Garbage in, garbage out. The architecture of the computer doesn't matter much if the forcefield (the set of equations used to model the interaction between the atoms in the drug, the atoms in the protein, and the atoms in the environment) isn't accurate enough. So far they aren't. This set up seems to have found the known and several putative binding sites for clozapine, but the article doesn't say anything about false positives/false negatives it reported. The setup also pre-selects the binding sites to be studied, which makes me think it would miss a lot of interactions that happen elsewhere on the proteins. The article also points out that Pharma companies have been doing the same type of calculations for years, just on fewer drugs. Pharma haven't managed to create in silico predictions of pre clinical trials yet, let alone clinical trials.
This is work worth doing, but like Folding At Home the results are easy to over-hype.
Pretty much this. Cable TV is hugely profitable, wireless is hugely profitable and growing. Telco companies really don't want a customer unless there is a wireless or cable subscription involved.
It's not that hard to do it right, it's just a lot more expensive than a system that operates at a lower bandwidth and which considers dropped or delayed packets acceptable.
There's no single, easy and cheap answers to complex problems.
I've been wondering for a while: during an emergency, why not formally limit mobile phones in the area to 911 calls and text messages? Or maybe limit voice to 1 minute calls once every ~10 minutes?
San Diego has allowed utilities to add extra fees to everyones' electric (SDG&E) bills to cover undergrounding for decades. Seeing as nothing was actually getting buried this got to be a sore point back in the 90's, neatly solved by the city formally allowing SDG&E to keep the money without burying anything. A new effort started ~10 years ago. The first neighborhood in the program had open trenches and dug up streets for two years while the various utilities and the city dickered over who would pay for what, and ended up with electric/cable being put underground while phone lines were left on the poles. Really the only people who are getting all of their cables put underground are the rich ones who have ocean views: those neighborhoods vote for assessments and then each homeowner coughs up $6-12K to pay for it. The rest of us are paying an extra $3.50 per month and can expect our poles to disappear sometime between next week and the scheduled end of the current undergrounding program: 2067.
I think height is the big issue at that point. Having a 27" tall monitor on your desk means you end up trying to look over the top of your glasses, craning your neck, or just not using the top third of the screen very much. Hmm. So long as you're not going to use part of the screen: set it up in portrait mode. Use the top half of the screen when standing, bottom half when sitting.
But the one very annoying recurring problem is when the battery swells, and grounds-out the trackpad. This happens about every year. You buy a new battery, and you have about 12 months. Plus, the chargers, also, keep burning out. They last about 1-2 years, and that's consistent with the mac books of that era as well.
Typing this on a 2006 macbook with a trackpad shimmed with a bit of folded up paper to prevent that very problem. Still have the original charger though; I seem to have gotten the magic one.
although I'll wait a bit for the price to drop before getting one with 3200x1800 pixels.
Lenovo convertibles with 13.3" 3200 x 1800 panels are already below $1k. What I will actually do with that resolution I don't know; I'm scheduled to start going farsighted soon so I'll probably just run everything except movies at 1600 x 900 in blissful ignorance.
The highest at the moment, actually: 3200 x 1800 on the (Ideapad) 13.3" Yoga 2 Pro. The Yoga flunks RAM upgradeability (soldered in), but battery and SSD are easily replaceable.
The author said that it's a bit better now after several revisions. At the end of the article he mentions losing 15 miles per day (off of a 300(? )mile range), or 3.5kWH per day. I'll guess that the wireless/GPS components stay live regardless of whether or not you "turned off" GPS. The Tesla has two Tegra computers to run the displays in the cabin, but that's still less than 10Watts. But then there are another 50 (!) processors that actually run the car, plus the sensors they are hooked up to. If most of them can't be put in standby, 125 Watts starts to make sense.
how about you simply don't plug it in unless you want to charge it? Duh!!!
