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Anti-Aging Stem Cell Treatment Proves Successful In Early Human Trials (newatlas.com)

Posted by BeauHD on from the FDA-approved dept.

An anonymous reader quotes a report from New Atlas: The results of two human clinical trials into a stem cell therapy that can reverse symptoms of age-associated frailty have been published, and the indications are that this landmark treatment is both safe and strikingly effective in tackling key factors in aging. Mesenchymal stem cells (MSCs) are a particular type of adult stem cell generating a great deal of interest in the world of science. This new MSC treatment is targeted at reducing the effects of frailty on senior citizens. This is the first anti-aging stem cell treatment directed specifically at the problem of age-associated frailty to move close to a final FDA approval stage. The treatment derives human mesenchymal stem cells from adult donor bone marrow and in these clinical trials involves a single infusion in patients with an average age of 76. Both Phase 1 and Phase 2 human trials have demonstrated the treatment to have no adverse health effects.

Although the two human trials were ostensibly designed to just demonstrate safety they do offer remarkable results in efficacy as well, paving the way for larger, Phase 3 clinical trials. In the first trial 15 frail patients received a single MSC infusion collected from bone marrow donors aged between 20 and 45 years old. Six months later all patients demonstrated improved fitness outcomes, tumor necrosis factor levels and overall quality of life. The second trial was a randomized, double blind study with placebo group. Again no adverse affects were reported and physical improvements were noted by the researchers as "remarkable." The next stage for the research is to move into an expanded Phase 2b clinical trial involving 120 subjects across 10 locations. After that a final, large randomized Phase 3 clinical trial will be the only thing holding the treatment back from final public approval. The results of the Phase 1 clinical trial were recently published in The Journals of Gerontology. The results of the Phase 2 clinical trial were recently published in The Journals of Gerontology. Further reading available via University of Miami, Miller School of Medicine.

84 comments

  1. Doesn't hold water by philmarcracken · · Score: 5, Interesting

    Reposted from a more reputable interpreter of the results on reddit:

    "I look at these results

    (Fig. 2 from the journal article, supposedly demonstrating an improvement in frailty markers) and just see noise. No dose-response. No consistent benefit across measures for different treatment groups.

    The figure shows four different tests for resilience to age-related frailty - each fig. 2a, 2b, 2c and 2d represent how each of the treatment groups performed on these tests at different time points.

    There were three treatment groups: patients receiving 100 million cells (100-M), patients receiving 200 million cells (200-M) and a placebo group.
    The 100 million cell group showed a stat dig improvement in the six minute walk test.

    The problem, though, is that the 200 million group did not. So there is no dose response relationship. Generally, if a drug is real, the more drug you apply the stronger treatment effect you observe (lots of caveats to this generality, but none seem too relevant here).
    Further, the 100 million group on showed a positive outcome in the six minute walk test. It failed to demonstrate efficacy consistently in the other three tests the researchers used to measure resilience against age-related frailty. In some cases it was even worse than placebo.

    I would happily bet an amount of money that mattered to me that this result would fail to be replicated in a randomized, placebo-controlled study."

    1. Re:Doesn't hold water by Bill+Hayden · · Score: 5, Interesting

      Very interesting results -- thanks for pointing them out.

      It's notable that the 200M cell group performed at best the same, but usually worse than placebo on almost every test at every time frame. I'd have to disagree with you about dose response, though. Every medicine is going to have a bell curve of efficacy, and it looks like they just guessed too high on higher dose.

      Also, you imply that the 100M cell group only improved on the 6 minute walk test. In fact, that group had statistically significant improvement on 3 out of 4 tests.

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    2. Re:Doesn't hold water by drunken_boxer777 · · Score: 5, Interesting

      I agree that it likely won't be replicated in a larger trial, but not for the reasons that you state.

      Dose response can be straightforward in small molecule drugs, like aspirin. It becomes more complicated in biologic drugs, like granulocyte colony stimulating factor (filgrastim). We don't really know how it will work with stem cells, and the authors do list biologically plausible reasons why they don't see a dose response.

