People breeding domestic animals had a pretty clear idea of what they were doing and what goals they wanted to achieve even if they did not understand the underlying mechanism. Portraying them as stupid bumbling barbarians making random modifications with no logic or method is incorrect.
They had aims, and the set about them with what knowledge they had. But like it or not, they were making random modifications, and being pretty clueless about the underlying mechanism means they didn't know what they were doing. In so doing they made mistakes, but we are still here despite it.
Now we are making specific, carefully controlled modifications, with a solid understanding of the mechanisms, having a very good idea of what we are doing. Portraying modern geneticists as 'bumbling barbarians' (which is what your arguments do, whether you intend it or not) is doing a far greater injustice.
Lastly, an argument that, 'We shouldn't do this simple, safe thing because someone else could complex, dangerous thing,' isn't really valid argument. Even if people proposed, and abandoned, dangerous ideas in the past. Each concept should be judged on its own merits. And when we do this, is seems we agree - controlled, targeted GE on mozzies is a good idea.
One thing that has been shown repeatedly is that if you reduce the childhood death rate, fertility goes down. People no longer have such large families, because the are pretty sure the first few children will survive. It is when parents have to assume that some of their children will die of disease that they have large families, just in case.
And we have been doing this for ages. The only difference is that before, we had no idea what we were doing. We looked for random changes caused by cosmic rays etc. in living things; we even put seeds under an X-Ray (or beta, or gamma-rays) to make random changes in the genetics; or we cross-bread two different plants, producing a random mix of genes that often was not viable of itself,but we could harvest the germ and make it grow outside the seed.
All this we do, and they even get to call the results of this random, uncontrolled gene editing 'organic'.
The difference is that now, we are making single changes that we have an ability to know and predict the results of. This is a much, much safer form of genetic modification than what we have been doing for centures.
The malaria mutates so it can infect the GE mosquitoes, slowing down reproduction of the GE mozzies. The End. So worst that could happen is that it doesn't work. Most likely cause of this is not being able to do a wide enough release, so there is a mixture of GE and non-GE mozzies, alowing the Malaria parasites to develop resistance before they are eliminated.
So, in short, no small-scale limited releases just to make sure!
One thing that has been shown in multiple countries is if you reduce the childhood death rate, fertility goes down. People no longer have large families, because the are pretty sure the first few will survive. It is when parents have to assume that some of their children will die of disease that they have large familes, just in case.
I don't disagree with you about mark-up for the Porsche parts. If they are the same parts as used on the VW, they should be the same price. You shouldn't be able to get a half-shaft labeled only "Porsche", as all of them should be labelled 'Porsche, VW'.... and probable half a dozen different manufacturers.
But the bracket welded on the side of the shocks could easily make the price $300 dearer. The $100 part is $100 because it is made identical in huge numbers. Re-setup to make a few hundred with a different bracket, and the cost increases a lot.
If you iDevice is damaged, an apple store will sell you a new one. If it is covered under warranty, they'll swap it for someone else's trade-in. If you have irreplaceable data on your phone, stiff cheese; you should have backed it up.
Meanwhile, a non-authorized repair shop will fix almost any problem you have, unless Apple has taken technological (and unnecessary) measures to prevent it, at least until those measures are worked around. And if the problem is serious and unrepairable, they'll still get your data back to you if you are willing to pay for the extensive, detailed work that is often needed.
And these 'unauthorized' repair shops will often work out problems, and fixes, before Apple does.
What you describe - free and unfettered access to the source code and tools, without having to agree to anything - is a good description of the GPL. You do not have to agree to the GPL to download, edit or use code - at least, not beyond the standard, 'no warranty, no liability' clauses. The only time you have to agree to the GPL is when you distribute it to someone else - you must share the code if you do distribute it - which, if you are fixing defective code, is exactly what you want to do.
Give someone the source code, or a compiled binary with the source code, and you have fulfilled all your GPL obligations.
Don't write off the Teslas on the handling stakes. The battery pack in the floor means that mass is low down. Really helps with body roll. Many hop in the S expecting it to handle poorly because of the mass, and are pleasantly surprised.