Then the battery will discharge, about 5% of a full charge per day. Not leaving it on the charger just means more charge/discharge cycles for the battery.
Achieving Campaign Goals
Another way of gauging the success or failure of a campaign is by analyzing third-party reports of whether the people who initiated the campaign achieved their stated goals. Many cases in the data set had no recorded outcomes, but we developed an indicator for those third-party or credible self-reports that demonstrated full, partial, or no success.
If someone familiar with social science statistics could explain to me whether table 3 claims that 25% of protests are successful or just that 25% of their sources fit their model or both I'd be grateful.
Old school republicans and libertarians both distaste government intervention.
What the what? Old school republicans distaste government intervention they personally or professionally find distasteful. If it's a subsidy for a company they own, an obstacle for that company's competitor, a beatdown for a minority, or anything involving a vagina they were ALL for intervention.
I know it is callous, but people worry more about deaths in their own countries than in others. Assuming they could be saved with effective antibiotics, at 23K per year lack of effective antibiotics is causing almost twice as many deaths as would removing all seatbelts and airbags in vehicles. Would you get excited if someone took all of the seatbelts out of your family's cars/trucks?
Most of the deaths are hospital acquired C. diff: shitting yourself to death. MRSA acquired outside of the hospital ('cause hospital hygiene is now good enough to prevent most MRSA infections) causes more excitement: it's very visible and very fast.
The molecule (efflux pump, enzyme, whatever) may have been there a loooong time but the amino acid sequence is changing - and thus evolving - due to selective pressures. Also - evolution refers to changes in population genetics: if an allele frequency goes from 0.1% to 95% in a population of an organism that is still evolution, even if nothing new has been created.
You're completely right about the difficulties of generating profits from new antibiotics. They are starting to be able to charge more for new antibiotics, but they aren't blockbusters by any means.
(I am sure there are some in the industry that would rather keep giving out statins than to cure heart disease.)
I do disagree with that: a cure would be MUCH more profitable than treatments for CVD, even if statins were still under patent. Consider this: to be cheaper for your insurance company, a cure for heart disease could charge $1 less than the combined sum they pay for hospitalizations, surgeries, stents, blood pressure meds, arrhythmia meds, and yes, statins. A Pharma could easily charge $150-200K for it and still save the insurance companies money. Then think about competition: none. A cure would replace the entire market for almost all cardiology products and services - until someone invented another cure. Then think about the time value of money. With a cure you get paid in full up front. $150k in your hands today, in your shareholders' hands this quarter. With a treatment your payments are spread out 10-12 years til the patent runs out. Meanwhile your patient might switch to a competing drug or die.
A cure for heart disease could easily be a trillion dollar drug.
Livestock doesn't get the same commercial product as people but they do get almost the same API (active pharmaceutical ingredient). Resistance to the livestock version confers resistance to the human-prescribed version. For example, chickens fed other fluoroquinolones breed bacteria resistant to cipro.
less easy: ban older antibiotics on a rotation schedule. This has been done in europe to some degree, but if the FDA, EMA, and WHO all got together to keep groups of generic antibiotics off the market for several years at a time (with exceptions for some emergencies) resistance would be much less severe.
Of course if the medical profession wants to get the public to take note, just tell them that we won't be able to treat syphilis anymore. If common STDs become untreatable and declared an epidemic, then the public will take notice.
Successful?? Your ROI is calculated in terms of stale bread and you haven't introduced a new product since before WW II. If your patents hadn't expired 1.5 billion years ago you might be a good merger/acquisition target, but until the answer to the question "what have you done for me lately?" is something other than "reproduce asexually" (eww), we're just gonna leave you in the petri dish.
New antibiotics are expensive (thousands of dollars per 10 day course), future ones will be more so. They don't and won't be handed out like candy, even more so the ones that have severe side effects. Costs will of course be lower in other countries, but still hundreds of dollars per course instead of a few dollars per course.