      The real issue (besides the really low # of subjects) is the statistical analysis. They compare change from baseline (outcomes at 6 months vs. baseline) within a treatment group and look for statistical significance. What they should be doing is comparing change from baseline within a group vs. the change from baseline of the placebo group. See how the error bars of the 100 M group at 90 and 180 days overlap with the error bars of the placebo group in figure 2A? Not statistically different from placebo.

      Granted, it would be crazy effective if it were statistically significant vs. placebo in such a small trial. However, their poor use of statistics (including no accounting for multiple analyses) is a major red flag. But this is about raising VC, as others might have pointed out. Multiple authors with MBAs rather than professional degrees (PhD, MD) is a giveaway.

    3. Re:Doesn't hold water by gurps_npc · · Score: 4, Interesting

      Dose response is for medication. This is not medicine, but instead a transplant of live cells.

      Live cell transplants often do not get a dose response.

      Compare with bread making - the difference between putting in 1 tablespoon of yeast and 2 tablespoons of yeast is minute.

      I am not saying the study did great, but your major criticism is not appropriate for this type of treatment.

      --
      excitingthingstodo.blogspot.com
    4. Re:Doesn't hold water by yndrd1984 · · Score: 5, Informative

      Generally, if a drug is real, the more drug you apply the stronger treatment effect you observe (lots of caveats to this generality, but none seem too relevant here).

      Why? First - it's not a drug. Second, even drugs (e.g. Seroquel) don't always do that - as you increase the dosage first it's an antihistamine, then causes low blood pressure, then it's an anti-psychotic - and that's a single molecule. Some drugs even manage to have a U-shaped response curve.

      I would happily bet an amount of money that mattered to me that this result would fail to be replicated in a randomized, placebo-controlled study.

      I would as well, just because of how often these early trials fail to produce usable results. But in the long run we have to make some long shots or we'll never get anywhere.

    5. Re:Doesn't hold water by clong83 · · Score: 1

      Interesting insights, and I won't disagree with those conclusions, as I am not an expert in the field, nor have I read the actual journal article.

      I will, however, point out that the purpose of the trial phase they were in was not to demonstrate efficacy, but to demonstrate the safety of the procedure. I would presume that many of the criticisms/questions you raise will be studied more thoroughly in the next phase. It would not be the first time that a drug or treatment was found to be safe, but mostly useless.

      I agree it is way too early to get excited yet, but then again "Potential anti-aging therapy found to be safe in clinical trials, and despite some hints that it may also work well, many questions linger as to the actual efficacy" doesn't make a good clickbaity headline...

  2. Too good to be true by Gavagai80 · · Score: 0

    We see health breakthroughs like this reported all the time, yet the ages people live to and the quality of life for the elderly haven't budged in the developed world for a long time. So what's the catch, what's the misrepresentation, what's the flaw in this treatment?

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    1. Re:Too good to be true by AutodidactLabrat · · Score: 0

      Actually,median age at death for white males is DOWN over the last 17 years.
      It's the outsourcing and Walmarting of jobs.

    2. Re:Too good to be true by omnichad · · Score: 1

      Or maybe it's the elimination of trans-fats in fast foods and snack foods. Who can say? It's not like our world population is a properly controlled study.

    3. Re:Too good to be true by AutodidactLabrat · · Score: 1

      Ahhh, notices the AGE AT DEATH is down, as in Dying YOUNGER

    4. Re:Too good to be true by Opportunist · · Score: 1

      People on average are poorer than they were. And being poor is a surprisingly huge factor when it comes to life expectancy.

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    5. Re:Too good to be true by jellomizer · · Score: 2

      I expect other factors (non medical) are coming into play that are counteracting it’s benefits for some people.

      The people who are in their 70’s and 80’s who are active and involved are actually in better conditions then they ever been in. However for the people the same age who have been more or less isolated and inactive are in worse case.

