[from above]Except that antibiotic-resistant strains are generally less virulent than the old-fashioned kind
The view that antibiotic-resistant strains are less virulent is rapidly falling out of favor with bugs such as community acquired MRSA, XDR-TB and VRE. We are seeing bugs that are as virulent if not more in the case of CA-MRSA that are wrecking havoc on human hosts as they not only are antibiotic resistant but have specific virulence factors to work in human hosts. Panton-. Valentin leukocidin (i may have spelled that incorrectly) allows CA-MRSA to hang on to human skin very nicely, and the bug is an absolute terror if it gets into the blood stream. Anyways, My point isn't to go into the nitty gritty of virulence of emerging pathogens but rather to say that we aren't seeing less virulent new bugs but rather very deadly new bugs.
THis is a whole subject in itself but let me break it down real quick.
Sugar is a huge problem for a couple of reasons, carbohydrates(sugar) cause increased insulin release more so than other energy forms (protiens and lipids), espcially in the form of simple sugars. Your body absorbs those very easily so you get a huge spike in your blood glucose concentrations which your stimulates your pancreatic beta cells to unload insulin. The problem with lots of insulin release is it causes the storage of energy, carbohydrates can be shunted into fatty acid synthesis. So a high sugar meal ends up causing the release of lots of insulin which puts your body into the store energy mode--->fat. A diet in complex carbohydrates takes a while to break down so in essence you have a sustained release of carbohydrates which doesn't cause such a huge spike in insulin so you don't as much energy storage. Protiens and Fat for the most part don't really stimulate insulin. So yes, sugar is a BIG problem with obesity in america, but so are sedentary life styles, and people eating like complete shit.
Peace
p.s. i made some simplifications in the interest of time, but if someone wants a more complete overview of insulin's actions, carbohydrate, protien, and lipid metabolism i suggest checking out this very fine medical biochemistry site, http://www.indstate.edu/thcme/mwking/home.html . It was a great help in my biochem classes.
I'm sorry, but LD50 says nothing about neurotoxicity. LD50 = the dose that kills 50% of the subjects taking it. Notice i said kills, not kills brain cells, nor causes adverse effects. Besides the LD50 is a pretty useless measurement in pharmacology anyways, you want to use the LD50/ED50 ratio or the LD1/ED99. ED= dose that is effective in X % of people. Those ratios give you the safety factor of a drug. For example, the LD1/ED99 is 9. That means a lethal dose for 1% of the population is 9 times as large as the dose that is effective for 99% of the population. A LD1/ED99 is quite good, lots of perscription drugs have a safety factor that is much lower than that. Anyways there are lots of other ways to use those #s but your use of LD50 is way off.
Great game, we play once or twice a week...can't say enough good about the game. Good mix of a competitive sport without being psycho. It doesn't seem to bring in the crazies.
My brother owns a dental office, part of being HIPPA compliant is getting anyplace you subcontract with to agree to the HIPPA privacy laws. I set up an offsite backup system for them but before they could upload any of their patient data they had to get the company to agree to their privacy statment.
Far be it from me to try to reduce anyone's cynicism with regard to the game press, but there's actually a reasonable explanation for this. Game previews are generally positive and non-judgemental, with good reason -- they're not looking at a final version. It would be wrong to taint readers' opinions on things that will eventually get fixed.
Anyone remember the game Trespasser? Before it came out there were nothing but glowing reviews, talking about how the game was going to change the face of the industry, blah blah blah. When the game finally came out it didn't really play on any of the then current compute (unless you like slideshows) and it was buggy as hell. In fact it took down my friends machine. Right around that time i realized that game reviews are basically worthless...i basically only read them to find the negatives of a game, and i discard pretty much anything else they say.
A: Oh. We just write scripts and then use videogames to act them out. It's a new style of animation that some people call machinima. It allows to make 4-5 minutes of animation with a small group of people.
Reading through those articles i noticed a couple of things
1) Rumor that a psp and ps2 will be able to link up
2) gfx power is about equal between ps2 and psp
3) Porting to psp is very easy
4) PS2 sales are expected to extend into 2010
(don't worry, i am getting to my point here shortly)
Basically what i am getting at is that Sony is going to use the psp to drive sales of the ps2 (although i doubt it will stay in its current form..they will probably redesign it like they did with the ps1). Why do i think that? Glad you asked. With other handheld gaming systems the power discrepancy is always so huge between the home gaming machine and the handheld (look at Gameboy advanced and the gamecube) there wasn't much possibility for a game that you could play on the move and that you could sit down in front of your t.v. and waste a couple of hours. I think nintendo tried doing that with some of the pokemon games but i am not sure on that so someone please correct me if i am wrong. Anyways my point is that the PS2 and PSP look like an electronic peanut butter and jam. Why wouldn?t a game developer develop for both platforms especially since it is supposedly very easy to do and both platforms have similar capabilities. I think this is why sony is saying that the PS2 will remain viable until 2010
peace
I understand where you are coming from but historically (and this is changing) the PC has been fairly unique in the type of games that are developed for it. The FPSes are a great example of this, a mouse and keyboard is vastly superiour to a gamepad. MMORPGs are another good example..have you ever seen the PS2 version of EQ? It is extremely tedious to try and communicate with anyone. All that is kind of besides the point though. Just because you don't want games on your PC doesn't mean other people don't also. My original point is that games would suffer if microsoft went down the tube, i still think it would although i think you make a valid point that their are alternatives out there
peace
I will be the first to tell you that i like open source software, but linux, apple, and everything else out there (but windows) just don't have good games. Some people mentioned standards is one thing microsoft has done for us, and the game world really reflects this..looks at direct x. Now i know lots of you will point out opengl as an alternative but with so many people trying to contribute to it (matrox, 3d labs, nvidia?, ati?, etc etc etc) nothing ever gets implemented.
