Just induced resistance like with pathogens. This mutation confers resistance to only one common insecticide (Malathion) - so they will use another one.
In the end, they have to remove breeding ponds, like they have done when building Panama Canal. Moskyto swamp solution: Nuke and pave.
The weight of the Helios plane is 1300 pounds while having larger wing-span than Jumbo. The cruising speed of Helios ranges **from 19 to 27 mph.**:)
AND this ultralight is solar-energy powered. They only need an additional source of power - i.e. power storage - during the night. The reason they use fuel cell/electrolysis instead of conventional battery is that it can be lighter overall (than Lead or NiFe rechargable battery, for example).
I was comparing weight and efficiency of a fuel-cell powered engine with a conventional jet engine, not with one that is powered by a car-battery.
[Btw.: hybrid = internal combustion+electro car engine efficiency is close to 30-40% of theory right now on commercial models - far better than fuel cell experimantal designs]
If I were a betting man, my money would be on wind power schemes and gullibility of laymen.
"Fuel cells are inherently cleaner and quieter than auxiliary power units, have fewer moving parts, and can generate more than twice as much electricity."
This quote makes clear that they are most interested in replacing the APUs that move the hydraulics on the plane wings with something more efficient. They are also trying to demonstrate that fuel cell can power a modified glider, but this is about ultralight plane with anciliary propeller, i.e. extremely weak engine.
Power cells will be always more difficult to operate and heavier than jet engines. No matter what the fuel (not hydrogen, to be sure), I would like to see a fuel cell that can slurp several galons per second of a fuel to provide the necessary lift for a Jumbo.
Do you plan to compete with databases like Merck Index? How are you going to select your contributors? How you are going check for the correctness of their data input? How do you plan to solve the problem with synonymous keywords in the search? [Good old- fashion Chemical Abstract database published realy extensive indexes on general subject keywords - apart from indexes on the substances, chemical core structures etc. You will need to do this and it is a lot of awful work]
The main problem is you will need alot good contributors and made them motivated to spend their (highly paid) time to do the work, which is not much fun to begin with. Then you will need a lot - I mean a lot - of highly qualified editors to go through the entries. You do not want to be hit with a lawsuit for inacuracy of your data. Also, the propaganda of the big pharma companies is done in very professional way - if it is good enough to fool the physicians, it will be hard to avoid swallowing it when it is submited masked as unbiased info. It is hard to check summary info about drugs - you will need to go into primary data - lots of articles and the underlying complex statistics - to see the validity of claims based on clinical trials. Skillful statistics data "renormalisation" can make wonders.
And who are your intended custommers? If it is pharma companies, physicians and other health care pros, the cost savings from open project will not be too important. The main priority of such custommers will be the data reliabilty.
1. Gold is not expensive. A lot of common chemicals (catalyst, some elaborate ligands, advanced intermediates etc) can be more than 20x more expensive than gold by weight. Almost every university and industry lab doing synthetic organic chemistry is using them. 2. Shuttle is extremely costly but the science done there is ho-hum and until recently a lot of it was not even done on level publishable in decent peer-revied journals.
I agree-Microwaves have only heating (non-ionising) effect on tissue. (Bad things happen though around metallic objects - like rings or wire-framed glasses - you could see some serious scoarching around these.
I do not understand how you can get radiation cataract (like from UV) - by time you start microwaving your eyes, your brain will probably have problem too. But testicles are extremely sensitive to heat damage, so the old myths about radar crews getting infertile from the exposure may have some basis. Certainly the radar people used to heat(microwawe) food attached to a stick in front of their radar dishes.
About home microwave repair: I heard a legend about a family man who fixed a broken microwave. And he blocked out the door sensor, turned microwave on, briefly sticked his hand in - and when he felt little warmth on his hand he said - now it works and turned off the microwave. But his hand hurt after this a bit and got swollen later at night. He ended up having it amputated - deep heat damage meesed it up beyond salvage. The heat sensors are on surface of the skin, but microwawes heated his hand from the bone, so it was too late for him when he finaly registered something.