      I think the problem isn’t Health Care but general Caring.
      As the boomers who grew up in the Hippie culture to the yuppie culture to the hot mess that Trump personifies. They have grown up in the Me culture and didn’t spend time actually caring about other people. And now they are older not so many people are caring about them. Medicare is great we can lock up the elderly and we don’t need to directly pay for it and we don’t need to face older people or bother being considerate of the inevitable fate that we are destined to have as well.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    6. Re:Too good to be true by micahraleigh · · Score: 1

      I agree that science and the click-baiters tend to over promise ... but hasn't budged? In this case I see the exact opposite.

    7. Re:Too good to be true by AutodidactLabrat · · Score: 1

      Wrong
      Median income for White Males is HIGHER than in 2001
      As always, the facts get in the way

    8. Re:Too good to be true by Opportunist · · Score: 1

      You had to go back to 2001 to make it true?

      Hey, guess what: You really did.

      And we're not even adjusting for inflation yet.

      Not to mention that median income says exactly zilch. If you have one leg in the oven and the other in the freezer, your median temperature is cozy. What you would at least have to add is the actual distribution.

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    9. Re:Too good to be true by AutodidactLabrat · · Score: 1

      Wrong.
      Check the Census links and the Dept. of Labor. EVERYTHING is in 2001 dollars
      MEDIAN means 50% of the PEOPLE are above that level and 50% below, so YES incomes for the majority of Americans are up, however slightly, in 2001 dollars
      Nice try though

    10. Re:Too good to be true by AutodidactLabrat · · Score: 1

      Oh, btw, I didn't use the 2010 census because, you know, BUSH CRASH still had 12 million MORE people out of work
      Which would have made you look even more incorrect (stupid)

    11. Re:Too good to be true by Opportunist · · Score: 1

      Median still means jack shit if you offer no deviation. The median income in some countries looks nice until you notice that you basically have a group of fantastically rich and a group of incredibly poor with little in between. Quite a few places in the middle east are looking that way and it looks like China is preparing to go that way too.

      But I guess as long as you find an excuse to call me stupid, it matters little to you, right?

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
  3. Great, more ways for boomers to f**k the rest by Anonymous Coward · · Score: 0, Troll

    >>> In the first trial 15 frail patients received a single MSC infusion collected from bone marrow donors aged between 20 and 45 years old.

    Great, yet another way for boomer to f**k millennials and gen-Y. Because outsourcing and gigantic debt wasn't enough. Now they are going to create market for selling your body (literally) and then use extra retirement years to bankrupt the social security and pensions systems.

    Anyone going for life-prolonging treatment should become ineligible for SS and pension payments at 80.

    1. Re:Great, more ways for boomers to f**k the rest by drunken_boxer777 · · Score: 1

      Great, yet another way for boomer to f**k millennials and gen-Y.

      Literally. The subjects were tested for changes in sexual functioning via the Sexual Quality of Life-Female (SQOL-F) and International Index of Erectile Dysfunction (IIEF) Questionnaires. The authors reported no improvement in the men, but in the women... bingo!

      With a mean age of 75.5, and improved sexual response and quality of life, they'll be preying on millennials and gen-Y.

    2. Re:Great, more ways for boomers to f**k the rest by Paradise+Pete · · Score: 2

      Great, yet another way for boomer to f**k millennials and gen-Y.

      The sense of entitlement is strong in this one. "Those old farts had better die on schedule and get out of my way." You too will be an old fart one day, except that these treatments will be much further along and you'll be the one telling the kids to fuck off.

    3. Re:Great, more ways for boomers to f**k the rest by omnichad · · Score: 1

      Anyone going for life-prolonging treatment should become ineligible for SS and pension payments at 80.

      Gradual increasing of retirement age has been the general rule for increasing longevity and more healthy years.

    4. Re:Great, more ways for boomers to f**k the rest by Opportunist · · Score: 2

      The problem we face today is that longevity increases, but healthy years don't.

