In most states, you DO need a "no trespassing" sign or a fence. Otherwise, you have to ask people to leave before you can have them arrested. NOCACHE is a simple way for the newspaper to ask Google to leave.
There should be an ultimatum: if there is another terrorist attack or attacks causing major loss of life, any country found to be harboring and/or funding Islamic terrorists will be attacked. Not invaded. Attacked. Their cities will be summarily carpet-bombed.
Perhaps you forgot that the last major terrorist attack in this country before 9/11/01 was hashed up by two guys from Oklahoma. Are you really advocating that we carpet-bomb Topeka?
Or do we make an exception when American authorities can't foil a terrorist plot but expect the Egyptian security to be fool-proof?
This whole thing stinks to high heaven. This is almost as bad as that cult that claimed to have cloned the baby. There is one way to tell real science from bogus science. Real scientists publish their results in peer-reviewed journals. Only afterwards do they hold press conferences. If this were in Science or NEJM I would believe it. But, I would bet anyone here that this story turns out to be bogus.
I expect to be modded down for this... too bad you never get modded back up on old threads a few weeks later once everyone sees you are right.
If you look at the context of the pictures, you will see that someone posted them on the web near text that said "Holloween" and "2004" but were posted in November of 2003.
Votes were not changed. The past was changed. Once the vote is altered there is no record of the vote being altered. It is as if the vote always had been altered.
IGNORANCE IS STRENGTH
If all else fails we can just blame Emanual Goldstien
A provider of electronic communication service or remote computing service shall disclose to a governmental entity the -
(A)
name;
(B)
address;
(C)
local and long distance telephone connection records, or records of session times and durations;
(D)
length of service (including start date) and types of service utilized;
(E)
telephone or instrument number or other subscriber number or identity, including any temporarily assigned network address; and
(F)
means and source of payment for such service (including any credit card or bank account number),
of a subscriber to or customer of such service when the governmental entity uses an administrative subpoena authorized by a Federal or State statute or a Federal or State grand jury or trial subpoena or any means available under paragraph (1).
(3)
A governmental entity receiving records or information under this subsection is not required to provide notice to a subscriber or customer.
Let's see...ultra-mechanical rhythms, very repetitive, cookie-monster vocals, no dynamics....I bet death metal would be easy.
Trance too. This has been available in parts of europe (Ibiza?) for several years. I think it's available as a subscription service there. I've been waiting for it to show up in the States. Does seem a bit pricy though.
Re:Too much coffee: Caffeine overdose and drowning
on
Death by Coffee?
·
· Score: 5, Informative
The LD50 (leathal dose, 50% occurance) of caffeine administered oraly in humans is 192 mg/kg. Meaning that a 70kg (150lbs) person who ingests 13.44g of pure caffeine has a 50% chance of survival. Since the standard cup of drip coffee has 150 mg of caffeine (a shot of espresso has substantially LESS) a 70kg individual would have to ingest 89.6 cups in once sitting to reach the 50% survival dose.
89.6 cups is a lot of volume so it is unlikely that one could drink that much at once. The question posed was whether 100 cups in 24 hours would be fatal. Since the metabolic half life of caffeine is 4 hours, this problem becomes a little more complicated. Assuming the 100 cups were spaced evenly throughout the 24 hour period (one each 14.4 minutes), we can calculate the total caffeine in the bloodstream at any time durring the 24 hour period.
At one cup every 15 minutes, the level of caffeine reaches an equilibrium with the rate of degredation arround cup #70 with a blood level of 2.4g -- much less than the LD50 of 13.4g. Even if you were drinking a cup every 5 minutes, the blood level would stabalize around 7.2g -- in the danger zone but still likely survivable especially with medical attention.
Caffeine is a dierettic (makes you pee) and so your biggest risk would likely be dehydration. But that's another story entierly.
----------------- Just in case: Drugs affect different people in different ways. Don't try doing your own experiments.
I for one don't like the idea that we're messing around and marketing something that we don't really understand.
