I believe they will isolate DNA from the micro-organism cocktail, and then sequence the DNA.
Using the collection of reads from the sequencer, and a large informatics pipeline, the sequences will be annotated and compared to all the known genes and gene products.
A large spreadsheet will be published, and scientist will debate for years on if this experiment had any real value.
/**off topic rant unless something is expicitly illegal then it is legal.
This is the mindset that keeps legal firms and accountants busy sifting through the books to find "loopholes" around the obvious intent of the laws. It happens at both extremes, we have rich people searching for loopholes to get out of paying their fairshare. We have people finding loopholes to get a free ride off taxpayers through what few social programs are provided in the USA.
Why is it that one of these two extremes is regarded as intelligent and saavy, while the other is exposed as a parasite on society. Are they different ?
Is there anyway to burn all the books and start over with an intent based law system. Seems like it would easier for everyone. Isn't the current legal system all about proving intent anyways ?
In this election, rather than make a principled stand and vote for who I believe in, I'm voting against Bush. In the two party,american system, that means I have to vote for Kerry.
I wish there was a negative vote. Something that would have the effect of, "I am unable to find any candidates worthy of my endorsement at this time. Rather than waive my right to participate in this election, or to cast my vote towards the election of a candidate I find non-suitable, I am casting a negative vote towards the Candidate/Candidate ticket because I find them the most unsuitable of all the candidates seeking office.
I hope this doesn't come off as flame bait or trolling . ..
When I hear educational software, I draw a blank. We didn't have educational software when I went to school, we had a typing tutor with a long stick, and, basic and logo for the programming inclined students.
I think it would be a rather simple project to put together an educational package for linux if I had some idea of what was supposed to be included in the package. I'm just getting old, and without kids of my own,I am out of touch with what is being taught in school now.
What are some of the more popular educational software packages that people are running on windows and mac ?
I know they want to believe I can't hold information in my head...but I could reproduce every experiment I have done from memory. I know all the results, the implications, and the next steps. I know where the reagents came from. I am the device they need to keep out to protect their information.
I can't take my notebook [paper pad that accepts data from a stream of graphite or pigmented fluids for the kids here] home . . . but I do get a company laptop, ssh access to the data, and well... if I really wanted too, I can print to an IP address half way across the country. My iPod is the least of their concerns, and if they ban iPods, so also must be banned the pen, printer, paper, pencil, and humans.
go ahead, treat me like a criminal,but don't be suprised if I live up to the expectations.
1) Test the accuracy of the gas pumps for one specific vendor. Inform vendor of results.
--show retest done next day, next week, and the following month . . . assuming of course it's not an honest mistake that will be fixed.
2) Get candid interviews with patrons of the station as they watch the video showing the bad measurments and the managments response when they are informed.
3) Show scenes from the class action lawsuit filed on behalf of anyone who bought gas from specific vendor in the time frame the testing was performed.
4) Hold flash mob at specific gas station to get incredible riot like footage to hype the film
4cyl of some size i don't recall. It was stickered at 26 city 33 hwy, and i generally get around 15 in the hills of berkely and 38-40 on highway trips. In San Diego my mpg is around 23-25. My average milage works out to about 28mpg over the 40,000 miles I've owned it, or roughly $1100 a year in fuel costs. I generally drive hard in city traffic, lots of stops and accelerations to avoid the pedestrians. On the highway, I don't really like to get pulled over, so I set the cruise at 80 and try to stay just at that speed and use good driving skills to make up time on the way.
A. I don't think natural selection is engineering. Natural selection falls under naturally existing.
I consider an engineered sequence to be a sequence that is designed to serve a purpose.
1. I spend 30 years searching through the rainforsts of one country looking for a plant which cures _(Fill in the Blank)_. I then extract the Active ingredient of said plant, and genetically modify the plant to produce more of said chemical. The sequence is in use in the wild, but I am using it in a new and novel way.
Patent the use of Active ingredient in the treatment of Disease foo. Patent the process of either manufacturing the Active ingredient either through extraction or in-vitro synthesis. Patent the vectors used to target the gene to the relevant cells. To me, patenting the naturally existing Active ingredient just doesn't seem patent worthy, I think it's the applications and methods that are patentable.
1a I would say if you have made a recombinant gene by fusing two different DNA sequences, you have made a novel product . . . profit as you see fit.
2...2a...
I'm not sure I understand the question. I don't believe it will ever be possible to culture an organ using just the subset of the DNA for the genes required in that organs function. Lots of opportunity for patents here though. You could patent the media in which an organs can grow, the process of transforming the stem cells into a specific tissue type, etc
3
I'm not qualified to comment on international law, these are good issues that I don't tend to put enough thought into.
Even as I click submit, I know I haven't given these issues the thought a good response deserves, but that's the nature of slashdot.
