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Breathalyzer That Detects Lung Cancer Early From a Single Breath Wins $100K Entrepreneurship Competition (mit.edu)

Lung cancer "breathalyzer," developed by a team of MIT and Harvard University students, has won $100K Entrepreneurship Competition. The breathalyzer connects to a smartphone and is able to detect lung cancer early from a single breath, reports MIT News. From the report: Astraeus Technologies has developed a postage-stamp-sized device, called the L CARD, that detects certain gases indicative of lung cancer. When someone blows onto the device, a connected mobile app turns a smartphone screen red if those gases are present and green if they aren't. "The L CARD reacts and sends instantaneous information to the physician that further attention is required," Joseph Azzarelli, an MIT PhD student in chemistry said while a ripple of excitement spread through the crowd. Lung cancer is the deadliest type of cancer in the United States, causing more deaths than breast, colon, and prostate cancers combined, according to the World Health Organization.

48 of 85 comments (clear)

  1. colon cancer, you say? by jjeffries · · Score: 4, Funny

    I wonder if it can detect cancer with other, err, bodily gas flows...

  2. Re:Is able to detect? Cause? Prevent? by NotInHere · · Score: 4, Interesting

    The key word here is "early". Apparently the device can detect lung cancer early on. The earlier you know sb has cancer, the better you can treat them.

  3. And of course by Anonymous Coward · · Score: 1

    it will cost $10,000.00 to breathe into it. They do that, you know. And insurance will not cover it. They do that, you know.

    1. Re:And of course by pr0fessor · · Score: 1

      It will cost $100,000 if you have insurance in which case your cost will be $10,000 otherwise they will charge you $15,000 if you don't have insurance.

    2. Re:And of course by tsotha · · Score: 2

      Not in the real world, no. It's not like insurance companies would rather pay hundreds of dollars for an X-ray, which is the alternative.

  4. Re:Is able to detect? Cause? Prevent? by sdguero · · Score: 1

    There was a typo in the original post, the word "detect" was missing. It's been fixed since.

  5. Re:Better idea by GLMDesigns · · Score: 3, Insightful

    Yes. It's called freedom. Freedom also allows you to do what other people consider to be stupid or immoral. Like, oh, for instance:

    drink
    eat pork
    eat beef
    eat any animal
    eat anything produced by an animal
    have sex before marriage
    have sex with someone of the same gender
    marry someone outside of your religion
    renounce your religion
    have an abortion
    take contraceptives
    and many other things

    If you have the right to abort a fetus you have the right to decide whether or not to consume tobacco, wear seat belts and every other aspect that ownership of ones body implies.

    --
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    Vote 3rd Party in 2016 and beyond
  6. coming to a Walgreen's near you by turkeydance · · Score: 2

    and any other doc-in-a-box.

  7. Re:Is able to detect? Cause? Prevent? by NotInHere · · Score: 1

    I see.

  8. Re:Better idea by Anonymous Coward · · Score: 2, Insightful

    As long as the smoke doesn't affect anyone else. In most cases, it does.

  9. Re: Better idea by GLMDesigns · · Score: 1

    And this, in a nutshell, spells out the argument between pro-choice and pro-life. At what point does the fetus have a right to life?

    Some say conception. Some say birth. Some say some point in between that. Roe v Wade said 3 months.

    --
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    Vote 3rd Party in 2016 and beyond
  10. Thanks, officer. by EntropySerpent · · Score: 1

    Officer: You just blew twice the legal limit, your life is probably ruined now. oh, and btw.. you also have lung cancer.

    1. Re:Thanks, officer. by tsotha · · Score: 1

      Heh. He'd probably let you go - the state doesn't want to pay to treat your cancer, which it's on the hook for if you're in jail.

  11. Re:Red / Green by GLMDesigns · · Score: 1

    It would be a poor UX designer who only used color to indicate something like this. Maybe the phrase: "See a Doctor" if it's bad or "Everything's OK" if you passed.