Perhaps, but, I for one don't like the idea of people suing to stop things that they don't understand. The same goes for slashdot posters being afraid of things they don't understand. As one of the minority of biologists who frequent slashdot, I feel a small primer on GM technology is in order. I appologise in advance if this sounds preachy.
First, gene's consist of two parts: a coding sequence (which defines the protien produced by the gene) and a promoter (which controls when and where that protein is made). Think of it as event driven programming -- when the promoter is activated, the protein is made. One good example is Heat Shock Protein (HSP). When the temperature of a cell get's too high, HSP changes shape and can then activate other genes' promoters. These genes mediate the cell's response to thermal stress.
Green Flourecent Protein is a protein that occures naturally in a species of jelly fish (Aequorea Victoria) and it happens to be flourecent, i.e. when put under UV light it glows green. Scientists have known about GFP for a while and have created versions of it such as Red Flourecent Protein (RFP) or Cyan Flourecent Protein (CFP) that, after small changes to the coding region glow in different colors.
Say, you want to study development. Early in animal development, there are three tissue types: endoderm, ectoderm, and mezoderm and all internal organs are decended from one of these three embryonic tissues. If you are interested in finding out which organs come from which early tissues, you could do it with transgenics as described below.
Now, how to make a transgenic (GM) animal? First, using biochemical techniques you take the GFP gene and attach it to a promoter for a gene that is expressed (or turned on) in the endoderm. Then you put that construct into a small peice of DNA called a plasmid. The plasmid has some other genes also, such as a replication origin (which allows the plasmid to be coppied in bacteria but not in animals) and a neomycin (antibiotic) resistance gene taken from bacteria that are resistant to neomycin. Then you transfect bacteria (usually a non-pathogenic strain of E. Coli) with the plasmid. That is, you get the plasmid inside the E. Coli. Only a very small percentage of the E. Coli are transfected, so you grow them in media that contains neomycin -- that way you know all of the surviving bacteria cary the plasmid. Using this technique you can "grow" a lot of plasmid. Then, using a little biochemistry, you can isolate the plasmid from the bacteria and inject it into zebrafish embryos. Again, only a very small percentage of the zebrafish will incorperate the DNA into their genomes. Those that do, are transgenic.
The entire process can then be repeated with RFP and the promoter for a mezoderm gene. Now you have a transgenic fish in which some organs glow green and some glow red. This is basically what the GloFish is.
Note that all of the gene's present in the zebrafish are present elsewhere in nature. All that has happened is the scientists have moved a gene from one species to another. Note also, that the gene has become incorporated into the genome of the zebrafish and is not just floating around. A larger fish that eats this zebrafish is no more transgenic than you are a cow for eating beef. The larger fish will not make the protein and it is not possible for the transgene to become incorporated into the genome of other fish it comes in contact with.
Likewise, the neomycin (or other antibiotic) resistance gene is not in bacteria and there is no way for it to get into bacteria. Only the zebrafish are neomycin resistant and (being vertibrate) neomycin never would have hurt them anyway.
This lawsuit is spreading an example of the classic fear, uncertainty, and doubt that is spread by those who oppose any genetic modifications. I agree that we need to have a substantive debate about
A recent Sprint Wireless survey of more than 500 college students found that half are cell-only customers
What? I don't understand. I thought you couldn't survey cell-only people. My slashdot has betrayed me.
Perhaps, this survey actually sent people out into the street to survey people. Perhaps the political polsters just need to change their methods (as i'm sure they will) rather than admit defeat to sampling error.
Of course, people on the street introduces biases also. Maybe the reason the percent of cellphone users was so high in the Sprint survey is because the people with landlines are at home on the phone and the people with cellphones are walking around, talking to their friends, and pissing everyone else off.
Every survey has bias. You correct for it as best you can and move on.
