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Microbiome Changes Drive the Dieting Yo-Yo Effect, Study Finds (smh.com.au)
wheelbarrio writes: We've known for a long time that diet-induced weight loss is rarely permanent but until now what has been a frustration for dieters has also been largely a mystery to scientists. A paper published today in the prestigious journal Nature presents good evidence that your gut microbiome may be to blame. Studying mice fed cycles of high-fat and normal diets, the authors found that the particular bacterial population that thrives in the high-fat regime persists in the gut even once the mice have returned to normal weight and normal metabolic function after a dieting cycle. This leaves them more susceptible to weight gain than control mice who were never overweight, when both populations are exposed to a cycle of high-fat diet. The details are fascinating, including the suggestion that dietary flavonoid supplementation might mitigate the effect. My guess is that this may end up being one of the most cited papers of the year, if not the decade.
This might explain why some recipients of FMT for treatment of C. diff. and CU have seen weight gain without changing their diets.
I feel so sig.
You're missing the point. This is about explaining why the same amount of food (or energy) intake affects people differently. Research into metabolic syndrome has shown that there is no simple relation: eat less -> lose weight -> get healthy. Once you know what influences weight gain or loss, given a certain amount of food intake you can adjust for other parameters.
I feel so sig.
So, what you're saying is that if they would just defy an inbuilt biological drive more powerful than reproduction and just below breathing for the rest of their existence without a single slip-up, they'd be fine?
Did you know we actually breath more than necessary? Try this. Inhale slowly and deliberately. But just half as deeply as normal. Now exhale. Continue like that for the next 24 hours. Ideally, you should feel just the slightest bit woozy. I'm going to say the woozy feeling will pass because people who give unsolicited advice like to say things like that, but really, it won't. Be careful not to let your attention wander, you wouldn't want to have a slip-up! People will call you horrible names relentlessly if you slip up!
Now hop to it you worthless slovenly spineless air-hog! My aesthetic sense must be appeased!
All this has very litle to do with willpower; that is the crux of the matter! I was in that situation with sugar some years ago. I got shakes, weakness and irregular hearth beat if I did not eat [plenty of] sugar. I knew it was bad, I knew I was too heavy, I knew it all - and it did not make any difference.
No one can fight their own biochemistry - you only have to pray it does not turn against you. It took me 2-3 years for the gut bugs to balance [more or less] and to [mostly] stop making me crave the carbs....true it was easier and easier with time but it was absolutely herrendous in the beggining. I repeat again with all sicerity - all this has very little to do with willpower.
Most of the this is simple crap is done by fat shamers who want to feel like they are a better person due to the lack of excess fat.
I have lost 50lbs and kept it off for over 3 years myself but it is hard, very hard to do. It was akin to getting my masters degree while working full time hard.
If you eat less you feel more hungry then when you get some food you will over eat.
When you start to exercise you get sore and hungry making you want to just sit and eat.
If you substitute your diet you are often not getting the nutrients you need causing you to feel out of sorts.
It isn't will power to not eat from the candy bowl, but to fight your most primal instinct for a long period. It takes a lot of hard work planning to do it. Any small factor could derail you at any time catching an illness, changing jobs, birth or death in the family.
Diet science has been pathetic because so much of us fall on the simple plan. With Diet food companies sell their plastic food as diet, where they are designed to fit this simple plan and cause us to fail.
If something is so important that you feel the need to post it on the internet... It probably isn't that important.
"Unless you intend to specifically analyse, combat and treat individual microbiomes in the stomach of every patient"
That's exactly where treatment is heading.
Personalised medicine is a huge emerging field and makes an awful lot of sense once you think about it.
Best comment in the thread.
Even the association between activity and body weight is not conclusive. Are people active because they are slim or slim because they are active? On a population level it is difficult to determine.
This Horizon program from the BBC is excellent viewing for those interested in such things.
http://www.bbc.co.uk/programmes/b01cywtq
On a hunch I decided to see if there's a correlation between obesity and antibiotics (which are known to kill both the good and bad types of gut bacteria)
Here's a map showing antibiotic prescribing rates.
http://www.cdc.gov/getsmart/co...
Here's a map showing obesity rates:
https://www.maxmasnick.com/med...
Correlation is not causation, but in my unprofessional opinion, these maps look eerily similar.
Some people have a more powerful drive to eat than others. Much like traditional pearl divers have a more easily controlled drive to breath (they also tend to die prematurely even if they don't drown).
My suggestion wasn't hold your breath for 24 hours, it was breath less for 24 hours. That's because people who are overweight cannot just fast for the rest of their lives (or they will die young) They have the more difficult task of eating less for the rest of their lives. That is, never again knowing the sensation of satiety. The breathing drive is stronger but I only asked for 24 hours.
