Ebola Vaccine 100% Successful In Guinea Trial
An anonymous reader writes: Doctors and researchers have been testing a vaccine to protect against Ebola in the west African nation of Guinea. Trials involving 4,000 people have now shown a 100% success rate in preventing infection. "When Ebola flared up in a village, researchers vaccinated all the contacts of the sick person who were willing — the family, friends and neighbors — and their immediate contacts. Children, adolescents and pregnant women were excluded because of an absence of safety data for them. In practice about 50% of people in these clusters were vaccinated. To test how well the vaccine protected people, the cluster outbreaks were randomly assigned either to receive the vaccine immediately or three weeks after Ebola was confirmed. Among the 2,014 people vaccinated immediately, there were no cases of Ebola from 10 days after vaccination — allowing time for immunity to develop — according to the results published online in the Lancet medical journal (PDF). In the clusters with delayed vaccination, there were 16 cases out of 2,380."
Almost a year exactly.
http://www.theonion.com/articl...
So, you're saying they were guinea pigs?
We don't have a state-run media we have a media-run state.
Having a 100% proof vaccine for Ebola is nice, as long as it works for the majority of strains and also lasts for life. Not so good if it lasts for 1 year and you need another, and only for one specific variety of Ebola, not all.
excitingthingstodo.blogspot.com
I think that's the stupidest fucking comparison I've ever seen on Slashdot. And that's a pretty impressive feat.
...in the unvaccinated control group?
Are you trolling? Did you even read the summary? The "trial" WAS the real world.
As an aside, the ethical implications of that are a little bit unfortunate. IE: Their "control" was to delay intervention for the control group by 3 weeks. As a consequence: 16 people were infected who could have received the vaccine...
Really... is it that convenient or is it because cancer is caused by cell mutations and every cancer and victim has a slightly different mutation. And some people have been surviving Ebola, which means their bodies have created antibodies.
Cancer will probably take more than 100 years after this point to completely wipe out. With medicine these days we will probably see better treatments for it and more people will survive over time, but cancer will not be wiped out any time soon.
Given the size of the trial, it's really unlikely that it prevents less than 90% of the cases of Ebola that would otherwise develop. So while I agree that 100% continuing is all that likely, especially if you start including immune suppressed people such as the HIV positive, those with cancer, transplants, young children, the elderly, etc... Still, if you vaccinate 100% of those eligible for it and it provides 95% immunity to Ebola, odds are the vulnerable won't be exposed at all, because you'll have something like 5% of the flare-ups from a wild source, and such flareups should mostly be individual, not thousands.
On the other hand, thinking about Ebola and vaccines reminded me that vaccines have made an even deadlier disease less problematic - Rabies. It wasn't until a relatively short time ago that we had any survivors from the symptomatic stage, and even then getting those requires putting them into a medical coma for a while.
But with the vaccine we realistically save thousands of human lives every year in the USA alone, and that's with mostly vaccinating animals, not people, and only vaccinating humans who we suspect have been exposed or work in a higher exposure risk area.
I don't read AC A human right
Wait I think I seen this movie some where, granted it was a cure for cancer but it doesn't end well for the humans unless of course you like zombies
news like this makes me so mad. because it demonstrates something wonderful we as a civilization have achieved time and again. something that should be applauded and celebrated and championed:
1. disease, unfair deaths
2. science, hard work by intelligent people
3. vaccine, innocent lives saved
it's obvious, straightforward, undeniable, a wonderful good
against that we have prideful ignorance, that continues to claim the lives of innocent children and others, simply because of their various paranoid conspiracy theories, lies, and petulant low iq
in a just world, those who don't vaccinate die from ebola
in the real world, those who do vaccinate protect those who do not, and when the herd immunity breaks down, because of the unvaccinated, the vulnerable innocent and the unlucky few who got a vaccine but it didn't take hold, also die
intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
You cannot be serious.... Look they vaccinated using TWO techniques and it may be hard to follow, but they where not doing a placebo double blind study, but a comparative study of two populations, which has value.
First group where vaccinated right away after someone nearby had been confirmed to have Ebola.. In the group of people who got the vaccine, NOBODY got Ebola who was subsequently exposed after 10 days. Yes, some people got Ebola who either already had it before the vaccine or who where exposed to it during the 10 days after the vaccine, but after that, things where great.
Just to be sure this wasn't a fluke, they vaccinated other groups 3 weeks after the confirmed case of Ebola was found and noted that there where then 16 cases of Ebola in this test group after the 10 day wait, meaning they where previously exposed and got Ebola via the normal route, before the vaccine built immunity in 3 weeks + 10 days. This indicates that the vaccine DOES affect the Ebola infection rate, seemingly very well in that after 10 days, subsequent exposure didn't not produce Ebola.
The implication is that the immediate vaccination prevented Ebola after the 10 day period...
"File to fit, pound to insert, paint to match" - Aircraft Maintenance 101
Ebola is not an airborne virus. Therefore if you detect it early enough in the first people you can vaccinate those around them.
And if you read about Ebola's normal course, it would normally take about a week for things to get very bad for patients (bleeding and diarrhea ). Yes, the vaccine might not work and 2,000 some people may have gotten lucky, or it could work for 90% of them and 200 of them got lucky. This does seem like a promising step forward, if people can put aside their disbelief and cynicism, but then again this is slashdot.
It is interesting that when there is a limited broad commercial viability, the "drug" designers and chemists are able to whip up a cure for something in under a year.