    --
    If you're scared of your govt then you need to further restrict its powers
    Vote 3rd Party in 2016 and beyond
  12. Re:Better idea by EvilSS · · Score: 3

    Because banning addictive substances works 100% of the time with 0 adverse effects.

    --
    I browse on +1 so AC's need not respond, I won't see it.
  13. The biomarker gasses are... by doug141 · · Score: 5, Informative

    ...discussed at length here:
    http://www.nature.com/articles...

  14. False positives vs. false negatives by tolleyl · · Score: 5, Insightful

    One of the problems with such devices is that they don't report the percentage of false positives. This is a much bigger problem than false negatives, since there are more people who are negative (don't have lung cancer) than positive (have lung cancer). It's generally considered very bad to tell someone that they have cancer and then later say "Sorry, but we made a mistake." Though that's good news for them, they get upset that you told them the false bad news first. However, early diagnosis of lung cancer is an important area and if they made progress toward that then I applaud them.

    1. Re:False positives vs. false negatives by Calibax · · Score: 4, Insightful

      A false positive is much less of a problem than a false negative. One can cause some loss of sleep, the other can result in a failure to get early treatment and subsequent death.

      If a positive result if presented to the patient as an indication that they should have further tests then the level of anxiety generated by the result can be managed.

    2. Re:False positives vs. false negatives by uncqual · · Score: 3, Insightful

      A false positive can result in additional testing such as CT scans, PET scans, and/or biopsies which were unneeded and expose the patient to risks such as increased risk of actually getting cancer due to increased exposure to radiation or infection or other complications from surgery/anesthesia.

      --
      Why is there an "insightful" mod and why isn't it "-1"? If I wanted insight, I wouldn't be reading /.
    3. Re:False positives vs. false negatives by Calibax · · Score: 2

      I would still prefer the false positive - yes there's a chance that subsequent testing may cause a cancer (possible but very unlikely) and the false negative causes treatment to be delayed.

      My first wife died of lung cancer. Her doctor diagnosed her initial symptoms as bronchitis and it was four months before the quack decided to send her to the hospital with pneumonia. Then the cancer was discovered and she died 16 months later. The type of lung cancer she had was unusual (non-small cell carcinoma) and is more treatable - that four months might have made a substantial different. We'll never know, of course.

    4. Re:False positives vs. false negatives by Agent0013 · · Score: 1

      There are women who have had breasts cut off completely because of a false positive. I don't think it is such a small mistake as you make it out to be. And just the stress alone could cause a lot of harm to a person.

      --

      -- ssoorrrryy,, dduupplleexx sswwiittcchh oonn.. -Quote found on actual fortune cookie.
  15. Why the smartphone? by Chelloveck · · Score: 2

    The L CARD (which stands for Chemically Actuated Resonate Device) is essentially a modified near-field communication tag. Certain volatile organic compounds unique to the breath of lung cancer patients modify the tagâ(TM)s radio frequency identification signal. A smartphone then pings the device and determines, from the modified signal, if those volatile compounds are present.

    Sounds like the thing just gives a binary yes/no reading. So why bother with the NFC and phone? Why not just have a red/green LED on the device itself?

    --
    Chelloveck
    I give up on debugging. From now on, SIGSEGV is a feature.
  16. Re:Is able to detect? Cause? Prevent? by Xenna · · Score: 1

    The key question is: how early? Is it 'early enough'?

    If it's early enough often enough they deserve a lot more than a measly 100K.

    Lung cancer is almost always deadly.

  17. Because the math is apparently not that easy by MAXOMENOS · · Score: 3, Informative

    If I understand correctly what I'm reading about the biomarker gasses, it's not just the absence or presence of a gas or gasses, but the quantities, and the profile of those quantities in normal vs. diseased lungs. So, they're hooking it up to a pattern classifier. In the prototype stage you need a computer with a fair amount of power --- fortunately these days a smart phone will do. Down the road I imagine they could hook it up to a FPGA or six and eventually engineer it down to one chip, but that's a lot more engineering and likely years down the road.