When I read the headline I instantly thought of Shanghai -- especially parts of the old city. The area east of the Huangou isn't as bad but there are places where you really can't see the sky. The photo in the arcicle doesn't give a good sense. Above every street -- all along the street in some neighborhoods -- is what looks like a net of wires. Some places it's so thick that you could crawl across it with little fear of falling through the spaces between the wires.
I think it's a great thing that they are doing this. Not just for aesthetics but for simplicity. Part of the problem with overhead lines in a place like China is that anyone can add to the mess. Underground you need permission before you go down and lay more cable.
Simple, funding.
It is a lot easier for researchers to get grant to "cure a disease" than it is to make computer access easier for everyone. It is also easier to get FDA approval for human trials when the goal is to improve quality of life for disabled people than it is when the goal is to make cooler video games.
Be patient. The medical applications come first, the consumer ones will follow.
THC is a small molecule not a protien. Individual genes code for protiens (peptide chains). Thus all of the trangenic crops we have seen so far are created with the addition of a single gene coding for a specific protien. One can make a glowing rabbit by adding the gene for green flourecent protien (GFP) from a jelly fish. The way that a plant makes THC is by converting one molecule to another using enzymes until THC is the final result. These enzymes are coded for by genes, so one could, in theory, make some plant produce THC but you would have to geneticly add the entire synthesis pathway, which is likely a large number of genes. It's not imposible but very difficult.
While you are right that there are a lot of different forms of blindness, most could be cured by an artificial retina. There is some promising work being done in this field. A battery powered implant tried in a group of people with retinitis pigmentosa had close to a 50% success rate.
The reason that we need to study vision loss pathologies is that many kinds of blindness may be much easier to cure. As an example, one of the most common genetic causes of blindness, conginital stationary night blindness (CSNB), has been mapped to a particular gene which makes a special protien (called RPE65) in the visual cycle. In a recent study, puppies with CSNB were able to have their vision restored simply by feeding them RPE65 from birth.
Slashdot Mirror
In most states, you DO need a "no trespassing" sign or a fence. Otherwise, you have to ask people to leave before you can have them arrested. NOCACHE is a simple way for the newspaper to ask Google to leave.
Google should block the Newspaper's IP addresses so that their reporters cannot use Google in their research.
$150,000 is a statutory penalty and has no relation to the cost to the label. The same penalty occures for infringement without monetary gain.
There should be an ultimatum: if there is another terrorist attack or attacks causing major loss of life, any country found to be harboring and/or funding Islamic terrorists will be attacked. Not invaded. Attacked. Their cities will be summarily carpet-bombed.
Perhaps you forgot that the last major terrorist attack in this country before 9/11/01 was hashed up by two guys from Oklahoma. Are you really advocating that we carpet-bomb Topeka?
Or do we make an exception when American authorities can't foil a terrorist plot but expect the Egyptian security to be fool-proof?
I expect to be modded down for this... too bad you never get modded back up on old threads a few weeks later once everyone sees you are right.
If you look at the context of the pictures, you will see that someone posted them on the web near text that said "Holloween" and "2004" but were posted in November of 2003.
Only if you are Brittish. We call that green wire "ground" over here.
My personal favorite is the genus of Molusk, "Tamu" which was named by the genus' discoverer, a professor at Texas A&M University.
Or perhaps more satirically (sp?):
Votes were not changed. The past was changed.
Once the vote is altered there is no record of the vote being altered. It is as if the vote always had been altered.
IGNORANCE IS STRENGTH
If all else fails we can just blame Emanual Goldstien
A provider of electronic communication service or remote computing service shall disclose to a governmental entity the -
(A)
name;
(B)
address;
(C)
local and long distance telephone connection records, or records of session times and durations;
(D)
length of service (including start date) and types of service utilized;
(E)
telephone or instrument number or other subscriber number or identity, including any temporarily assigned network address; and
(F)
means and source of payment for such service (including any credit card or bank account number),
of a subscriber to or customer of such service when the governmental entity uses an administrative subpoena authorized by a Federal or State statute or a Federal or State grand jury or trial subpoena or any means available under paragraph (1).
