Now, we 'detect genes' by a few methods: heuristics that look for sequence characteristics (ATG starts, open reading frames, GC content, etc), and use the sequences of other organisms to look for higher than normal conservation between genomes to indicate that these regions are mutating more slowly than chance (under selection.)
I work at the Broad institute, and we just had our yearly retreat this year. One of the amusing things that's come out recently: we've got about 2K-3K 'genes' annotated for the human genome that probably aren't there, according to new data and detection.
Not many genes are found by positionally cloning anymore. It's difficult, time consuming, and used to be 'the task' that PhD students would get stuck doing.
Besides all this, you can't patent genes, just methods on/using them. And there's lots of room for me to have a drug that works better on you because you have a mutation on a gene, and you can get a detection method for a disease, etc.
I'd guess this is most likely complete fear mongering, and if it was a "CS Technical" discussion, people would recognise it as such.
With a sample size that small, you're not going to see any effect unless it's incredibly dramatic. If people were either going deaf or keeping perfect hearing, I don't think you have the power to differentiate the two groups.
Statistics - what sinks most published papers.
And yes, I'm in the middle of generating data for reviewers on my nature paper...
The electricity can be used while it is being generated, or it can be stored in a lightweight rechargeable battery for later use, greatly reducing the need to haul and use heavy replacement batteries.
I have the new edition. It's facinating reading, though I have to take it 10-20 pages at a time. I'm almost done with egg at this point, and I've learned so many interesting side notes in how to, for example, make souffles turn out the way I want. Or, how many meringues there are, and the chemical and physical processes involved.
As a biologist, it is very satisfying to know *why* the processes I go through to cook something work, and to understand where I have tollerance to play with, and where I must adhere to the 'rules'.
What impresses me the most about the new played is that it's flash based, instead of hard drive based. In the past, my mp3 players that were HD based had a lot of problems with durability.
I currently use a Rio Karma (which I'd love and recommend, if it held up well), but I travel with my player too much, including biking. HD based players are much more easily ruined by jaring motions, drops, etc. Your HD begins to degrade, sometimes songs skip or the player freezes up. Perhaps you cant use the full capacity of the player for very long.
Since an music player is mostly in 'read' mode, the fact that flash memory will eventually wear out is very acceptable. The nano should last until a much nicer player comes out that has a much higher capacity for the form factor.
I've never been interested in apple products before (my rio does a lot more than the apple products do - ogg support, better playlist support, DJ modes, etc), but it's on it's way out, due to the HD. When it dies, I know where i'll be looking next...
I've had 'em before, served with Tofu and peanuts. Salty, but not bad. It might look strange to you, but it's not nearly as strange tasting as you'd think it is...at least if you're cuisine range extends past mcdonnalds.
Interesting. I've seen many chefs say that americans are too tentitive with their spicing, and seem to *under* spice much of their food.
Of course, 'texas pete' is not a spice or herb. It's some crappy added on hot sauce, that you use to obliterate the taste of bland food.
Try indian, or thai, or chinese, or japanese, or korean (etc, etc,etc) and you can have plenty of spice, and it taste great.
I may not be a chef, but my friends prefer my home cooked meals to resteraunts in town (and I live in Boston - we're no slouch when it comes to resturaunts.) So, I have at least a little clue what I'm talking about. (On the other hand, I'd love to have access to a professional chef to talk to about technique occasionally...)
So, someone's finally gotten around to reading all of Harold McGee's "On Food and Cooking the science and lore of the kitchen".
This is a book about food stuffs through history, and their chemical and physical reactions to different processes used in cooking. The book has ~70 pages on milk, about about ~60-70 pages on eggs alone.
You get a chance to understand how your food works, at the molecular level. You can read about what protiens are in eggs, and how they change due to heat, acidity, etc. How whipped cream supports air, and how the fat molecules wrap around air (including pictures with a scanning electron microscope!)
Good stuff for cooks, and very much the science of cooking.
However, this book was originally written 20 years ago, so this isn't as new as it's played out to be...Now Pravda is just supplementing the story with a bit of 'wouldn't it be cool if we used technology to make things better?'
Great, then we can outsource all those open positions that we don't have right now.
Finally, a positive outlook on outsourcing.
Not to mention the growing gap that's destroying the middle class, and all the poor people that will never be able to kick back and enjoy their retirement.
One of the few comments were "LOL" would actually be appropriate.
Of course, my girlfriend recently told me (yesterday) that she was interested in anime, but didn't know much about it. I can just imagine exactly which anime I'm _not_ going to show her first.