Every person writing the documentation just assumed you already knew
Excellent point. I am frequently critized for assuming that everything I know is common knowledge, and giving presentations that don't present enough background to the audience.
I can imagine this is a downfall with geeks writing documentation in general. Everything we know is now obvious [to us], so we only document the non-obvious parts. The new reader tries to use the docs, but finds themselves frustrated because the docs start out at too high of a level, and the additional resources they refer to are also at too high of a level for the beginner.
I only have very limited experience with non-geeks using linux, but my experience has shown that they don't read, and don't think they should have to read to use linux. My non-geeks don't even pretend to solve or diagnose the problems, they just call for help immediately. I think the non-geeks this book would help most, are those already solving their problems using google.
a clarification on why i don't think the host should be patentable,
DNA is data that can be read by any cell. Think of DNA like a language that runs on a VM. All cells have this VM, so by moving the sequence from a VM machine in the mosquito doesn't change the gene sequence or gene product when the sequence is run on the human VM.
An organism is just a collection of cells that hold VMs that run DNA code (where a gene is analogous to a program) and produce gene products. Even though the human cell never would hold a patented gene sequence under natural conditions, nothing about the gene or it's function has changed. It's still behaving the same as it does in it's natural host environment.
I do think there may be a usefulness to patent the application of naturally occuring genes to treat illness A thought pathway X, but not the actual DNA sequence.
DNA sequences should only be patented for new engineered sequences, and not 'discoveries' that were found occuring naturally in other organisms.
1) DNA sequences appearing in nature should not be patentable. They are already in widespread use, similar to prior art.
2) Engineered sequences can be patented, but not the organism holding the engineered sequence.
3) Engineered sequences which escape into the natural population through natural reproductive means loose their patent, with a caveat, the former patent owner should be held responsible for all clean up cost, and may be subject to bio-terrorism charges for endangering a nations eco-system.
I figured that a jerri rigged hack that lets the iPod flop around in the glove box was exactly the type of feature BMW owners used to make their buying decisions.
Also, backwards compatible means I can trade in my old console when I get a new one. It reduces the cost of the purchase, and I don't loose any of the games I bought for the old system.
Good question,
Looking back, the DVD player might have been the bonus feature that made me upgrade hardware. I didn't have one at the time, or a vcr.
For me, the backwards compatibility means that I don't have to move a lot of cords, and furniture, around to play different games. It's a small feature, but I appreciate everytime I hook up the old intellivision system.
If I had a better entertainment setup, with more available inputs, I probably would just have all the old systems hooked up and wouldn't care at all about backwords compatibility.
because it was backwords compatible with my PS1 game collection. I suspect the PS3 will be backwards compatible with PS2 games. Microsoft has a history of making their latest release be incompatible with earlier version.
In short, it doesn't matter if company X releases a product ahead of the competition. If the company has shown itself to be untrustable, and MS has, then I won't be buying into their products.
If MS really wants to get a jump on the competition, they need the Xbox2 to be compatible with PS2 games:-), plus provide some additional value that isn't available on the market, and meet my price point.
Web readers get the same content as the paper-and-ink edition without paying for it, it's fair to ask them for personal information in exchange for access.
Either sell the newspaper online or give it away free, but registration sucks. bob@hotmail.com is getting upset with me.
Also, Apple has already demonstrated that if you have something worth paying for, then transactions can be handled at sub dollar amounts. Sell subscriptions online for a buck a month, problem solved.
Advertisers cover the production and distribution costs, $0.25 for the paper is probably about the worth of that much paper, plus the news after it's been sanitized from anything that might alienate the cash cow. So if the e-paper doesn't have the value of the actual paper, that leaves just the value of the news. About $0.03/day sounds about right to me.
Don't laugh, $0.03 is worth a lot more than the information with which I pollute their datasets.
A long time ago, in the distant past, there were Finders. Dedicated individuals that wandered around outside the camps and found stuff. Over time, it became more difficult to find stuff, and the Finders became the Searchers. Many times the Searchers would return empty handed. As technologies improve and new insights are gained, the same fruitless searches of the past were repeated. Sometimes with a new results, sometimes as fruitless as before. Regardless, it was this not giving up on an idea just because it failed once that led the change in title from Searcher to Researcher.
Most reseachers I know produce one magnificent failure after another on the quest for a new piece of knowledge. Everything that is easy to find has probably already been discovered, and mathematics is no different. So the guy made a few failed attempts at solving the puzzle, this doesn't make each sucessor to the first attempt a garaunteed failure.
Slashdot Mirror
Or the alternative to those, buy an Apple. Runs Unix programs, Has Office.
I believe they will isolate DNA from the micro-organism cocktail, and then sequence the DNA.
Using the collection of reads from the sequencer, and a large informatics pipeline, the sequences will be annotated and compared to all the known genes and gene products.