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    5. Re:Great, more ways for boomers to f**k the rest by omnichad · · Score: 1

      That hasn't actually stopped retirement age from increasing. Knowledge workers don't need to be healthy to get work done (says the 3-letter bosses, anyway).

    6. Re:Great, more ways for boomers to f**k the rest by Opportunist · · Score: 1

      That's fine for jobs where brain power is more relevant than brawn power, but what are you going to tell the 60 year old bricklayer with a bad enough back that he can't sit straight for more than a few minutes, let alone stand?

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    7. Re:Great, more ways for boomers to f**k the rest by omnichad · · Score: 1

      The bad news is that you've been replaced by a robot....the good news is that you are the robot (after a few more surgeries).

  4. Next is Modern Human Trials? by Scarletdown · · Score: 1, Funny

    So, where did they manage to find early Humans to do these trials on? I mean, everything from Homo Habilis through Neanderthal is extinct. :D

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    1. Re:Next is Modern Human Trials? by Anonymous Coward · · Score: 0

      I'm pretty sure I've seen some of them alive and well.

    2. Re:Next is Modern Human Trials? by Scarletdown · · Score: 1

      Most likely in COBOL shops?

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    3. Re:Next is Modern Human Trials? by Opportunist · · Score: 1

      More in Apple shops. You know them as "genius".

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
  5. Once again by 93+Escort+Wagon · · Score: 1

    Life imitates Futurama.

    --
    #DeleteChrome
    1. Re: Once again by Anonymous Coward · · Score: 0

      Didn't see futurama but in "the 100" they we're doing this exact thing; bone marrow transplants

    2. Re:Once again by msauve · · Score: 1

      I don't think they were testing on heads in jars.

      --
      "National Security is the chief cause of national insecurity." - Celine's First Law
    3. Re:Once again by 93+Escort+Wagon · · Score: 1

      I was thinking about this scene: https://youtu.be/6FFnPjhEoF4?t...

      --
      #DeleteChrome
    4. Re:Once again by fahrbot-bot · · Score: 1

      Life imitates Futurama.

      Or South Park

      In "Krazy Kripples", Christopher Reeve comes to town to promote stem cell research. In order to 'cure' his quadriplegia, he is shown sucking the fluids out of fetuses from a medical bio-hazard container. With each fetus he sucks dry, Reeves becomes healthier and more dependent on them for his developing super human strength.

      Hmm... Maybe it's art imitating life.

      --
      It must have been something you assimilated. . . .
  6. Too late guys. They already did this. by Anonymous Coward · · Score: 0

    Back in the 1980s.

  7. This kind of PR is to lure gullible investors... by ffkom · · Score: 4, Insightful

    ... into investing their fortune into some pot of gold that waits at the end of the rainbow.

    And BTW: If such a method actually worked well, people would rather not make this public, but use it in seclusion, knowing well that otherwise they would soon compete with way too many eternal-living people for resources on this planet.
    Or would you think that somebody who's able to live for 1000 years would still want to work for others after the first 100?

  8. Re:This kind of PR is to lure gullible investors.. by Anonymous Coward · · Score: 0

    Sure, sure, but asteroid mining and space-based solar power totally aren't. I'd rather back anti-aging instead of 1960s pipe dreams.

  9. Re:It'll be regulated into the ground by Anonymous Coward · · Score: 2, Informative

    "I've never seen a Government do anything good, ever, when revolutionary new advances occur."

    Really? You've never seen treated municipal drinking water (reducing water-borne illnesses), sewer systems, regulated hospitals, food safety laws, etc?

    Put down the Ayn Rand, and perhaps join us in reality?

  10. Mysterious disappearances... by kimgkimg · · Score: 1

    In a related story, authorities are investigating the mysterious disappearance of a number of people aged 20 to 45 years old who lived near the testing facilities conducting the Trials...

    1. Re:Mysterious disappearances... by fahrbot-bot · · Score: 1

      In a related story, authorities are investigating the mysterious disappearance of a number of people aged 20 to 45 years old who lived near the testing facilities conducting the Trials...

