least go back to the roots of the phrase for the abbreviation? Latin "Panem et circenses" PAeCR1 would at least look like a real gene or protein pathway. Maybe a neuron condition that causes blind following of those one agrees with? But...oh gods, that would mean you would be expressing that gene too!

  14. The horror, the horror ... by Anonymous Coward · · Score: 0

    And now if you will excuse me I have some severed heads I need to
    mount on fence posts ...

  15. gene causes individuals to perceive negative side by Alsee · · Score: 3, Funny

    Well that sucks.

    -

    --
    - - You can't take something off the Internet! That's like trying to take pee out of a swimming pool.
  16. Talking in cliches by Kohath · · Score: 1

    Is there a gene variant for always having to express ideas in terns of cliches, idioms, colloquialisms, metaphors, and/or pop-culture references?

    1. Re:Talking in cliches by PPH · · Score: 1

      I'll bet you dollars to donuts that there is.

      --
      Have gnu, will travel.
    2. Re:Talking in cliches by Anonymous Coward · · Score: 0

      Mmmmm... Donuts...

    3. Re:Talking in cliches by Anonymous Coward · · Score: 0

      Would it have "Sheldon" in the name somewhere?

  17. The gene for Software Testing by Btrot69 · · Score: 2

    It's probably the gene that makes me really good at software testing. I have a knack for zeroing in on whatever is screwed up ;)

    1. Re:The gene for Software Testing by PolygamousRanchKid+ · · Score: 3, Interesting

      It certainly makes a better programmer. Having a negative attitude makes you assume every statement is going to throw an exception sooner than later, so you become obsessive compulsive about handling exceptions. As opposed to other programmers who just toss them and let others deal with them. Or catch and swallow them with an empty TODO comment clause.

      So you end up sitting in design meetings thinking about what can go wrong in a system instead of cheering on how great the design is with the other folks. Unfortunately, I'm the only person in the world who thinks that a new design should be scrubbed with a thorough wash of toxic pessimism.

      Hey, what doesn't kill a design, makes it stronger.

      --
      Schroedinger's Brexit: The UK is both in and out of the EU at the same time!
    2. Re:The gene for Software Testing by russotto · · Score: 1

      It's probably the gene that makes me really good at software testing. I have a knack for zeroing in on whatever is screwed up ;)

      No, that's a different one. Because software developers have the opposite version, even total pessimists; problems which are reproducible when we aren't around vanish when we are. It's the "works on my machine" gene.

    3. Re:The gene for Software Testing by Anonymous Coward · · Score: 0

      That's why others get the stuff done and the OCD guy never gets promoted...

  18. Gene Variant Causes Rosetinted Worldwiew by Anonymous Coward · · Score: 0

    "Researchers from the University of British Columbia, Cornell University and Toronto's Centre for Addiction and Mental Health report in the journal Psychological Science [abstract; press release] that lack of a gene variant can cause individuals to perceive the unrealistically positive side of every situation. UBC Prof. Rebecca Todd said lack of the ADRA2b deletion variant influences not only poorer emotional memory, which was previously known, but also amplifies a person's real-time perception of events, for better or for worse. 'Some individuals are predisposed to see the world more darkly than others,' Todd said. 'What we found is that a previously known genetic variation causes some individuals to perceive the world more vividly than others and, particularly, negative aspects of the world.' Everyone else suffers from ignoring negative aspects, believing in the health benefits of unicorn poop, enjoying Justin Bieber, believing whatever they're told can't possibly be that bad, cherishing lies like ‘it will all work out in the end’ and ‘make love not war’, and voting for touchy-feely criminal terror-pedo-politicians hiding behind vapid ideological promises and in particular socialism."

    And if anyone disagrees they can now say I have a genetic disorder, how swell; it's better than the racism card!

    [only mildly sarcastic] Someone needs to fire the nukes already, come on Skynet I dare you! (Unless you have a better solution; I'm fine with that). [end mild sarcasm]

  19. > Gene Variant Can Cause Nattering Nabobs of Negativity

    What makes the opposite gene so special? Fuck those Bloviating Brownnosers of Buttkissing.

    --
    (-1: Post disagrees with my already-settled worldview) is not a valid mod option.
  20. The gene pool by dutchwhizzman · · Score: 3, Funny

    The gene pool is half empty!

    --
    I was promised a flying car. Where is my flying car?
    1. Re:The gene pool by Okian+Warrior · · Score: 1

      The gene pool is half empty!

      No, the gene pool is twice as big as it needs to be.

  21. No good can come of this by Doh! · · Score: 1

    I probably have this gene. I doubt they'll be able to find a cure for it. Even if they did, I'm sure I wouldn't be able to afford it. There'll probably be some horrible side effects, too—there always are. Bummer...