Infectious vector that can swap genes with a similar virus spreadable through air - therapeutic brain-SARS is what the doctor prescribed! - I hope that I won't become bystander, once we get this common cold that could whack our glial cells!
Do you remember that antibody therapy recently that worked so great on Alzheimer patients (removing their plaques by immune activation) that they all started dying due to immediate brain inflamation? That was non-infective therapy.
Physics people are far ahead of other fields in this - because there is not money to be made in the field.
Chemistry journals and searchable databases are in clutches of major publishers - which solicit the free work of their referees but charge top dollars. The trouble is: the major customers are pharma companies and large universities and they can afford to pay large fees They are more interested in reliability of the online service rather than cost savings from an open project.
"In times of universal broadband deceit, telling the truth becomes a revolutionary act."
"While all this talking about reasons for failure and collapses of society may seem pessimistic, the flip side is optimistic: namely, successful decision-making. Perhaps if we understand the reasons why groups make bad decisions, we can use that knowledge as a check list to help groups make good decisions."
My morale: Now when we know that we have a future, we can party as if there was no tomorrow.
Ozone has nothing to do with it. The discussion is about dust particle removal. (To avoid clogging fans in your hardware).
Ozone does not remove dust particles from air. Ozone is bleach-like oxidizer that destroys stinky odors (and yor nose, lungs and latex/rubber object in the process). Ozone generators can be found in pet hotels to supress the stink - and and I found myself the iritating ozone background less tolerable then the animal urine odor.
The technique is very clever, but it is fringe. This is a very small company developing new technology. They may win big, but right now they do not have anything marketable and won't have too soon. They operate on private financing and have to advertise their cutting-edge proprietary technology breakthrough whatever to attract investment to keep going.
I worked for a company like this, so I take it with some scepticism.
New Scientisct article writen by somebody ignorant in material science: skips the important stuff and dwells on marginal. The company site more informative.
Magnetic particles in storage media must be evenly spaced and right size. This protein is used as a mold and spacer for making and placing the magnetic particles. The protein is spherical, has cavity which can be filled with magnetic stuff and forms crystal-ordered-like monolayer on support surface. Burning the protein leaves the magnetic particles in caramelized yuck. All this done in with external magnetic field. And since we are baking it well above Curie temperature of the magnetic material, cooling will produce the particles nicely magneticaly aligned.
[To organize apricot pits, place a baking tray covered with apricots in oven pre-heated to 475F for 2 hours, and do not stir.]
Biologists have to find target. Produce the protein artificialy, study it and validate it (=conclusive evidence that blocking it will blocks the virus). Ten they have to develop a reliable high-throughput assay and huge collections of chemicals are screened to see if there is any decent inhibitor found. Chemists select the most reasonable candidates and start elaborating them (=derivatomania). Once they get very potent inhibitors, they do a lot of other optimisation - to get drug candidate that is cell-permeable cells, not metabolized/excreeted too fast, has low protein binding and good distribution, is not toxic and is preferably oraly available. At this point a lot of detailed biology research has to be done in animals, which is slow. Then there is study on healthy volunteers (subject of government aproval), then pilot clinic study just to see if they can get decent dosing in patients, then second large double-blind clinical study to see efficiency and the third phase even larger study to compare the drug with other therapies. Human trials are extremely costly.
Pre-clinical development can take several years, as it was case with AIDS, clinical trials 4-6 years. It goes this fast only if there is a big profit potencial(to justify $400M cost of development), which so far there is not.
Government now tests a collection of *all* known approved drugs (concidered reasonably safe) to see if any of them has any effect. If we get lucky on this - slim chances - it would cut the development time and the clinical testing too, since only 1-2 studies would be needed.
Ask the person who is likely receive most of the money to make a proposal about his revard and distribution amongst others. Publish the proposal and take poll about it. Have an authoritative person of good reputation (not financialy involved) to make the final decision. Anything else is heuristic balooney.
