Walked into the living room one day to see my 3 year old running a program on the windows log in screen! I've since looked it up, and it's possible. So much for my preconceptions.
Utilities actually have two businesses: Generation and distribution. We pay one bill and conflate the two. Solar just makes it clear they are different.
With home solar increasing, utilities will just invest less and less in generation. The transition is pretty gradual, so they can adapt just fine. Profits from generation will decline... life will go on. But only if we accept that distribution also needs to be paid for.
If and until home power storage also becomes economical, homes are still going to need to connect to the grid. That infrastructure will need to be paid for. It's going to be tacked onto the utility bill. In the past, we subsidized small users by paying by the kwh. Now we have to decide if connection fees are more appropriate. That's what the debate is going to turn into.
Stiffness for a solid rectangular bar is h^3*w. The 5s is 7.6 mm thick, the 6 is 6.9, the 6+ is 7.1. Ignoring width and internals, this would mean the 6 and 6+ are 75% and 82% as stiff as the 5s.
But hold on, the length of of a beam also greatly affects the bending moment. Deflection for a cantilever beam is a cube function on length.
Together, the 6 and 6+ will be much more flexible than the 5s.
Stresses causing yielding will be a bit less extreme. And exact type of stress matters. But being longer and thinner is (duh) going to make it weaker.
Careful with that word "we." I'm an engineer, but put a huge emphasis on industrial design. The form of my designs are integral to the function. They don't just hold the electro-mechanicals I'm designing (which is my specialty), they are the interface with my users.
So I fuss for days sometimes to get the right distances and sizes to fit 95% asian woman and 95% western men. Tweaking the curvature transition of complex surfaces to feel natural, give tactile feedback, and be able to be injection molded from a single pull mold (yeah, I do preliminary mold design too). While still containing and constraining internal mechanisms (which I also design). Choosing textures and colors that build on that base. And so on. Often I have people with industrial design or fine arts degrees consulting on the designs.
It's not rocket science, but you are right: it shouldn't just be slapped together at the last minute.
Bevels and rounded corners? Easy stuff. There's an optimum, but not a huge sensitivity. Where Apple and others excel is under the skin, as well as fit and finish.
Bingo. You seem to have done a better job of choosing key words for searches than I did. I'm also in Asia at the moment, which sends the search engines off on odd tangents.
It was pretty incremental improvement. Just a pair of ostomies. Stick a hose in each end and flush with dialysate. It doesn't sound like much, but solved a couple problems. We also had a pretty refined formulate (I can't recall details). But it was simpler to make than baking a cake. Mostly manitol and some salts to control ion flow. I think we even used tap water just to prove it worked. Trying to turn it into protected IP would have been like trying to protect S'mores.
We dialysied several pigs that has simulated renal failure. It just worked. The only problem we ever had was early on when we didn't realize how powerful it could be and pulled too much fluid out of a pig over the course of a couple hours. She died of dehydration. I guess that could be construed as a potential fatal flaw.
If you are truly interested in picking up the research, I can put you in touch with the clinician. I believe he was interested in the procedure, but he and the hospital had to make a call on what research they would pursue. He's done amazing work in other areas and just might not have been able to juggle two lines of research. I don't fault them. Just disappointed.
Oh, I'd be happy to point you in the right direction if I could. But this was 13 years ago. All I read were excerpts and summaries from dozens of old medical journals in half a dozen countries. I was the engineer, not the guy searching old archives, so didn't pay any attention to where the stuff was published. Heck, I've searched for information since, and can barely find anything useful. The only thing I found even related was through a link in Wikipedia: http://www.medscape.com/medlin...
Scattered in the old literature were about 100 reports of different forms of lavaging bowel to affect blood chemistry. Sometimes it was serious research on one or two patients. Sometimes it was accidental. In one case, a guy drank 4 gallons of colon cleanser each day and managed to stay alive. Most patients were extremely sick and didn't do well, but improved vs no treatment. We used some surgery to greatly improve outcome and potential quality of life. A breakthrough we couldn't make a dime from.
And unfortunately, the non-profit research hospital we donated it to did not publish the research (they were a consultant to the company for the work, so could have easily published). It was animal research, but still relevant.
Active work was done the 1920's to 1930's. Accidental discoveries were made even decades later. There are over 100 different citations in as many publications. I wouldn't even be able to recall one of them. And you'd be hard pressed to access the publications.
If you want to claim that development was done by a non-capitalist system (which is a weird statement for other reasons), then you'd find they eff'ed it up big-time. They figured out bits and pieces but neglected to optimize, make it patient friendly (I swear one dude probably lived on a toilet), or roll it out for general use.
We made one critical breakthrough. But it was the procedure. Patenting it would mean suing thousands of individual customers for a thousand dollars. That's would have been stupid on so many levels, we didn't bother.
