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Eating World's Hottest Pepper Sparks Brain Disorder, Thunderclap Headaches (arstechnica.com)

An anonymous reader quotes a report from Ars Technica: Extremely hot peppers don't just blister your mouth and bum -- they can also spark fiery havoc in your brain, according to a report published Monday in BMJ Case Reports. An otherwise healthy 34-year-old man developed a blood-flow disorder in his brain and suffered several debilitating "thunderclap" headaches after entering a hot pepper eating contest, U.S. doctors reported. The man had managed to get down a Carolina Reaper pepper, which in 2013 earned the title of the world's hottest chili by Guinness World Records.

The searing pepper didn't sit well in the chili-eating contestant. Immediately after slaying a Reaper, the man began dry heaving and developed pain in his neck and the back of his skull. That morphed into a diffuse, painful headache. Over the next few days, he experienced thunderclap headaches at least twice -- but likely more, he just couldn't recall exactly. Thunderclap headaches are severe, sudden, with quick pains that strike like a clap of thunder rumbling through your skull. They tend to peak within 60 seconds and can be accompanied by nausea, vomiting, altered mental state, seizures, and fever. Their stormy aches can be a sign of serious problems, like bleeding in the brain, a brain infection, or a cerebrospinal fluid leak. The pain was excruciating enough that the man went to the emergency room. But doctors didn't find any immediate problems with him to explain the episodes. He didn't have any slurred speech, loss of vision, neurological deficits, muscle weakness, or tingling. His blood pressure was a little high, but not extremely so, at 134/69 mmHg. Initial CT scans found no problems in his neck and head.

38 of 155 comments (clear)

  1. Peppers are very good for you by Anonymous Coward · · Score: 5, Informative

    All varieties of pepper are nutrient-rich, and the heat will boost the metabolism a bit helping control weight, provide pain relief, help manage diabetes, and directly fights prostate cancer.

    Don't give up on peppers just because overdoing it can cause harm.

    Just don't overdo it.

    1. Re:Peppers are very good for you by Bobrick · · Score: 3, Insightful

      PETA is a -major- animal abuser. Pro tip: you care about animals' rights and well-being, don't support PETA.

    2. Re:Peppers are very good for you by sad_ · · Score: 3, Insightful

      best advice for everything - don't overdo it.
      drinking too much water can kill you.
      doesn't mean we all should suddenly stop drinking water.

      --
      On a long enough timeline, the survival rate for everyone drops to zero.
    3. Re:Peppers are very good for you by geekmux · · Score: 4, Insightful

      All varieties of pepper are nutrient-rich, and the heat will boost the metabolism a bit helping control weight, provide pain relief, help manage diabetes, and directly fights prostate cancer.

      I fully agree.

      Don't give up on peppers just because overdoing it can cause harm.

      Just don't overdo it.

      Pepper mad scientists overdid it about 2 million scoville units ago. It was nice back when the habanero was king, and people still enjoyed the taste of a good pepper.

      Now the pepper world has morphed into the food equivalent of Jackass.

    4. Re:Peppers are very good for you by Gilgaron · · Score: 3, Insightful

      I don't use anything hotter than habeneros, are the ghost peppers and so on useful for recipes where additional less spicy peppers would be detrimental or is it all just a pissing match?

    5. Re:Peppers are very good for you by Falconhell · · Score: 2

      If its about laying off of the insanity chillis, Im way ahead of you.

    6. Re:Peppers are very good for you by LaminatorX · · Score: 5, Informative

      I like that ghost peppers can be smoked/dried/roasted and still have substantial heat left. I don't use them fresh. Habaneros are about the hottest thing I'll use fresh, and even then I more often go for seranos, as you've got more control.