Corporate members said yes. They stacked it until they had 50%. Develpers and users said no. The W3C said, 'Corporate members aren't going to compromise, so we'll ratify it anyway. Sorry angry (real) majority.
Are there any glowing-white-hats with ion hammers that will promise to blast any site using this protocol off the internet until they stop?
Literally not possible. You can't give a party access to content while simultaneously preventing them from having access to it. Somewhere between the encrypted stream coming in and the glowing lights on the screen, the content is in the clear and available to be copied.
I'd be happy with DRM that worked like that. The DRM code is multi-platform open source, like SSH and SSL. I generate a key, submit it to them, they send me encrypted content. I can put it the key in any device I want. Including my copy of mencoder.
That system would be a lot more convenient, as well as being exactly as effective as any other.
All three, really. Great timing and unusual sounds to match with events, changes in feel to match to seams, and it was never a serious piece of music. And Monty Python references always make people smile.
Entirely correct. A 3.5mm jack can be made waterproof, and the functions of the air-pressure balancing diaphragm built into the jack's molding.
This shows that the decision to drop the jack was made late in the design process, and left empty space in the device. Nest phone will be designed from the start not to have the jack, and won't have that space.
Yup. There's one that goes by the end of my street - There's a sugar mill on the highlands, and heavy loads of sugar to be brought down the range to the port. There's enough travel across the tablelands to mean that they probably wouldn't be able to do it indefinitely on regenerated power, but they'd end up with much more than 300 miles per charge. Anyone who has smelled their brakes as they bring those loads down the range knows there's lots of energy to be had in bringing a truck down a hill.
There are a number of routes where an electric truck would never need to charge - ones where they drive an empty truck up a hill to a mine or agricultural area, pick up a heavy load, and then have it push you back down the hill. I can foresee drivers needing to watch that the battery is empty enough to make it down the hill.
I trust that they have built the regenerative system heavily. Driving a truck down a hill is where truck drivers earn their money, and drivers will love them if they make that job easy.
Here are the questions that the questionnaire asks:
Over the last 2 weeks, how often have you been bothered by any of the following problems?
1. Little interest or pleasure in doing things
2. Feeling down, depressed, or hopeless
3. Trouble falling or staying asleep, or sleeping too much
4. Feeling tired or having little energy
5. Poor appetite or overeating
6. Feeling bad about yourself—or that you are a failure or have let yourself or your family down
7. Trouble concentrating on things, such as reading the newspaper or watching television
8. Moving or speaking so slowly that other people could have noticed? Or the opposite—being so fidgety or restless that you have been moving around a lot more than usual
9. Thoughts that you would be better off dead or of hurting yourself in some way
You may have noticed something - where are the questions asking if you had, in the last few weeks, been interested in something, excited, enjoyed a meal, felt energetic etc: all the things that strongly indicate that you are not clinically depressed? Reading through that, it seems as if it is designed to make you think more about the bad things in your life, to make you think you are depressed.
Which isn't surprising - because, like most things in medicine, this questionnaire was written by a company selling depression medication.
So while a questionnaire about depression would be a good idea, it needs to be one that is much more balanced than this.
Do this and you create methane, which you can further react into larger hydrocarbons to create synthetic gasoline.
But I doubt this will happen. The technology for electric vehicles is moving apace, will soon become less expensive than the high-level engineering required to produce an internal combustion drivetrain, and it is much more convenient and cheaper to run. The writing is on the wall for the internal combustion engine.
Cycles and circles. Unless you collect the oxygen instead for industrial use, but then you would have just burnt it with something else somewhere else - and it would replace industrial oxygen created by cooling and distilling the air.....
This study had several limitations. First, a major limitation is ascertainment bias associated with participation in this brain donation program. Although the criteria for participation were based on exposure to repetitive head trauma rather than on clinical signs of brain trauma, public awareness of a possible link between repetitive head trauma and CTE may have motivated players and their families with symptoms and signs of brain injury to participate in this research. Therefore, caution must be used in interpreting the high frequency of CTE in this sample, and estimates of prevalence cannot be concluded or implied from this sample.
