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Century-Old Drug Reverses Signs of Autism In Mice
sciencehabit writes: A single dose of a century-old drug has eliminated autism symptoms in adult mice with an experimental form of the disorder. Originally developed to treat African sleeping sickness, the compound, called suramin, quells a heightened stress response in neurons that researchers believe may underlie some traits of autism. The finding raises the hope that some hallmarks of the disorder may not be permanent, but could be correctable even in adulthood.
Any idea what will be at this domain when its entire userbase is cured?
I like to increase symptoms of autism using Adderall.
Whether I'm lashing out at my peers, or mumbling and shaking uncontrollably, Adderall is my go-to drug for augmenting autism!
It's no wonder so many parents shove this medication down their throats!
When it comes to Autism, I like to turn it up to 11 and RIP THE NOB OFF!
Gaining a drug's approval by the Food and Drug Administration in the US — and similar government agencies in other countries — is a very expensive process. The expense is normally offset for by the patent(s) granted to the pharmaceutical company, that developed the drug, which make it an exclusive maker/seller of the medicine for decades.
However, if the drug is long-known — and only needs an approval for new application — who will undertake to pay for the approval, if there is no way to patent it and the approval will allow all drug-makers (both domestic and foreign) to put their own versions on the market?
In Soviet Washington the swamp drains you.
How about people?
If something is so important that you feel the need to post it on the internet... It probably isn't that important.
As someone with Aspergers Syndrome this would be a godsend for me. There are many times where my adrenaline level is far above what is needed for the situation. It is extremely frustrating when most of my body is in full fight/flight response and there is a small voice in the back of my head saying "chill out dude, it's not that important". The problem is that the adrenal response usually overrides the cognitive response and bad things happen.
I just hope it does not impact the good things about autism such as the heightened ability to find and keep track of details.
provided it works on people (which is a big if, given that mice can't be autistic; they can only either exhibit behavior that when displayed in a human would be considered autistic, or otherwise have brain structures similar to those of people with autism. Also keep in mind that neural correlates of anything, though, are still rather tricky in contemporary neuroscience), I would take it if it alleviated the symptoms I experience negatively. If it would reduce the stress and anxiety I experience simply being around people or in about fifteen other situations, I would take it in a heartbeat. If it stopped me from enjoying the things I enjoy to the extent that I enjoy them, I would never take it. But maybe that's obvious.
If it let me correctly interpret what other people are thinking I would also take it.
Okay, it's not neurotypical... but so fucking what?
Can people just not fucking embrace the fact that every individual is unique and special, and stop trying to hunt for ways make every child born today into a carbon-copy of some theoretical "normal", when in actuality, that doesn't even exist in the first place?
File under 'M' for 'Manic ranting'
There is a greater than 50% chance of adrenal cortical damage, but only a smaller proportion will require lifelong corticosteroid replacement.
http://en.wikipedia.org/wiki/Suramin
Ask not what big pharama can do for you, ask what you can do for big pharma, said Kohn F Jennedy, don't ever forget that.
sed -e 's/Chuck Norris/Rajnikant/g' joke > fact
n/t
Build it, and they will come^Hplain.
the chill pill will actually be able to be taken.
in the form of a vaccine?
basically.. selfish gene richard dawkins meets the origin of life? I think autism might be caused by a mild brain damage within science. Humbug!
Also, I read it as Saruman... is there a cure for dyslexia?
Let me know when Dr. Oz (TM) gives it his approval as a miracle cure (TM).
The guy is a fraud. He has found 16 weight loss miracles so far:
http://www.forbes.com/sites/ro...
You might think that the first 5 miracles would suffice.
Funny enough the supporters of "deaf culture" made the same noise as cochlear implants became more common. And the same thing will happen to the "autism rights" imbeciles that is now happening to the "deaf culture" ones--slow but sure annihilation. Good riddance, I say.
"Politicians and diapers must be changed often, and for the same reason."
I was diagnosed by a psychologist and expert in Autism and Asperger's Syndrome. I actually get a tax deduction due to it.
I know there are a few other Slashdot readers with a professional diagnosis of AS. What country gives out such tax deductions?
It seems divided:
1) Aspies mostly believes self-diagnosis is OK, even when properly diagnosed by professionals. That's probably the way they took the first step towards diagnosis after all. However, not everybody wants to be "tagged", for some future culling (history being the only evidence you need for that).
2) Non-aspies thinks illogical thoughts as usual, lacking insight, intuition and reality-checks. However, they DO excel at patting eachother's backs and dissing everyone who is "different". Same old, same old.
How anyone can be jealous on aspies are beyond me. If we're lucky we can socialize, but get very "hot" in the head quickly, and it always drains us of energy. In the worse cases, aspies can hardly function socially at all, as well as in life even.
Btw, someone who self-diagnose are probably way more introspective and insightful than someone accepting any external advice without any discrimination and verification, and thus more mentally and physically healthy as a result.
People need to eat to live, and people need to get a job to eat. I've found that not enough employers understand how to make the most of an employee with noticeable autism symptoms.
I control my adrenaline response with propranolol. Totally gets rid of that 0-60 in .5 seconds response to irritants that I used to have. I'm pretty mellow most of the time now.
There's a good chance you are correct, but don't wrap your life around it. This is evidence based on mice, and people are significantly different. Many things that work on mice don't work on people.
