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New Drug Rapidly Repairs Age-Related Memory Loss, Improves Mood (newatlas.com)
A team of Canadian scientists has developed a fascinating new experimental drug that is purported to result in rapid improvements to both mood and memory following extensive animal testing. It's hoped the drug will move to human trials within the next two years. New Atlas reports: Gamma-aminobutyric acid (GABA) is a key neurotransmitter, and when altered it can play a role in the development of everything from psychiatric conditions to cognitive degeneration. Benzodiazepines, such as Xanax or Valium, are a class of drugs well known to function by modulating the brain's GABA systems. This new research describes the development of several new molecules that are structurally based on benzodiazepines, but with small tweaks to enhance their ability to specifically target certain brain areas. The goal was to create a new therapeutic agent that can effectively combat age-related mood and memory alterations caused by disruptions in the GABA systems.
In animal tests the drug has been found to be remarkably effective, with old mice displaying rapid improvements in memory tests within an hour of administration, resulting in performance similar to that of young mice. Daily administration of the drug over two months was also seen to result in an actual structural regrowth of brain cells, returning their brains to a state that resembles a young animal. The new study was published in the journal Molecular Neuropsychiatry.
In animal tests the drug has been found to be remarkably effective, with old mice displaying rapid improvements in memory tests within an hour of administration, resulting in performance similar to that of young mice. Daily administration of the drug over two months was also seen to result in an actual structural regrowth of brain cells, returning their brains to a state that resembles a young animal. The new study was published in the journal Molecular Neuropsychiatry.
They've invented cocaine1
Weed? Doesn't weed do this?
Like, how long does it last, and, oh by the way, how much will they charge for a dose?
how much will they charge for a dose?
How much do you have?
What were we talking about?
They say that memory is the second thing to go when you get older. I can't remember the first thing.
Getting old sux.
Here's the paper abstract:
Altered gamma-aminobutyric acid (GABA) function is consistently reported in psychiatric disorders, normal aging, and neurodegenerative disorders and reduced function of GABA interneurons is associated with both mood and cognitive symptoms. Benzodiazepines (BZ) have broad anxiolytic, but also sedative, anticonvulsant and amnesic effects, due to nonspecific GABA-A receptor (GABAA-R) targeting. Varying the profile of activity of BZs at GABAA-Rs is predicted to uncover additional therapeutic potential. We synthesized four novel imidazobenzodiazepine (IBZD) amide ligands and tested them for positive allosteric modulation at multiple α-GABAA-R (α-positive allosteric modulators), pharmacokinetic properties, as well as anxiolytic and antidepressant activities in adult mice. Efficacy at reversing stress-induced or age-related working memory deficits was assessed using a spontaneous alternation task. Diazepam (DZP) was used as a control. Three ligands (GL-II-73, GL-II-74, and GL-II-75) demonstrated adequate brain penetration and showed predictive anxiolytic and antidepressant efficacies. GL-II-73 and GL-II-75 significantly reversed stress-induced and age-related working memory deficits. In contrast, DZP displayed anxiolytic but no antidepressant effects or effects on working memory. We demonstrate distinct profiles of anxiolytic, antidepressant, and/or pro-cognitive activities of newly designed IBZD amide ligands, suggesting novel therapeutic potential for IBZD derivatives in depression and aging.
Bruce Perens.
This article is by a subset of the authors and seems to be about the same molecules.
Bruce Perens.
If this new drug helped to reverse the effects of long-term alcohol abuse, millions of people would benefit.
It might help your memory, but it won't help your liver ...
It must have been something you assimilated. . . .
Canadians, they'll practically give it away and a US company will swoop in with a similar patent and gouge everyone while burying anyone who tries to make the low cost version.
and then you never hear about it again, i bet the government and the financial elite buy it and then make it disappear so nobody can use it except them, leaving the wider world to just do without
Politics is Treachery, Religion is Brainwashing
Can we pick which young animal we will resemble?
Quick, send some of this to every internet user, stat!
"There is more worth loving than we have strength to love." - Brian Jay Stanley
is it multiple choice?
And preferably hold his head under till the bubbles stop.
https://med.stanford.edu/sbfnl...
Y Maze Spontaneous Alternation Test
Y Maze Spontaneous Alternation is a behavioral test for measuring the willingness of rodents to explore new environments. Rodents typically prefer to investigate a new arm of the maze rather than returning to one that was previously visited. Many parts of the brain--including the hippocampus, septum, basal forebrain, and prefrontal cortex--are involved in this task.
Testing occurs in a Y-shaped maze with three white, opaque plastic arms at a 120Â angle from each other. After introduction to the center of the maze, the animal is allowed to freely explore the three arms. Over the course of multiple arm entries, the subject should show a tendency to enter a less recently visited arm. The number of arm entries and the number of triads are recorded in order to calculate the percentage of alternation. An entry occurs when all four limbs are within the arm. This test is used to quantify cognitive deficits in transgenic strains of mice and evaluate novel chemical entities for their effects on cognition.
Mit der Dummheit kämpfen Götter selbst vergebens
When the rodents replace us, they'll look back on the age when Homo sapiens invested massive effort to make them immortal with some perplexity. Why did we do it?
Yes, he does. Cannabis use has acute - and potentially chronic - affects on memory.