    1. Re:No good can come of this by Anonymous Coward · · Score: 0

      No, don't worry: your negativity is rational, not genetic.

  22. Nattering Nabob by Anonymous Coward · · Score: 0

    I thought this was an article about Ubuntu.

  23. Ubuntu? by Anonymous Coward · · Score: 0

    Nattering Nabob of Negativity

    Sounds like the codename of an Ubuntu distribution.

    1. Re:Ubuntu? by Swave+An+deBwoner · · Score: 1

      Actually, a reference to a former US vice president:

      Agnew was known for his scathing criticisms of political opponents, especially journalists and anti-war activists. Emulating the "blistering blue barnacles" verbal style of Tintin's Captain Haddock with striking similarity, Agnew attacked his adversaries with relish, hurling unusual, often alliterative epithets, some of which were coined by White House speechwriters William Safire and Pat Buchanan, including "pusillanimous pussyfooters," "nattering nabobs of negativism" (written by Safire) and "hopeless, hysterical hypochondriacs of history."

      http://en.wikipedia.org/wiki/Spiro_Agnew

  24. Alternative explanation by Anonymous Coward · · Score: 0

    An alternative explanation might be that the world is actually an extremely negative place.
    Just one critical piece of alternate information blows this theory right out of the water.
    Wouldn't the first diligence in such "research" be to determine whether the world is actually an inherently positive or negative place?

    Typical pseudo-psychological claptrap that is more-or-less the norm from the pseudo-psychology-science (wow, am I negative!?)

  25. Found the elusive gene for Sanity by Anonymous Coward · · Score: 0

    It allows people to see the world in it's true light. The rest of the world seems to be under the false delusion that there is some hope and meaning out there. Some people are just weak. They are unable to take on the world in all it's horror. For them to survive they must create a dream world where everything is 'all right'.

  26. What does this gibberish mean? by mark_reh · · Score: 1

    'Some individuals are predisposed to see the world more darkly than others,' Todd said. 'What we found is that a previously known genetic variation causes some individuals to perceive the world more vividly than others and, particularly, negative aspects of the world.'"

    1. Re: What does this gibberish mean? by Imaman · · Score: 2

      It means that depressed/cynical/apathetic people may have a gene that enables them to see the world more clearly.
      It makes some of us think.
      I just realized why I've been unable to ignore our path straight towards Idiocracy (the planet won't survive, but our path is clear).

    2. Re: What does this gibberish mean? by Baldorcete · · Score: 1

      Don't worry, the planet will survive just OK for a few thousands of millions years more. The human racem otherwise...

  27. Pharma Marketing by Anonymous Coward · · Score: 0

    Depression is a mental disorder caused by a chemical imbalance in the brain, ...

    No. Nobody knows what causes depression and neither does anyone know why anti-depressants work. Researchers are going batty trying to figure out why anti-depressants work on some people - many times, anti-depressants are no more effective than exercise or talk therapy and in some cases actually do worse. YMMV and talk to your doc.

    The whole "depression is caused by a chemical imbalance in the brain" was pretty much made up by the pharmaceutical industry to sell drugs.

  28. Why does positive thinking work? by Cryacin · · Score: 1

    You walk up to a giant impassable wall, and from a distance, it cannot be done. It cannot be scaled, it cannot be undermined. Realists and pessimists turn around and try to find another way. Those who worry less get closer, and notice the small gap that can't be seen from a distance, and can walk right through.

    --
    Science advances one funeral at a time- Max Planck
    1. Re:Why does positive thinking work? by malkavian · · Score: 2

      A realist will examine it properly, and notice that there's a small gap (and thus take that, as it's more efficient). If the gap isn't there, they'll look for a way round..
      In your analogy, the people who are the "positive" adjusted ones will quite possibly spend the time until they starve to death or die of thirst looking for that small gap "that must be there, just near here", while the realist acknowledges that there's something insurmountable, so routes round it.

    2. Re:Why does positive thinking work? by FatdogHaiku · · Score: 2

      I always liked this quote of George Bernard Shaw:
      "The reasonable man adapts himself to the world: the unreasonable one persists in trying to adapt the world to himself. Therefore all progress depends on the unreasonable man."

      --
      You have the right to remain sentient. If you give up the right to remain sentient, you will be elected to public office
    3. Re:Why does positive thinking work? by Mikkeles · · Score: 1

      ... for some perverse definition of progress :(

      --
      Great minds think alike; fools seldom differ.
    4. Re:Why does positive thinking work? by Anonymous Coward · · Score: 0

      It's the same reason most inventions are done by the young. 'Cuase experience gets in the way of blindly trying out the ``impossible'' and realizing that it actually works. That experience is correct in 99.9999% of situations, but that just means one in a million "idiots" who tries the impossible gets super lucky...and manages to run a multibillion dollar corporation at age 20 or something.