A large spreadsheet will be published, and scientist will debate for years on if this experiment had any real value.
/**off topic rant
unless something is expicitly illegal then it is legal.
This is the mindset that keeps legal firms and accountants busy sifting through the books to find "loopholes" around the obvious intent of the laws.
It happens at both extremes, we have rich people searching for loopholes to get out of paying their fairshare. We have people finding loopholes to get a free ride off taxpayers through what few social programs are provided in the USA.
Why is it that one of these two extremes is regarded as intelligent and saavy, while the other is exposed as a parasite on society. Are they different ?
Is there anyway to burn all the books and start over with an intent based law system. Seems like it would easier for everyone. Isn't the current legal system all about proving intent anyways ?
In this election, rather than make a principled stand and vote for who I believe in, I'm voting against Bush. In the two party ,american system, that means I have to vote for Kerry.
I wish there was a negative vote. Something that would have the effect of, "I am unable to find any candidates worthy of my endorsement at this time. Rather than waive my right to participate in this election, or to cast my vote towards the election of a candidate I find non-suitable, I am casting a negative vote towards the Candidate/Candidate ticket because I find them the most unsuitable of all the candidates seeking office.
I hope this doesn't come off as flame bait or trolling . . .
When I hear educational software, I draw a blank. We didn't have educational software when I went to school, we had a typing tutor with a long stick, and, basic and logo for the programming inclined students.
I think it would be a rather simple project to put together an educational package for linux if I had some idea of what was supposed to be included in the package. I'm just getting old, and without kids of my own,I am out of touch with what is being taught in school now.
What are some of the more popular educational software packages that people are running on windows and mac ?
Won't solve a thing.
I know they want to believe I can't hold information in my head...but I could reproduce every experiment I have done from memory. I know all the results, the implications, and the next steps. I know where the reagents came from. I am the device they need to keep out to protect their information.
I can't take my notebook [paper pad that accepts data from a stream of graphite or pigmented fluids for the kids here] home . . . but I do get a company laptop, ssh access to the data, and well... if I really wanted too, I can print to an IP address half way across the country. My iPod is the least of their concerns, and if they ban iPods, so also must be banned the pen, printer, paper, pencil, and humans.
go ahead, treat me like a criminal,but don't be suprised if I live up to the expectations.
Take mass of empty legal container.
Take mass of container filled with gasonline, better if done before a noticeable amount evaporates.
Note measurement on the pump for calculations.
Go home and measure mass of 1 liter of gas using calibrated measuring unit.
Calculate how much gas was received vs what the pump said.
This has the makings of a great documentary.
1) Test the accuracy of the gas pumps for one specific vendor. Inform vendor of results.
--show retest done next day, next week, and the following month . . . assuming of course it's not an honest mistake that will be fixed.
2) Get candid interviews with patrons of the station as they watch the video showing the bad measurments and the managments response when they are informed.
3) Show scenes from the class action lawsuit filed on behalf of anyone who bought gas from specific vendor in the time frame the testing was performed.
4) Hold flash mob at specific gas station to get incredible riot like footage to hype the film
5) profit.
4cyl of some size i don't recall. It was stickered at 26 city 33 hwy, and i generally get around 15 in the hills of berkely and 38-40 on highway trips. In San Diego my mpg is around 23-25. My average milage works out to about 28mpg over the 40,000 miles I've owned it, or roughly $1100 a year in fuel costs. I generally drive hard in city traffic, lots of stops and accelerations to avoid the pedestrians. On the highway, I don't really like to get pulled over, so I set the cruise at 80 and try to stay just at that speed and use good driving skills to make up time on the way.
I'll answer this later, my browser is doing funny things right now . . . like posting the first line of my post when I hit return type in the box.
A. I don't think natural selection is engineering. Natural selection falls under naturally existing. I consider an engineered sequence to be a sequence that is designed to serve a purpose.
Patent the use of Active ingredient in the treatment of Disease foo. Patent the process of either manufacturing the Active ingredient either through extraction or in-vitro synthesis. Patent the vectors used to target the gene to the relevant cells. To me, patenting the naturally existing Active ingredient just doesn't seem patent worthy, I think it's the applications and methods that are patentable.
1a
I would say if you have made a recombinant gene by fusing two different DNA sequences, you have made a novel product . . . profit as you see fit.
2...2a...
I'm not sure I understand the question. I don't believe it will ever be possible to culture an organ using just the subset of the DNA for the genes required in that organs function. Lots of opportunity for patents here though. You could patent the media in which an organs can grow, the process of transforming the stem cells into a specific tissue type, etc
3
I'm not qualified to comment on international law, these are good issues that I don't tend to put enough thought into.
Even as I click submit, I know I haven't given these issues the thought a good response deserves, but that's the nature of slashdot.