Sorry to rain on that thought, but it was a capitalist company that spent $250k doing research that from day 1 they weren't sure would make money. Then when they decided it wasn't a good fit, donated the research and some money to a non-profit institution. Trying to snatch victory form the jaws of defeat.
As far as I can tell, the government supported non-profit took the money and never did anything at all. Not exactly a ringing endorsement of government funded organizations.
Sorry, there are no links. Take a look at the response to another guy for a description.
As for why we couldn't make money, the work was based on research 70 years old. Patents would have been nearly impossible. And the supplies were commodity already. As in Home Depot and supermarket commodity. And about as hard to make as baking a cake (probably easier).
The final straw was that it was in a market that was too different. It would have been like Apple deciding to sell oatmeal.
Sorry, but we never published. The original work was 70 years old, so a bit hard to find online. But I can describe it.
We called it intestinal dialysis. In the early 20th century, there was research on 3 kinds of dialysis: hemo, peritoneal, and intestinal. Hemo made the first breakthrough. The others were forgotten until peritoneal was reexamined in the 80's.
If you google intestinal dialysis, you'll find something distantly related to the old research and what we worked with. But very different. We found in animal studies that you could isolate a section of small intestine to turn it into an "artificial kidney". Intestine has good blood flow and a huge surface area designed for gently moving fluids and compounds into the blood stream. We use an osmotic gradient to reverse how the intestine works.
In other words, we created precise diarrhea.
The only supplies required were tap water, a bucket, baby laxative, and a hose. Adding salts made it more precise. A touch of sugar is important (to feed the intestine). Our test system was computerized, but was essentially still just a bucket up on a shelf and a hose for siphoning.
The procedure was a bit like hemodialysis, but done non-sterile. The big difference is not removing blood from a patient. The dialysis unit is the patient's own section of intestine. Robust, self repairing, able to repel bacteria, etc.
But it was too different from our main business. It would be like Apple deciding to sell breakfast cereal. So we gave it away.
It will be a lot more expensive than that. Harvesting from a donor means using a "free" kidney. Free in that no one had to be paid to make it. Here are some prices of dissimilar items:
I work with several biomedical companies. A simple metal part can cost $10k. And that's not gouging. Getting that metal part to clinical trials took millions of dollars and 15 years. The amount of testing and paperwork are outrageous. But easier to make than a kidney.
An artificial leg for above the knee amputation can cost $50k and up. Those guys are gouging. But easier to make than a kidney.
I would expect a lab grown kidney to go for $50k-$100k, not including implantation costs. And that's IF they figure out a cheap way to make them.
And ironically, your wife would probably be denied insurance coverage for it. Because she already has a kidney.
(On a related side note, I worked on a non-sterile dialysis system that was so cheap, we couldn't figure out how to make money from it. A few hundred bucks a year, could be done at home, 0% risk of infection. We donated the research and $100k to a research hospital.)
The FDA also has oversight of exported drugs and devices. They don't have to be approved for sale in the US in order to be exported, but do have to meet some requirements.
On the other end, most countries require an export certificate from the country of origin.
Funny fact: 3 Mile failed because of a safety procedure. When a gage went bad, it was red tagged. Good idea... unless it hangs over the gage that would have warned the operators the reactor was going wonky. So, as you say, they interpreted the conditions on the gages they could see, not the critical one the couldn't, and made the wrong call.
Airbus didn't patent jack squat. They file a patent application. If the patent is granted, then you can say they patented something. The difference is pretty enormous. It's like saying you are married to someone when all you did was ask them to marry you (and haven't even gotten a response). There are a few more steps involved.
Do any of the Slashdot editors know the first thing about patents? Seriously. Any?
It was handled remotely. Operators used manipulators to handle the material behind glass shielding. Worked fine until some nitric acid exploded. He was blasted with shattered glass and americium.
Because the incremental improvement adding all of these optics and electronics, make it robust, and make it work is not cheap. And most cooks do pretty darn good with just what they have.
Slashdot Mirror
Swear to God he had MS Word up and running on the login screen. Why and how, I have no idea. Just random banging on the keyboard probably.
"Human infections caused by Ebola-Reston virus in the US in 1990"
Source: http://www.cdc.gov/ncidod/dvrd...
More info: http://en.wikipedia.org/wiki/R...
Yeah. Pigs and monkeys. And in the US and Philippines. Enjoy your day!
Amen.
Walked into the living room one day to see my 3 year old running a program on the windows log in screen! I've since looked it up, and it's possible. So much for my preconceptions.
Utilities actually have two businesses: Generation and distribution. We pay one bill and conflate the two. Solar just makes it clear they are different.