I think she'd dig cowboy bebop, or ghost in the shell...
The problem is, you're quoting an untested hypothesis. They have no evidence to point out that this hypothesis may be true. Instead, the idea is left as something for further testing.
To claim that because a scientist thinks there's a possibility something 'might' be true, without real, statistical or biochemical tests is absurd.
And yes, I am a scientist (population geneticist), and I research obesity for a living.
If people went around quoting alternate hypothesis that I was busy thinking up as fact before I had data, you'd believe a lot of crap in front of you. Part of our jobs is to think up plausable stories, then test those stories with data. Only when we have a sufficent body of data do we start to suspect the story is true.
I've always had a harder time pinning down bitter items myself: chicory, endive, radicchio, dandelion greens, olives. Oh, and overextracted espresso is bitter. Underextracted espresso is sour.
They really are two different tastes, but I think since people are very familiar with sour, sometimes they misuse the word bitter in it's place, because bitter foods are avoided more than sour ones, and people simply lack the properly trained palate to discern the differences.
If you're really enjoying your life, then it *is* "that much of a life". Just because you don't have someone else's ideal life doesn't make yours any less ideal for you.
It's subjective, so start telling other people who tell you that you're life isn't good enough for *them* to...kindly...fuck off.
We all suffer from the founder effect. It's not enough to quote an effect, but to claim how severe it is by estimating how large the true founder population size at the maximum bottleneck was.
After all, it was only about 10,000 people who migrated out of africa and founded the rest of the world. That's a pretty significant bottleneck, and you see that in genetic data today - african ethnicities tend to have a larger number of common variation than say, european ethnicities. That's because the bottleneck filtered diversity out of the group.
Boston. Children's Hospital and the Broad. I'm working 'officially' at CH, and a visting scientist at the Broad.
Wooo...encode data. I just had to write a bunch of code to calculate pi/theta for conserved regions in encode vs. non conserved regions in the ENCODE dataset. Good times.
Please listen to a DJ with talent, like Kid Koala. He does things that you'd consider remixing, but they are entirely different than just playing a record or two. There's only shreds of the orignal performace left, and what's left is being used in entirely different ways.
Watch the documentary "Scratch", and check out exactly how and why DJ's are creating music.
Check out DJ QBert's film "Wave Twisters". He's a DJ, but it's entirely different, new music.
Of course, you can go to a club and a "DJ" is there, just playing music, not engaged in beatmixing, turntabilism, or any form of creativity. That's what I call - in technical terms - a "Shitty DJ". I try to avoid those clubs.
You've probably never been exposed to any talented DJ's, so it's difficult for you to judge. It's like if you've never had a well cooked meal in your life, you'd have no great expectations if someone were to cook for you - you just lack the experience to make global judgements.
People who slag "DJ's" with a broad stroke show as much knowledge as is typical for slashdot posts. If it isn't directly related to computers, the most people come across sounding like they know what they are talking about...unless you're at all informed, then you realize that people confidently spout bullshit.
My lab is preparing to submit my work on looking at conserved regions between mice, dogs, and humans in intragenic regions, and our hypothesis as to selective forces acting in intragenic regions.
If I'm lucky, it'll be my 1st first author nature paper. (crosses fingers).
We tell a good story (oh, and the data now even matches with Eddie Rubin's data about deleting a 1 megabase region in gene desert...)
There's a lot left to be explored in intragenic regions, and it's become a very hot topic in a number of labs following the release of the Hapmap project's full dataset.
I got a pair of B&W 604's. They're worth every penny, if you have the money to get the right electronics to drive them.
On the other hand, might be a hell of a lot of fun to build your own speakers - but if it's $1000 for a $2000 sounding speaker (without support), then I might be tempted to still buy - ascetics can be important, and minor errors in building your speakers may result in getting $100 boom boxes instead of quality sound reproduction.
Slashdot Mirror
Are we talking positional cloning of genes?
Now, we 'detect genes' by a few methods: heuristics that look for sequence characteristics (ATG starts, open reading frames, GC content, etc), and use the sequences of other organisms to look for higher than normal conservation between genomes to indicate that these regions are mutating more slowly than chance (under selection.)
I work at the Broad institute, and we just had our yearly retreat this year. One of the amusing things that's come out recently: we've got about 2K-3K 'genes' annotated for the human genome that probably aren't there, according to new data and detection.
Not many genes are found by positionally cloning anymore. It's difficult, time consuming, and used to be 'the task' that PhD students would get stuck doing.
Besides all this, you can't patent genes, just methods on/using them. And there's lots of room for me to have a drug that works better on you because you have a mutation on a gene, and you can get a detection method for a disease, etc.