It is true that all these infected male mosquitoes cannot produce offspring, but that's not the important part. They are being released to infect the female population. When infected, the female mosquitoes can breed, producing infected offspring, and infected females don't then later get infected with Dengue.
Just a little correction - while these Aedes aegypti mosquitoes do carry Dengue, Zika and West Nile, they don't spread malaria. That is left to a range of different mosquito species in the Anopheles genus.
Mosquitoes in general are an important part of the web of life. The are the foundation of a number of food chains, and they are major pollinators of many plants. (Yes, for most of their adult life, mosquitoes drink nectar.) Mosquitoes in general are important.
But there are a small number of species that carry human disease. These could safely be eliminated, and their ecological niche would be filled by similar species that don't carry human diseases.
The biology of a human and the biology of a mosquito is so different, that it's hard to think of anything safer.
And I am more often told, by some ignorant enviromentalist, that something clearly and obviously safe is dangerous, than being told by researchers that something is safe before long experience and epidemiology find it problematic. The later is something that happens a few times a generation, the former is two-thirds of the internet
Mosquitoes with Wolbachia do breed, and pass their infection on to their offspring. It is only the first generation - when infected males mate with clean females - that the eggs don't hatch. Once the female is infected and mates with either infected or clean males, she lays viable eggs, and the offspring all have Wolbachia.
The benefit is that the existance of the Wolbachia virus in the mozquito reduces the ability of the Dengue and Zika viruses to infect the it, reducing transmission.
Now, resistance among Dengue and Zika virus strains is a different matter - but where they are largely being used, where the infections are not endemic, but imported - the virus won't be exposed to Wolbachia for long enough for that to happen. But we'll have to see how this goes in area where these viruses are endemic.
Slashdot Mirror
People breeding domestic animals had a pretty clear idea of what they were doing and what goals they wanted to achieve even if they did not understand the underlying mechanism. Portraying them as stupid bumbling barbarians making random modifications with no logic or method is incorrect.
They had aims, and the set about them with what knowledge they had. But like it or not, they were making random modifications, and being pretty clueless about the underlying mechanism means they didn't know what they were doing. In so doing they made mistakes, but we are still here despite it.
Now we are making specific, carefully controlled modifications, with a solid understanding of the mechanisms, having a very good idea of what we are doing. Portraying modern geneticists as 'bumbling barbarians' (which is what your arguments do, whether you intend it or not) is doing a far greater injustice.
Lastly, an argument that, 'We shouldn't do this simple, safe thing because someone else could complex, dangerous thing,' isn't really valid argument. Even if people proposed, and abandoned, dangerous ideas in the past. Each concept should be judged on its own merits. And when we do this, is seems we agree - controlled, targeted GE on mozzies is a good idea.
One thing that has been shown repeatedly is that if you reduce the childhood death rate, fertility goes down. People no longer have such large families, because the are pretty sure the first few children will survive. It is when parents have to assume that some of their children will die of disease that they have large families, just in case.
And we have been doing this for ages. The only difference is that before, we had no idea what we were doing. We looked for random changes caused by cosmic rays etc. in living things; we even put seeds under an X-Ray (or beta, or gamma-rays) to make random changes in the genetics; or we cross-bread two different plants, producing a random mix of genes that often was not viable of itself,but we could harvest the germ and make it grow outside the seed.
All this we do, and they even get to call the results of this random, uncontrolled gene editing 'organic'.
The difference is that now, we are making single changes that we have an ability to know and predict the results of. This is a much, much safer form of genetic modification than what we have been doing for centures.
The malaria mutates so it can infect the GE mosquitoes, slowing down reproduction of the GE mozzies. The End. So worst that could happen is that it doesn't work. Most likely cause of this is not being able to do a wide enough release, so there is a mixture of GE and non-GE mozzies, alowing the Malaria parasites to develop resistance before they are eliminated.
So, in short, no small-scale limited releases just to make sure!