  18. Probably... by denzacar · · Score: 4, Informative

    Actually... since the tech behind it is based on these sensors and since dogs can already be trained to detect bacteria and prostate cancer by smell, while bladder cancer can be detected by smell as well...
    The answer is probably yes.

    --
    Mit der Dummheit kämpfen Götter selbst vergebens
  19. Re:Better idea by kybred · · Score: 1

    Cigarette smoke is not the only cause of lung cancer.

  20. Re:Is able to detect? Cause? Prevent? by tsotha · · Score: 1

    Though "medical media" people repeat this, it's not true as a general rule. On thing that came out of the Obamacare debates, when people spent a lot of time comparing the US health care system (which is very test heavy) to others throughout the world (particularly in Europe), is that for many cancers the fact that you survive longer after a cancer is detected is purely a statistical artifact of the early detection. For example, let's say you have a cancer that will kill you in five years. Dr A has a test that will detect it in one year. Dr B has a test that will detect it in three years. Further, let's suppose Dr A and Dr B treat you with snake oil, and that after five years you succumb to the cancer. Dr A claims his treatment allowed you to live twice as long as Dr B's, even though the early detection had no effect whatsoever on the course of the disease.

    I think the situation has changed in recent years with new treatment options, but the medical establishment pushed mammograms for decades in pursuit of early detection when it made no statistical difference whatsoever to patient longevity.

    Most of these newsworthy testing breakthroughs turn out to be useless because they produce too many false positives. In the near term this test really only moves the ball forward if that turns out not to be the case and also we have effective treatments we can employ between the new detection threshold and the old one.

  21. We will see by Smiddi · · Score: 2

    Now if the police really want to save lives (and not just revenue raise) they will incorporate this into random breath tests (RBT's)

  22. Re:Better idea by gweihir · · Score: 1

    Ban alcohol, non-marital sex and undesirable thoughts at the same time! That has the same excellent justification as your demand.

    --
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  23. Re:Better idea by gweihir · · Score: 1

    Because banning addictive substances works 100% of the time with 0 adverse effects.*

    * (Actual real-world observations may differ.)

    --
    Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
  24. Re:Call me when it does prostrate cancer by Calibax · · Score: 4, Informative

    I had a colonoscopy when I turned 50. It discovered a stage 3 adenocarcinoma in the ascending colon. Without a colonoscopy these are generally not found until the colon is blocked or it ruptures - either way the cancer has usually metastasized by this point and the live expectancy is of the order of 18 months to two years.

    The day after the colonoscopy a cat scan confirmed the result (not that there was a doubt) and a week later the tumor was removed. The surgery was followed by 6 months of chemotherapy. That was 12 years ago.

    A colonoscopy saved my life. It might save yours also. Man up and get it taken care of.

  25. Re:Better idea by tsotha · · Score: 3, Informative

    Cigarettes are not the only cause of lung cancer. Lung cancer existed before cigarettes, and will exist even if we ban them. Offhand I can think of a half dozen celebrities and people I know who never smoked but died of lung cancer.

    Anything that can damage your DNA can cause cancer - radiation, various kinds of chemicals, viruses, or just errors in replication. All these things can cause cancer in the lungs. While it's true tobacco drastically increases your odds of lung cancer, you still have about a 14/1000 chance of developing lung cancer even if you've never smoked a cigarette and aren't exposed to statistically significant amounts of secondhand smoke, i.e. you don't live with a smoker or tend bar at a smoke-filled pub.

    So yes, you need early detection.

  26. Re:Call me when it does prostrate cancer by tsotha · · Score: 2

    This. A colonoscopy has a bigger statistical impact on your longevity than any other screening test.

