Slashdot Mirror


Scientists Call For Global Moratorium On Gene Editing of Embryos (theguardian.com)

An anonymous reader quotes a report from The Guardian: Leading scientists have called for a global moratorium on the use of powerful DNA editing tools to make genetically modified children. The move is intended to send a clear signal to maverick researchers, and the scientific community more broadly, that any attempt to rewrite the DNA of sperm, eggs or embryos destined for live births is not acceptable. Beyond a formal freeze on any such work, the experts want countries to register and declare any plans that scientists may put forward in the future, and have these discussed through an international body, potentially run by the World Health Organization. Alongside technical debates about the possible benefits of creating genetically modified babies, the scientists said no decisions should be made to go ahead without broad public support. Eric Lander, founding director of the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, calls for the moratorium with 16 other experts in the journal Nature. Emmanuelle Charpentier and Feng Zhang, who helped discover and develop the most common gene editing tool, CRISPR, contributed to the article.

The call comes four months after Chinese researcher He Jiankui used human embryos modified with CRISPR to create twin girls resistant to HIV.

59 of 111 comments (clear)

  1. Yea Right! by oldgraybeard · · Score: 4, Insightful

    Those with the money will do it no matter what. Enhanced humans are a future given.

    Just my 2 cents ;)

    1. Re:Yea Right! by alvinrod · · Score: 3, Interesting

      Yeah, but it's genetics. They'll filter out to the rest of humanity over time as well. Unless they alter themselves to the extent that they're a different species.

    2. Re:Yea Right! by quantaman · · Score: 1

      Those with the money will do it no matter what. Enhanced humans are a future given.

      Just my 2 cents ;)

      Eventually, but the tech isn't ready yet, so we might as well buy ourselves a bit more time to figure out how to deal with it.

      --
      I stole this Sig
    3. Re:Yea Right! by Humbubba · · Score: 1
      oldgraybeard said

      Those with the money will do it no matter what. Enhanced humans are a future given.

      Just my 2 cents ;)

      I take it you've read "Homo Deus" by Yuval Noah Harari. That's its main point.

      Bet the DOD is funding such genetic engineering research now. They're famous for funding biological and medical research. What really scares me is how they might apply genetic editing. Alphas, Betas, Gammas, Deltas, Epsilons, then me. "How beauteous mankind is! O brave new world, That has such people in't!" - The Tempest, by Wm Shakespeare (with an obvious reference to Aldous Huxley.)

    4. Re:Yea Right! by dcw3 · · Score: 2

      The tech isn't ready? What do you think just happened here?

      "The call comes four months after Chinese researcher He Jiankui used human embryos modified with CRISPR to create twin girls resistant to HIV."

      --
      Just another day in Paradise
    5. Re:Yea Right! by Applehu+Akbar · · Score: 2

      Eventually, but the tech isn't ready yet, so we might as well buy ourselves a bit more time to figure out how to deal with it.

      Let's hope that this is the only motive for this moratorium.

  2. No arguments here by rsilvergun · · Score: 4, Insightful

    at least, not unless there's a health issue involved. There's a couple genes that cause childhood leukemia and if that can be edited out go for it. But we're not ready to start making super babies. Not that I don't think we should. Of course we should. But we need a _much_ better understanding of the long term effects before we do. The best way to find that out would be trying to fix the sick.

    --
    Hi! I make Firefox Plug-ins. Check 'em out @ https://addons.mozilla.org/en-US/firefox/addon/youtube-mp3-podcaster/
    1. Re:No arguments here by alvinrod · · Score: 1

      Why not just test it out with rats first? Set up a secret project in the labs at the National Institute of Mental Health and see how it turns out.

    2. Re:No arguments here by quenda · · Score: 1

      There's a couple genes that cause childhood leukemia and if that can be edited out go for it.

      You don't need gene editing for that, just embryonic screening, which is much easier.
      Gene editing is for adding new gene variants. It could be the great equaliser, allowing everyone to have smart, healthy babies.
      No longer will your children's achievement be limited by the quality of your own genes.
      This could be good, or lead to the collapse of civilisation.

    3. Re:No arguments here by Krishnoid · · Score: 1

      I'm thinking of a project involving a genetically enhanced organism, supplementing it with access to an implantable artificial intelligence, and since it's NIMH, have it start questioning the nature of mental health and sanity, giving up, and creating a networked cyborg intelligence that tries to take over the world.