Also, it's not certain that it would have precisely the effect that you are hoping for. It *might*.
That said, check out the side effects of suramin, and *if* they aren't too bad you might see if you can get a doctor to prescribe some for "off label" use. Your insurance probably won't pay, but the patents have probably expired, so it might well be cheap enough to afford.
I think we've pushed this "anyone can grow up to be president" thing too far.
In the United States, my Asperger's diagnosis qualified me for vocational rehabilitation services from the state of Indiana, mostly assistance with job placement and interviews. But I'm not aware of any sort of tax deduction for having an impairment unless the impairment is severe enough to make the person unable to engage in "substantial gainful activity". Unless an individual is blind, the SSA defines SGA as an income close to the current poverty level.
Want to do a fun activity? Close your eyes and count to ten. By the time you get to 2, someone will have magically pulled a renewed 100 year old patent out of their ass so they can collect royalties and make it cost $1000 a dose instead of $10. Yay medical patents!
Why fucking bother with the goddamned autistitards?
Why not let natural selection take its course instead?
GO AHEAD FUCKING FLAME AWAY OR
WASTE YOUR GODDAMNED MODPOINTS
FUCKTARDED SHITDOT SHEEPLE!!!!
to the millions of dollars spent on advertising a new drug?
... it is revealed the cure for Autism is pure, undiluted Thimerosal.
When will we get a drug that cures bitchiness?
Now that would be a hit.
Comment removed based on user account deletion
Not the original poster, but here you go...
What aspects of autism predispose to talent?
http://www.ncbi.nlm.nih.gov/pu...
Talent in autism: hyper-systemizing, hyper-attention to detail and sensory hypersensitivity
http://www.ncbi.nlm.nih.gov/pu...
Enhanced perception in savant syndrome: patterns, structure and creativity.
http://www.ncbi.nlm.nih.gov/pu...
The savant syndrome: intellectual impairment and exceptional skill.
http://www.ncbi.nlm.nih.gov/pu...
Comparing the intelligence profiles of savant and nonsavant individuals with autistic disorder
http://www.sciencedirect.com/s...
So basically you are profiting off of the disabled. Opportunist indeed. You sicken me.
The Obama party obviously. Everything is his fault!
Corrected? I dont need to be corrected. Please correct the insensitive non-autists you insensitive cloth. No more drama or you-cant-sing shows, no more toiletpaper rolls placed incorrectly, no more garbage on the street, no more ill designed tabloid covers, no more people crossing the street when its red, perfect order and symetry everywhere. I'm ready!
I agree why bother. .. they'll outsmart, outperform and outbreed the non-autists anyway. Nature will run its course, natural selection ftw!
Autists dont need to be corrected
Unless these non-autists get themselves corrected by medicine ofcourse..
Hivemind harvest in progress..
http://en.wikipedia.org/wiki/Suramin
"...but only a smaller proportion will require lifelong corticosteroid replacement."
Well that is reassuring.
Another one of these drugs is NAC (n-acetylcystein) which is sold as an OTC expectorant in some countries (not in the US for some reason):
http://www.ncbi.nlm.nih.gov/pu...
I had always misinterpreted the term "helicopter parenting" to mean the exact opposite of what it means: To me the thing that characterizes a helicopter is the fact that it can land and take off at arbitrary places... So I assumed that this mean a parent who drops in on their child (out of the blue) and then disappears... i.e. intermittent parenting. But apparently people think that helicopters can hover in one place for long periods of time and use it to mean the opposite - a parent who hangs around / hovers around their child too much. I have never gotten used to the term... It just strikes me as the wrong way to think about helicopters :)
Same... when I first heard the term I thought it was similar in meaning to "Seagull manager", but for parents. It does make sense when you see parents hanging around like a news chopper over a house fire, though.
Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
Kirk: Damn it, Bones, you're a doctor. You know that pain and guilt can't be taken away with a wave of a magic wand. They're the things we carry with us, the things that make us who we are. If we lose them, we lose ourselves. I don't want my pain taken away! I need my pain!
If you don't risk failure you don't risk success.
"Like children with autism, the mice born after these pregnancies were less social and did not seek novelty; they avoided unfamiliar mice and passed up the chance to explore new runs of a maze. In the 2013 paper, the researchers reported that these traits vanished after weekly injections of suramin begun when the mice were 6 weeks old (equivalent to 15-year-old humans)." Those are autism traits? Seems more like those are basic survival traits. Right? I mean you wouldn't want your kid hanging out with strangers and checking out every dark alley they come across.
Finally the world will get rid of this horrible plague of mouse autism!!
-- 29A the number of the Beast
This goes to show limitations in the mouse-specific experimental form of autism more than it ever gets used by humans.
I agree why bother. .. they'll outsmart, outperform and outbreed the non-autists anyway. Nature will run its course, natural selection ftw!
Autists dont need to be corrected
Unless these non-autists get themselves corrected by medicine ofcourse..
If you mean as in outsmart and outperform in ways such as focusing all their attention on one part of an object resulting in weird sights such as spinning the wheel on a toy car over 9000 times? Then by all fucking means you have me. Face it, autistitards like Adam Lanza are worthless and are very stupid. When their obsessions, much like that autistitard Adam Lanza, turn to guns and violence then they become very dangerous. The autistitard gene needs to be weeded from the gene pool.