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Human Clinical Trials To Begin On Drug That Reverses Diabetes In Animal Models
Zothecula writes: A study at the University of Alabama at Birmingham has shown that verapamil, a drug widely used to treat high blood pressure, irregular heartbeat and migraine headaches, is able to completely reverse diabetes in animal models. The UAB team will now move onto clinical trials to see if the same results are repeated in humans.
....moderation?
Get rid of corn subsidies and watch your obesity/diabestes epidemic grind to a halt.
What is the difference between an animal model and an animal used in scientific experimentation?
now I can be as fat as I want!
Are they talking about type 1 diabetes (lack of insulin production) or type 2 diabetes (insulin resistance)? I suspect it's type 2 because fixing a pancreas that's not producing insulin would be quite difficult if not impossible.
If the drug is already in use (for other purposes), wouldn't we be able to see its effects on people already?
Incidentally, I have type 2 diabetes and my body/mass index is exactly where it should be, I'm not overweight and never have been. It doesn't just affect big people.
Never email donotemail@WeAreSpammers.com
I believe it skips having to redo some of the regulatory requirements - they don't have to test it for safety - so they can get straight to the "does this actually work in humans?" test, which is what they're looking for people for. You /might/ be able to find some diabetics already on it and do some studies on that information as well, but this way is more controllable.
It's the type you're born with, not the type from too much corn syrup. Keep yer snark to yourselves until you read the fucking article.
.
There's all sorts of causes of Type 2. Some like me have a pancreas kicking out less insulin.. it's called type 1.5 and it's considered type 2.
type 1.5 with less insulin sensitivity. crap.. I'll take it since gliburide gets my glucose in the normal zone.
6 liters of soda and half a dozen bacon cheeseburgers aren't on the pyramid you fat fuck.
Clearly you don't understand how the disorder works.
You can't 'cure' type I diabetes. Pancreatic transplants are the closest thing we currently have, and they are subject to the same trouble that the native pancreas suffers - destruction of the beta islet cells due to an autoimmune response.
I'm starting to think GNU is the problem with "GNU/Linux" these days.
This isn't a "cure" per say, as you'd still have to take verapamil on a daily basis. You'd just be replacing one drug (insulin) with another (verapamil). You'd need less insulin though, and the verapamil will probably help regulate glucose levels more closely. I'm sure verapamil comes with a nice list of side effects of it's own though.
As someone with Type 1, I really want to be hopeful about this.....but it seems like we've been 5 years away from a cure for the last 30 years now.
If you post as Anonymous Coward, don't expect a reply.
How does the food pyramid exactly cause type I diabetes?
6 liters of soda and half a dozen bacon cheeseburgers aren't on the pyramid you fat fuck.
Ah, but cereals and breads are you, dumb shit. They're essentially sugar in a different form. Eating those, regardless of type of diabetes, is bad for you yet the government recommends the same amount regardless of your condition. A cheeseburger without a bun has less impact on a type ii diabetic than bread.
Why not just find a bunch of diabetics with HBP who have been taking this drug and see if they really still have diabetes?
Except that people with pancreas transplants, due to them have a "TRANSPLANTED ORGAN" in their body from someone else have to take immune suppressing drugs for life to prevent organ rejection. Due to this fact the auto-immune condition subsides because they have oppressed their immune system.
Also realize that when you take immune suppressing drugs you SERIOUSLY increase your chance of getting cancer and having other problems. Living with a transplanted organ != a cure.
Get rid of corn subsidies and watch your obesity/diabestes epidemic grind to a halt.
I'm the OP and I'm really surprised the notion of corn subsides is even remotely controvertial on a site like this -- ??
I'd like to find a person that adheres to a strict vegan diet devoid of GMOs (corn being the primary offender) that suffers from diabetes. I doubt such a person exists, but I'm willing to entertain the idea of a 300+ lb. diabetic vegan if anyone can provide evidence to the contrary.
Short answer:
It doesn't but it is bound to happen in an operation this large.
There is actually not a consensus on what a healthy, well balanced diet is exactly.
Never forget mr_mischief,
"One man's meat is another man's poison."