I'd guess this is most likely complete fear mongering, and if it was a "CS Technical" discussion, people would recognise it as such.
With a sample size that small, you're not going to see any effect unless it's incredibly dramatic. If people were either going deaf or keeping perfect hearing, I don't think you have the power to differentiate the two groups.
Statistics - what sinks most published papers.
And yes, I'm in the middle of generating data for reviewers on my nature paper...
You missed this part as well:
The electricity can be used while it is being generated, or it can be stored in a lightweight rechargeable battery for later use, greatly reducing the need to haul and use heavy replacement batteries.
I have the new edition. It's facinating reading, though I have to take it 10-20 pages at a time. I'm almost done with egg at this point, and I've learned so many interesting side notes in how to, for example, make souffles turn out the way I want. Or, how many meringues there are, and the chemical and physical processes involved.
As a biologist, it is very satisfying to know *why* the processes I go through to cook something work, and to understand where I have tollerance to play with, and where I must adhere to the 'rules'.
What impresses me the most about the new played is that it's flash based, instead of hard drive based. In the past, my mp3 players that were HD based had a lot of problems with durability.
I currently use a Rio Karma (which I'd love and recommend, if it held up well), but I travel with my player too much, including biking. HD based players are much more easily ruined by jaring motions, drops, etc. Your HD begins to degrade, sometimes songs skip or the player freezes up. Perhaps you cant use the full capacity of the player for very long.
Since an music player is mostly in 'read' mode, the fact that flash memory will eventually wear out is very acceptable. The nano should last until a much nicer player comes out that has a much higher capacity for the form factor.
I've never been interested in apple products before (my rio does a lot more than the apple products do - ogg support, better playlist support, DJ modes, etc), but it's on it's way out, due to the HD. When it dies, I know where i'll be looking next...
I've had 'em before, served with Tofu and peanuts. Salty, but not bad. It might look strange to you, but it's not nearly as strange tasting as you'd think it is...at least if you're cuisine range extends past mcdonnalds.
Read Harold McGee's Book "On food and cooking - the science and lore of the kitchen".
Then, season your foot. You're gonna have to make it tasty to get it all down.
Interesting. I've seen many chefs say that americans are too tentitive with their spicing, and seem to *under* spice much of their food.
Of course, 'texas pete' is not a spice or herb. It's some crappy added on hot sauce, that you use to obliterate the taste of bland food.
Try indian, or thai, or chinese, or japanese, or korean (etc, etc,etc) and you can have plenty of spice, and it taste great.
I may not be a chef, but my friends prefer my home cooked meals to resteraunts in town (and I live in Boston - we're no slouch when it comes to resturaunts.) So, I have at least a little clue what I'm talking about. (On the other hand, I'd love to have access to a professional chef to talk to about technique occasionally...)
So, someone's finally gotten around to reading all of Harold McGee's "On Food and Cooking the science and lore of the kitchen".
This is a book about food stuffs through history, and their chemical and physical reactions to different processes used in cooking. The book has ~70 pages on milk, about about ~60-70 pages on eggs alone.
You get a chance to understand how your food works, at the molecular level. You can read about what protiens are in eggs, and how they change due to heat, acidity, etc. How whipped cream supports air, and how the fat molecules wrap around air (including pictures with a scanning electron microscope!)
Good stuff for cooks, and very much the science of cooking.
However, this book was originally written 20 years ago, so this isn't as new as it's played out to be...Now Pravda is just supplementing the story with a bit of 'wouldn't it be cool if we used technology to make things better?'
Ya know, Mc D's held the coffee at much hotter temperatures than the industry standard. So hot that it rapidly degrades in taste.
However, they have to deal with people like you, who want it hot, not fresh (or can't tell the difference. McD's coffee is complete shit anyway.)
Great, then we can outsource all those open positions that we don't have right now.
Finally, a positive outlook on outsourcing.
Not to mention the growing gap that's destroying the middle class, and all the poor people that will never be able to kick back and enjoy their retirement.
Never underestimate the power of the swimming pool noodle.
Perhaps you'll come across as the savior of man, the flying spaghetti monster .
One of the few comments were "LOL" would actually be appropriate.
Of course, my girlfriend recently told me (yesterday) that she was interested in anime, but didn't know much about it. I can just imagine exactly which anime I'm _not_ going to show her first.
I think she'd dig cowboy bebop, or ghost in the shell...
