I wonder if the "hidden" message here is that Gateway sees PC sales to continue to be weak and they are desperately looking to do something with all of those retail outlets...
Sure, human genomes share a lot of identity - and this is great when trying to figure out what makes people different from, say, frogs. But (as you suggest) it is precisely this 0.01 % difference where things get interesting... Look at Venter's genome, he found out that he had a mutant apo E4 allele and this specific information caused him to alter his lifestyle.
The first few genomes give the basic outline - but the real payoff will be when we can easily sequence everybody's genome to be able to use an individual's genomic DNA as a diagnostic tool. This kind of technology is still a ways away and will require a much larger sample size to be interpretable in a meaningful way.
CS Not really--I was doing it in the same 6 hours. The main reason is that I couldn't sort and ride at the same time. With more practice, I'm sure I'd shave time.
Does this mean that he's usually sorting mail and driving at the same time?
For what it's worth: Henry Huang looks like he has a pretty impressive CV. He worked with Lee Hood from 1977-1982, a time period where Hood was making the transition from being a molecular immunologist to more of a DNA sequencing technologist. So the timing was right for him to have made a significant contribution to the DNA sequencing method. Pretty bad move to leave him off the patent if he did make a contribution.
MJ Research, who filed the lawsuit, is a manufacturer of "affordable" lab equipment - including thermocyclers for PCR amplificaton of DNA - which might have been a previous patent issue for them (since they don't explicitly mention PCR in the description). Judging from their product line, they'd like to crack the sequencing market. As an aside, they have offices "all over the world", including Lake Tahoe (Incline Village, NV) - I wonder if that's a condo?
I agree - this is why NIH sponsored research in Alternative Medicine is important. You'd be amazed at how much NIH funded research in conventional areas is utter nonsense. The key problem with Alternative Medicine is that much of it is anecdotal. The irresponsible thing to do is to simply dismiss it as crackpot medicine, especially when the potential exists to test whether alternative therapies have merit. Which option is better?
Continue to categorize Alternatve Medicine as a separate, parallel track to "Conventional" or "Western" Medicine filled with misinformaton, voodoo and people taking supplements with potentially damaging outcoms.
Use the scientific method to distinguish what works from what doesn't - with the idea of incorporating the best that Alternative Medicine has to offer into everyday healthcare.
Not everyone in medical research is out on a vendetta to disprove Alternative Medicine.
One advantage of Archos Jukebox players is that they double as hard drives. In practical terms, what this means is that you transfer.mp3 and other files back and forth between the Archos Jukebox and other PCs. As far as I know, the Nomad units can only receive files from PCs - I guess as an "anti-piracy" measure.
But I'd much rather see this article in Nature than from the BBC
.... or Microbiology for that matter. Much as I'm tempted to go to the library to look up the hard copy of New Scientist, I have a suspicion that there won't be too much experimental detail there either. Yeah, I know that this is a frequent whine about science in the popular press - but it's still frustrating.
This study looked at genetically modified mice, not the effects of a drug. Finding a drug to specifically upregulate CaM Kinase could be tricky, even if gene therapy approaches are considered.
Even given this, one downside of too much mitochondrial activity is that you will generate higher levels of reactive oxygen species (free radicals) - which have been implicated in aging, since they can cause damage to membranes, proteins and DNA. In other words, the overactive metabolism might cause premature aging as a trade-off for muscle overdevelopment.
In high school for me (1974, yeah there's a geezer factor there), programming consisted of typing out a series of FORTRAN lines on punch cards. You'd send them off to be run on an IBM 1401 and the next day you'd get your printout back. Typos were deadly, particularly the "oh" - "zero" problem. Talk about low throughput.
This is an abstract of what looks like a comparable study done with dolphins. Most of the original classification of species was done using fairly gross comparisons - almost to the level of "are they basically the same shape?" (sympatric morphotypes). What Heyning's group is doing is to compare the DNA sequence of a elements from a mitochondrial gene, cytochrome b, isolated from different dolphins or whales. Mitochondrial DNA is unique, in that it does not mix with nuclear DNA and is only transmitted to offspring from the mother, not the father. This means that since different species do not interbreed, species specific differences in mitochondrial DNA sequences will be more pronounced than in the more "typical" gene sequence. By grouping individual animals by mitochondrial DNA sequences, they can then use this to go back and identify subtle differences in physiology that you otherwise couldn't do with the small subpopulation of beached whales.
A similar approach has been used to analyze human evolution, among other things.
"The threat is a lot worse today than two years ago," said Harris Miller, president of the Information Technology Association of America (ITAA) in Arlington, Virginia. "There are lots of indications that since September 11, the number of DoS attacks have greatly increased."
Nope, all that activity on e-Bay is Osama Bin Laden working on his Pez dispenser collection
Yes, the Microsoft Windows platform, coupled with bundled software suites, enables me to seamlessly integrate multiple tasks and increase productivity.
One of the themes of the Salon article is that Microsoft is using Digital Rights Management to further promote Windows as the single dominant PC operating system for commercial transactions involving intellectual property with end users. The author argues that if Windows gets intertwined with commercial transactions as the sole approved method, than this single (weak) operating standard will be a boon to thieves and terrorists. The parallel was that this is essentially the equivalent of the monoculture problem which lead to the Potato Famine, where populations of genetically identical potatoes are more susceptable to diseases (e.g. viruses) than genetically diverse ones.
I'm wondering whether Microsoft is ideally placed to take advantage of this.... If Open Source software is intertwined with free transfer of intellectual property, then it seems like the media companies will almost be driven to Microsoft by default.