    7. Re:Peppers are very good for you by jellomizer · · Score: 3, Interesting

      Much like Vanilla Extract or the variety of other extracts. A Ghost Pepper can be used to give heat to a dish, but its small size will not bring pepper flavor to it. Eating raw Ghost peppers, is like eating baking chocolate, or drinking a shot of Vanilla Extract or Vinegar. Unpleasant by itself but used in the right amounts it adds flavor and/or changes the chemical composition of the food to make it palatable.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    8. Re:Peppers are very good for you by mujadaddy · · Score: 2

      Mrs. Renfro's Ghost Pepper Salsa (actually mostly habenero w/ a touch of ghost chile): a spoonful gives a great heat to a whole pot of what-have-you. But on the main topic, I completely agree that nobody wants to taste things anymore.

      --
      Populus vult decipi, ergo decipiatur...
      "Force shits upon Reason's back." - Poor Richard's Almanac
    9. Re: Peppers are very good for you by Psion · · Score: 2

      The editor is "BeauHD". The troll is "BeauHD(+6, Expert)". Do you see the difference now?

    10. Re:Peppers are very good for you by Sumus+Semper+Una · · Score: 2

      It's much the same with any food or drink. If it's something known to be safe for consumption, don't go to extremes with it and you'll be fine.

      If you drink enough water in a short period, it will poison you and you will die. In no way does that mean you should stop drinking water.

      If you're someone who likes sour tastes, don't go creating the ultimate sour taste beyond anything ever seen before and expect it to continue to be just as safe as a lemon.

    11. Re:Peppers are very good for you by apoc.famine · · Score: 2

      Some of the hotter ones are fucking delicious, in moderation. Extreme moderation. Rather than deal with the peppers themselves, check out some of the hot sauces from Heatonist. Use them very, very sparingly, and you'll be pleasantly surprised by how good they are. I've lightly dosed a pork roast with some of the hottest ones there and slow roasted it, and it was stunning.

      --
      Velociraptor = Distiraptor / Timeraptor
    12. Re:Peppers are very good for you by bugs2squash · · Score: 4, Funny

      It's easy to overdo the peppers though. I ate just half a red bell pepper and drank 12 shots of Tequila and I had a terrible pepper headache the next day.

      --
      Nullius in verba
    13. Re:Peppers are very good for you by Green+Mountain+Bot · · Score: 3, Informative

      Serranos are the sweet spot. Hot enough for most applications, but not so hot that you lose the flavor. As you note, they give you great control. Jalapenos will overwhelm the flavor balance of a dish if you add more for more heat. Habaneros will lose their flavor contribution if you dial them back. Serranos have enough heat that you don't need to throw off the taste profile to increase heat, and enough flavor that you can still taste them if you need to take the heat down a notch or three.

    14. Re:Peppers are very good for you by crunchygranola · · Score: 2

      I am partial to that grand-daddy of hot pepper cuisines - the Tabasco pepper, a cultivar of Capsicum frutescens. Most hot peppers are a different species, Capsicum annuum. The Tabasco pepper, like Tabasco Sauce (the first hot sauce ever marketed), has a nice sharp clean bite, then a quick fade - no lingering burning.

      --
      Second class citizen of the New Gilded Age
  2. Summary cuts off too early by pots · · Score: 5, Interesting

    The summary is perhaps a little misleading, the paper says in the very next sentence that CT angiography turned up reversible cerebral vasoconstriction syndrome which can cause this kind of headache. Since capsaicin can cause arterial constriction, and this started immediately after eating the pepper, they are tentatively assuming a causal relationship.

    1. Re:Summary cuts off too early by burtosis · · Score: 5, Informative

      Further the guy was fine 5 weeks later as you can see from the photos here. If this was indeed the cause then it would be the first case ever of RVCS induced by capsaicin. The peppers aren't as hot as nearly pure capsaicin extract, which is used as an ingredient in those hot wings you often have to sign a waiver for as well as topical pain relief creams (DO NOT TASTE THESE). I like spicy foods, even extremely spicy foods, but after eating several of those extract laden wings, not only did my hands start burning through the skin (I now know why the chefs wear them), but I suffered pretty severe abdominal pain for 12 hours on top of the usual exit wounds. Not really worth your picture on a wall if you ask me.