No matter what the algorythm, your input is allways going to be subjective.
TISA experts conceded that while Earth has fairly dense atmosphere, its very high surface temperature and presence of oxygen makes the existence of liquid methane on Earth unlikely.
[Increase your sprout and root potency! 6 day free trial! Guaranteed success or your ferricyanide back!]
there were no vineries in Iceland (or Greenland) and Vikings had knack for blueberries anyway. (Having their teeth stained blue was a sign of good oral hygiene)
The vineries were in England at that time, though. The englishmen transition back to beer and whiskey coincided with the little ice age of 1200'.
Hydrogen-based energy is pure and unmitigated bull***.
By weight, H2 is the most energetic nonuclear fuel - which is why the use liquid cryogenic hydrogen in shuttle despite problems with keeping cryogenic material close to zero Kelvins (they actualy boil off about 1/3 of all hydrogen in shuttle, depending how long sits on the pad - they just keep filling her up).
But otherwise hydrogen it is completely nonpractical. There is no good way to store it and there never will be unless new, yet undiscovered laws of nature are employed. You may not wish to have a big Dewar flask or thick-wall cylinder (which is way heavier then the content: 200 atm H2 will give you hydrogen density less than 20g/L) or hydrogen absorber (which take maximum single digit % of H2 by weight and is still a pressure system) or a chemical factory recycling borohydride. So you are basicaly stucked with hydrogen being supplied by a tube. Not good for cars.
Plus the manufacture of hydrogen: electrolysis or petrochemical reforming. In both cases you are much better of just burning the petrochemical or using the electricity.
There is nothing more crazy and dangerous than the curent enviromentalist agenda.
I have seen recent articles claiming actualy that it was severe and repeated droughts spread over more than one century that finished off the poor Anasazis.
The of this study measured tree-ring density and the vegetation pattern from remains in the deposits. I have not seen their raw data, but I tend to believe them. I was interested in Anasazis at one point. Water is scarce in the Southwest to begin with and if you have seen the actual Anasazi places, you can immediately understand that it would not take too much drought to make their agriculture+hunting pretty difficult.
Yeah, but too many (or too little) beta cells and you have a problem.
Few years ago, there was an article about patient with tumor from beta cells: She found out that she had to eat a lot of sugar to feel OK. As the tumor grew, her sweet taste grew too - eventualy she was consuming over half a pound of sugar daily. She became grossly overweight at that point.
Even if they can get better vector (non-viral)which does not cause the modified cells to be eliminated, they will still have hard time to produce the right level of insulin in this way. The right insulin level is very individual thing (type II diabetics have a lot their own insulin - except that their cells ignore it).
Insulin excretion by pancreas is tightly regulated - you get a peak production about 30min-1 hour after the meal, which causes you to feel non-hungry.
High insulin levels are toxic. Intravenous insulin users can overdose easily (if they skip the meal, for example), so they usualy carry with them a source of sugar to avoid hypoglyceamia shock. Hypoglycaemia from insulin causes you to fell very tired and disoriented; you can actualy collapse and die.
I was thinking about using the hybrid design in reverse: to have a gaseous compressed fuel and solid non-explosive oxidiser. Ethane would be a good fuel: it has similar physical property to N20 or CO2, and it should be superior as fuel to the butadiene rubber they use (ethane has higher H/C ratio, hence better energy and gas volume per weight).
The solid oxidizer I would use would be sodium or magnesium perchlorate: The active oxygen weight content in these perchlorates is better than 50% (in N2O it is 35%) and they are cheap and tested as rocket propellant oxidizers.
The opposite arrangement - gaseous fuel/solid oxidiser would be a new thing in hybrid design, though. Could perform better than what they have now.
Slashdot Mirror
Just induced resistance like with pathogens. This mutation confers resistance to only one common insecticide (Malathion) - so they will use another one.
In the end, they have to remove breeding ponds, like they have done when building Panama Canal.
Moskyto swamp solution: Nuke and pave.