Slashdot Mirror
Garbage in, garbage out. The architecture of the computer doesn't matter much if the forcefield (the set of equations used to model the interaction between the atoms in the drug, the atoms in the protein, and the atoms in the environment) isn't accurate enough. So far they aren't. This set up seems to have found the known and several putative binding sites for clozapine, but the article doesn't say anything about false positives/false negatives it reported. The setup also pre-selects the binding sites to be studied, which makes me think it would miss a lot of interactions that happen elsewhere on the proteins. The article also points out that Pharma companies have been doing the same type of calculations for years, just on fewer drugs. Pharma haven't managed to create in silico predictions of pre clinical trials yet, let alone clinical trials. This is work worth doing, but like Folding At Home the results are easy to over-hype.
You will most likely not lose your POTs service unless an IP based equivalent were available and reliable.
With the proviso that the IP providers will be the ones who determine what "reliable" means.
Pretty much this. Cable TV is hugely profitable, wireless is hugely profitable and growing. Telco companies really don't want a customer unless there is a wireless or cable subscription involved.
It's not that hard to do it right, it's just a lot more expensive than a system that operates at a lower bandwidth and which considers dropped or delayed packets acceptable.
There's no single, easy and cheap answers to complex problems.
I've been wondering for a while: during an emergency, why not formally limit mobile phones in the area to 911 calls and text messages? Or maybe limit voice to 1 minute calls once every ~10 minutes?
San Diego has allowed utilities to add extra fees to everyones' electric (SDG&E) bills to cover undergrounding for decades. Seeing as nothing was actually getting buried this got to be a sore point back in the 90's, neatly solved by the city formally allowing SDG&E to keep the money without burying anything. A new effort started ~10 years ago. The first neighborhood in the program had open trenches and dug up streets for two years while the various utilities and the city dickered over who would pay for what, and ended up with electric/cable being put underground while phone lines were left on the poles. Really the only people who are getting all of their cables put underground are the rich ones who have ocean views: those neighborhoods vote for assessments and then each homeowner coughs up $6-12K to pay for it. The rest of us are paying an extra $3.50 per month and can expect our poles to disappear sometime between next week and the scheduled end of the current undergrounding program: 2067.
Be careful what you wish for.
if the taste-providing ingredients taste savory then they quite probably contain a lot of glutamate as well.
I think height is the big issue at that point. Having a 27" tall monitor on your desk means you end up trying to look over the top of your glasses, craning your neck, or just not using the top third of the screen very much. Hmm. So long as you're not going to use part of the screen: set it up in portrait mode. Use the top half of the screen when standing, bottom half when sitting.
Well we got our great depression. So we have that going for us, I guess ...
But the one very annoying recurring problem is when the battery swells, and grounds-out the trackpad. This happens about every year. You buy a new battery, and you have about 12 months. Plus, the chargers, also, keep burning out. They last about 1-2 years, and that's consistent with the mac books of that era as well.
Typing this on a 2006 macbook with a trackpad shimmed with a bit of folded up paper to prevent that very problem. Still have the original charger though; I seem to have gotten the magic one.
although I'll wait a bit for the price to drop before getting one with 3200x1800 pixels.
Lenovo convertibles with 13.3" 3200 x 1800 panels are already below $1k. What I will actually do with that resolution I don't know; I'm scheduled to start going farsighted soon so I'll probably just run everything except movies at 1600 x 900 in blissful ignorance.
The highest at the moment, actually: 3200 x 1800 on the (Ideapad) 13.3" Yoga 2 Pro. The Yoga flunks RAM upgradeability (soldered in), but battery and SSD are easily replaceable.
http://teslatap.com/undocumented/model-s-processors-count/
how about you simply don't plug it in unless you want to charge it? Duh!!!
