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Moderate Drinking Can Damage the Brain, Claim Researchers (theguardian.com)

An anonymous reader quotes a report from The Guardian: Drinking even moderate amounts of alcohol can damage the brain and impair cognitive function over time, researchers have claimed. Writing in the British Medical Journal, researchers from the University of Oxford and University College London, describe how they followed the alcohol intake and cognitive performance of 550 men and women over 30 years from 1985. At the end of the study the team took MRI scans of the participants' brains. None of the participants were deemed to have an alcohol dependence, but levels of drinking varied. After excluding 23 participants due to gaps in data or other issues, the team looked at participants' alcohol intake as well as their performance on various cognitive tasks, as measured at six points over the 30 year period. The team also looked at the structure of the participants' brains, as shown by the MRI scan, including the structure of the white matter and the state of the hippocampus -- a seahorse-shaped area of the brain associated with memory. After taking into account a host of other factors including age, sex, social activity and education, the team found that those who reported higher levels of drinking were more often found to have a shrunken hippocampus, with the effect greater for the right side of the brain. While 35% of those who didn't drink were found to have shrinkage on the right side of the hippocampus, the figure was 65% for those who drank on average between 14 and 21 units a week, and 77% for those who drank 30 or more units a week.

33 of 325 comments (clear)

  1. How much is a unit? by RobinH · · Score: 5, Informative

    From the study: 1 unit is 10mL or 8g of alcohol. 14 units (UK guidance per week for men an women) is 4 pints of high strength beer (5.2%) or 5 large glasses of 14% wine. 24.5 units (US guidance for men) is equivalent to 7 pints of beer or 9 glasses of wine.

    --
    "I have never let my schooling interfere with my education." - Mark Twain
    1. Re:How much is a unit? by KozmoStevnNaut · · Score: 2, Insightful

      So these people did not have a "moderate" alcohol intake, they had a high alcohol intake.

      --
      Eat the rich.
    2. Re:How much is a unit? by Anonymous Coward · · Score: 3, Informative

      They were drinking this over the course of a week. It would be a high amount if consumed in a single day, but not when spread out over 7.

    3. Re:How much is a unit? by s_p_oneil · · Score: 2

      It's all relative. My wife keeps trying to convince me I'm an alcoholic, and I only drink 1-3 16oz US beers (2.5%) each week. I never drink more than 1 on the same day, never on consecutive days, never more than 3 in a week, and when I pick up one of the 5% beers, I actually get a buzz so that's considered a "binge" for me.

      To my wife, 3-7 units per week = alcoholic.

      To my Irish-descended Navy family, 3-7 units per week = teetotaler.

  2. Moderate? by sjbe · · Score: 3, Insightful

    While 35% of those who didn't drink were found to have shrinkage on the right side of the hippocampus, the figure was 65% for those who drank on average between 14 and 21 units a week, and 77% for those who drank 30 or more units a week.

    Per the article 14 units = approximately 6 pints of beer. Is that really moderate drinking? That's basically having a drink or more a day. Not alcoholic territory or anything but that's pretty steady consumption. Moderate drinking to my mind would be maybe a pint or two a week at most. Not having a drink with dinner every night. I'm not being critical. If someone enjoys a beer or glass of wine with dinner that's fine as long as they do so responsibly but it isn't what I consider moderate consumption.

    Anyway, alcohol isn't good for you. News at 11... I'm pretty sure that anyone drinking a pint a day isn't overly concerned about the health effects, good or bad.

    1. Re:Moderate? by Entrope · · Score: 2

      The 1920s called, they wanted their busybody-temperance movement back.

      The UK government is funding studies like these by the boatload. Who cares if 95% of them have negative results? 5% of them have findings that are statistically significant at the 5% level, so that's enough for the government to order people what to do (or not to do).

    2. Re:Moderate? by Entrope · · Score: 4, Insightful

      The high-school-level statistical explanation: Statistical studies are often described as "statistically significant" if their results could happen by chance less than 5% of the time. You can usually find such a study by luck if you try 14 times.

      The ugly reality: You usually need many fewer than 14 tries, because of how exploratory analyses and controlling for related variables violate the assumptions underlying the probability calculations. Researchers never have enough information to really adjust for their statistical manipulations of the data. This study is particularly weak because it only used ~511 people (out of the 550 claimed in the summary, 23 had pre-existing anomalies in brain structure or missing data, and 16 had poor-quality brain scans, and they dropped some other people out for specific sub-analyses) and they broke these into lots of smaller groups to try to control for variables that could influence alcohol consumption and/or hippocampus shrinkage.

    3. Re:Moderate? by bradley13 · · Score: 3, Informative

      A drink or two a week? That's light drinking. I think you must move in social circles where people rarely drink at all.

      In southern Germany, for example, it's not at all unusual to have a beer with your lunch, and another with dinner. In France or Italy, it will be a glass of wine - about the same amount of alcohol. That's 1-2 drinks per day, every day. Plus a couple of extra drinks with your buddies on Friday or Saturday. That's average, or moderate drinking in cultures where alcohol is a normal part of life. I'm typing this in the evening, after work, while sipping my second beer of the day.