(3)
A governmental entity receiving records or information under this subsection is not required to provide notice to a subscriber or customer.
Trance too.
This has been available in parts of europe (Ibiza?) for several years. I think it's available as a subscription service there. I've been waiting for it to show up in the States. Does seem a bit pricy though.
The LD50 (leathal dose, 50% occurance) of caffeine administered oraly in humans is 192 mg/kg. Meaning that a 70kg (150lbs) person who ingests 13.44g of pure caffeine has a 50% chance of survival. Since the standard cup of drip coffee has 150 mg of caffeine (a shot of espresso has substantially LESS) a 70kg individual would have to ingest 89.6 cups in once sitting to reach the 50% survival dose.
89.6 cups is a lot of volume so it is unlikely that one could drink that much at once. The question posed was whether 100 cups in 24 hours would be fatal. Since the metabolic half life of caffeine is 4 hours, this problem becomes a little more complicated. Assuming the 100 cups were spaced evenly throughout the 24 hour period (one each 14.4 minutes), we can calculate the total caffeine in the bloodstream at any time durring the 24 hour period.
At one cup every 15 minutes, the level of caffeine reaches an equilibrium with the rate of degredation arround cup #70 with a blood level of 2.4g -- much less than the LD50 of 13.4g. Even if you were drinking a cup every 5 minutes, the blood level would stabalize around 7.2g -- in the danger zone but still likely survivable especially with medical attention.
Caffeine is a dierettic (makes you pee) and so your biggest risk would likely be dehydration. But that's another story entierly.
-----------------
Just in case:
Drugs affect different people in different ways. Don't try doing your own experiments.
You are almost certainly in violation of part 15 of the FCC rules.
Perhaps that's why the AutoPen is one of those technologies that wont die either?
If someone just shot your map, finding out where you are is probably the least of your worries.
This debate about what is or is not a "real study" vs. "irational paranoia" can be settled with two words: Peer Review
Try searching pubmed rather than google
Perhaps, but, I for one don't like the idea of people suing to stop things that they don't understand. The same goes for slashdot posters being afraid of things they don't understand. As one of the minority of biologists who frequent slashdot, I feel a small primer on GM technology is in order. I appologise in advance if this sounds preachy.
First, gene's consist of two parts: a coding sequence (which defines the protien produced by the gene) and a promoter (which controls when and where that protein is made). Think of it as event driven programming -- when the promoter is activated, the protein is made. One good example is Heat Shock Protein (HSP). When the temperature of a cell get's too high, HSP changes shape and can then activate other genes' promoters. These genes mediate the cell's response to thermal stress. Green Flourecent Protein is a protein that occures naturally in a species of jelly fish (Aequorea Victoria) and it happens to be flourecent, i.e. when put under UV light it glows green. Scientists have known about GFP for a while and have created versions of it such as Red Flourecent Protein (RFP) or Cyan Flourecent Protein (CFP) that, after small changes to the coding region glow in different colors.
Say, you want to study development. Early in animal development, there are three tissue types: endoderm, ectoderm, and mezoderm and all internal organs are decended from one of these three embryonic tissues. If you are interested in finding out which organs come from which early tissues, you could do it with transgenics as described below.
Now, how to make a transgenic (GM) animal? First, using biochemical techniques you take the GFP gene and attach it to a promoter for a gene that is expressed (or turned on) in the endoderm. Then you put that construct into a small peice of DNA called a plasmid. The plasmid has some other genes also, such as a replication origin (which allows the plasmid to be coppied in bacteria but not in animals) and a neomycin (antibiotic) resistance gene taken from bacteria that are resistant to neomycin. Then you transfect bacteria (usually a non-pathogenic strain of E. Coli) with the plasmid. That is, you get the plasmid inside the E. Coli. Only a very small percentage of the E. Coli are transfected, so you grow them in media that contains neomycin -- that way you know all of the surviving bacteria cary the plasmid. Using this technique you can "grow" a lot of plasmid. Then, using a little biochemistry, you can isolate the plasmid from the bacteria and inject it into zebrafish embryos. Again, only a very small percentage of the zebrafish will incorperate the DNA into their genomes. Those that do, are transgenic.