The food pyramid does not cause type 1 or type 2 directly, but individuals with latent susceptibility have to know about the condition and do specific things to counter the risk. Also , take into consideration, even if someone does eat according to the food pyramid, do they really comply with it?
https://www.drfuhrman.com/dise... ... With proper care, a type 1 diabetic can live a long and healthy life, with almost no risk of heart attack, stroke, or complications. Type 1 diabetics need not feel doomed to a life of medical disasters and a possible early death. With a truly health-supporting Nutritarian lifestyle, even the Type 1 diabetic can have the potential for a disease-free life and a better than average life expectancy. I find that when Type 1 diabetics adopt my high-nutrient dietary approach, they reduce their insulin requirements by at least one half. They protect their body against the heart attack promoting effects of the American diet style. They no longer have swings of highs and lows, their weight remains stable, and their glucose levels and lipids stay under excellent control. Even though the Type 1 diabetic will still require exogenous (external) insulin, they will no longer need excessive amounts of it. Remember, it is not the Type 1 diabetes that is so damaging, it is the SAD, the typical dietary advice given to Type 1s and the excessive amounts of insulin required by the SAD that are so harmful. It is simply essential for all Type 1 diabetics to learn and adopt nutritional excellence; they can use much less insulin, achieve a normal, healthy lifespan and dramatically reduce their risk of complications later in life."
https://www.drfuhrman.com/libr...
"Treating Type 1, Type 2, and Gestational Diabetes with Superior Nutrition
An important aspect is getting enough micronutrients and fiber, which were not mentioned in your post (but you may well do).
He also has a book out on it:
http://www.drfuhrman.com/shop/...
"This New York Times best seller offers a scientifically proven, practical program to prevent and reverse [type 2] diabetes -- without drugs. Diabetes does not have to shorten your life span or result in high blood pressure, heart disease, kidney failure, blindness or other life-threatening ailments. In fact, most type 2 diabetics can get off medication and become 100 percent healthy in just a few simple steps. This book offers no compromises, it is the most aggressive and effective approach to reverse obesity, high blood pressure, high cholesterol, and heart disease; which typically accompany type 2 diabetes. The information about Type 1 diabetes is simply life saving. It is a must read for every diabetic, as well as any nutritionally-aware person wanting to understand the failure of conventional medical care for diabetic treatments and the "no-brainer" of using nutritional excellence, not drugs."
Another aspect of this may be gut bacteria. You don't drink diet soda by any chance?
http://www.prevention.com/heal...
http://www.npr.org/blogs/thesa...
Ongoing research on vitamin D deficiency and diabetes:
http://www.nih.gov/news/health...
BTW, in general, I've heard that exercise, while good for our health, does not help with weight loss because we just eat more afterwards to make up for it. What controls weight in the long term is what we eat, especially micronutrients and fiber, but also good fats and some other things.
Anyway, thanks for the informative post! Glad you found an approach that works for you. Good luck. I helped manage my mother's diabetes for a time (including for a time after my father died giving her injections three times a day and monitoring blood glucose with finger sticks four times a day) and it was not easy (she had dementia and could not do it herself, and even denied she had diabetes sometimes). As you point ou
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
But human models suffer from anorexia.
"Get rid of corn subsidies and watch your obesity/diabestes epidemic grind to a halt."
http://www.seriouseats.com/200...
"The Physicians Committee for Responsible Medicine has posted an easy-to-understand visual on its site that shows which foods U.S. tax dollars go to support under the nation's farm bill. It's titled "Why Does a Salad Cost More Than a Big Mac?" and depicts two pyramids -- subsidized foods and the old recommended food pyramid. It's interesting to note that the two are almost inversely proportional to each other."
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
Slashdot may usually be progressive technologically (sometimes even too progressive in some ways), but it can be backward/conservative in other ways (especially regurgitating mainstream medicine's party line, which is why your amusing-to-me over-generalization got modded flamebait). Obviously, there is still a lot of variety here, so this is just an observation on trends...
A couple things on that tangent: ... ..."
http://www.disciplined-minds.c...
http://www.nytimes.com/2010/09...
"They say they believe in freedom and share our values. They say a few bad apples shouldn't bring down judgment on their entire kind. Don't be fooled. Though they walk among us with impunity, they are, in the words of Henry Farrell, a political scientist at George Washington University, "a group that is notoriously associated with terrorist violence and fundamentalist political beliefs."
They are engineers.
Farrell, of course, was kidding. He posted that comment on a blog shortly after Umar Farouk Abdulmutallab (confessed Al Qaeda operative and engineering student) tried to blow up an airliner over Detroit last winter. But the satire was rooted in a statistical fact: in the ranks of captured and confessed terrorists, engineers and engineering students are significantly overrepresented. Maybe that's a numerological accident. The sociologist Diego Gambetta and the political scientist Steffen Hertog don't think so.