The weight of the Helios plane is 1300 pounds while having larger wing-span than Jumbo. :)
The cruising speed of Helios ranges **from 19 to 27 mph.**
AND this ultralight is solar-energy powered. They only need an additional source of power - i.e. power storage - during the night. The reason they use fuel cell/electrolysis instead of conventional battery is that it can be lighter overall (than Lead or NiFe rechargable battery, for example).
I was comparing weight and efficiency of a fuel-cell powered engine with a conventional jet engine, not with one that is powered by a car-battery.
[Btw.: hybrid = internal combustion+electro car engine efficiency is close to 30-40% of theory right now on commercial models - far better than fuel cell experimantal designs]
If I were a betting man, my money would be on wind power schemes and gullibility of laymen.
"Fuel cells are inherently cleaner and quieter than auxiliary power units, have fewer moving parts, and can generate more than twice as much electricity."
This quote makes clear that they are most interested in replacing the APUs that move the hydraulics on the plane wings with something more efficient. They are also trying to demonstrate that fuel cell can power a modified glider, but this is about ultralight plane with anciliary propeller, i.e. extremely weak engine.
Power cells will be always more difficult to operate and heavier than jet engines. No matter what the fuel (not hydrogen, to be sure), I would like to see a fuel cell that can slurp several galons per second of a fuel to provide the necessary lift for a Jumbo.
Do you plan to compete with databases like Merck Index?
How are you going to select your contributors? How you are going check for the correctness of their data input?
How do you plan to solve the problem with synonymous keywords in the search? [Good old- fashion Chemical Abstract database published realy extensive indexes on general subject keywords - apart from indexes on the substances, chemical core structures etc. You will need to do this and it is a lot of awful work]
The main problem is you will need alot good contributors and made them motivated to spend their (highly paid) time to do the work, which is not much fun to begin with. Then you will need a lot - I mean a lot - of highly qualified editors to go through the entries. You do not want to be hit with a lawsuit for inacuracy of your data. Also, the propaganda of the big pharma companies is done in very professional way - if it is good enough to fool the physicians, it will be hard to avoid swallowing it when it is submited masked as unbiased info. It is hard to check summary info about drugs - you will need to go into primary data - lots of articles and the underlying complex statistics - to see the validity of claims based on clinical trials. Skillful statistics data "renormalisation" can make wonders.
And who are your intended custommers? If it is pharma companies, physicians and other health care pros, the cost savings from open project will not be too important. The main priority of such custommers will be the data reliabilty.
1. Gold is not expensive. A lot of common chemicals (catalyst, some elaborate ligands, advanced intermediates etc) can be more than 20x more expensive than gold by weight. Almost every university and industry lab doing synthetic organic chemistry is using them.
2. Shuttle is extremely costly but the science done there is ho-hum and until recently a lot of it was not even done on level publishable in decent peer-revied journals.
I agree-Microwaves have only heating (non-ionising) effect on tissue. (Bad things happen though around metallic objects - like rings or wire-framed glasses - you could see some serious scoarching around these.
I do not understand how you can get radiation cataract (like from UV) - by time you start microwaving your eyes, your brain will probably have problem too. But testicles are extremely sensitive to heat damage, so the old myths about radar crews getting infertile from the exposure may have some basis. Certainly the radar people used to heat(microwawe) food attached to a stick in front of their radar dishes.
About home microwave repair: I heard a legend about a family man who fixed a broken microwave. And he blocked out the door sensor, turned microwave on, briefly sticked his hand in - and when he felt little warmth on his hand he said - now it works and turned off the microwave. But his hand hurt after this a bit and got swollen later at night. He ended up having it amputated - deep heat damage meesed it up beyond salvage. The heat sensors are on surface of the skin, but microwawes heated his hand from the bone, so it was too late for him when he finaly registered something.
Infectious vector that can swap genes with a similar virus spreadable through air - therapeutic brain-SARS is what the doctor prescribed! - I hope that I won't become bystander, once we get this common cold that could whack our glial cells!