      Ya, but the testing facility is also next to the Soylent Green processing plant.

      --
      It must have been something you assimilated. . . .
  11. Re:It'll be regulated into the ground by Ichijo · · Score: 0

    Yes, but other than treated municipal drinking water, sewer systems, regulated hospitals, and food safety laws, what has the government ever done for us?

    --
    Any sufficiently unpopular but cohesive argument is indistinguishable from trolling.
  12. Cloning & this = immortality... apk by Anonymous Coward · · Score: 0

    See subject & THINK about it: A few years ago, a paraplegic began moving her fingers after stemcell treatment - so, to avoid tissue rejection, those sufficiently wealthy can clone themselves & JUST LIKE dropping an engine out of 1 engine bay into another (except w/ whatever wisdom you acquired over a lifetime), sever the spinal cord & drop it into a NEW body (of your OWN self & wait out the healing (what's that? A YEAR OR 2 PRICE?? Next to nothing compared to unlimited lifetimes...)

    APK

    P.S.=> I was told DECADES ago by Prof. Carl Ellerman that this was only around the corner (1985) & here we are... apk

    1. Re:Cloning & this = immortality... apk by crow · · Score: 2

      For specific organs, it's likely that they'll be able to clone them without having to clone an entire person. Just figure out the right chemical signals, and have your DNA grow a new heart in a pig to be harvested in a year. Oh, and edit the DNA a touch first to remove any known issues that won't lead to organ rejection.

      Probably the hardest part in all of this is wiring up the nerves that get disconnected. Much of the organ control in the body is chemical, but there's still plenty we don't know. That's the big thing getting in the way of growing replacement limbs--if you can't wire up the nerves, they won't work. And this isn't like wiring a device where there are defined connections--I suspect it's all random, and the brain just develops to use whatever it finds, but an adult brain isn't prepared to start over.

    2. Re:Cloning & this = immortality... apk by Opportunist · · Score: 1

      I'll start with the severing of their spinal cords, you try the rest, deal?

      --
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  13. No thanks by PopeRatzo · · Score: 3, Insightful

    I don't mind aging. As I get older, I just get more dangerous.

    --
    You are welcome on my lawn.
    1. Re:No thanks by Anonymous Coward · · Score: 0

      Yes, to yourself. I mind aging, a lot. Watching my body slow down, get fatter and more fragile, sensing my brain get dumber, this is no longer acceptable.

    2. Re:No thanks by Anonymous Coward · · Score: 0

      No, to others. You ever see a 92-year old racing down the highway?

    3. Re:No thanks by Anonymous Coward · · Score: 0

      Yep, I admire my grandfather. He lived to a ripe old age and died peacefully in his sleep.

      The passengers in his car as it went over the cliff are another matter.

    4. Re:No thanks by PopeRatzo · · Score: 1

      Yep, I admire my grandfather. He lived to a ripe old age and died peacefully in his sleep.

      The passengers in his car as it went over the cliff are another matter.

      Live fast, die old is my motto. Anyway, nobody's wanted to be a passenger in my car since about 1987. Blasting Suicidal Tendencies on the car stereo made sure of that.

      --
      You are welcome on my lawn.
    5. Re:No thanks by Opportunist · · Score: 1

      Don't worry, there are three stages of brain aging.

      First only you notice. This is worrying.
      Then others notice it too. This sucks.
      Then only others notice it anymore. This is great.

      --
      We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
    6. Re:No thanks by Quirkz · · Score: 1

      Yes. In my lane, coming toward me, on the interstate. With two other terrified passengers sitting inside.

      Luckily he was half on the shoulder and I was looking far enough ahead and had space to get over into the other lane.

      To this day, I don't know why he didn't just stop and turn around. Or just pull over and stop.

      --
      The Quirkz Handbook of Self-Improvement for People Who Are Already Pretty Okay
    7. Re:No thanks by Anonymous Coward · · Score: 0

      New Zealand doesn't have states.