With home solar increasing, utilities will just invest less and less in generation. The transition is pretty gradual, so they can adapt just fine. Profits from generation will decline ... life will go on. But only if we accept that distribution also needs to be paid for.
If and until home power storage also becomes economical, homes are still going to need to connect to the grid. That infrastructure will need to be paid for. It's going to be tacked onto the utility bill. In the past, we subsidized small users by paying by the kwh. Now we have to decide if connection fees are more appropriate. That's what the debate is going to turn into.
Some more engineering thoughts:
Stiffness for a solid rectangular bar is h^3*w. The 5s is 7.6 mm thick, the 6 is 6.9, the 6+ is 7.1. Ignoring width and internals, this would mean the 6 and 6+ are 75% and 82% as stiff as the 5s.
But hold on, the length of of a beam also greatly affects the bending moment. Deflection for a cantilever beam is a cube function on length.
Together, the 6 and 6+ will be much more flexible than the 5s.
Stresses causing yielding will be a bit less extreme. And exact type of stress matters. But being longer and thinner is (duh) going to make it weaker.
Careful with that word "we." I'm an engineer, but put a huge emphasis on industrial design. The form of my designs are integral to the function. They don't just hold the electro-mechanicals I'm designing (which is my specialty), they are the interface with my users.
So I fuss for days sometimes to get the right distances and sizes to fit 95% asian woman and 95% western men. Tweaking the curvature transition of complex surfaces to feel natural, give tactile feedback, and be able to be injection molded from a single pull mold (yeah, I do preliminary mold design too). While still containing and constraining internal mechanisms (which I also design). Choosing textures and colors that build on that base. And so on. Often I have people with industrial design or fine arts degrees consulting on the designs.
It's not rocket science, but you are right: it shouldn't just be slapped together at the last minute.
Bevels and rounded corners? Easy stuff. There's an optimum, but not a huge sensitivity. Where Apple and others excel is under the skin, as well as fit and finish.
Bingo. You seem to have done a better job of choosing key words for searches than I did. I'm also in Asia at the moment, which sends the search engines off on odd tangents.
It was pretty incremental improvement. Just a pair of ostomies. Stick a hose in each end and flush with dialysate. It doesn't sound like much, but solved a couple problems. We also had a pretty refined formulate (I can't recall details). But it was simpler to make than baking a cake. Mostly manitol and some salts to control ion flow. I think we even used tap water just to prove it worked. Trying to turn it into protected IP would have been like trying to protect S'mores.
We dialysied several pigs that has simulated renal failure. It just worked. The only problem we ever had was early on when we didn't realize how powerful it could be and pulled too much fluid out of a pig over the course of a couple hours. She died of dehydration. I guess that could be construed as a potential fatal flaw.
If you are truly interested in picking up the research, I can put you in touch with the clinician. I believe he was interested in the procedure, but he and the hospital had to make a call on what research they would pursue. He's done amazing work in other areas and just might not have been able to juggle two lines of research. I don't fault them. Just disappointed.
Oh, I'd be happy to point you in the right direction if I could. But this was 13 years ago. All I read were excerpts and summaries from dozens of old medical journals in half a dozen countries. I was the engineer, not the guy searching old archives, so didn't pay any attention to where the stuff was published. Heck, I've searched for information since, and can barely find anything useful. The only thing I found even related was through a link in Wikipedia: http://www.medscape.com/medlin...
Scattered in the old literature were about 100 reports of different forms of lavaging bowel to affect blood chemistry. Sometimes it was serious research on one or two patients. Sometimes it was accidental. In one case, a guy drank 4 gallons of colon cleanser each day and managed to stay alive. Most patients were extremely sick and didn't do well, but improved vs no treatment. We used some surgery to greatly improve outcome and potential quality of life. A breakthrough we couldn't make a dime from.
And unfortunately, the non-profit research hospital we donated it to did not publish the research (they were a consultant to the company for the work, so could have easily published). It was animal research, but still relevant.
Active work was done the 1920's to 1930's. Accidental discoveries were made even decades later. There are over 100 different citations in as many publications. I wouldn't even be able to recall one of them. And you'd be hard pressed to access the publications.
If you want to claim that development was done by a non-capitalist system (which is a weird statement for other reasons), then you'd find they eff'ed it up big-time. They figured out bits and pieces but neglected to optimize, make it patient friendly (I swear one dude probably lived on a toilet), or roll it out for general use.
We made one critical breakthrough. But it was the procedure. Patenting it would mean suing thousands of individual customers for a thousand dollars. That's would have been stupid on so many levels, we didn't bother.
The reason we couldn't make money is that it is published and is in the public domain.
The non-profit is a pediatric research hospital. Traditional dialysis doesn't work well on small children, so they were interested.
