We are encouraged to use phones for major communication from one person to another - it leaves no paper trail. There have been WAY too many lawsuits where email chains were used as evidence.
While interesting, this research is far too late to be remotely useful. There are multiple Phase III trials currently ongoing with new generations of HCV treatments - at least one of these will become the de facto standard of treatment for HCV cures in the future, with REAL human cure rates of > 90% if not 100%, depending on genotype and statues re: failed previous treatment courses of course. That puts them about 8 years ahead of these guys. Interesting science though, and I wish them luck.
Working in drug discovery, I'm still amazed at how often a small change of sometimes even a single atom of a molecule can take an pharmacologically active molecule and make it near-worthless - or even worse take a (relatively) safe molecule and turn it unacceptably toxic. I'd stay FAR away from any "analogue" being created with the sole purpose of rounding a ban without having any sort of safety and probably minimal efficacy testing.
I'd say this kind of story gives even stronger evidence for why illicit drugs (the less-toxic at least) should be legalized & controlled - if this article is not overly sensational and there really is an escalating war of chemistry we could get into some pretty nasty stuff being marketed to consumers who do not know any better.
Honestly, if a "revolution" in animal testing is going to occur, they watershed paper will not be out of this journal. The researchers appear to be microscopy specialists, not animal research specialists. Not to denigrate their work, but the literature is littered with people making grandiose claims about how their research can be applied with very little understanding about the other discipline where they suggest it could be useful.
This article has nothing to do with leeches, it's about willful tampering with a particular protocol for their entire user population, leech or otherwise.
And yes, you are the only one. I guess it's OK if you get to decide who is a "leech" and screw the other guy.
"...to improving chemotherapy drugs whose side effects arise from their solubility or insolubility in water."
This is absolutely not true. The side effect is inherent to the molecular structure of the molecule, not its solubility or lack thereof. (If it's insoluble it doesn't get into the body, and hence doesn't have a side effect... but then it has no effect at all.)
Yes, that's right, AnimeMUD. And this was back before Dragonball Z was all the rage. We're talking Akira and MD Geist level anime here. I was bored with most of the standard Tolkein-esque MUDs, so this one was a nice change of pace.
This has been coming for years. Bell Labs had been bleeding talent at least since 2002, maybe even earlier. My undergraduate advisor at Uni was a brilliant scientist who fled Bell Labs (in '02) as the culture changed.
This begs the question... should OO.o investigate putting their software on a DVD in nice packaging, and put it on CC/BB shelves for $5? (Just enough $ to cover the packaging/distribution) Honestly, everyone I know is shocked and pleased to learn that they could have "Office for free!" when I tell them about OO.o. If it were on store shelves, it would really take off.
I started smoking pipe tobacco when I was 24 (2 yrs ago). I had completely forgotten about that Sesame Street bit where Cookie Monster ate the pipe. I had wondered all along why I was tempted to eat my pipes after finishing a bowl, turns out it was Sesame Street's fault. Damn you Sesame Street!
"The biggest expense to Big Pharma is not research and development (which mainly takes place in universities, including a lot of public ones. Big Pharma does not fund those. You and I do.)"
I call BS. Where is your source for this? Name one drug that was discovered in an academic setting. The VAST majority are discovered by industry, universities simply cannot afford to cost of discovering/developing drugs. Believe me, if not for pharma, we wouldn't have ANY drugs.
"At least a third of the drugs marketed by industry leaders were discovered by universities or small biotech companies, writes Angell, but they're sold to the public at inflated prices." http://www.motherjones.com/news/qa/2004/09/09_401. html
So 1/3, and this writer includes small biotech in that 1/3 (which is still pharma, just not "big" pharma), so you can hardly support your claim.
Being a graduate student, I have access to the ISI Web of Science, a very complete database of scientific papers. A query for "Peiser, B" returns only two papers. Neither have been cited by other publications, but they were published fairly recently.
"Peiser B, Reilly T Environmental factors in the summer Olympics in historical perspective JOURNAL OF SPORTS SCIENCES 22 (10): 981-1001 OCT 2004 Times Cited: 0"
"Paine M, Peiser B The frequency and predicted consequences of cosmic impacts in the last 65 million years IAU SYMPOSIA (213): 289-293 2004 Times Cited: 0 "
This work was done in 1996 by Herb Waite. He not only did the same work, he did it in a superior manner, with more definitive proof. And he not only POSTULATED the Fe(III) mediated crosslinking, he proved it. The appropriate reference is:
"Ferric Ion Complexes of a DOPA-Containing Adhesive Protein from Mytilus edulis", Inorg. Chem., 35 (1996), p7572
In other words, don't get your science from popular news outlets... and apparently one can't even trust Angewandte Chemie anymore. Their reviewer must have been out to lunch.
Considering I am listed on the linux counter and have not used linux for about 5-6 years now, I wouldn't put much faith in this list. To be honest, I don't even remember how my name got here, as I used an old distro of Slackware for about 2 weeks and was not exactly happy with it.
As far back as I can remember, I have been a fan of fantasy literature. During this time period, I don't believe I've ever seen a pure fantasy movie that was any good. Now all of a sudden we have a Final Fantasy movie, a Dungeons and Dragons movie, and a Lord of the Rings movie coming. If only one of them is good, I will be the happiest little camper you've ever seen.
Slashdot Mirror
We are encouraged to use phones for major communication from one person to another - it leaves no paper trail. There have been WAY too many lawsuits where email chains were used as evidence.