Excellent point. I am frequently critized for assuming that everything I know is common knowledge, and giving presentations that don't present enough background to the audience.
I can imagine this is a downfall with geeks writing documentation in general. Everything we know is now obvious [to us], so we only document the non-obvious parts.
The new reader tries to use the docs, but finds themselves frustrated because the docs start out at too high of a level, and the additional resources they refer to are also at too high of a level for the beginner.
I only have very limited experience with non-geeks using linux, but my experience has shown that they don't read, and don't think they should have to read to use linux. My non-geeks don't even pretend to solve or diagnose the problems, they just call for help immediately. I think the non-geeks this book would help most, are those already solving their problems using google.
a clarification on why i don't think the host should be patentable,
DNA is data that can be read by any cell. Think of DNA like a language that runs on a VM. All cells have this VM, so by moving the sequence from a VM machine in the mosquito doesn't change the gene sequence or gene product when the sequence is run on the human VM.
An organism is just a collection of cells that hold VMs that run DNA code (where a gene is analogous to a program) and produce gene products. Even though the human cell never would hold a patented gene sequence under natural conditions, nothing about the gene or it's function has changed. It's still behaving the same as it does in it's natural host environment.
I do think there may be a usefulness to patent the application of naturally occuring genes to treat illness A thought pathway X, but not the actual DNA sequence.
DNA sequences should only be patented for new engineered sequences, and not 'discoveries' that were found occuring naturally in other organisms.
2) Engineered sequences can be patented, but not the organism holding the engineered sequence.
3) Engineered sequences which escape into the natural population through natural reproductive means loose their patent, with a caveat, the former patent owner should be held responsible for all clean up cost, and may be subject to bio-terrorism charges for endangering a nations eco-system.
Just thinking outloud, sorry.
I figured that a jerri rigged hack that lets the iPod flop around in the glove box was exactly the type of feature BMW owners used to make their buying decisions.
Also, backwards compatible means I can trade in my old console when I get a new one. It reduces the cost of the purchase, and I don't loose any of the games I bought for the old system.
For me, the backwards compatibility means that I don't have to move a lot of cords, and furniture, around to play different games. It's a small feature, but I appreciate everytime I hook up the old intellivision system. If I had a better entertainment setup, with more available inputs, I probably would just have all the old systems hooked up and wouldn't care at all about backwords compatibility.
because it was backwords compatible with my PS1 game collection. I suspect the PS3 will be backwards compatible with PS2 games. Microsoft has a history of making their latest release be incompatible with earlier version.
:-), plus provide some additional value that isn't available on the market, and meet my price point.
In short, it doesn't matter if company X releases a product ahead of the competition. If the company has shown itself to be untrustable, and MS has, then I won't be buying into their products.
If MS really wants to get a jump on the competition, they need the Xbox2 to be compatible with PS2 games
1)The make the OS.
2)They find the holes.
3)They write a virus and release the fix on their antivirus software shortly after the virus is releases.
4)PR/Marketing comes out with propaganda showing MS-AntiV consistently releases blocks and fixes faster than the competition.
5)Marketing starts hyping longhorn as having the best anti-virus software built into the OS !
I can't tell if this is supposed to be funny, insightful, or informative. Someone mod parent as appropriate.
Web readers get the same content as the paper-and-ink edition without paying for it, it's fair to ask them for personal information in exchange for access.
Either sell the newspaper online or give it away free, but registration sucks. bob@hotmail.com is getting upset with me.
Also, Apple has already demonstrated that if you have something worth paying for, then transactions can be handled at sub dollar amounts. Sell subscriptions online for a buck a month, problem solved.
Advertisers cover the production and distribution costs, $0.25 for the paper is probably about the worth of that much paper, plus the news after it's been sanitized from anything that might alienate the cash cow. So if the e-paper doesn't have the value of the actual paper, that leaves just the value of the news. About $0.03/day sounds about right to me.
Don't laugh, $0.03 is worth a lot more than the information with which I pollute their datasets.
Genome assembly, annotation pipelines,comparitive genomics, live video aquisition and encoding, image deconvolution.
A long time ago, in the distant past, there were Finders. Dedicated individuals that wandered around outside the camps and found stuff. Over time, it became more difficult to find stuff, and the Finders became the Searchers. Many times the Searchers would return empty handed. As technologies improve and new insights are gained, the same fruitless searches of the past were repeated. Sometimes with a new results, sometimes as fruitless as before. Regardless, it was this not giving up on an idea just because it failed once that led the change in title from Searcher to Researcher.
Most reseachers I know produce one magnificent failure after another on the quest for a new piece of knowledge. Everything that is easy to find has probably already been discovered, and mathematics is no different. So the guy made a few failed attempts at solving the puzzle, this doesn't make each sucessor to the first attempt a garaunteed failure.