peace
Slashdot Mirror
[from above]Except that antibiotic-resistant strains are generally less virulent than the old-fashioned kind
The view that antibiotic-resistant strains are less virulent is rapidly falling out of favor with bugs such as community acquired MRSA, XDR-TB and VRE. We are seeing bugs that are as virulent if not more in the case of CA-MRSA that are wrecking havoc on human hosts as they not only are antibiotic resistant but have specific virulence factors to work in human hosts. Panton-. Valentin leukocidin (i may have spelled that incorrectly) allows CA-MRSA to hang on to human skin very nicely, and the bug is an absolute terror if it gets into the blood stream. Anyways, My point isn't to go into the nitty gritty of virulence of emerging pathogens but rather to say that we aren't seeing less virulent new bugs but rather very deadly new bugs.
Z
Sugar is a huge problem for a couple of reasons, carbohydrates(sugar) cause increased insulin release more so than other energy forms (protiens and lipids), espcially in the form of simple sugars. Your body absorbs those very easily so you get a huge spike in your blood glucose concentrations which your stimulates your pancreatic beta cells to unload insulin. The problem with lots of insulin release is it causes the storage of energy, carbohydrates can be shunted into fatty acid synthesis. So a high sugar meal ends up causing the release of lots of insulin which puts your body into the store energy mode--->fat. A diet in complex carbohydrates takes a while to break down so in essence you have a sustained release of carbohydrates which doesn't cause such a huge spike in insulin so you don't as much energy storage. Protiens and Fat for the most part don't really stimulate insulin. So yes, sugar is a BIG problem with obesity in america, but so are sedentary life styles, and people eating like complete shit.
Peace
p.s. i made some simplifications in the interest of time, but if someone wants a more complete overview of insulin's actions, carbohydrate, protien, and lipid metabolism i suggest checking out this very fine medical biochemistry site, http://www.indstate.edu/thcme/mwking/home.html . It was a great help in my biochem classes.
That dog fails to be cute
I don't know why but the first thing i thought of when i read that carmack had a wife is, "what does she look like" Thanks for the pic.
Peace
I'm sorry, but LD50 says nothing about neurotoxicity. LD50 = the dose that kills 50% of the subjects taking it. Notice i said kills, not kills brain cells, nor causes adverse effects. Besides the LD50 is a pretty useless measurement in pharmacology anyways, you want to use the LD50/ED50 ratio or the LD1/ED99. ED= dose that is effective in X % of people. Those ratios give you the safety factor of a drug. For example, the LD1/ED99 is 9. That means a lethal dose for 1% of the population is 9 times as large as the dose that is effective for 99% of the population. A LD1/ED99 is quite good, lots of perscription drugs have a safety factor that is much lower than that. Anyways there are lots of other ways to use those #s but your use of LD50 is way off.
i guess they should be proud
Great game, we play once or twice a week...can't say enough good about the game. Good mix of a competitive sport without being psycho. It doesn't seem to bring in the crazies.
Hurray for me...i officially added nothing to this discussion
My brother owns a dental office, part of being HIPPA compliant is getting anyplace you subcontract with to agree to the HIPPA privacy laws. I set up an offsite backup system for them but before they could upload any of their patient data they had to get the company to agree to their privacy statment.
Robson, you make a good point. I stand corrected
cynical? yup
Q: No seriously. What the hell?
A: Oh. We just write scripts and then use videogames to act them out. It's a new style of animation that some people call machinima. It allows to make 4-5 minutes of animation with a small group of people.
http://www.redvsblue.com
The stories are simple but well done with humor that i would guess most slashdotters would appreciate
Reading through those articles i noticed a couple of things 1) Rumor that a psp and ps2 will be able to link up 2) gfx power is about equal between ps2 and psp 3) Porting to psp is very easy 4) PS2 sales are expected to extend into 2010 (don't worry, i am getting to my point here shortly) Basically what i am getting at is that Sony is going to use the psp to drive sales of the ps2 (although i doubt it will stay in its current form..they will probably redesign it like they did with the ps1). Why do i think that? Glad you asked. With other handheld gaming systems the power discrepancy is always so huge between the home gaming machine and the handheld (look at Gameboy advanced and the gamecube) there wasn't much possibility for a game that you could play on the move and that you could sit down in front of your t.v. and waste a couple of hours. I think nintendo tried doing that with some of the pokemon games but i am not sure on that so someone please correct me if i am wrong. Anyways my point is that the PS2 and PSP look like an electronic peanut butter and jam. Why wouldn?t a game developer develop for both platforms especially since it is supposedly very easy to do and both platforms have similar capabilities. I think this is why sony is saying that the PS2 will remain viable until 2010 peace
I understand where you are coming from but historically (and this is changing) the PC has been fairly unique in the type of games that are developed for it. The FPSes are a great example of this, a mouse and keyboard is vastly superiour to a gamepad. MMORPGs are another good example..have you ever seen the PS2 version of EQ? It is extremely tedious to try and communicate with anyone. All that is kind of besides the point though. Just because you don't want games on your PC doesn't mean other people don't also. My original point is that games would suffer if microsoft went down the tube, i still think it would although i think you make a valid point that their are alternatives out there peace
I will be the first to tell you that i like open source software, but linux, apple, and everything else out there (but windows) just don't have good games. Some people mentioned standards is one thing microsoft has done for us, and the game world really reflects this..looks at direct x. Now i know lots of you will point out opengl as an alternative but with so many people trying to contribute to it (matrox, 3d labs, nvidia?, ati?, etc etc etc) nothing ever gets implemented. peace