While interesting, this research is far too late to be remotely useful. There are multiple Phase III trials currently ongoing with new generations of HCV treatments - at least one of these will become the de facto standard of treatment for HCV cures in the future, with REAL human cure rates of > 90% if not 100%, depending on genotype and statues re: failed previous treatment courses of course. That puts them about 8 years ahead of these guys. Interesting science though, and I wish them luck.
Working in drug discovery, I'm still amazed at how often a small change of sometimes even a single atom of a molecule can take an pharmacologically active molecule and make it near-worthless - or even worse take a (relatively) safe molecule and turn it unacceptably toxic. I'd stay FAR away from any "analogue" being created with the sole purpose of rounding a ban without having any sort of safety and probably minimal efficacy testing.
I'd say this kind of story gives even stronger evidence for why illicit drugs (the less-toxic at least) should be legalized & controlled - if this article is not overly sensational and there really is an escalating war of chemistry we could get into some pretty nasty stuff being marketed to consumers who do not know any better.
Honestly, if a "revolution" in animal testing is going to occur, they watershed paper will not be out of this journal. The researchers appear to be microscopy specialists, not animal research specialists. Not to denigrate their work, but the literature is littered with people making grandiose claims about how their research can be applied with very little understanding about the other discipline where they suggest it could be useful.
This article has nothing to do with leeches, it's about willful tampering with a particular protocol for their entire user population, leech or otherwise.
And yes, you are the only one. I guess it's OK if you get to decide who is a "leech" and screw the other guy.
"...to improving chemotherapy drugs whose side effects arise from their solubility or insolubility in water."
This is absolutely not true. The side effect is inherent to the molecular structure of the molecule, not its solubility or lack thereof. (If it's insoluble it doesn't get into the body, and hence doesn't have a side effect... but then it has no effect at all.)
Yes, that's right, AnimeMUD. And this was back before Dragonball Z was all the rage. We're talking Akira and MD Geist level anime here. I was bored with most of the standard Tolkein-esque MUDs, so this one was a nice change of pace.
This has been coming for years. Bell Labs had been bleeding talent at least since 2002, maybe even earlier. My undergraduate advisor at Uni was a brilliant scientist who fled Bell Labs (in '02) as the culture changed.
This begs the question... should OO.o investigate putting their software on a DVD in nice packaging, and put it on CC/BB shelves for $5? (Just enough $ to cover the packaging/distribution) Honestly, everyone I know is shocked and pleased to learn that they could have "Office for free!" when I tell them about OO.o. If it were on store shelves, it would really take off.
I started smoking pipe tobacco when I was 24 (2 yrs ago). I had completely forgotten about that Sesame Street bit where Cookie Monster ate the pipe. I had wondered all along why I was tempted to eat my pipes after finishing a bowl, turns out it was Sesame Street's fault. Damn you Sesame Street!
"The biggest expense to Big Pharma is not research and development (which mainly takes place in universities, including a lot of public ones. Big Pharma does not fund those. You and I do.)"
. html
I call BS. Where is your source for this? Name one drug that was discovered in an academic setting. The VAST majority are discovered by industry, universities simply cannot afford to cost of discovering/developing drugs. Believe me, if not for pharma, we wouldn't have ANY drugs.
"At least a third of the drugs marketed by industry leaders were discovered by universities or small biotech companies, writes Angell, but they're sold to the public at inflated prices."
http://www.motherjones.com/news/qa/2004/09/09_401
So 1/3, and this writer includes small biotech in that 1/3 (which is still pharma, just not "big" pharma), so you can hardly support your claim.
In grade school, a book published in the 60's that covered all the wonderful advancements arriving soon. Flying cars et. al.
I wonder if this book will end up in a grade school library in 20 years for the kids to laugh at.
Being a graduate student, I have access to the ISI Web of Science, a very complete database of scientific papers. A query for "Peiser, B" returns only two papers. Neither have been cited by other publications, but they were published fairly recently.
"Peiser B, Reilly T
Environmental factors in the summer Olympics in historical perspective
JOURNAL OF SPORTS SCIENCES 22 (10): 981-1001 OCT 2004
Times Cited: 0"
"Paine M, Peiser B
The frequency and predicted consequences of cosmic impacts in the last 65 million years
IAU SYMPOSIA (213): 289-293 2004
Times Cited: 0 "
The article points out that Microsoft may add popup blocking to IE... is it just me, or did that already happen with WinXP SP2?
This work was done in 1996 by Herb Waite. He not only did the same work, he did it in a superior manner, with more definitive proof. And he not only POSTULATED the Fe(III) mediated crosslinking, he proved it. The appropriate reference is:
"Ferric Ion Complexes of a DOPA-Containing Adhesive Protein from Mytilus edulis", Inorg. Chem., 35 (1996), p7572
In other words, don't get your science from popular news outlets... and apparently one can't even trust Angewandte Chemie anymore. Their reviewer must have been out to lunch.
Considering I am listed on the linux counter and have not used linux for about 5-6 years now, I wouldn't put much faith in this list. To be honest, I don't even remember how my name got here, as I used an old distro of Slackware for about 2 weeks and was not exactly happy with it.
As far back as I can remember, I have been a fan of fantasy literature. During this time period, I don't believe I've ever seen a pure fantasy movie that was any good. Now all of a sudden we have a Final Fantasy movie, a Dungeons and Dragons movie, and a Lord of the Rings movie coming. If only one of them is good, I will be the happiest little camper you've ever seen.
-Now vilified fantasy nut