      Or maybe I'm thinking of the sequel. Either way, I say go for it.

    4. Re:No arguments here by Antique+Geekmeister · · Score: 1

      Might I oint out that genetic editing is already in progress, by performing testing of fetuses for their gender and aborting females? The over-population of young men in China is a predictable and not well managed result. The unforeseen consequences of more direct editing are an understandable concern.

    5. Re:No arguments here by kenai_alpenglow · · Score: 1

      which according to some economist and demographers may cause China a world of grief in a generation or two. Possibly sending them down the same demographic spiral as Japan/Russia/Italy/Germany. Hindsight is 20/20...

    6. Re:No arguments here by dcw3 · · Score: 1

      And what makes you think there wouldn't be an even larger population if China had not? I'm not advocating it, I'm merely pointing out that with more females, you'd have an even larger population of both.

      --
      Just another day in Paradise
  3. Yup by rsmith-mac · · Score: 4, Interesting

    I'd mod you up if I could. The individual and collective rewards for gene editing are far too great to ignore. Someone (or likely many someones) will do it, even with the risks.

    Anyone who voluntarily follows this moratorium is, by definition, going to fall behind on the genetic arms race. And falling behind means that your society will eventually become the genetically inferior one.

    1. Re: Yup by jabuzz · · Score: 1

      You might just want to Google up on that. Tldr you are wrong they did have a breeding program.

    2. Re:Yup by Cmdln+Daco · · Score: 1

      reckless research in this area,

      So, uh, maybe we should elaborate on this concept of Forbidden Knowledge.

      Furthermore, these 'Scientists' are not Ethicists. So the article should be titled 'Laymen Call for Global....' They are no more or less qualified to make the ethical judgement than the rest of us.

    3. Re: Yup by Cmdln+Daco · · Score: 1

      whose family history included Judaism or brownness

      Brownness didn't really enter into it. That's a modern prejudicial term. The NAZIs even had allies in places where human pigmentation is more brown.

  4. Moratorium schmoratorium by Wizardess · · Score: 2

    There is one simple fact to consider here; and, it's best to consider its ramifications when or if trying to render something illegal so it won't be done where you control life and liberty of others. "If something is technologically possible to do and there is a market for doing it, then it WILL get done at least one somewhere by at least one somebody." All making it illegal means is that when it is done you end up with a technological deficit, the technological mookie end of the stick.
    {^_^}

  5. "Broad public support? by gweihir · · Score: 3, Insightful

    That is even worse than decision by committee. This is decision by uninformed masses that have no clue how things work and what is and is not important.

    While I am all for moving forward with extremely care in this area, letting the public decide about it is the worst idea possible. They will either be panicked irrationally or overoptimistic just as irrationally. Not good at all.

    --
    Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
    1. Re:"Broad public support? by phantomfive · · Score: 1

      What we need is a protest by teenagers to tell us what to do.

      --
      "First they came for the slanderers and i said nothing."
    2. Re:"Broad public support? by Applehu+Akbar · · Score: 1

      Seconded. Look at the mess that mob rule in the energy sector got us into. If we allow "the public" to decide, Hollywood stars will lobby for bringing back smallpox and polio. They are "natural" after all, and giving in to monster diseases will be rebranded as, let's see now...vegan body management!

    3. Re:"Broad public support? by dcw3 · · Score: 1

      Can't believe I'm actually applauding your sarcasm.

      --
      Just another day in Paradise
    4. Re:"Broad public support? by phantomfive · · Score: 1

      Even a broken clock is sarcastically correct twice a day, eh? Unless it's military.

      --
      "First they came for the slanderers and i said nothing."
    5. Re:"Broad public support? by dcw3 · · Score: 1

      /golf-clap

      --
      Just another day in Paradise
    6. Re:"Broad public support? by gweihir · · Score: 1

      Funny. Or tragic.

      --
      Most ACs are not even worth the keystrokes to insult them. Be generically insulted by this and ignored otherwise.
  6. Definitely keep this legal by Miles_O'Toole · · Score: 1

    Imagine how wonderful it would be if a family that had been 100% black for five or six generations could produce a child who physically appeared to be 100% white. It would be fun to watch all the racists try to find some kind of test to figure out who was a "real" white person and who was just a pale imitation.