      As in all things in life, there's a trade-off. Alcohol helps people relax after a stressful day. It also has a few health benefits (or some of the other things contained in drinks do). However, it's also not great for your liver, and possibly your brain, and alcohol abuse is a possibility. Life's a bitch, and then you die.

      Heck, you can die from drinking too much water.

      --
      Enjoy life! This is not a dress rehearsal.
  3. isn't that the point? by turkeydance · · Score: 2

    isn't it?

  4. Re:Cause and effect... by KozmoStevnNaut · · Score: 4, Insightful

    So consumption of alcohol is simply stupid?

    Could it be that a lot of people enjoy alcohol because it tastes good, and that we happen to enjoy a light buzz, without feeling the urge to get totally plastered?

    --
    Eat the rich.
  5. Re:Cause and effect... by butzwonker · · Score: 4, Insightful

    That's all consistent with being stupid, so the two explanations are not mutually exclusive.

  6. Re:Perhaps something more complex is involved by TimothyHollins · · Score: 5, Interesting

    Well no, not even close. Epidemiologically we do not know everything that leads to drinking, nor everything that drinking leads to, which means we have unknown confounders in a complex system. Over 30 years those confounders will grow to a massive interference level.

    Consider this conundrum that caused a lot of panic in the early days of epidemiology. Does drinking cause lung cancer? The answer was a surprising yes. Every study came up positive.
    Today, we know that to be false. Why? Because drinkers also tend to be smokers. When you control for smoking and keeping company with smokers, the effect goes away completely. That is what we call a confounder.

    Now we see that moderate drinking leads to hippocampal shrinkage. Does that mean drinking is the problem? Not necessarily. As TFS says, they did control for a host of things, but were those ALL the relevant things? The answer is usually no.
    Over a period of 30 years things change, ALOT. The lifestyles of the subjects change, their exposure to various environmental effects change, their hormonal setups change. What if drinkers tend to be more social? Just that single difference would introduce them to a whole host of different exposures when compared to non-drinkers, and none of those exposures would have anything to do with drinking itself.

    There is no doubt an association between hipppocampal shrinkage and drinking, but what that association consists of is less certain. That is why the original point stands.

  7. Re:Cause and effect... by Anonymous Coward · · Score: 2, Insightful

    Fuck yeah. And get rid of refined sugar, candies, and deep fried foods. Those, too, are poisons that are consumed by stupid people to make themselves feel better while destroying their bodies.

  8. Re:Cause and effect... by Entrope · · Score: 2, Funny

    Be aware! Overconsumption of water can lead to death. Even moderate consumption, if sustained over time, can poison your brain and body. There's no right or wrong, but that is the choice being made here.

    I read that on the Internet, so it must be true.

  9. Re:Cause and effect... by MangoCats · · Score: 5, Insightful

    This is self reported levels of drinking. While I tend to believe people who self-report "never drinking" I tend to doubt that the 14-21 units of alcohol per week crowd are 100% truthful about "never binging" - occasional weeks might include 21 units of alcohol in a 6 hour period.

    Plus, I know it's England, but since when is 3 drinks a day, every day of the week, moderate?

  10. Re:Alcohol consumed daily != moderate consumption by GrumpySteen · · Score: 3, Informative

    Four pints over seven days isn't one or more per day.

  11. Re:Perhaps something more complex is involved by Entrope · · Score: 2

    They claimed correlation, while admitting there were some notable uncontrolled confounders, exceptions to the implied rule, and limitations to their analysis.

    Then they went on to say this justified the British government's recent move to reduce the alcohol consumption guidelines, which would only be a valid conclusion if they demonstrated cause and effect, so maybe they think they did demonstrate that.

  12. Re:Cause and effect... by geekmux · · Score: 2

    Fuck yeah. And get rid of refined sugar, candies, and deep fried foods. Those, too, are poisons that are consumed by stupid people to make themselves feel better while destroying their bodies.

    Ironically, this behavior is quite evident to be by design when reviewing the ingredients used to create McFood.

    Yeast extracts and hydrolyzed proteins are considered excitotoxins, and are added to create that feel-good effect, and also make you crave it again.

    Just another day in the land of Greed and Capitalism.

  13. Or maybe... by zifn4b · · Score: 4, Interesting

    They turned to drinking to cope with dealing with stupid people at their work and the real cause of the problem is that they lost brain cells from dealing with said stupid people.

    --
    We'll make great pets
  14. Re:Cause and effect... by KozmoStevnNaut · · Score: 3, Insightful

    So it's stupid to enjoy something that tastes good and makes you pleasantly light-headed?

    Neo-puritans be crazy.