Gambetta and Hertog found engineers only in right-wing groups -- the ones that claim to fight for the pious past of Islamic fundamentalists or the white-supremacy America of the Aryan Nations (founder: Richard Butler, engineer) or the minimal pre-modern U.S. government that Stack and Bedell extolled.
Among Communists, anarchists and other groups whose shining ideal lies in the future, the researchers found almost no engineers. Yet these organizations mastered the same technical skills as the right-wingers. Between 1970 and 1978, for instance, the Baader-Meinhof gang in Germany staged kidnappings, assassinations, bank robberies and bombings. Seventeen of its members had college or graduate degrees, mostly in law or the humanities. Not one studied engineering.
The engineer mind-set, Gambetta and Hertog suggest, might be a mix of emotional conservatism and intellectual habits that prefers clear answers to ambiguous questions -- "the combination of a sharp mind with a loyal acceptance of authority." Do people become engineers because they are this way? Or does engineering work shape them? Itâ(TM)s probably a feedback loop of both, Gambetta says.
Much of medicine is filled with ambiguity (if you ignore nutritional missteps being at the root of much chronic disease that plays out in a variety of different symptoms). Much of the rest of disease is related to lifestyle or environment (e.g. leaded gas causing the past few decades of increasing crime, now dropping as leaded gas has been banned). As Dr. Fuhrman says, genes may give us weak links, but whether they get pulled on to the breaking point is a function of diet and lifestyle and environment. That is not the sort of thing engineers are going to like to here... They want a quick answer prescribed by an authority like a drug. Dr. Fuhrman calls prescriptions for drugs like blood pressure medicine or diabetes-related medicines for type II diabetics as "permission slips" by authority to continue with current bad behavior regarding diet, lifestyle, and environment. Likewise, getting the label of "bad genes" is another permission slip for misbehavior... Not saying some people don't get dealt a much worse hand of cards in terms of genes, family habits, and environment than others... Still, consider how so much of life is what we make of it:
"An Afternoon with comedian Brett Leake '82"
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
"I'd like to find a person that adheres to a strict vegan diet devoid of GMOs (corn being the primary offender) that suffers from diabetes. I doubt such a person exists, but I'm willing to entertain the idea of a 300+ lb. diabetic vegan if anyone can provide evidence to the contrary."
BTW, a lot of vegans eat terrible. Too much processed vegan junk foods, too many carbs, not enough vegetables, nutritional deficiencies relating to B, D, Iodine, Omega 3s/DHA, etc.. Dr. Fuhrman talks about this. ... A vegetarian whose diet is mainly refined grains, cold breakfast cereals, processed health food store products, vegetarian fast foods, white rice, and pasta will be worse off than a person who eats a little turkey, chicken, fish, or eggs but consumes large volumes of fruits, vegetables, and beans. That combination of little or no animal products with a higher consumption of fresh produce is the crucial factor that makes a vegetarian diet healthful."
https://www.drfuhrman.com/libr...
http://www.drfuhrman.com/libra...
"What You Need to Know About Vegetarian or Vegan Diets; Following a strict vegetarian diet is not as important as eating a diet rich in fruits and vegetables.
Personally, considering even Gorillas get about 5% of their calories from termites and such, I don't think any primate is adapted to be totally vegan. Maybe it is possible, but it is really pushing it. In the West, we just don't eat many insects or enough dirt (yes, I mean that, about gut bacteria and vitamin B12, although dirt today is probably not what it used to be like with lead and mercury contamination and e coli contamination and such).
However, there are lots of people for whom turning vegan improved their health for a couple years until various deficiencies set in. And I think those deficiencies could be managed for people who are aware of them or do various tests. A big thing is to eat a larger variety of foods than most people in Western society on a SAD diet are used to eating. I'd guess iodine deficiency is a big issue for many Western vegans, since some soils are depleted and sea vegetables are not common in a Western diet, and now that much bread has bromine in it instead of iodine as a dough conditioner, the situation is even worse. I also think there may be vitamins in various animal fats that we may not get enough of easily on a vegan diet for some people, especially those whose genetics are more adapted to some situations (same as lactose intolerance, but in reverse, like they are not as good at making vitamin A from plants compared to absorbing it from animal products...)