    --
    Only two things are infinite, the universe and human stupidity, and I'm not sure about the former.
    1. Re:Definitely keep this legal by mentil · · Score: 1

      who was just a pale imitation.

      ISWYDT
      Seriously, they'd use the standard "just one drop" test.

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    2. Re:Definitely keep this legal by Krishnoid · · Score: 1

      At that point, would they even care if they couldn't visually tell the difference?

    3. Re:Definitely keep this legal by Miles_O'Toole · · Score: 1

      Sadly, you're probably right. And thanks.

      --
      Only two things are infinite, the universe and human stupidity, and I'm not sure about the former.
    4. Re:Definitely keep this legal by kenai_alpenglow · · Score: 1

      With "reparations" making a comeback in the democrat party, that may become a serious issue. How many "white" people have an ancestor that is "black"? I've got one that came from the slave coast of Africa...pretty sure how that one came over here (some of my ancestors sold some of my other ancestors into slavery). So, how do we determine who is black and who is white anyway? As far as I'm concerned I'm just human....breeds are for dogs. Why can't we just drop it?

    5. Re:Definitely keep this legal by drinkypoo · · Score: 1

      because IQ is largely influenced by genes, and genes are not spread equally between races.

      There's no such thing as races, racists' misguided ideas to the contrary, and there's no a finite number of "good" genes to be allocated amongst humanity.

      --
      "You're right," Fisheye says. "I should have set it on 'whip' or 'chop.'"
  7. yes lets never improve ourselves by 0111+1110 · · Score: 2

    We aren't evolving anymore or if we are it is not for the better (see Idiocracy), but god forbid we should try to improve ourselves as a species. Boy wouldn't that be awful. It is too bad that only a tiny percentage of the human population is intelligent and the rest are total retards who are against any sort of change. Just imagine if we could give every baby an IQ of 150 or even 180, but most people would regard that as a horrific dystopia I guess. Totally sad that these people call themselves 'scientists'. This is anti-science.

    --
    Quite an experience to live in fear, isn't it? That's what it is to be a slave.
    1. Re:yes lets never improve ourselves by mentil · · Score: 1

      If the plebeians are able to pull themselves out of the genetic gutter, then who are the bourgeois going to systematically oppress? They won't want their children to have more mate competition at the genetic high-end, either.

      --
      Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
    2. Re:yes lets never improve ourselves by phantomfive · · Score: 1

      We aren't evolving anymore or if we are it is not for the better (see Idiocracy),

      The clear evidence that we aren't evolving for the better is the people are using comedy shows as support for their ideas. Don't you have anything better than that?

      --
      "First they came for the slanderers and i said nothing."
    3. Re:yes lets never improve ourselves by SirAstral · · Score: 1

      The proletariat will forever be ruled because they ask to be ruled. They do not understand that the creation of governments of man is the creation of bourgeois itself. Any attempt to enlighten them is visited with derision and accusations of anarchy.

      Anarchy and Government are not polar opposites, they can quite readily be had together or apart, neither cares about the presence of the other and often times a bend too far in either of their directions strengthen the desire for the other.

      The folks espousing the idea of democracy are specifically seeking oppression the most under the false idea that people actually agree with them. A lot of people do not realize that most people are just there and going with the flow to avoid being harmed by the hive mind. You step out of line too much and could be mobbed by a bunch of "anarchists" telling you to follow their laws that you never voted for or was even asked for... they like to call it "social justice"... the very platform of Anarchy itself masquerading as "Justice".

    4. Re:yes lets never improve ourselves by fenrif · · Score: 1

      "Anarchy and Government are not polar opposites" Government Pronunciation /vm()nt//v()nm()nt/ noun 1treated as singular or plural The group of people with the authority to govern a country or state; a particular ministry in office. ‘the government's economic record’ ‘successive Labour governments’ 1.1mass noun The system by which a state or community is governed. ‘a democratic form of government’ 1.2mass noun The action or manner of controlling or regulating a state, organization, or people. Anarchy noun mass noun 1A state of disorder due to absence or non-recognition of authority or other controlling systems. ‘he must ensure public order in a country threatened with anarchy’ 2Absence of government and absolute freedom of the individual, regarded as a political ideal. Yeah, you seem to know what you are talking about. I'm sure the Oxford dictionary has their definitions wrong. Happens all the time, I'm sure. You should give them a call and enlighten them. I'm sure they'll be thrilled to know that these two polar opposites are actually not, according to you, because reasons.