Do you remember that antibody therapy recently that worked so great on Alzheimer patients (removing their plaques by immune activation) that they all started dying due to immediate brain inflamation? That was non-infective therapy.
This article is what you get when you get the hype+excitement sales pitch (for suckers-investors) re-told by an oh-so-bright journalist.
Physics people are far ahead of other fields in this - because there is not money to be made in the field.
Chemistry journals and searchable databases are in clutches of major publishers - which solicit the free work of their referees but charge top dollars. The trouble is: the major customers are pharma companies and large universities and they can afford to pay large fees They are more interested in reliability of the online service rather than cost savings from an open project.
"In times of universal broadband deceit, telling the truth becomes a revolutionary act."
"While all this talking about reasons for failure and collapses of society may seem pessimistic, the flip side is optimistic: namely, successful decision-making. Perhaps if we understand the reasons why groups make bad decisions, we can use that knowledge as a check list to help groups make good decisions."
My morale: Now when we know that we have a future, we can party as if there was no tomorrow.
Ozone has nothing to do with it.
The discussion is about dust particle removal. (To avoid clogging fans in your hardware).
Ozone does not remove dust particles from air. Ozone is bleach-like oxidizer that destroys stinky odors (and yor nose, lungs and latex/rubber object in the process). Ozone generators can be found in pet hotels to supress the stink - and and I found myself the iritating ozone background less tolerable then the animal urine odor.
The technique is very clever, but it is fringe. This is a very small company developing new technology. They may win big, but right now they do not have anything marketable and won't have too soon. They operate on private financing and have to advertise their cutting-edge proprietary technology breakthrough whatever to attract investment to keep going.
I worked for a company like this, so I take it with some scepticism.
New Scientisct article writen by somebody ignorant in material science: skips the important stuff and dwells on marginal. The company site more informative.
Magnetic particles in storage media must be evenly spaced and right size. This protein is used as a mold and spacer for making and placing the magnetic particles. The protein is spherical, has cavity which can be filled with magnetic stuff and forms crystal-ordered-like monolayer on support surface. Burning the protein leaves the magnetic particles in caramelized yuck. All this done in with external magnetic field. And since we are baking it well above Curie temperature of the magnetic material, cooling will produce the particles nicely magneticaly aligned.
[To organize apricot pits, place a baking tray covered with apricots in oven pre-heated to 475F for 2 hours, and do not stir.]
Yes, you are right. That is the only good way to stop the spreading. And vaccine can be available in maybe half year.
Biologists have to find target. Produce the protein artificialy, study it and validate it (=conclusive evidence that blocking it will blocks the virus). Ten they have to develop a reliable high-throughput assay and huge collections of chemicals are screened to see if there is any decent inhibitor found. Chemists select the most reasonable candidates and start elaborating them (=derivatomania). Once they get very potent inhibitors, they do a lot of other optimisation - to get drug candidate that is cell-permeable cells, not metabolized/excreeted too fast, has low protein binding and good distribution, is not toxic and is preferably oraly available. At this point a lot of detailed biology research has to be done in animals, which is slow. Then there is study on healthy volunteers (subject of government aproval), then pilot clinic study just to see if they can get decent dosing in patients, then second large double-blind clinical study to see efficiency and the third phase even larger study to compare the drug with other therapies. Human trials are extremely costly.
Pre-clinical development can take several years, as it was case with AIDS, clinical trials 4-6 years. It goes this fast only if there is a big profit potencial(to justify $400M cost of development), which so far there is not.
Government now tests a collection of *all* known approved drugs (concidered reasonably safe) to see if any of them has any effect. If we get lucky on this - slim chances - it would cut the development time and the clinical testing too, since only 1-2 studies would be needed.
Ask the person who is likely receive most of the money to make a proposal about his revard and distribution amongst others. Publish the proposal and take poll about it. Have an authoritative person of good reputation (not financialy involved) to make the final decision.
Anything else is heuristic balooney.
