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Biohackers Are Engineering Yeast To Make THC

meghan elizabeth writes How do you get weed without the weed? By genetically engineering yeast to produce THC, of course. Once theorized in a stoner magazine column more than a decade ago, a biotech startup working in Ireland is actively trying to transplant the genetic information that codes for both THC and another cannabinoid called CBD into yeast so that "marijuana" can be grown in a lab—no plants necessary.

9 of 159 comments (clear)

  1. "Biohackers" by dugancent · · Score: 4, Insightful

    In my lab, we call them scientists (or chemist, biologist, etc).

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  2. Re:Holy grey area! by Anonymous Coward · · Score: 4, Insightful

    If it's legal it won't be for long. Two points:

    1) Most likely the yeast bodies will have trace amounts of THC.
    2) Look at what happened with Psilocybin, the spores of the mushrooms contain no Psilocybin however the mushrooms do. You used to be able to order the spores legally because there were no psychoactive chemicals however they are now also on the DEA schedule.

    So .. no.

  3. Re:Holy grey area! by Alien7 · · Score: 5, Informative

    Provided you make a warning against doing just that it's okay. During alcohol prohibition breweries used to sell malt extract with a warning that went something like "don't add water and yeast and leave in a dark room for 3 weeks, it will make alcohol and that's illegal!"

  4. Whoa by SpankiMonki · · Score: 3, Informative

    Dude, we are totally gonna get baked.

  5. Re:Need fast-acting yeast by bill_mcgonigle · · Score: 4, Insightful

    They better act fast if they want to skirt the law with yeast, while there's still a law to break.

    It's still a good idea if you want pure chemicals - yeast can produce chemicals faster (to both grow and purify) than plants. Companies like the one Gov. Johnson is heading up would probably be very interested as a supply source for their refined products.

    The trick is medicinal cannabis has something like 250 active compounds. A few years ago everybody assumed that it was only THC that did anything (marinol, for instance). Now they know that CBD is the most active medicinally and Johnson is now talking about CBG as well. There's still more unknown about the others than there is known, so focusing on just a couple pure chemicals might miss out on benefits. Human bodies do a lot of signalling with various cannabinoids and here's this one plant that happens to also grow most of them. It should be a biotech bonanza, except for the crapitalistic reasons politicians try to keep it off the market.

    But, um, yeah, get high on THC beer if you want. It would actually probably be a net-benefit for society since people will be satisfied with being less drunk. As a user of the road monopoly, I'd strongly support THC beer on the market.

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  6. I've been calling for this for 20+ years... by jeffb+(2.718) · · Score: 4, Funny

    Actually, I've been calling for someone to graft the THC-production complex into kudzu. That way, either we get government help to wipe it out, or the government finally gives up; either way, kudzu becomes useful for something.

    Of course, I don't have much deep knowledge about GM or plant biology, so coming up with this idea was about on a par with saying "somebody ought to build a flying car". Here's hoping that the task these folks are tackling turns out more tractable than that one.

  7. Re:Holy grey area! by newcastlejon · · Score: 5, Funny

    So, in other words, what you're saying is that bread bakes you?

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  8. No wouldnt be fun at all by Anonymous Coward · · Score: 3, Interesting

    With only THC and none of the other cannabinoids all you are just going to get is very anxious and very paranoid and I doubt anybody wants that. We discover something new about the endocannabinoid system almost every day. If you expose yourselves to chronic high levels of THC alone you are going to find some of those receptors downregulated retarding the action of GABA. Cannabidiol (CBD) is essential, it is a weak cannabinoid receptor antagonist/agonist the role depends on dose concentration and is highly anxiolytic. Trust me you want it.

  9. Re:Need fast-acting yeast by garyebickford · · Score: 3, Informative

    Minor point - IIRC weed was targeted by William Randolph Hearst back in the 20s. Hearst owned the largest newspaper chain in the US, and had bought the global rights to the new method for making paper out of wood. His goal was to eliminate hemp as a fiber source for paper. He set up a huge tree plantation in Guyana (or thereabouts) and began a major attack on weed. He began a publicity campaign in his papers about the evils of weed, funded the making of "Reefer Madness", and lobbied and bribed congresscritters to include weed in the Volstead Act as a dangerous drug.

    At that time hemp, which is a slightly different variety of cannabis, was a major source of quality fiber for rope as well as paper (and still better than any other vegetable fiber AFAIK). The hemp growing industry was destroyed. But even today, cannabis is a major 'weed' throughout the midwest, and is a primary source of seeds for birds.

    Once when motorcycling around the wilds of Illinois we came upon a large tract - probably 40 acres - of hemp, complete with a set of beehives. I have no idea if this was just fallow land or being grown on purpose. We came back with a car and collected one 14 foot plant for a Christmas tree in the dorm. The branches were two feet apart. Smoking was tried, it was pretty much smoking a rope.

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