      CAPTCHA "autonomy" sigh...

  14. Re:This kind of PR is to lure gullible investors.. by superdave80 · · Score: 2

    I don't think we can expect gigantic leaps in age. I think the main benefit is that the years you do have are healthier.

  15. Re:It'll be regulated into the ground by Anonymous Coward · · Score: 0

    Yeah yeah, you're just upset that the Vorlons killed you Deathwalker.

  16. Re:This kind of PR is to lure gullible investors.. by Eloking · · Score: 2

    ... into investing their fortune into some pot of gold that waits at the end of the rainbow.

    And BTW: If such a method actually worked well, people would rather not make this public, but use it in seclusion, knowing well that otherwise they would soon compete with way too many eternal-living people for resources on this planet.

    Or would you think that somebody who's able to live for 1000 years would still want to work for others after the first 100?

    Not gonna happen. At least not for long.

    Such a discovery will require a lot of people. Lot of people with even more friend/families that you would need to shut up.

    Add to this the greed. You live forever, but you could be rich by selling the thing to billionaire. And now you got even more people to shut up.

    --
    Elok
  17. Is it better than HGH (human growth hormone)? by Anonymous Coward · · Score: 0

    Have four friends that work at Microsoft that are spending about $75 a day from an illegal source, and it's great for them. Two had COPD from cotton textile mill exposure where they worked while growing up and while in college which included bad chronic coughs. That cured those two. All four are noticeable healthier and can now work longer hours. It's sad the FDA blocks HGH for the vast majority of people.

  18. Wish I could get my fellow Americans by rsilvergun · · Score: 1

    see stuff like this and give up on the concept of 'insurance' for health care. When tech lets us do maintenance to the human body insurance no longer makes sense. After all, you won't find anyone who'll tell you that extended car warrantees are anything more than a scam. And besides, google the phrase "Wallet Biopsy" some time and despair.

    --
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    1. Re:Wish I could get my fellow Americans by Motard · · Score: 1

      Yes, by all means, let's 86 the whole concept of insurance because future tech might do something useful. After all, health insurance is exactly like a car warranty.

      My God, why didn't we think of this before?

    2. Re:Wish I could get my fellow Americans by stabiesoft · · Score: 1

      Normally I'd agree with you and normally I'd never buy one. BUT, I've got mag shocks in a car and saw they are like 1200/pr. I got an extended warranty for around 1.6K that covered the shocks along with almost everything else. 2 months out of manufacturer warranty the rear diff went. The extended warranty covered it. 4K with labor. Paid for the extended warranty and then some and I still have a couple years left on the extended. First one I have ever bought (and this is like my 10th car) and I am normally anything but lucky. But yes I still recommend to people not to get the warranty.

    3. Re: Wish I could get my fellow Americans by Anonymous Coward · · Score: 0

      Because the tech will be free, right?

      Just like as medicine improved from hacking off infected limbs and applying fire to the stump all the way to sewing severed limbs back on and stitching the nerve endings back together, prices have gone down as tech has improved.

      Riiiiiight!

  19. I'd TAKE THAT CHANCE (how about you?) by Anonymous Coward · · Score: 0

    Brain movement was what I was about & I've seen enough the past few years I spoke of that make it a practical reality...

    * BESIDES - if you had the coin? Would you REALLY care if it failed? Doubt it - It'd be a hell of a GOOD "calculated risk" & I've done the calculation for it, based on scientific precedent (not impossibility). WHAT WOULD YOU HAVE TO LOSE? Nothing (you can't take it with you, OR can you->) Nothing & EVERTHING to gain.

    REMEMBER - there is relatively NO POSSIBLE of tissue rejection from a CLONE (of you, hell, possibly BETTER engineeering via retroviral reprogramming vs. your native defects (e.g. myopia)).

