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Scientists Create 'Designer Yeast' In Major Step Toward Synthetic Life (washingtonpost.com)
An anonymous reader quotes a report from Washington Post: In a significant advance toward creating the first "designer" complex cell, scientists say they are one-third of the way to synthesizing the complete genome of baker's yeast. In seven studies published Thursday in the journal Science, the researchers describe how they built six of the 16 chromosomes required for the yeast Saccharomyces cerevisiae, altering the genetic material to edit out some genes and write in new characteristics. The chromosomes generated this time represent the largest amount of genetic material ever synthesized, and the new Sc2.0 cells are substantially different from their natural, or "wild type," relatives. Among the most significant of these new features is a program the scientists called "SCRaMbLE," or "Synthetic Chromosome Recombination and Modification by LoxP-mediated Evolution" (scientists are congenitally disposed toward convoluted acronyms). The program allows scientists to rearrange elements within the genome to generate new and potentially useful permutations. Whereas many of Boeke's peers labor for years in the lab trying to genetically modify organisms, the SCRaMbLE system "lets the yeast do the work and lets the yeast teach us new biology," Jef Boeke, director of New York University Langone's Institute for Systems Genetics and an organizer of the project, said. It's like a version of the lottery in which you can continuously and instantaneously roll new numbers until you get a result you want. Other innovations in the Sc2.0 genome include the removal of duplicate bits of genetic code and the addition of short genetic sequences that distinguish synthetic chromosomes from their natural counterparts. Unlike other synthetic organisms, the engineered yeast is a eukaryote -- a complex cell with diverse internal structures, just like the cells in the human body. It has more genetic material than the bacteria synthesized by the Venter Institute and Harvard projects.
maybe these scientists have a taste for good booze and can make custom yeasts to brew some extra good beers & wines and brandies and some brews that distill better than your average spirits
Politics is Treachery, Religion is Brainwashing
He watched R. Daneel leave, then said to Clousarr, "You're a chemist?" "I'm a zymologist, if you don't mind." "What's the difference?" Clousan looked lofty. "A chemist is a soup-pusher, a stink- operator. A zymologist is a man who helps keep a few billion people alive. I'm a yeast-culture specialist." "All right," said Baley. But Clousarr went on, "This laboratory keeps New York Yeast going. There isn't one day, not one damned hour, that we haven't got cultures of every strain of yeast in the company growing in our kettles. We check and adjust the food factor requirements. We make sure it's breeding true. We twist the genetics, start the new strains and weed them out, sort out their properties and mold them again. "When New Yorkers started getting strawberries out of season a couple of years back, those weren't strawberries, fella. Those were a special high-sugar yeast culture with true-bred color and just a dash of flavor additive. It was developed right here in this room."
...and their designer candida.
I love stacking my barbecues in the shed at the end of summer - you can't beat a bit of grill on grill action.
"It's like a version of the lottery in which you can continuously and instantaneously roll new numbers until you get a result you want."
Or a result you don't want. What could possibly go wrong?
"National Security is the chief cause of national insecurity." - Celine's First Law
There has been a proof-of-concept for synthesizing opioids with genetically modified yeast.
we engineered yeast to produce the selected opioid compounds thebaine and hydrocodone starting from sugar. All work was conducted in a laboratory that is permitted and secured for work with controlled substances. We combined enzyme discovery, enzyme engineering, and pathway and strain optimization to realize full opiate biosynthesis in yeast. The resulting opioid biosynthesis strains required expression of 21 (thebaine) and 23 (hydrocodone) enzyme activities from plants, mammals, bacteria, and yeast itself. This is a proof-of-principle, and major hurdles remain before optimization and scale up could be achieved. Open discussions of options for governing this technology are also needed in order to responsibly realize alternative supplies for these medically relevant compounds.
If implemented successfully on a large scale, what are the consequences for traditional opium farmers from already poor regions?
I see the haters are already out, but it looks like we're closer to being the masters of DNA. This is f'ing awesome.
No, that link you posted to a web comic we've all seen a hundred times is not "obligatory."