So the mice gained weight when they were fed a crap diet. And, quelle surprise, when human porkers give up their short-lived attempts to stick to a Mediterranean diet and shove their noses back in the McDonald's trough, they pile back on the pounds.
Neither article says that the mice had a calorie-controlled diet. It seem far more likely that the gut microbiome changes have an impact on appetite.
You obviously didn't read the article you quoted.
"To test whether it was due to the microbiome, the researchers transferred the altered microbiomes into mice that had not previously been exposed to yo-yo diets - and here too they found unusually rapid and excessive weight gain when the mice were given high-fat foods."
The amount of weight gained on a given diet depended on the gut biome of the mouse more than the calorific content of their diet.
Yes, anyone can freely choose to feel tired and hungry all the time or to eat and be overweight but feel fine.
Troll was rated Troll because he trolled (yes, he touched a nerve - but that's part of trolling).
The underlying premise of the article is your gut is an extension of your neural and hormonal systems. Change its ecosystem's chemistry, and you'd think better and eat better. Have more fruit and vegetables, and your health will improve in a non-linear fashion - more than can be explained by better nutrition alone.
"Some people can't exercise because they have a physical health condition that prevents them from doing so."
Odd how it doesn't prevent them heading off to buy a burger or doughnut isn't it?
Are you really that dense? Just because a person's in a wheelchair, you think they can't eat? Just because a person's fat doesn't mean they eat junk food, just as just because a person's skinny doesn't mean they eat a "healthy" diet. What I find really odd is that the level of comments in a science and technology site aren't much better than on YouTube.
-- sudon't
Air-ride Equipped
Yeah, it is not simple thermodynamics. The complexity of the interactions in the body is overwhelmingly mind-boggling.
Interestingly enough, more and more researchers are buying into the lower-carb side of the diet controversy. And it seems that if you lower the amount of carbohydrates in your diet, you probably have to increase your fat intake to get enough energy to prevent starvation responses. And a gut that is adapted to burning fat for energy is significantly different from a gut that burns sugars. And so on....
However, the report of a single study doesn't provide a prescription for health. Some time ago there was good discussion about creating a comprehensive science database to compare outcomes of different research. This database would report on both successful and unsuccessful experiments and research, which could possibly cut down on instances of "fads" by identifying what works, what doesn't work, and what hasn't been tested yet.
"The mind works quicker than you think!"
...Personalised medicine is a huge emerging field and makes an awful lot of sense once you think about it.
That depends on if anyone can actually afford it.
Nothing like holding your cure over your head for the right price, which of course will be dictated by millionaires demanding to become billionaires.
The only thing that "makes an awful lot of sense" here is understanding that medicine creates massive profits and isn't getting any cheaper for anyone, no matter who propagates bullshit to the masses to claim otherwise.
Never trust science reporting. Here's a better source, the summary of the paper that was linked to:
Here, we identify an intestinal microbiome signature that persists after successful dieting of obese mice, which contributes to faster weight regain and metabolic aberrations upon re-exposure to obesity-promoting conditions and transmits the accelerated weight regain phenotype upon inter-animal transfer.
In other words, once a mouse has this microbiome signature they are more susceptible to obesity, i.e. it is harder for people who were once obese to remain at normal weight than for someone who was never obese.
Other studies have shown that once people become obese and start dieting their bodies go into a kind of starvation mode, where they need to keep calorie consumption down below normal levels to maintain their weight. In fact for people who were obese (not just overweight) it can be so bad that the number of calories they need to take in can be below the level at which normal western food can supply enough nutrition.
Of course this can be offset by doing a lot of exercise, but realistically people can't go for a long run every day or spend an hour on the exercise bike, especially as they get older and are probably already dealing with damaged joints from being too heavy.
So if we can find a way to reset that, perhaps by transferring the microbiome from one person to another, we can help people recover and stay at a healthy weight. I imagine it will be more effective than just berating them for being weak minded, at any rate.
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SJW, n: "Someone I don't like, and by the way I'm a fuckwit" - AC
Yes, anyone can freely choose to feel tired and hungry all the time or to eat and be overweight but feel fine.
As someone who's recently lost some weight, no, that's not right. You shouldn't be going at it so hard that you feel tired all the time. If you do, you're either trying to lose weight too fast, or there's something not optimal about what you're eating.
I found that even before I lost weight, eating high GI foods led to a nice full feeling followd by a carb crash where I'd feel sleepy, which I usually solved by guzzling coffee. Switching to less easily digestible stuff helped a great deal, though I still guzzle coffee, just not quite as much.
SJW n. One who posts facts.