Problem: They've been working on the Ebola vaccine for a lot longer than a year. What really happened is that they had a vaccine in the early testing stages, with something like an estimated 5 years of testing left before it could be commercially deployed. Then we have a relatively huge ebola outbreak, panic sets in and they grant a waiver for the testing. Basically, they had enough information that 'We think this will probably help you survive exposure to Ebola. We're pretty sure it won't hurt you'. So they administer the vaccine in a sort of accelerated study, because it might save lives. Turns out it probably did.
Outside of an Ebola outbreak, the risks weren't worth it. During one? Worth it.
It actually reminds me of the first vaccination methods - Variolation. Fascinating history. Various versions around, but had a top end of 1% chance of death. Yes, the vaccination itself killed 1% of those treated. But it was against smallpox - with a death rate of 30% during epidemics. As long as the chances of catching smallpox was above 4%, it was 'worth it' to variate. And in Europe, the chances were a lot higher than 4%. Even royalty variolated their children.
As for cancer - apples and oranges dude. The problem with cancer is that it's actually lots of different problems, all under the same name. Causes, effects, treatments, all different.
We've developed lots of cures for various cancers, just not all of them yet.
I don't read AC A human right
Come on now, be nice..... it's possible he's just extremely ignorant.
"First they came for the slanderers and i said nothing."
i'm not a nice person. and this is not couple's therapy
if someone says something stupefyingly dumb (on a "news for nerds" website no less), they deserve to be pilloried
i understand the concept of educating the ignorant patiently. but then there is stupidity so amazing there is no hope
prideful ignorance exists in this world. it resists logic reason and patience. such stupidity needs to be attacked for the cancer it is (irony intended). blind and dumb people actually cause real damage in this world
intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
Why isn't there funding? Probably spent on some beachfront property beach cleanup in the Hamptons as "shore protection".
Or maybe the $325B that people spent on snack foods last year
Or maybe the $182B that people gave to Apple computer last year
Or maybe the $11.4B that people spent on video games last year.
Or how about the $38B spent on movies?
Now, I am sure YOU don't spend any of YOUR money on those kinds of frivolous things, right? I mean, surely you live at a subsistance only level and contribute everything else to finding ebola solutions, right?
Nope. We could blame it on ignorance if, for instance, he asked why it is possible to develop an ebola vaccine but not kill cancer. But he didn't do that, he claimed some kind of conspiracy that is stopping us from curing cancer.
Serious question: are placebos normally used in a vaccine trial? Is there really such a thing as a placebo effect for something like ebola?
I bet it's 100%.
i'm not a nice person.
That's true.
"First they came for the slanderers and i said nothing."
Africa can feed itself. It could feed the entire world if it wasn't full of thousands of waring gangs (tribes) with over 60% of the arable land on the planet.
To be fair to the idiot you replied to, there is a cancer vaccine for one type of cancer, HPV.
https://en.wikipedia.org/wiki/...
http://www.cdc.gov/cancer/hpv/...
However, trying to tie every cancer together as one cause is absurd. Implying someone is sitting on a cure for cancer is much worse.
APK likes to ask for responses to the same things over and over. Maybe he just likes the responses?
You can be treated for rabies after you been infected. Pets are routinely given rabies shots after an encounter with a wild animal even when they are currently vaccinated.
I own Apple stock. And have owned MSFT and Sony stock. How is this frivolous?
Beachfront shore protection - that's frivolous. Waste of time, too. Spends 95 percent of the funds on the richest 1 percent on land areas that will be under water by 2025 regardless. Better spent on Africa.
-- Tigger warning: This post may contain tiggers! --
rotfl <3 even if you're not nice, sometimes you're fun to talk to. <3
"First they came for the slanderers and i said nothing."
The governments in some of those countries are also thoroughly corrupt, which doesn't help things any.
"When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
HPV isn't cancer, it's a virus. It is the usual cause of cervical cancer, but maybe 10% of the cancers are not associated with HPV.
"When you have eliminated the unacceptable, whatever is left, however improbable, must be the truthiness" - Holmes
Nice troll, bro
"If you have nothing to hide, you have nothing to fear." - Every fascist, ever
I stand by my assessment.
-- Tigger warning: This post may contain tiggers! --
From the article: "The rVSV-ZEBOV vaccine is sometimes known as the Canadian vaccine as it was originally developed by the Public Health Agency of Canada before being sold to Merck to conclude the testing."
Which is actually leaving out a step. Newlink Genetics bought it, sat on it for years, then sold it to Merck.
thank you
intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
Believe what you want. This is just bad statistics. Are there any real epidemiologists or statisticians in the study that claim it's 100% effective?
If there were only 16 cases in the delayed vaccination groups, you simply do not have enough information to calculate the real efficacy.
So it turns out the vaccine wasn't developed by a private organisation. But what were you attempting to prove anyway? A vaccine is developed by a private organisation, so... private organisations will always be better at something (or everything?) than public ones?
We could make long lists of good things done by private and public organisations, and also bad things done by both. A convincing argument that one or the other is better suited to any particular role requires more than one anecdote (or antidote).
Now if we can only get Malaria, Dengue and Chikungunya to US soil we're sure to cure those devastating third world epidemics as well!
This a human vaccine, which is great, but it will probably won't avoid the next break out.
Wouldn't it be a good idea to also develop a vaccine for bats, which act as a reservoir for the virus?