Still, in general, vegans tend to be more health conscious, so:
http://www.veganhealth.org/art...
"The only prospective study measuring rates of diabetes in vegans, the Adventist Health Study 2, found them to have a 60% less chance of developing the disease than non-vegetarians after two years of follow-up. Previously, a cross-sectional report from the Adventist Health Study-2 showed vegans to have a 68% lower rate of diabetes than non-vegetarians. A number of clinical trials have now shown that a vegan, or mostly vegan, diet can lower body weight, reduce blood sugar, and improve other parameters for type 2 diabetes."
Corn syrup manufacturers used to (maybe some still do?) clean their equipment with a mercury-based cleaning agent, and so some batches of high fructose corn syrup were contaminated with higher levels of mercury that would have contributed to ill health. Also, in any society with a dominant food (like corn in the USA) more people tend to get allergic to it. An undiagnosed food allergy is going to cause all sorts of problems including stress, which might contribute to obesity. Few people in the USA are probably allergic to rice since the US does not eat so much of it, but a rice or soy allerg
A 21st century issue: the irony of technologies of abundance in the hands of those still thinking in terms of scarcity.
I am extremely aware of the post-transplant requirements and complications, as my father was post-transplant (kidney and pancreas) and towards the end of his life I was one of his main caregivers.
I'm starting to think GNU is the problem with "GNU/Linux" these days.
Speaking of idiots...
Diet has a 0% cure rate for type I (which they are talking about) and isn't nearly as effective as you seem to think for type II.
Speaking of idiots ...
people still believe that myth? HAHAHAHAHA
You would effectively starve to death within a year of symptoms showing up, regardless of how much you ate. (IIRC, actual starvation could prevent/slow the progress in some way)
Well from a purely theoretical point of view:
it could be possible to survive on a low-carb diet, eating only proteins and fats and avoiding sugar completely.
Basically, eating only steak and salad, never bread.
(The kind of diet that bodybuilders use).
In that situation the body obtains most of its energy by burning fat and maintains blood sugar levels by gluconeogenesis.
(This metabolic regime consumes some proteins, hence the increase need of meat to avoid starvation).
But it's complicated to get correctly.
Compensating the Type 1's lack of insulin is much simpler.
That's what some think early human diet looked like before agriculture (the theory basis behind the paleo diet). /. recently.
That's also used by body builders to burn fat (as mentionned above).
Before insulin that was the only way to keep Type 1 diabetics alive.
It was also recently been mentionned as a insuline-free alternative treatment. Was mentionned on
"Sufficiently advanced satire is indistinguishable from reality." - [Tips: 1DrYakQDKCQ6y52z6QbnkxHXAocMZJE61o ]
It does not. It causes type II.
Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
Can there be a real cure for diabetes? The glucose eaten can only have a few destinations:
What can we expect from a drug? Moving more glucose to fat storage? It is better than diabetes, but still much less desirable result than eating less carbs..
Look at http://www.faustmanlab.org/.
It's already been demonstrated in lab animals, and in the first round of human testing, that the BCG vaccine can be used in small doses for 30 days, with tight blood sugar, to treat the auto-immune problem at the root of most cases of Type 1 diabetes. They're gathering funding for their second round of human testing, the first round was quite successful.
Basically, once the auto-immune problem is addressed, the body makes insulin producing cells from adult stem cells. And yes, it *is* a cure for most Type 1. Frankly, instead of pursuing Yet Another Promising New Treatment(tm), I'd like to see this one get funded. The BCG faccine has already been used for hundreds of millions, if not billions, of people worldwide with few side effects, it's now cheap as spit due to bulk production, and if the FDA in the US refers it to
"require more study", I personally plan to take a trip to Bangalore for a sabbatical, review the literature for dosages, and buy a supply of the vaccine and a big pile of glucose test strips to nail down my blood sugars for the necessary month of treatment.
They say that the effect was transient. Are you really going to inject yourself with BCG vaccine for the rest of your life?
"Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
Verapamil has some serious side effects and possible drug-drug interactions, making it not a very widely used. Within it's class (the calcium-antagonists) the dihydropyridine derivatives like amlodipine and nifedipine are much friendlier drugs.
It doesn't even do that.
Learn to love Alaska
What myth?
Learn to love Alaska
This is really dumb to try new drugs before changing diet. Eat low carb diet period. You don't need drugs. Diabetes many people suffer now is the result of bad diet.