The entire process can then be repeated with RFP and the promoter for a mezoderm gene. Now you have a transgenic fish in which some organs glow green and some glow red. This is basically what the GloFish is.
Note that all of the gene's present in the zebrafish are present elsewhere in nature. All that has happened is the scientists have moved a gene from one species to another. Note also, that the gene has become incorporated into the genome of the zebrafish and is not just floating around. A larger fish that eats this zebrafish is no more transgenic than you are a cow for eating beef. The larger fish will not make the protein and it is not possible for the transgene to become incorporated into the genome of other fish it comes in contact with.
Likewise, the neomycin (or other antibiotic) resistance gene is not in bacteria and there is no way for it to get into bacteria. Only the zebrafish are neomycin resistant and (being vertibrate) neomycin never would have hurt them anyway.
This lawsuit is spreading an example of the classic fear, uncertainty, and doubt that is spread by those who oppose any genetic modifications. I agree that we need to have a substantive debate about
What? I don't understand. I thought you couldn't survey cell-only people. My slashdot has betrayed me.
Perhaps, this survey actually sent people out into the street to survey people. Perhaps the political polsters just need to change their methods (as i'm sure they will) rather than admit defeat to sampling error.
Of course, people on the street introduces biases also. Maybe the reason the percent of cellphone users was so high in the Sprint survey is because the people with landlines are at home on the phone and the people with cellphones are walking around, talking to their friends, and pissing everyone else off.
Every survey has bias. You correct for it as best you can and move on.
You, sir, clearly have never been to Shanghai.
When I read the headline I instantly thought of Shanghai -- especially parts of the old city. The area east of the Huangou isn't as bad but there are places where you really can't see the sky. The photo in the arcicle doesn't give a good sense. Above every street -- all along the street in some neighborhoods -- is what looks like a net of wires. Some places it's so thick that you could crawl across it with little fear of falling through the spaces between the wires.
I think it's a great thing that they are doing this. Not just for aesthetics but for simplicity. Part of the problem with overhead lines in a place like China is that anyone can add to the mess. Underground you need permission before you go down and lay more cable.
Ahem...
I believe you have stumbled on to the difference between the default settings of gnuplot and excel.
Moreover, where are the questions asked by the often skeptical senators?
Simple, funding.
It is a lot easier for researchers to get grant to "cure a disease" than it is to make computer access easier for everyone. It is also easier to get FDA approval for human trials when the goal is to improve quality of life for disabled people than it is when the goal is to make cooler video games.
Be patient. The medical applications come first, the consumer ones will follow.
THC is a small molecule not a protien. Individual genes code for protiens (peptide chains). Thus all of the trangenic crops we have seen so far are created with the addition of a single gene coding for a specific protien. One can make a glowing rabbit by adding the gene for green flourecent protien (GFP) from a jelly fish. The way that a plant makes THC is by converting one molecule to another using enzymes until THC is the final result. These enzymes are coded for by genes, so one could, in theory, make some plant produce THC but you would have to geneticly add the entire synthesis pathway, which is likely a large number of genes. It's not imposible but very difficult.
While you are right that there are a lot of different forms of blindness, most could be cured by an artificial retina. There is some promising work being done in this field. A battery powered implant tried in a group of people with retinitis pigmentosa had close to a 50% success rate.
The reason that we need to study vision loss pathologies is that many kinds of blindness may be much easier to cure. As an example, one of the most common genetic causes of blindness, conginital stationary night blindness (CSNB), has been mapped to a particular gene which makes a special protien (called RPE65) in the visual cycle. In a recent study, puppies with CSNB were able to have their vision restored simply by feeding them RPE65 from birth.
There is one that is pretty good. Not all science but there is quite a bit.