    5. Re:Why does positive thinking work? by hairyfish · · Score: 1

      Through the process of evolution, progress comes through in the end. It doesn't matter how many Bush's or Obama's we have leading us down the garden path, every now and again you get a Jefferson or a Lincoln which gives a net gain.

  29. Happiness Hypothesis - The American Perfect Strom by transporter_ii · · Score: 1

    Anyone interested in this should get a copy of the Happiness Hypothesis, by Jonathan Haidt. If a good thing happens and a similar bad thing happens, most people remember the bad thing. In fact, it takes something way better to happen to cancel out a run-of-the-mill bad thing.

    I think this is why people are preppers and are stockpiling guns and ammo. And, it's why zombie movies are all the rage. America is in a perfect storm for all of it to happen. Why? Because our crazy American worldview mixed with our religious beliefs. It's a dangerous combination when the future doesn't look real bright anyway, but now you think it is inevitable that we are in the End Times.

    Throw in a federal government that can't stop printing money, a large number of blockbuster movies about The End, the guy standing at the front of the church telling you it was foreordained, and mix it with America, which isn't hinged real well to begin with, and what do you get? The crazies that we are.

    I don't think we are going to find the answer to our problems in a pill. It's consumed us. We take 3/4ths of the world's pills here in America. How well has it worked for us?

    ALL HOPE IS LOST. :)

    I see the world totally different after reading this book, though: The Happiness Hypothesis: Finding Modern Truth in Ancient Wisdom by Jonathan Haidt

    Life is what *you* make it.

    --
    Doctors destroy health, lawyers destroy justice, universities destroy knowledge, religion destroys spirituality
  30. Re:Happiness Hypothesis - The American Perfect Str by transporter_ii · · Score: 1

    A PBS series described it like this:

    For bad things, it's like your brain and bad things have Velcro on each other, and everything bad thrown at the brain sticks. And for good things, it is like our brains are coated in Teflon; everything good thrown at it slides right off.

    --
    Doctors destroy health, lawyers destroy justice, universities destroy knowledge, religion destroys spirituality
  31. Re:Happiness Hypothesis - The American Perfect Str by iggymanz · · Score: 1

    Nothing wrong with being a "prepper",that just means being prepared for disasters. Look what happens each and every time there is a power outage or big storm, people mob stores looking for bottled water, ice, flashlights and batteries, etc. Sometimes people in that situation get a little rude and rough with each other too 8D

    Happened in my town a month ago, but I wasn't at the store with the mob scene, I was home relaxing because I already had stocked up for *nothing in particular*, but I grew up in an area that flooded every couple years and power was out. You'll notice even the federal govenment a couple years back started a campaign to tell people to at least be prepared for three days of no water, no grocery stores, no power, etc.

    It's not foolish to be a "prepper", shit happens. Be a prepper, stock up on some bottled water, dry food / canned goods (and can opener, the preppers most important tool!), first aid kit, camping stove, kerosene heater or wood for the fireplace. The once in a while use and rotate the perishables.

    Couldn't hurt and might help.....

  32. a realist can be a solipsist by Anonymous Coward · · Score: 0

    A realist most certainly can be a solipsist, he just has to believe that he is the only thing that is real. And what could be a more natural belief for a solipsist than that?

  33. And joke for us older /.ers by Anonymous Coward · · Score: 0

    Finally! Some (ag)news we can kick around!

  34. What a pessimist? by ebno-10db · · Score: 1

    A pessimist is what an optimist calls a realist.

  35. religions rejoice! by Anonymous Coward · · Score: 0

    so there IS a fundamental ethical-phlogiston embedded into the universe. the genes have a direct link to this "field" of good and bad ...

  36. 23andme? by jo7hs2 · · Score: 1

    Anybody knows if this is a location tested by 23andme (or Ancestry)? I've got results from several providers and I'd be curious to see my results, as I'm a fairly negative person.

    1. Re:23andme? by koan · · Score: 1

      Seeing the negative doesn't make you negative.

      --
      "If any question why we died, Tell them because our fathers lied."
    2. Re:23andme? by Senescent+Nerd · · Score: 1

      http://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRA2B&snp=99 lists 99 SNPs in the ADRA2B gene. The following 8 of these SNPs also appear in my 23andMe results: rs3813662 rs29000571 rs4907299 rs2229169 rs29000569 rs4426564 rs28932482 rs35053873 . The available abstract doesn't say where on the gene the deletion mutation occurs, so I can't tell which of these SNPs is closest to it. (I would expect that a deletion mutation would never be a SNP.) Since they're all pretty close together, any one of them would be very likely to track the mutation over many generations.