    --
    Eat the rich.
  15. Age corrected. by DrYak · · Score: 4, Informative

    are you sure it is not age related? between 20 & 50 is a long time

    Age was taken into account.
    Still, some people degraded faster than others in this span of time.
    And those were significantly more likely to also be drinking.
    - Thus the actual conclusion that one real scientist should take home : there's a statistical link between the two.
    - Thus also the baseless spin that the press (and even the original BMJ article) are trying to take on it : even light drinking cause brain destruction

    --
    "Sufficiently advanced satire is indistinguishable from reality." - [Tips: 1DrYakQDKCQ6y52z6QbnkxHXAocMZJE61o ]
  16. Re:Cause and effect... by KozmoStevnNaut · · Score: 2

    By comparison, there is no amount of alcohol that has been proven to be of benefit, even with moderation. It is quite clearly, a poison.

    Stop lying. You're basing your statements on one flawed study. Notice the amounts consumed by the participants. They're way over what any reasonable person would call "moderate".

    Also, this:
    https://www.hsph.harvard.edu/n...

    --
    Eat the rich.
  17. Re:Cause and effect... by KozmoStevnNaut · · Score: 4, Informative

    The study cites 14-21 units/week of alcohol as "moderate consumption". That is not moderate, it's definitely into the "high" range. Thus, the conclusion is flawed when the paper talks about moderate consumption, because it isn't.

    It you would read the paper, it supports the current UK recommended limits (14 units per week maximum) and posits that the current US limits are too high.

    That is perfectly in line with what I've stated in this thread and in other comments on this article.

    --
    Eat the rich.
  18. Re:Cause and effect... by BarbaraHudson · · Score: 2

    People always minimize their consumption. A couple of months ago a medical professional was taking my history, and asked me about my alcohol consumption and I laughed. She said that usually means either you drink a LOT or none at all. I told her that the only times I had any alcohol last year were Thanksgiving and Christmas at family suppers, and it wasn't much. Getting loaded is considered bad form and makes you a boring conversationalist, even if YOU think you're brilliant.

    --
    "Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
  19. Re:Cause and effect... by David_Hart · · Score: 2

    The study cites 14-21 units/week of alcohol as "moderate consumption". That is not moderate, it's definitely into the "high" range. Thus, the conclusion is flawed when the paper talks about moderate consumption, because it isn't.

    It you would read the paper, it supports the current UK recommended limits (14 units per week maximum) and posits that the current US limits are too high.

    That is perfectly in line with what I've stated in this thread and in other comments on this article.

    BTW, the definition of units is poorly defined here. Below is a link to the UK web page that shows what they mean. For me, I would have to be on a drinking spree to drink 6L of lager a week. I enjoy alcohol but I tend to limit it to a couple of coolers at occasional BBQs and a couple of glasses of wine at special occasions and nights out with friends.

    https://www.drinkaware.co.uk/a...

  20. Re:Moderate drinking? by PopeRatzo · · Score: 2

    That's 2-3 beers or glasses of wine a day on average. I'd call that pretty heavy drinking.

    I'd call that a fucking lightweight.

    --
    You are welcome on my lawn.
  21. Official response from Scottish peer reviewers: by PopeRatzo · · Score: 2

    "U feckin' knobs are lookin' fer a burst mooth."

    --
    You are welcome on my lawn.
  22. Re:Cause and effect... by HornWumpus · · Score: 5, Funny

    The drinking culture of England isn't stupid?

    Bullshit. If a Brit drinks 21/week. That's 21 on Friday night.

    If a Scot drinks 21/week, he's just lying. That was monday.

    We're not even going to talk about the Mics. If they have less than 21 in their blood they shake.

    --
    John McAfee 'It was like that time I hired that Bangkok prostitute; to do my taxes, while I fucked my accountant'
  23. Re: Cause and effect... by KGIII · · Score: 4, Funny

    I kinda suspect that sex didn't even cross their mind. This is Slashdot, after all.

    --
    "So long and thanks for all the fish."
  24. SkÃl, as they say here in Iceland by Applehu+Akbar · · Score: 2

    Think I'll wait a week, until the next study contradicts this one.

  25. Re:Cause and effect... by Quirkz · · Score: 2

    I want to find a way to say "drinking increases creativity" in a way that doesn't sound so unilateral.

    I'm not really sure it helps much with creativity, at least in my case, but there's something there. For me, I almost want to say it just facilitates my willingness to sit in one place and work on the thing I've been meaning to work on, whether it's something creative or some kind of drudgery/chore. I don't know that it makes a lot of sense, because promoting focus isn't something I'd attribute to alcohol.

  26. Re:Cause and effect... by BarbaraHudson · · Score: 2

    Slightly intoxicated folks tend to enjoy having conversations with slightly intoxicated folks the same way that heavily intoxicated folks tend to enjoy having conversations with other heavily intoxicated folks. But even slightly intoxicated folks don't want to talk with those same heavily intoxicated folks. And the bullshit factor rises quickly with every drink. After a certain point, nobody can put up with a drunk's bullshit. Or someone who's slightly intoxicated and doesn't realize they're being boorish or offensive.

    --
    "Transparent" is a shit show that trades on every stereotype going. A man in drag is NOT a transsexual.
  27. One reason for drinking is PTSD by WillAffleckUW · · Score: 2

    The inability to get to sleep, financial stress, and environmental stress, and general levels of pain all lead to increased drinking.

    All of those things are correlated with this area of the brain being smaller.

    Going to need a more finely tuned study.

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