    2. Re:Summary cuts off too early by cstacy · · Score: 3, Funny

      you often have to sign a waiver for as well as topical pain relief creams (DO NOT TASTE THESE).

      Having lived through the Merciless Peppers of Quetzalacatenango grown deep in the jungle primeval by the inmates of a Guatemalan insane asylum, I am ready for the Capsagel Challengem dude!

      Or is it brah? I have trouble remembering things since the Tide Pods last week...Can't even figure out where my condoms have gone.

    3. Re:Summary cuts off too early by thegarbz · · Score: 3, Funny

      on top of the usual exit wounds

      Today you fancy yourself a fire breathing dragon!
      Tomorrow the Rocket Maaaaaaaaannnnnnnn!

    4. Re:Summary cuts off too early by Rei · · Score: 2

      To put that into perspective:

        * A half teaspoon of resiniferatoxin mixed into a two-litre bottle of water will make it hotter than the same two litre bottle full of pure capsaicin.
        * A kilogram of bell peppers, soaked in a solution with a single drop of resiniferatoxin, would be rendered as hot as a kilogram of ghost peppers.
        * Six olympic swimming pools of resiniferatoxin could render Lake Erie as hot as a mild pepper, and 30 could make it as hot as a jalapeno. Given that the total synthesis of resiniferatoxin is a solved problem, this actually quite an achievable task.

      --
      I will pull over this spaceship right now!
  3. One case... by Anonymous Coward · · Score: 2, Insightful

    is hardly evidence. This is speculation, not science.

  4. Hmm by tylersoze · · Score: 4, Funny

    I pretty sure the brain disorder is wanting to put that shit in your mouth in the first place.

    1. Re:Hmm by adolf · · Score: 5, Interesting

      Perhaps.

      I grow Carolina Reapers. I do not eat Carolina Reapers.

      Well, I mean, I do eat them: I blend them with a lot of salt and plenty of strong vinegar and freeze them in squeeze-bottles until it is time to consume. The mixture seems to keep indefinitely, once thawed, under normal refrigeration.

      I've also fermented them and done the same sort of thing with them, which produces very different taste.

      The sauce is a crowd pleaser and it is very tasty. But despite being made from the hottest of peppers, I've had it described as being "surprisingly mild." In sauce form, it's easy to use tiny amounts.

      But I don't eat them. I've chopped up tiny slivers of one and put it on a baked potato (with plenty of butter, sour cream, and cheese), many times, and I ate those potatoes, but I don't just -- you know -- eat them as they are.

      Eating these peppers as they are is a really fucking stupid thing to do. Then-girlfriend's much-younger then-high-school-aged brother liked to take them to school with him; I encouraged him not to. He used them as dare material. I feel bad for those poor bastards.

      These fuckers are mean. When I had a surplus of some of these and some other scary-hot peppers one year (more than I could bottle), I tried to give some to the Asian grocery store next door who was always kind to me, just a basket on the counter of peppers for folks to -- you know -- just take for free. "Too hot," they said after a couple of days. "Nobody wants these," they added when they gave them back). A bunch of spicey-food-loving Mexicans that my Dad knows also rejected them ("too hot," they said too)..

      And yes, it's "all in your head," but the body's reaction to what's in your head can be very damaging to said body.

      That all said: I'm lead to wonder if the "thunderclap headaches" in TFA weren't caused directly by the violent retching. The human body is pretty fucking hard on itself when it comes to expelling (what it considers to be) poisons.

    2. Re:Hmm by pjt33 · · Score: 2

      Then and there I sort of decided that anything beyond banana peppers and jalapenos was just pointless masochism.

      It depends on quantity. A small amount of habanero doesn't contain more capsaicin than a large amount of jalapeño, but it does have a more fruity flavour. Just make sure you don't touch it when you're chopping it up: that really is pointless masochism.

  5. Re:Here's the thing! by tonique · · Score: 5, Informative

    Or dimethylmercury. If you get one drop on your lab gloves, you're going to die in six months and be convulsing the final months without functioning brain.