This report on how the Metal Men are spending their twilight years:
Only a few of The Metal Men survive. Platimun is a robo-hooker, Iron is a rusting construction worker, and Gold is in hiding because, well, he's gold and people want part of him! Dr. Will Magnus died ages ago, so none of them can be repaired if something goes wrong. Tin and Mercury have already died, and Lead is a living reactor shield in a closed-down nuclear power plant.
This was already covered. Read this press release, released following the BBC article.
"Stoker has said they did not find evidence of chlorophyll or any evidence of life on Mars," the spokesperson said. "There's really nothing to report. I think they [the BBC] read more into the abstract than is really there."
Researchers led by Carnegie Mellon's Sebastian Thrun are field-testing the "nursebot," a talking robot that guides nursing home residents from their rooms to the dining hall or other areas -- offering weather reports and television schedules along the way -- and are working on an "intelligent walker" that can both navigate and physically support elderly patients.
Now I'm really looking forward to my "golden years"
"Please follow me.... nice weather we're having.... there's a Miss Cleo infomercial on channel 62..."
Slashdot Mirror
I wonder if the "hidden" message here is that Gateway sees PC sales to continue to be weak and they are desperately looking to do something with all of those retail outlets ...
The first few genomes give the basic outline - but the real payoff will be when we can easily sequence everybody's genome to be able to use an individual's genomic DNA as a diagnostic tool. This kind of technology is still a ways away and will require a much larger sample size to be interpretable in a meaningful way.
CS Not really--I was doing it in the same 6 hours. The main reason is that I couldn't sort and ride at the same time. With more practice, I'm sure I'd shave time.
Does this mean that he's usually sorting mail and driving at the same time?
MJ Research, who filed the lawsuit, is a manufacturer of "affordable" lab equipment - including thermocyclers for PCR amplificaton of DNA - which might have been a previous patent issue for them (since they don't explicitly mention PCR in the description). Judging from their product line, they'd like to crack the sequencing market. As an aside, they have offices "all over the world", including Lake Tahoe (Incline Village, NV) - I wonder if that's a condo?
Not everyone in medical research is out on a vendetta to disprove Alternative Medicine.
One advantage of Archos Jukebox players is that they double as hard drives. In practical terms, what this means is that you transfer .mp3 and other files back and forth between the Archos Jukebox and other PCs. As far as I know, the Nomad units can only receive files from PCs - I guess as an "anti-piracy" measure.
You'll know if you start seeing banner ads for Nomad tomorrow...
When I think of condors and chicks, I think of The Condor in SF - Former home of Carol Doda
.... or Microbiology for that matter. Much as I'm tempted to go to the library to look up the hard copy of New Scientist, I have a suspicion that there won't be too much experimental detail there either. Yeah, I know that this is a frequent whine about science in the popular press - but it's still frustrating.
Even given this, one downside of too much mitochondrial activity is that you will generate higher levels of reactive oxygen species (free radicals) - which have been implicated in aging, since they can cause damage to membranes, proteins and DNA. In other words, the overactive metabolism might cause premature aging as a trade-off for muscle overdevelopment.
Come on, you haven't lived until you've toggled in binary to bootstrap a PDP-11!
In high school for me (1974, yeah there's a geezer factor there), programming consisted of typing out a series of FORTRAN lines on punch cards. You'd send them off to be run on an IBM 1401 and the next day you'd get your printout back. Typos were deadly, particularly the "oh" - "zero" problem. Talk about low throughput.
well .... I can see where that came from"
This is an abstract of what looks like a comparable study done with dolphins. Most of the original classification of species was done using fairly gross comparisons - almost to the level of "are they basically the same shape?" (sympatric morphotypes). What Heyning's group is doing is to compare the DNA sequence of a elements from a mitochondrial gene, cytochrome b, isolated from different dolphins or whales. Mitochondrial DNA is unique, in that it does not mix with nuclear DNA and is only transmitted to offspring from the mother, not the father. This means that since different species do not interbreed, species specific differences in mitochondrial DNA sequences will be more pronounced than in the more "typical" gene sequence. By grouping individual animals by mitochondrial DNA sequences, they can then use this to go back and identify subtle differences in physiology that you otherwise couldn't do with the small subpopulation of beached whales.
A similar approach has been used to analyze human evolution, among other things.
Nope, all that activity on e-Bay is Osama Bin Laden working on his Pez dispenser collection
That's what they get for trying to fly through the Gateway Arch.
Yes, the Microsoft Windows platform, coupled with bundled software suites, enables me to seamlessly integrate multiple tasks and increase productivity.
anti-matter equivalent of Explodium
I'm wondering whether Microsoft is ideally placed to take advantage of this .... If Open Source software is intertwined with free transfer of intellectual property, then it seems like the media companies will almost be driven to Microsoft by default.
Only a few of The Metal Men survive. Platimun is a robo-hooker, Iron is a rusting construction worker, and Gold is in hiding because, well, he's gold and people want part of him! Dr. Will Magnus died ages ago, so none of them can be repaired if something goes wrong. Tin and Mercury have already died, and Lead is a living reactor shield in a closed-down nuclear power plant.
I thought Philip Morris and Jack Daniels invented cancer
Does this mean that Napster is finally out of beta-mode?
"Stoker has said they did not find evidence of chlorophyll or any evidence of life on Mars," the spokesperson said. "There's really nothing to report. I think they [the BBC] read more into the abstract than is really there."
Now I'm really looking forward to my "golden years"
"Please follow me .... nice weather we're having .... there's a Miss Cleo infomercial on channel 62 ..."
If they rounded off from 2.54, then this is exactly one inch/sec - I'm wondering whether the speed was calibrated to English units.