No matter what the algorythm, your input is allways going to be subjective.
"They may have mass, they can hide - but we are gonna smoke them out!", Mr. Bush said during his Fermilab lecture.
e rr or.html
http://www.lns.cornell.edu/~neubert/bush_finds_
TISA experts conceded that while Earth has fairly dense atmosphere, its very high surface temperature and presence of oxygen makes the existence of liquid methane on Earth unlikely.
[Increase your sprout and root potency! 6 day free trial! Guaranteed success or your ferricyanide back!]
there were no vineries in Iceland (or Greenland) and Vikings had knack for blueberries anyway. (Having their teeth stained blue was a sign of good oral hygiene)
The vineries were in England at that time, though. The englishmen transition back to beer and whiskey coincided with the little ice age of 1200'.
Hydrogen-based energy is pure and unmitigated bull***.
By weight, H2 is the most energetic nonuclear fuel - which is why the use liquid cryogenic hydrogen in shuttle despite problems with keeping cryogenic material close to zero Kelvins (they actualy boil off about 1/3 of all hydrogen in shuttle, depending how long sits on the pad - they just keep filling her up).
But otherwise hydrogen it is completely nonpractical. There is no good way to store it and there never will be unless new, yet undiscovered laws of nature are employed. You may not wish to have a big Dewar flask or thick-wall cylinder (which is way heavier then the content: 200 atm H2 will give you hydrogen density less than 20g/L) or hydrogen absorber (which take maximum single digit % of H2 by weight and is still a pressure system) or a chemical factory recycling borohydride. So you are basicaly stucked with hydrogen being supplied by a tube. Not good for cars.
Plus the manufacture of hydrogen: electrolysis or petrochemical reforming. In both cases you are much better of just burning the petrochemical or using the electricity.
There is nothing more crazy and dangerous than the curent enviromentalist agenda.
I have seen recent articles claiming actualy that it was severe and repeated droughts spread over more than one century that finished off the poor Anasazis.
The of this study measured tree-ring density and the vegetation pattern from remains in the deposits. I have not seen their raw data, but I tend to believe them. I was interested in Anasazis at one point. Water is scarce in the Southwest to begin with and if you have seen the actual Anasazi places, you can immediately understand that it would not take too much drought to make their agriculture+hunting pretty difficult.
Nay, they can be farmed.
And the teeth harvesting would be done in ethical and enviromentaly friendly way.
Yeah, but too many (or too little) beta cells and you have a problem.
Few years ago, there was an article about patient with tumor from beta cells: She found out that she had to eat a lot of sugar to feel OK. As the tumor grew, her sweet taste grew too - eventualy she was consuming over half a pound of sugar daily. She became grossly overweight at that point.
Even if they can get better vector (non-viral)which does not cause the modified cells to be eliminated, they will still have hard time to produce the right level of insulin in this way. The right insulin level is very individual thing (type II diabetics have a lot their own insulin - except that their cells ignore it).
Insulin excretion by pancreas is tightly regulated - you get a peak production about 30min-1 hour after the meal, which causes you to feel non-hungry.
High insulin levels are toxic. Intravenous insulin users can overdose easily (if they skip the meal, for example), so they usualy carry with them a source of sugar to avoid hypoglyceamia shock. Hypoglycaemia from insulin causes you to fell very tired and disoriented; you can actualy collapse and die.
I was thinking about using the hybrid design in reverse: to have a gaseous compressed fuel and solid non-explosive oxidiser. Ethane would be a good fuel: it has similar physical property to N20 or CO2, and it should be superior as fuel to the butadiene rubber they use (ethane has higher H/C ratio, hence better energy and gas volume per weight).
The solid oxidizer I would use would be sodium or magnesium perchlorate: The active oxygen weight content in these perchlorates is better than 50% (in N2O it is 35%) and they are cheap and tested as rocket propellant oxidizers.
The opposite arrangement - gaseous fuel/solid oxidiser would be a new thing in hybrid design, though. Could perform better than what they have now.