  37. Re:Happiness Hypothesis - The American Perfect Str by swb · · Score: 1

    My sense is that the best things to have are water and food.

    I figure if I can make fresh water, the food situation will solve itself as after about a month as the people who can't get fresh water will die off or become noncompetitive with illness.

  38. Realism by PPH · · Score: 1

    The consequences of a missed positive opportunity are far less harmful than those of a negative one. I can afford to miss the occasional babe who smiles at me as a come-on. The crazy jealous boyfriend standing behind her carrying the Bowie knife I notice.

    --
    Have gnu, will travel.
    1. Re:Realism by russotto · · Score: 1

      The consequences of a missed positive opportunity are far less harmful than those of a negative one. I can afford to miss the occasional babe who smiles at me as a come-on.

      The realist realizes she's smiling at the much better looking guy behind you.

  39. So by koan · · Score: 2

    It's the reality gene.

    --
    "If any question why we died, Tell them because our fathers lied."
  40. "I'm allergic to bullshit." by johnny0099 · · Score: 1

    Is there a pill for that?

    --
    Get your dogma outta my yard!
  41. Not Science by Anonymous Coward · · Score: 0

    Sorry but too many of these statistical studies are being presented to the public as "SCIENCE" but the old saw about causation and correlation applies: Do these quasi-scientists (they might have science degrees but they seem to belong in the accounting department) understand exactly how genes work and how cells process genes? Obviously not (else they would be capable of creating "designer" life forms). If you do not absolutely know how genes do what they do and how cells do everything they do, then you do not understand the mechanisms. Not understanding the mechanisms means you do not actually know what the latest magical gene at the center of your latest published paper does (or does not) - so you are actually only announcing that you *think* this particular thing causes some particular thing that seems to statistically correlate. This is going to be like the "lazy gene", the "fat gene", the "gay gene", the "shy gene" etc. Which is to say that certain political activist groups will grab onto it as justification for/against some group/policy, and some government/academic institutions will shovel some research money into it (as the paper's authors are no-doubt hoping) and within a couple of months nobody will remember it (the money will have been handed-out of course.....) Five years from now, nobody will remember it and it will have contributed nothing of value to the store of human knowledge (but it will still be there as residue on the internet to be mined by future bloggers who need scraps of "evidence" for their positions on this or that argument over this or that largely-unrelated political fight)

    We have been giving out too many degrees, too easily, to too many sloppy people who's other agendas are bigger than their academic ethics.

    1. Re:Not Science by marcosdumay · · Score: 1

      but the old saw about causation and correlation applies

      Are you saying that negative (or realistic, whatever) world view may cause a gene to appear?

  42. The Software Tester Gene Found by nixkuroi · · Score: 1

    The downside is... Hmmm, I guess I don't have it.

  43. Spiro Agnew by Anonymous Coward · · Score: 0

    There, SOMEONE had to say it!

  44. That's only part of the answer... by Anonymous Coward · · Score: 0

    This so called gene variant directly relates to the metabolic system, specifically the Cytochrome P450 system, so the negativity is transitory due to the inability to metabolize xenobiotic substances in a timely manner, this is what triggers the negativity, and if the offending "triggers" are removed, eventually the xenobiotic substances will metabolize and the negativity goes away.

  45. Variant Gene by Anonymous Coward · · Score: 0

    These finding will come to no good end.

  46. Re:Happiness Hypothesis - The American Perfect Str by volmtech · · Score: 1

    I'm sure you do things "just in case". As the EBT glitch shows our access to food can be interrupted. Or it could be a windstorm or flood. A months stockpile of food is prudent. I hope I never need any of the 2000 rounds of 9mm and .30 cal I have. I m 61 years old. I have found out if you are ready for trouble, it rarely happens.

  47. What's in a name? by BigTalker · · Score: 1

    I suppose this won't be known as Eeyore's Syndrome. Never mind, it doesn't matter anyway. Nobody cares.

  48. obvious post by gzuckier · · Score: 1

    And how many /. commenters did they have to test before concluding this?

    --
    Star Trek transporters are just 3d printers.
  49. Chemical imbalance myth by UpnAtom · · Score: 1

    "Depression is a mental disorder caused by a chemical imbalance in the brain"

    No, that's an explanation made up by pharmaceutical companies to sell £tens of billions of ineffective drugs to the most vulnerable people in society.

    http://news.bbc.co.uk/1/hi/health/8138893.stm

  50. Re:Happiness Hypothesis - The American Perfect Str by UpnAtom · · Score: 1

    Not quite. Negative things can stick around whether we want them to or not. There's no such rule for positive things.

    I will be explaining why in a book.