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Banned Weight-loss Drug Could Combat Liver Disease, Diabetes
sciencehabit writes: A drug the U.S. government once branded "extremely dangerous and not fit for human consumption" deserves a second chance, a study of rats suggests. Researchers report (abstract) that a slow-release version of the compound reverses diabetes and nonalcoholic fatty liver disease (NAFLD), an untreatable condition that can lead to cirrhosis and liver cancer.
...they fire it up and let it run for 18 hours.
When Fascism comes to America, it will call itself Anti-Fascism, and tell you to give up your guns.
I couldn't figure how to post to the thread with no previous comments (where was the reply button?)
I'm looking at my comments in my section, but can't figure now how to find my comments to see the ratings, etc?
What the hell did they do to the interface? It looks like it is now only for cell phones? Sheesh....
This sucks.
Gotta see if I can find a way to revert to old look, if they left that in...
Light travels faster than sound. This is why some people appear bright until you hear them speak.........
Funny, I would label a rust remover "extremely dangerous and not fit for human consumption". Especially if by drinking it you are just begging for diabetes. But Cola is still not banned from the supermarket.
Nae king! Nae laird! Nae yurrupiean pressedent! We willna be fooled again!
Title and summary didn't name the subject of the article, adding here.
The drug is dinitrophenol. From the medical texts:
DNP is an ATP inhibitor, which means it prevents cell mitochondria from synthesising ATP from simple sugars. Taken in excess, DNP can cause cell death by starvation and organism death by hyperthermia (it causes an imbalance in the proton gradient which results in the release of large amounts of heat). The good: you'll be thin. The bad: you'll be dead. But at least you won't be cold.
Industrial uses include a precursor to sulphur dyes, and a component in liquid and plastic explosives. The US FDA and the UK's Food Standards Agency have both condemned DNP as a dangerous industrial chemical that should not be taken internally. Doses as low as 20mg/kg (in humans) are shown to be lethal (http://dx.doi.org/10.1081%2Fclt-200058946).
Political debates have me rolling my eyes so much I think I got optical whiplash. I should sue. - Foamy The Squirrel
McDonald's is not a weight loss drug...
It's not known as NAFLD. It's known as NASH. Non Alcoholic SteatoHepatitis. It's even in the title of the TFA FFS.
I should use this sig to advertise my book ISBN-13 : 978-1501515132.
It was banned after it was discovered to be the cause of severe birth defects. Later it was discovered to be useful for:
URL.
Any drug that is sufficiently powerful to cure you, also has the power to hurt you. The converse is true also.
In the land of the blind, the one-eyed man is king.
That is why they keep banning drugs that help us. They hate us. The politician that banned this one was the guy that was going around shitting on the chests of little boys. Of course the Republican-ruled media refused to report on that. I saw it in our local paper, but then they buried the story. That is the way of our media. They hate the truth and want us to die.
"Banned Weight-loss Drug Could Combat Liver Disease, Diabetes"
And that drug? Exercise. That's right. Exercise.
In the future, our laws and the FDA are going to have to reform to adjust to a new realty. In brief, there no bad chemicals or bad drugs, only bad uses. Medicine has been so extraordinarily good at providing near miraculous cures, that we have come to have a "magic pill" mindset. This drug magically cures this disease and is "safe". The reality of medicine is a series of tradeoffs, typically the tradeoffs are greatly to our advantage, but not always. Further, it has long been known that a drug that works for one person doesn't work for someone else. There is no doubt that targeted medicine, what I consider a subset of open source medicine, is the next critical system break through. For example, this is why it is so intriguing to be putting IBM Watson on the task of medicine, Watson will be able to analysis your personal health makeup and suggest a drug appropriate for you, along with recommended possible side effect markers to watch and even possibly test for! How do you go about regulating medicine is such an environment, in the future it will no longer make sense for the FDA to "approve" or "disapprove" a drug. Rather the most sensible course will be to monitor an accurate database of effects and make sure all the participants are following correct recording procedures, along with assuring purity of products. If you follow through this logic, you will quickly realize it calls into question the current system of patents. Where an entity has a financial interest is promoting a particular drug, it also has an interest in suppressing negative information and promoting positive. Under such circumstances it isn’t strongly in anyone personal interest, other than an illegal cartel, to promote inappropriate uses of a particular drug. Obviously some system of financial rewards/incentives need to be applied, and of course no can work for free. But just as the open source software movement hasn’t killed off software companies, nor will making a space for open source medicine kill of drug companies. Indeed the free flow of ideas has only enhanced technological progress. I hope I have convinced some of you to embrace a move to open source medicine.
I prevent non-alcholic fatty liver disease with large volumes of alcohol.
The power of diabetes is both a blessing and a curse. But mostly a curse.
Vitamin E. Of course you'll write this off because it's a vitamin and sounds like click bait, but I say it because it literally saved my life.
http://www.ncbi.nlm.nih.gov/pubmed/23075940
With 400 IU of Vitamin E, a low carb diet, and daily light exercise ( 30 min ) , I have lost 45 pounds in 1 year and my liver enzymes went down to within normal range ( ALT was 98 down to 55 ). After 2 weeks of Vitamin E alone, doing nothing else I suddenly felt "normal" again for the first time in years. I didn't even realize how weak, tired and ... awful I felt prior because it had become my baseline. It inspired me to continue on.
Diet and exercise is the long term solution, but the Vitimin E was key for me.
YMMV, but I urge you to talk to an hepatologist abouit it if you have NAFLD or NASH.
The dose makes the poison: There is an excellent book by that name: http://www.amazon.com/Dose-Mak... It should be required reading before posting on this topic.
DNP is an ATP inhibitor, which means it prevents cell mitochondria from synthesising ATP from simple sugars.
I think I understand what you're trying to say, but let me make it a bit more clear using a car analogy. Yes, you get less ATP out at the end, but that's not really the point of the drug.
DNP is an oxidative phosphorylation decoupler. What this means, it that it does the equivalent of popping your clutch into neutral, and then stomping on the gas. Your mitochondria will rev-up furiously, but no ATP is produced as you have just decoupled the connection between the engine and the wheels. In the meantime, you burn a lot of gas.
"Check out this one weird trick the FDA doesn't want you to know about a banned weight-loss drug that could combat liver disease & diabetes."