Which reminds me; would someone put some flowers on Algernon's grave for me?
Just ask him out already, this is getting unbearable
Don't worry, if you're in the USA you can't afford this drug. It's for the rest of the world only, because we have the greatest system in the world that nobody can afford.
Even fucking Rand Paul goes to Canada for health care.
You are welcome on my lawn.
that a volunteer, identified only as "Charlie", has been recruited to be the first human trial subject. https://en.wikipedia.org/wiki/...
I've been on my own GABA influencer journey and wanted to mention an already easy to get substance, at least outside of Russia where it is a prescription only substance, that I'm 99% sure many people take already with great effect. And that it also focuses on the same GABA alpha receptors like they mention targeting in the paper, though the paper's substance is attempting to be selective about where they trigger things. Most GABA alpha items are used for anxiety, at least when given out by prescription. GABA itself is a relaxing/calming neurotransmitter.
Phenibut is pretty cheap, seemingly safe at high doses (yes people take WAY more than the typical prescription dose used in Russia for fun), and the way people talk about it I think it can have some of the same effects as the goal of this new substance when used in moderation. Phenibut doesn't only affect GABA, but seems to release a bit of Dopamine too...the reward chemical.
For a more global GABA increaser for the brain...Inositol. Taking GABA won't get into your brain because it doesn't pass through the blood brain barrier easily. Inositol definitely calms me initially, and makes me more ready for sleep. It was originally misclassified as a B vitamin, and is generally safe up to really huge doses. I've read 6-12g/day is a typical dose for anxiety. I can't seem to stomach more than a gram a day, and I'm getting lots of nausea and other side effects. So not my "magic bullet" solution. But it's another cheap, safe option for GABA manipulation/influence.
I'm not advocating anything here. Please research anything you put in your body. And yes, you can hurt yourself if you take too much phenibut. Or if you take too much for too long, your body will start to downregulate those receptors and you won't get the same effects. And stopping suddenly will be VERY uncomfortable from what I read.
But many people already use GABA beta substances daily (alcohol). The alpha vs. beta refer to a fast vs. slow change substance, as I've understood it. The alpha receptor is designed to react quickly to changing levels of triggers (agonists). The beta, much more slowly. Hence how large a dose of alcohol we need before we can feel it (comparatively), compared to a pill like typical benzodiazepines.
And one of the reasons healthy eating helps calm us is the probiotic organisms we'd be encouraging create GABA in our guts for us. Those eat fiber and other things, are killed off by alcohol, and generate GABA and many other helpful substances we cannot. This is one of the reasons that changes in gut flora is so scary/bad for many people.
For those curious to read more...Google it, :D. There are tons of articles and reddit posts on experiences, and safe places to order from. Below is a wikipedia article on the two GABA receptor types as I'm sure I'm not explaining it all well.
https://en.wikipedia.org/wiki/...
Could you please, next time, put the really important info into the title? "New Drug Rapidly Repairs Age-Related Memory Loss, Improves Mood *in Mice*. Thank you.
You can have something similar right now, it is called phenibut. It is not very expensive.
"It's such a fine line between stupid and clever" -- David St. Hubbins, Spinal Tap
GABA can kill you. It works as a roofie afaik. A bit too much and you can die.
Wait. Cops are allowed to take steroids?
Who is going to bust them for it?
Bantam Dominique roosters crow a four-note song. Once you've heard it as "Happy BIRTHday" you can't NOT hear it that way
You can't remember the first thing? I'll give you a hint: It's the thing that hurts now but didn't hurt when you were 30.
Velociraptor = Distiraptor / Timeraptor
The opioid crisis has caused politicians, and hence doctors, to become extremely skiddish about anything that produces euphoria, regardless of how helpful it might be for patients. People love easy answers to complicated problems, so prohibition and paternalism are the watchwords here.
If you aren't already, try taking inositol with a meal.
Contribute to civilization: ari.aynrand.org/donate
Started doing something similar recently. I don't feel particularly better yet, partly because of an unrelated painful back injury. But there are other benefits. For instance, it's had a dramatic effect on my blood sugar. Turns out that if one isn't eating much sugar or high-glycemic carbs, it's a lot harder to be hyperglycemic, no matter one bad one's insulin or leptin tolerance may be. And eating bunches of healthy greens, nuts, seeds, etc. makes it a lot less likely that one will try to satisfy hunger through massive overconsumption of carbs. I'm not sure type-2 diabetes can survive a low-carb diet. And if mine improves, it's likely that my hypertension will improve as well. Some long-term damage has already been done, but hopefully this will arrest any further damage, and perhaps even reverse some of it. (NOTE: There is some evidence that high-fat diets . . as distinct from low-carb diets . . . may harm the liver and increase, rather than reduce, insulin tolerance. So I do include a fair amount of protein and lower-glycemic carbs such as beans as well.)
Nonaggression works!
Thanks. Nope, I actually have a pretty strong stomach normally (take tons of pills daily, empty stomach or not) so hadn't thought about taking it with food before.
I think simultaneous glutamine powder (just before bed) wasn't helping either (I've read muscles and our intestines can repair better with enough glutamine). Apparently we turn glutamine into glutamate, which is a stimulant in our brains...kept me awake a couple times much later than planned. Guessing it made me a little nauseous too.