  27. good luck by Goldsmith · · Score: 2

    I'm a scientist and have worked in the sensor field for a long time. I have had students I've trained attempt this (commercial breath detection of cancer) with promising initial results. It's pretty easy to do the demo these guys are doing. It's very hard to do this with real people. The gap between cool academic demo and manufactured product is huge. The gap between product and FDA cleared diagnostic is even larger.

  28. Re: Call me when it does prostrate cancer by denzacar · · Score: 1

    How about a dog?

    www.medicalnewstoday.com/articles/190633.php

    --
    Mit der Dummheit kämpfen Götter selbst vergebens
  29. Nice! by nospam007 · · Score: 1

    And now we just need a toilet that can detect colon, stomach and prostate cancer and we're good to go.

  30. Re:Better idea by KozmoStevnNaut · · Score: 2

    Nobody should be dictating what an adult is allowed to willingly put in his or her body.

    When said willful self-damage causes increased rates of death and illness, which has to be treated by tax-funded services, it is only right for the tax payers to have some say in the matter.

    I'm not saying an outright ban is the solution, because it absolutely isn't, but the taxes on self-damage products such as tobacco and alcohol should match or slightly exceed the increased burden placed on public services as a consequence of their use. That plus smoking bans inside workplaces and other places like public buildings, plus information campaigns will not work as an outright ban, but it will help. Enforced plain packaging like in Australia is another good idea, I just wish it could be applied to all products and marketing in general.

    And before the smokers get to whine about how "oppressed" they are, they can start by picking up every single goddamn cigarette butt they just throw wherever, out of car windows and on the streets.

    --
    Eat the rich.
  31. Corollary by ThatsNotPudding · · Score: 1

    If a positive result [is] presented to the patient as an indication that they should have further tests then, the level of profit generated by the result can be maximized.

  32. Pay attention, Theranos by RogueWarrior65 · · Score: 1

    Theranos needs to start over by hiring these students.

  33. Re: Better idea by Agent0013 · · Score: 1

    The moment that fetus decides to stop being a parasite on someone else it can have its right to stay alive.

    --

    -- ssoorrrryy,, dduupplleexx sswwiittcchh oonn.. -Quote found on actual fortune cookie.
  34. Early detection from a single breath by LeadSongDog · · Score: 1

    Wouldn't it be earilier if they just detected the smoke instead?

    --
    Oh, I'm sorry sir, I thought you were referring to me, Mr. Wensleydale.
  35. Re:Better idea by Sperbels · · Score: 1

    There's a difference between allowing them to destroy themselves, and selling the means to do so at every gas station and grocery in the country.

  36. Yeah - one's better for business. by mmell · · Score: 1
    Of course, we could just deregulate alcohol and tobacco immediately. Even if these can't be sold on every streetcorner, once deregulated anybody who wants these items can readily learn how to obtain them, almost certainly at a price lower than that which the government would like.

    What? You thought it really cost $10.00 to manufacture a pack of cigarettes? $20.00 to distill a bottle of vodka? Or did you think these things were hard to get before the government began regulating their manufacture, distribution and sale?

    1. Re:Yeah - one's better for business. by Sperbels · · Score: 1

      Cigarettes are more like a food craving. It's very easy to satisfy that craving by going to the store and getting a familiar product that does the same thing to you time after time. But if you take away that ease of acquisition, product consistency, and safety then you've really made the product much less palatable.

  37. Re: Better idea by Falos · · Score: 2

    Someone already made the "21 years" joke.

  38. Re:Better idea by Falos · · Score: 1

    You're probably thinking of second-hand toxin.

    I'm thinking of America's for-profit healthcare system combined with "we demand you give him the best" snowflakes. THAT affects others more than a bit of odor at the bus station.

  39. Re: Better idea by Agent0013 · · Score: 1

    Wow! That was good. I laughed at that reply. Kudos to you and thanks for the chuckle.

    --

    -- ssoorrrryy,, dduupplleexx sswwiittcchh oonn.. -Quote found on actual fortune cookie.