    5. Re:yes lets never improve ourselves by kenai_alpenglow · · Score: 1

      Mathematically impossible. If every one had an IQ of "150", their IQ would by definition be "100".

    6. Re:yes lets never improve ourselves by dcw3 · · Score: 1

      You lost me at "proletariat". You come off sounding like you're trying to be Lenin, and failing miserably.

      --
      Just another day in Paradise
  8. Re:scientist i dont give a shit! by RazorSharp · · Score: 1

    scientist i dont give a shit!
    my neighbor with PHd med. is abusing her kids. the opinion of those ppl dont matter to me.

    Sound logic.

    --
    "From the depths of my skeptical and rationalist soul, I ask the Lord to protect me from California touchie-feeliedom."
  9. Re:Why exactly are genetically edited humans bad? by novakyu · · Score: 1

    Because for every Bashir, there are a dozen Khans.

  10. Exact Words by mentil · · Score: 1

    So it's ok to gene edit fetuses or zygotes?

    I'm curious how the debate will shake out on whether these gene-edited girls should be allowed to reproduce. That debate WILL happen by the time they reach child-bearing age. IIRC it was a germ-line change.

    --
    Corruption is convincing someone that the selfless ideal is the same as their selfish ideal.
  11. Re:Thanks for the bullshit libertarian perspective by SirAstral · · Score: 3, Insightful

    " We'll have laws instead."

    That everyone is breaking anyways, especially if you are wealthy or have power or connections to power. It is always a gas to see folks like you pretend that someone else's idea would never work while looking as your own idea already not working.

    There is only 1 law... and that is of the jungle. The rich and powerful just like to hold the threat of anarchy over your head to get you to agree to anarchy anyways. You can be murdered by your government and how many of your fellow citizens will care enough to do anything about that? Not even your own family will do anything, except sue and get some money... your murder would benefit them.

    What the poster is really trying to tell you that this just like the war on drugs will set us back more than it would wind up benefiting us. So yes, go ahead and law it all away... you only lose to powerful people getting you to fear your own shadow and preventing you from not being able to do anything while they still get to do everything. Sadly it works all too well.

  12. Re:Thanks for a new bullshit libertarian perspecti by SirAstral · · Score: 1

    Nice strawman argument...

    Yes, YOU will definitely be having some laws over your head, while those in a position of power still have that low bar for entry you think you are preventing. You have a vast amount of ignorance. Laws are not there to stop or prevent crime. They are there to punish people that violate the law and cannot afford to pay the piper or stupid enough to publicly flaunt their positions of power. Like Shkreli... his only mistake was running his pie hole. Had he only kept a low profile he would still be filthy stinking rich and NOT being punished by your idea of "government". I have personally seen people steal police cars and get less punishment than someone jay-walking. Was in court that day. I think you have no idea of what you are talking about.

  13. Broad public is not competent in such questions by SurenEnfiajyan · · Score: 1

    Of course, we should be cautious, firstly, because we little understand how most human genes work and interact with each other and thus mistakes can screw up peoples' health. But it's actually a bad idea to rely on incompetent peoples' opinions. Other than that, I don't see anything wrong with the idea of enhancing ourselves in the genetic level. There are numerous diseases/disorders/weaknesses which are at least partially genetic. They have screwed up lives of tens if not hundreds of millions of people and also are burden to our society.Diabetes, autism spectrum disorders, schizophrenia, ADHD, do i need to say more? And finally, as someone with a neurodevelopmental problem, I consider diversity(pathological)/neurodiversity advocacy a dangerous thing.

  14. Gene therapy exists by jd · · Score: 1

    And it is being used on individuals but not the germ line.

    It needs to move there, though. There are a number of rare genetic conditions we can edit out safely. We should do so.

    We don't know the genes for intelligence, it seems more complex than that anyway, so I'm not worried about that.

    Therapy should never be at family request but should have agreed life-or-death medical value as understood by genetic experts with no political or commercial links whatsoever.

    In other words, pharmaceutical companies, churches and government agencies can bog off. This is for the adults in the room and that lot don't qualify.