I'm not an apple fan boy. That said:
Fact:
With Apple sueing fan sites for allegedly inducing people to break their contracts (NDA is a type of contract) and winning
Opinion
they've paved the way for people to be sued* for allegedly inducing someone to break a contract.
You're right, it's annoying when people point out facts, but it's more annoying when people claim their opinion is fact. IMHO...:)
You misunderstand. Scientists don't get stirred up. We feel bad that people misunderstand methodologies. We feel bad that you don't 'get it'.
Nice try to troll. Write again when you get back to highschool and can check your 'scientific journals'...
The problem is, you're quoting an untested hypothesis. They have no evidence to point out that this hypothesis may be true. Instead, the idea is left as something for further testing.
To claim that because a scientist thinks there's a possibility something 'might' be true, without real, statistical or biochemical tests is absurd.
And yes, I am a scientist (population geneticist), and I research obesity for a living.
If people went around quoting alternate hypothesis that I was busy thinking up as fact before I had data, you'd believe a lot of crap in front of you. Part of our jobs is to think up plausable stories, then test those stories with data. Only when we have a sufficent body of data do we start to suspect the story is true.
Completely off topic...
Bitter vs. sour:
Lemon would be citric acid. That's sour.
I've always had a harder time pinning down bitter items myself: chicory, endive, radicchio, dandelion greens, olives. Oh, and overextracted espresso is bitter. Underextracted espresso is sour.
They really are two different tastes, but I think since people are very familiar with sour, sometimes they misuse the word bitter in it's place, because bitter foods are avoided more than sour ones, and people simply lack the properly trained palate to discern the differences.
Yeah, completely off topic, perfect for slashdot.
Oh, I do know James. I think I destroy his sanity occasionally when I use far too much diskspace.
If you're really enjoying your life, then it *is* "that much of a life". Just because you don't have someone else's ideal life doesn't make yours any less ideal for you.
It's subjective, so start telling other people who tell you that you're life isn't good enough for *them* to...kindly...fuck off.
Your post is a dupe of all the other editor complaints on slashdot.
We all suffer from the founder effect. It's not enough to quote an effect, but to claim how severe it is by estimating how large the true founder population size at the maximum bottleneck was.
After all, it was only about 10,000 people who migrated out of africa and founded the rest of the world. That's a pretty significant bottleneck, and you see that in genetic data today - african ethnicities tend to have a larger number of common variation than say, european ethnicities. That's because the bottleneck filtered diversity out of the group.
Boston. Children's Hospital and the Broad. I'm working 'officially' at CH, and a visting scientist at the Broad.
Wooo...encode data. I just had to write a bunch of code to calculate pi/theta for conserved regions in encode vs. non conserved regions in the ENCODE dataset. Good times.
Please listen to a DJ with talent, like Kid Koala. He does things that you'd consider remixing, but they are entirely different than just playing a record or two. There's only shreds of the orignal performace left, and what's left is being used in entirely different ways.
Watch the documentary "Scratch", and check out exactly how and why DJ's are creating music.
Check out DJ QBert's film "Wave Twisters". He's a DJ, but it's entirely different, new music.
Of course, you can go to a club and a "DJ" is there, just playing music, not engaged in beatmixing, turntabilism, or any form of creativity. That's what I call - in technical terms - a "Shitty DJ". I try to avoid those clubs.
You've probably never been exposed to any talented DJ's, so it's difficult for you to judge. It's like if you've never had a well cooked meal in your life, you'd have no great expectations if someone were to cook for you - you just lack the experience to make global judgements.
People who slag "DJ's" with a broad stroke show as much knowledge as is typical for slashdot posts. If it isn't directly related to computers, the most people come across sounding like they know what they are talking about...unless you're at all informed, then you realize that people confidently spout bullshit.
I know, I know. Welcome to slashdot.
My lab is preparing to submit my work on looking at conserved regions between mice, dogs, and humans in intragenic regions, and our hypothesis as to selective forces acting in intragenic regions.
If I'm lucky, it'll be my 1st first author nature paper. (crosses fingers).
We tell a good story (oh, and the data now even matches with Eddie Rubin's data about deleting a 1 megabase region in gene desert...)
There's a lot left to be explored in intragenic regions, and it's become a very hot topic in a number of labs following the release of the Hapmap project's full dataset.
I got a pair of B&W 604's. They're worth every penny, if you have the money to get the right electronics to drive them.
On the other hand, might be a hell of a lot of fun to build your own speakers - but if it's $1000 for a $2000 sounding speaker (without support), then I might be tempted to still buy - ascetics can be important, and minor errors in building your speakers may result in getting $100 boom boxes instead of quality sound reproduction.