    APK

    P.S>=> The stem cells do the reconnection work (look @ what I 1st posted - yes, it's reality (my mom worked w/ paraplegics & when I read of that, hushed down REAL fast too (go figure), there ya are)... apk

  20. 92-year-old with 7 speeding tickets in 5 months by Mostly+a+lurker · · Score: 1

    How about this example. Being old is no guarantee that you will be responsible.

  21. There may be some side effects by Anonymous Coward · · Score: 0

    But me and my Quatto never looked better

  22. Fox News won't be pleased. by fahrbot-bot · · Score: 0

    Anti-aging treatments will decimate their demographics, the median age, someone noted, is "dead five years".

    --
    It must have been something you assimilated. . . .
  23. Re: It'll be regulated into the ground by Anonymous Coward · · Score: 0

    Been the direct cause of more deaths than anything else ever.

  24. So this is the new perpetual machine? by Anonymous Coward · · Score: 0

    I can't stop thinking of this as quak science, also we spend so much resources in creating new and perpetuating old problems instead of solving the actual problems... Just because we could do it doesn't mean we should do it

  25. As I'm getting older ... by Qbertino · · Score: 3, Informative

    my body starts to wear - f.e. my eyes are getting worse and I'll need glasses soon ... annoying. Anyway, as my body starts to wear and show signs of the perpetual usage it's under I phantasize about being able to counteract signs of age, cyberpunk style. Like imagineing some drug I could take to regain brain performance (I feel that declining a little even though I'm putting it to good use (47, just enrolled in college for a BSc+MSc in Media-CompSci now that my daughter is out of the house) or some bioware/cyber treatment that replenishes joints and vertebrae disks and pushes bones back into shape.

    Just at the turn of this year I finally had a long overdue laser surgery on my inner nose. I've got an ever so slightly lopsided skull and had breathing problems as a result - this is not that uncommen. However, the mordern laser surgery was minimaly invasive and changed my quality of life in leaps and bounds - for the first time I can breathe correctly through the nose for extended periods of time. A change that has countless minor effects on my everday life including how I can socially interact.

    Long story short, we have bodies that are imperfect, wear out and we eventually die and that *does* suck. We all have our personal apocalypse coming and I really wish we'd have some way to add another 5 decades or so. I personally can't complain - I have good long-life genes in the family, I'm notably fit for my age - performing arts training, social dancing, cute ladies and sex as a hobby, bike as main means of transport, lean minimalist lifestyle - and I plan to get fitter - but I still notice end of warranty moving in on me.

    If there were a way to slow this, even if it were expensive - costing like a house or something - I'd try to do it. However, if I had the means to extend my life notably vis-a-vis my peers and I'd have to watch them wither and die whilst I stay lean and fit, I am well aware of the fact that that would only work out for me if I'd go along with a notable change of perspective on life in general. I'd probably eventually move to become some sort of guru to help people live their life to the fullest. ... After all, imagine what wisdom you gain from consciously living for 150 years or so. ... Quite awesome a proposition if you ask me.

    My thoughts on this. I do have those these days and I sure hope that someone makes some significant advances in anti-aging tech. Soon. That would be cool.

    --
    We suffer more in our imagination than in reality. - Seneca
    1. Re:As I'm getting older ... by fruey · · Score: 1

      The older you get, the more you wish you could slow aging and the more you tut at 7 figure Slashdot IDs.

      --
      Conversion Rate Optimisation French / English consultant
    2. Re:As I'm getting older ... by Anonymous Coward · · Score: 0

      cute ladies and sex as a hobby

      You on the right website? Or is this an extension of your "phantasy"?

    3. Re:As I'm getting older ... by Miser · · Score: 1

      Tut, tut!

    4. Re: As I'm getting older ... by Qbertino · · Score: 1

      Or is this an extension of your "phantasy"?

      Nope. I am partly prototypical nerd and nice guy but I managed to systematically get a little handle on the heterosexual mating game, with an, shall I say, OK throughput of intimate encounters and occasional mind-blowing sex. I could use and would want more, but I guess every heterosexual male could say that.