  6. you're usually not cleverer than nature by supernova87a · · Score: 3, Insightful

    Maybe we should heed the signals that thousands, if not millions of years of evolution have given some plants/animals the capability to send, and us the benefit of being able to receive?

    1. Re:you're usually not cleverer than nature by Gilgaron · · Score: 2

      Primates like us are pretty good at eating poison, probably only the rodents do it better. A good example would be chocolate, which is famously poisonous to dogs, but also highly toxic to birds, but any pet owner has surely had to spend time figuring out which table scraps to have to keep away from their pets. The spiceyness in peppers is to discourage mammals from eating the peppers, but they aren't poisonous. Humans eat them for novelty, and birds can't taste the capsaicin, the latter of which probably help disperse seeds (also why berries that are toxic to humans are generally harmless to birds).

    2. Re:you're usually not cleverer than nature by drinkypoo · · Score: 2

      Maybe we should heed the signals that thousands, if not millions of years of evolution have given some plants/animals the capability to send, and us the benefit of being able to receive?

      The message is "I don't want you to eat me" and it has been received loud and clear. The response is "nom nom nom".

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
    3. Re:you're usually not cleverer than nature by budgenator · · Score: 2

      I've heard that birds lack a digestive enzyme that breaks down the seed casings, so any that aren't ground up in the gizzard pass through fertile. Birds also seem to defecate on flat surfaces like bare ground or your car. This tends to grow the plants the birds like to eat near where the roost, and is why the lack of the enzyme is beneficial. Mammals both have the enzyme and feel the heat.

      --
      Apocalypse Cancelled, Sorry, No Ticket Refunds
  7. Re:Here's the thing! by Anonymous Coward · · Score: 3, Insightful

    He is wrong. Take methylmercury for eg. Basically you touch it, your dead.

    Or dimethylmercury. If you get one drop on your lab gloves, you're going to die in six months and be convulsing the final months without functioning brain.

    Well, for both of those examples, that wouldn't exactly be using it properly, now would it?

  8. Well, I eat some pretty hot stuff by cdsparrow · · Score: 4, Interesting

    Most days. I have become a big fan of reaper powder sprinkled on stuff. In my experience, the peppers will usually make my headaches (even migraines) go away better than any medicine I've tried, so ymmv...

  9. Grandma was right... by ChunderDownunder · · Score: 4, Funny

    ...when she threw out my music collection.

    Red Hot Chili Peppers do rot your brain!

  10. Doctor's orders by LostMonk · · Score: 5, Funny

    PATIENT: It hurts when I do that.

    DOCTOR: Stop doing that!

  11. Re:Here's the thing! by Cryacin · · Score: 3, Interesting

    In some cases, "proper amount" means homeopathatic medicine. I.e. not even an atom of the substance. Also known as placebo medication.

    Powerful stuff.

    --
    Science advances one funeral at a time- Max Planck
  12. I don't follow the logic by skovnymfe · · Score: 3, Funny

    Guy eats neurotoxins. Guy gets brain damage. Somehow I don't see the connection here. Can someone point it out for me? OH WAIT SO HE IS EATING NEUROTOXINS AND HE GETS BRAIN DAMAGE? Well who would'a fucking thunk that could happen?

  13. Re:A study of one person? by Opportunist · · Score: 2

    You're right.

    Here, eat this. For science.

    --
    We used to have a Bill of Rights. Now, with the rights gone, all we have left is the bill.
  14. Re:Blisters? by careysub · · Score: 3, Interesting

    Yes, the stuff about hot peppers literally causing physical lesions as if they were thermally hot is folklore. Capsaicin stimulates nerves via the TRPV1 receptor that also responds to heat, and so gives the sensation of burning. It causes no physical changes directly.

    As another poster here has noted rare idiosyncratic rashes can occur, but lots of things can cause rashes in some people, it is really an immune system abnormality in the victim.

    --
    Starships were meant to fly, Hands up and touch the sky - Nicky Minaj
  15. Play stupid games... by neo-mkrey · · Score: 2

    ...win stupid prizes.