    Until we've a better understanding of shared genes (genes perform multiple roles and change those roles over a lifetime) and a better understanding of how to leverage genetic conditions advantageously, only things that are almost certain to kill should qualify for treatment.

    So hair and eye colour are out.

    --
    It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
  15. I have to laugh at this by Sqreater · · Score: 1

    They make it sound like there will be a strict control of gene editing of embryos, but what they will actually do is control who gets to do it and set up guidelines for actually doing it. Essentially they are just setting up the bureaucracy to do the thing, not forbid it. And scientists will just move out of their purview anyway. And if there is money in it - and of course there is - the whole system will become corrupted. In short, gene editing is here to stay and will grow greatly. So come the mutants.

    --
    E Proelio Veritas.
  16. Re:Khan? by Applehu+Akbar · · Score: 1

    "Creating superior humans" would require being able to execute many gene edits at the same time. Let's start out by knocking out point mutation diseases like sickle-cell anemia and Tay-Sachs.

  17. Re:Why exactly are genetically edited humans bad? by Applehu+Akbar · · Score: 1

    In the US, it will turn into a debate between progress and Congress.

  18. Call me old-fashioned... by Izhido · · Score: 1

    ...all you like, but I really find it odd to see âoepowerfulâ and âoeDNA editing toolâ in the same sentence.

  19. Re:Thanks for the bullshit libertarian perspective by dcw3 · · Score: 1

    You sir, win the tin-foil hat award of the year.

    --
    Just another day in Paradise
  20. Re:Thanks for a new bullshit libertarian perspecti by dcw3 · · Score: 1

    As someone who actually is Libertarian, I just called him out. You clearly have no idea what the meaning of the word actually is.

    --
    Just another day in Paradise
  21. Re:Why exactly are genetically edited humans bad? by dcw3 · · Score: 2

    Stop it before we Bashir head in.

    --
    Just another day in Paradise
  22. Re:scientist i dont give a shit! by dcw3 · · Score: 1

    Please describe the abuse. One person's abuse is often another's sound parental discipline.

    I've seen too many entitled brats raised by people who let their children do whatever they want.

    --
    Just another day in Paradise
  23. Oh yay, another black market by fyngyrz · · Score: 1

    Leading scientists have called for a global moratorium on the use of powerful DNA editing tools to make genetically modified children. The move is intended to send a clear signal to maverick researchers, and the scientific community more broadly, that any attempt to rewrite the DNA of sperm, eggs or embryos destined for live births is not acceptable.

    All this will do is create a(nother) black market. Just as the "war on drugs" and "war on prostitution" have done, and for exactly the same reasons: This is something people will really want because there are obvious and significant benefits to be had, and in the long run, such a thing won't take significant resources to accomplish.

    --
    I've fallen off your lawn, and I can't get up.
  24. Not optional by r2kordmaa · · Score: 2

    We are already screwing up our gene pool, sooner or later it will become a necessity to fix it. Consider for example cesarean section, what happened historically when a woman could not give live birth the natural way? Well, as sad as it is Darwin happened and genes that lead to this faulty morphology were removed from gene pool. Now medicine can bypass that particular selection pressure and the genes remain in circulation. That's the same for every life modern medicine saves prior to procreation. Give it enough generations and every life will start in an incubator with constant medical intervention for a lifetime just to not die. If fatal errors do not get removed by natural selection, then we need an artificial method to do it. It may not be an imminent concern, it's fine to wait on it for decades, but it's not wise to put a permanent moratorium on gene editing humans, because eventually we must do it.

    1. Re:Not optional by SurenEnfiajyan · · Score: 1

      Yeah, all you said is there: http://wasdarwinwrong.com/kort... .

    2. Re:Not optional by r2kordmaa · · Score: 1

      Yeah, it's not exactly a brilliant and groundbreaking idea, it's a pretty obvious consequence of how our biology and medicine works. But it must be pointed out, because for some reason it's conveniently forgotten every time the topic of gene editing ethics and dangers comes up.

  25. Lets solve two problems at once by LesFerg · · Score: 2

    Why not edit up some babies that can digest plastic. Then let em loose in all those places that people are complaining about all the plastic pollution. Hell we wouldn't even need to educate them, just let em loose to eat and breed.

    --
    If I had a DeLorean... I would probably only drive it from time to time.