Sorry to rain on that thought, but it was a capitalist company that spent $250k doing research that from day 1 they weren't sure would make money. Then when they decided it wasn't a good fit, donated the research and some money to a non-profit institution. Trying to snatch victory form the jaws of defeat.
As far as I can tell, the government supported non-profit took the money and never did anything at all. Not exactly a ringing endorsement of government funded organizations.
Sorry, there are no links. Take a look at the response to another guy for a description.
As for why we couldn't make money, the work was based on research 70 years old. Patents would have been nearly impossible. And the supplies were commodity already. As in Home Depot and supermarket commodity. And about as hard to make as baking a cake (probably easier).
The final straw was that it was in a market that was too different. It would have been like Apple deciding to sell oatmeal.
Sorry, but we never published. The original work was 70 years old, so a bit hard to find online. But I can describe it.
We called it intestinal dialysis. In the early 20th century, there was research on 3 kinds of dialysis: hemo, peritoneal, and intestinal. Hemo made the first breakthrough. The others were forgotten until peritoneal was reexamined in the 80's.
If you google intestinal dialysis, you'll find something distantly related to the old research and what we worked with. But very different. We found in animal studies that you could isolate a section of small intestine to turn it into an "artificial kidney". Intestine has good blood flow and a huge surface area designed for gently moving fluids and compounds into the blood stream. We use an osmotic gradient to reverse how the intestine works.
In other words, we created precise diarrhea.
The only supplies required were tap water, a bucket, baby laxative, and a hose. Adding salts made it more precise. A touch of sugar is important (to feed the intestine). Our test system was computerized, but was essentially still just a bucket up on a shelf and a hose for siphoning.
The procedure was a bit like hemodialysis, but done non-sterile. The big difference is not removing blood from a patient. The dialysis unit is the patient's own section of intestine. Robust, self repairing, able to repel bacteria, etc.
But it was too different from our main business. It would be like Apple deciding to sell breakfast cereal. So we gave it away.
It will be a lot more expensive than that. Harvesting from a donor means using a "free" kidney. Free in that no one had to be paid to make it. Here are some prices of dissimilar items:
I work with several biomedical companies. A simple metal part can cost $10k. And that's not gouging. Getting that metal part to clinical trials took millions of dollars and 15 years. The amount of testing and paperwork are outrageous. But easier to make than a kidney.
An artificial leg for above the knee amputation can cost $50k and up. Those guys are gouging. But easier to make than a kidney.
I would expect a lab grown kidney to go for $50k-$100k, not including implantation costs. And that's IF they figure out a cheap way to make them.
And ironically, your wife would probably be denied insurance coverage for it. Because she already has a kidney.
(On a related side note, I worked on a non-sterile dialysis system that was so cheap, we couldn't figure out how to make money from it. A few hundred bucks a year, could be done at home, 0% risk of infection. We donated the research and $100k to a research hospital.)
I like the quote: "If you're not paying for it, you're not the customer. Your the product."
As in years ago.
http://www.linuxinsider.com/st...
I'd rather use thermochromic paints.
You might be able to find other references, but here is a whole study. http://heatisland2009.lbl.gov/...
I'm not sure I agree with the explanation in the article, but it does look like Apple tried to make the phones look artificially thinner
http://qz.com/262355/apple-use...
Yes. My flip phone did this 5 years ago.
The real problem was when visiting somewhere that had the necessary network port blocked.
You don't have to affiliate with a terrorist group to be a terrorist. i.e. Unibomber.
But your question is still reasonable: why are they on the list? It must be some other undisclosed reason(s). Some might be valid, some might not.
The FDA also has oversight of exported drugs and devices. They don't have to be approved for sale in the US in order to be exported, but do have to meet some requirements.
On the other end, most countries require an export certificate from the country of origin.
http://www.fda.gov/Internation...
Funny fact: 3 Mile failed because of a safety procedure. When a gage went bad, it was red tagged. Good idea ... unless it hangs over the gage that would have warned the operators the reactor was going wonky. So, as you say, they interpreted the conditions on the gages they could see, not the critical one the couldn't, and made the wrong call.
Airbus didn't patent jack squat. They file a patent application. If the patent is granted, then you can say they patented something. The difference is pretty enormous. It's like saying you are married to someone when all you did was ask them to marry you (and haven't even gotten a response). There are a few more steps involved.
Do any of the Slashdot editors know the first thing about patents? Seriously. Any?
It was handled remotely. Operators used manipulators to handle the material behind glass shielding. Worked fine until some nitric acid exploded. He was blasted with shattered glass and americium.
Because the incremental improvement adding all of these optics and electronics, make it robust, and make it work is not cheap. And most cooks do pretty darn good with just what they have.
Small benefit vs big cost => no change