      Interacting a lot with ladies, being genuinely interested/fascinated by them, writing poetry and, this did 98% of the way in the last 10 years, getting into Argentine tango got me where I am today. I still have a reasonable chance of finding the love of my life but right now am actually quite exausted and just about happy being single for a while for the first time in decades. ... This can be a prerequisite to good sex btw, although I'm not sure whether I want more or less ONS in my life - it probably depends on the style and vibe they come with.

      --
      We suffer more in our imagination than in reality. - Seneca
  26. Re: It'll be regulated into the ground by Opportunist · · Score: 2

    Well, mostly because they eliminated most other ways you could die.

    You know why most people die of cancer these days? Because we don't die earlier from diseases anymore.

    --
    We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
  27. Reminds me of a book... by Anonymous Coward · · Score: 0

    2030 by Albert Brooks What Really Happens To America in which an anti-aging treatment pits boomers against everyone under 50.

  28. Re:It'll be regulated into the ground by butchersong · · Score: 1

    Technically, the federal government is responsible for none of those things other than food safety laws.

  29. One Possible Outcome by Anonymous Coward · · Score: 0

    I welcome our Super Rich, Immortal Overlords!! Long live the 0.1 percent!! By the way, my Capcha word was"agitator"!

  30. Stem cells by Anonymous Coward · · Score: 0

    Anyone else find it funny that after the whole fight to get approval for embryonic stem cell research, that any and all of the benefits and treatments that we're seeing are coming from adult stem cells?

  31. yum! by Anonymous Coward · · Score: 0

    can't wait to suck the bone marrow out of those annoying millennials. any idea if i can do this in my garage?

  32. At the point of death? I would... apk by Anonymous Coward · · Score: 0

    See subject: IF I had a setup like I noted & had personnel that were as good as possible for such an attempt? I'd try it: Why??

    Well, heck - @ that point, what would I have to lose??? Everything to gain really... you'd actually get me to honor that deal (I just can't afford a clone &/or stemcell treatments for such an undertaking).

    APK

    P.S.=> Now, as far as "tearing out spines"? Heck - I've ALREADY accomplished that by forcing my "troll fanclub" to use UNIDENTIFIABLE anonymous posts vs. me (vs. using their FAKE NAME for their FAKE LIE OF THEIR LIVES "Registered 'luser'" accounts, probably many sockpuppets too) only to show they longer have a spine/backbone when I tear 'em up factually, ala/e.g. https://tech.slashdot.org/comments.pl?sid=11259667&cid=55425509/ as I did yesterday w/ help from a few folks here like DontBeAMoran & PhantomFive to do so... apk

  33. Re:This kind of PR is to lure gullible investors.. by micahraleigh · · Score: 1

    Everyone could live forever. Comfortably.

    When tylenol was introduced there may have been some people who tried to hide their stash, but I wouldn't call them the super-geniuses.

    The premise here is blatantly false.

  34. Re:It'll be regulated into the ground by micahraleigh · · Score: 1

    Your odds are better in the wild than in regulated hospitals.

    MD's look at it in terms of ... "Well, it will cost us this much to resuscitate, and she creates this much civil liability ... so probably not worth saving."

    HHS was set up to ENFORCE that this perspective is shoved down the throats of people with morals.

    I am close with a health director at a major hospital and she is always telling me how obscene it is that people who are barely sick or not sick at all get euthenized in one form or flavor.

    It wasn't like this when people took personal interest in the outcome of the patient. The secular/professional mentality has systematically eradicated all of that.

    If you're a health worker trying to do no harm you are swimming upstream and probably a target.

  35. Re: It'll be regulated into the ground by skids · · Score: 1

    Cancer's starting a downtrend as well. Next up is either COPD or age related neurologicals. Though the pill epidemic is certainly taking its toll.

    I don't know why so many people react so badly to news of anti-senescence research. Maybe they are afraid if they live too long all their bullshit will catch up to them?

    --
    Someone had to do it.