Then the battery will discharge, about 5% of a full charge per day. Not leaving it on the charger just means more charge/discharge cycles for the battery.
http://digital-activism.org/download/1270/
Achieving Campaign Goals Another way of gauging the success or failure of a campaign is by analyzing third-party reports of whether the people who initiated the campaign achieved their stated goals. Many cases in the data set had no recorded outcomes, but we developed an indicator for those third-party or credible self-reports that demonstrated full, partial, or no success.
If someone familiar with social science statistics could explain to me whether table 3 claims that 25% of protests are successful or just that 25% of their sources fit their model or both I'd be grateful.
Old school republicans and libertarians both distaste government intervention.
What the what? Old school republicans distaste government intervention they personally or professionally find distasteful. If it's a subsidy for a company they own, an obstacle for that company's competitor, a beatdown for a minority, or anything involving a vagina they were ALL for intervention.
I know it is callous, but people worry more about deaths in their own countries than in others. Assuming they could be saved with effective antibiotics, at 23K per year lack of effective antibiotics is causing almost twice as many deaths as would removing all seatbelts and airbags in vehicles. Would you get excited if someone took all of the seatbelts out of your family's cars/trucks?
http://www-nrd.nhtsa.dot.gov/pdf/esv/esv18/CD/Files/18ESV-000500.pdf
Most of the deaths are hospital acquired C. diff: shitting yourself to death. MRSA acquired outside of the hospital ('cause hospital hygiene is now good enough to prevent most MRSA infections) causes more excitement: it's very visible and very fast.
The molecule (efflux pump, enzyme, whatever) may have been there a loooong time but the amino acid sequence is changing - and thus evolving - due to selective pressures. Also - evolution refers to changes in population genetics: if an allele frequency goes from 0.1% to 95% in a population of an organism that is still evolution, even if nothing new has been created.
(I am sure there are some in the industry that would rather keep giving out statins than to cure heart disease.)
I do disagree with that: a cure would be MUCH more profitable than treatments for CVD, even if statins were still under patent. Consider this: to be cheaper for your insurance company, a cure for heart disease could charge $1 less than the combined sum they pay for hospitalizations, surgeries, stents, blood pressure meds, arrhythmia meds, and yes, statins. A Pharma could easily charge $150-200K for it and still save the insurance companies money. Then think about competition: none. A cure would replace the entire market for almost all cardiology products and services - until someone invented another cure. Then think about the time value of money. With a cure you get paid in full up front. $150k in your hands today, in your shareholders' hands this quarter. With a treatment your payments are spread out 10-12 years til the patent runs out. Meanwhile your patient might switch to a competing drug or die.
A cure for heart disease could easily be a trillion dollar drug.
Livestock doesn't get the same commercial product as people but they do get almost the same API (active pharmaceutical ingredient). Resistance to the livestock version confers resistance to the human-prescribed version. For example, chickens fed other fluoroquinolones breed bacteria resistant to cipro.
less easy: ban older antibiotics on a rotation schedule. This has been done in europe to some degree, but if the FDA, EMA, and WHO all got together to keep groups of generic antibiotics off the market for several years at a time (with exceptions for some emergencies) resistance would be much less severe.
Of course if the medical profession wants to get the public to take note, just tell them that we won't be able to treat syphilis anymore. If common STDs become untreatable and declared an epidemic, then the public will take notice.
Getting close with gonorrhea already.
Is the current 23,000 deaths per year in the US due to antibiotic resistant bacteria enough to get excited about?
Successful?? Your ROI is calculated in terms of stale bread and you haven't introduced a new product since before WW II. If your patents hadn't expired 1.5 billion years ago you might be a good merger/acquisition target, but until the answer to the question "what have you done for me lately?" is something other than "reproduce asexually" (eww), we're just gonna leave you in the petri dish.
New antibiotics are expensive (thousands of dollars per 10 day course), future ones will be more so. They don't and won't be handed out like candy, even more so the ones that have severe side effects. Costs will of course be lower in other countries, but still hundreds of dollars per course instead of a few dollars per course.