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Scientists Discover Antibody That Neutralizes 98% of HIV Strains (inquisitr.com)
An anonymous reader quotes a report from The Inquisitr: The National Institute of Allergy and Infectious Diseases (NIAID) announced this week that a "remarkable" breakthrough has been made in the study of preventing and treating the human immunodeficiency virus (HIV), the virus that leads to acquired immunodeficiency syndrome (AIDS), according to a press release posted on the agency's official website. The breakthrough centers around the discovery of a powerful antibody named N6 that is highly effective in both binding to the surface of the HIV virus and neutralizing it. The former has proved elusive in the past. "Identifying broadly neutralizing antibodies against HIV has been difficult because the virus rapidly changes its surface proteins to evade recognition by the immune system," the press release explains. The antibody was initially discovered in an HIV-positive person and has since proven to potentially neutralize 98 percent of HIV isolates, "including 16 of 20 strains resistant to other antibodies of the same class," according to the press release. Researchers have had previous success with other antibodies, but N6 appears to be more effective. The new discovery has potential benefits far beyond preventing and treating HIV as well. Studying exactly how N6 works could potentially lead to breakthroughs in other anti-viral antibodies. "Findings from the current study showed that N6 evolved a unique mode of binding that depends less on a variable area of the HIV envelope known as the V5 region and focuses more on conserved regions, which change relatively little among HIV strains," NIAID explains. "This allows N6 to tolerate changes in the HIV envelope, including the attachment of sugars in the V5 region, a major mechanism by which HIV develops resistance to other VRC01-class antibodies. Due to its potency, N6 may offer stronger and more durable prevention and treatment benefits, and researchers may be able to administer it subcutaneously (into the fat under the skin) rather than intravenously. In addition, its ability to neutralize nearly all HIV strains would be advantageous for both prevention and treatment strategies."
>"Identifying broadly neutralizing antibodies against HIV has been difficult because the virus rapidly changes" ... "since proven to potentially neutralize 98 percent of HIV isolates"
So the remaining 2% quickly change to be resistant and in a few years we are back where we started again? 98% sounds great for some things. But if you had 200 fleas and got rid of 396, those remaining 4 can potentially become 200 again pretty quickly.
Let me be the first (seriously, the first despite so many other assholes who already posted) to congratulate them on this discovery. Sadly, I'm quite sure this is not a cure since I don't see how it would affect infected cells, but at least it can prevent the spread both within the body and transmission to other people.
Don't waste your vote! Vote for whoever you want, unless you live in a swing state it won't matter anyways
I guess so. My kid, who was working on a PhD in Math (like her mom) suddenly up and decided to change to some kind of "bio-mathematics" that has all sorts of the stuff you mentioned. Since my academic career was strictly in the Humanities, I don't have a clue about any of it, but it sounds like there's a lot of stuff going on. Some big lab recruited her to work there while she's finishing her degree and damned if she's not making as much as an associate professor. And she'll be graduating without a dime of debt, which makes Mom and I happy, since we told her we'd cover the cost of her education. Maybe now I can buy that sports car.
Me, I wish I'd learned HVAC. People will always need ducts in their houses, and heat and cooling. And there's very little math, which is good.
You are welcome on my lawn.
Where Bob at?
Why bother with the gratuitous "is"?
You are welcome on my lawn.
Once there was a man who painted a new sign for his store: "Fresh Fish for Sale"
His friend came along, saw what he was doing, and said, "Of course they're fresh, what kind of jerk sells unfresh fish?"
The man decided he was right, and crossed out the word fish.
The friend thought a bit and said, "Well........why say for sale? Why would you have fish in your store if they're not for sale?"
So,,,,,,,,,the man crossed off the words 'for sale,' becoming more efficient.
Then his friend thought some more, and said, "Ya know, everyone can tell they're fish, we can smell them from a block away."
The man crossed off the word fish, thankful he had such a wise friend.
Words are redundant, as can be proven by this following paragraph:
.
"First they came for the slanderers and i said nothing."
Well not exactly.
The discovery of an antibody that targets a non-variable site is important in several ways. I'm not sure how good a therapeutic drug it will make. Antibodies are huge and hard to make so depending on the dose required it could be prohibitive to inject enough of the stuff in an active form to do any good. Massive proteins often are lousy drugs. THat's not to say that antibodies can't be used as drugs. There's a lot that are on the market now, for example Humira. But that's going after receptors in the host not viruses so it's a different regime.
But what is good about this is three things. You learn where you can bind on the virus, you learn the binding mode of the contact points, and finally you learn that that binding mode is protective across most HIV. It's not uncommon to have something that binds HIV well but fails to be protective. Given this structural knowledge one can now try to design either small molecules or other smaller proteins than an anti-body that bind in a similar manner and target either the same binding site or the same origins of protection.
Some drink at the fountain of knowledge. Others just gargle.
And there's very little math, which is good.
How little you know about HVAC.
Corrected headline:
"Persons Immune System Discovers Antibody That Neutralizes 98% of HIV Strains; Scientists Take Credit"
Betting pool on how long it takes to patent, and who gets the patent, starts now...
Yeah, worked great for the #BringBackOurGirls.
"Awareness," the participation trophy of activism.
Ken
I just want to bend sheet metal. I have a TI-83 to do the math.
You are welcome on my lawn.
Oh look, a Nevada desert conspiracy guy. Just the type I was using as an example the other day in the thread on anti-science attitudes.
Your man redundantly crossed out fish twice. (yeah, I guess I could have left out redundantly)