One thing that has been shown in multiple countries is if you reduce the childhood death rate, fertility goes down. People no longer have large families, because the are pretty sure the first few will survive. It is when parents have to assume that some of their children will die of disease that they have large familes, just in case.
I don't disagree with you about mark-up for the Porsche parts. If they are the same parts as used on the VW, they should be the same price. You shouldn't be able to get a half-shaft labeled only "Porsche", as all of them should be labelled 'Porsche, VW'.... and probable half a dozen different manufacturers.
But the bracket welded on the side of the shocks could easily make the price $300 dearer. The $100 part is $100 because it is made identical in huge numbers. Re-setup to make a few hundred with a different bracket, and the cost increases a lot.
If you iDevice is damaged, an apple store will sell you a new one. If it is covered under warranty, they'll swap it for someone else's trade-in. If you have irreplaceable data on your phone, stiff cheese; you should have backed it up.
Meanwhile, a non-authorized repair shop will fix almost any problem you have, unless Apple has taken technological (and unnecessary) measures to prevent it, at least until those measures are worked around. And if the problem is serious and unrepairable, they'll still get your data back to you if you are willing to pay for the extensive, detailed work that is often needed.
And these 'unauthorized' repair shops will often work out problems, and fixes, before Apple does.
What you describe - free and unfettered access to the source code and tools, without having to agree to anything - is a good description of the GPL. You do not have to agree to the GPL to download, edit or use code - at least, not beyond the standard, 'no warranty, no liability' clauses. The only time you have to agree to the GPL is when you distribute it to someone else - you must share the code if you do distribute it - which, if you are fixing defective code, is exactly what you want to do. Give someone the source code, or a compiled binary with the source code, and you have fulfilled all your GPL obligations.
Don't write off the Teslas on the handling stakes. The battery pack in the floor means that mass is low down. Really helps with body roll. Many hop in the S expecting it to handle poorly because of the mass, and are pleasantly surprised.
Corporate members said yes. They stacked it until they had 50%. Develpers and users said no. The W3C said, 'Corporate members aren't going to compromise, so we'll ratify it anyway. Sorry angry (real) majority.
Are there any glowing-white-hats with ion hammers that will promise to blast any site using this protocol off the internet until they stop?
Literally not possible. You can't give a party access to content while simultaneously preventing them from having access to it. Somewhere between the encrypted stream coming in and the glowing lights on the screen, the content is in the clear and available to be copied.
I'd be happy with DRM that worked like that. The DRM code is multi-platform open source, like SSH and SSL. I generate a key, submit it to them, they send me encrypted content. I can put it the key in any device I want. Including my copy of mencoder.
That system would be a lot more convenient, as well as being exactly as effective as any other.
All three, really. Great timing and unusual sounds to match with events, changes in feel to match to seams, and it was never a serious piece of music. And Monty Python references always make people smile.
Entirely correct. A 3.5mm jack can be made waterproof, and the functions of the air-pressure balancing diaphragm built into the jack's molding. This shows that the decision to drop the jack was made late in the design process, and left empty space in the device. Nest phone will be designed from the start not to have the jack, and won't have that space.
Yup. There's one that goes by the end of my street - There's a sugar mill on the highlands, and heavy loads of sugar to be brought down the range to the port. There's enough travel across the tablelands to mean that they probably wouldn't be able to do it indefinitely on regenerated power, but they'd end up with much more than 300 miles per charge. Anyone who has smelled their brakes as they bring those loads down the range knows there's lots of energy to be had in bringing a truck down a hill.
There are a number of routes where an electric truck would never need to charge - ones where they drive an empty truck up a hill to a mine or agricultural area, pick up a heavy load, and then have it push you back down the hill. I can foresee drivers needing to watch that the battery is empty enough to make it down the hill.
I trust that they have built the regenerative system heavily. Driving a truck down a hill is where truck drivers earn their money, and drivers will love them if they make that job easy.
Over the last 2 weeks, how often have you been bothered by any of the following problems?
1. Little interest or pleasure in doing things
2. Feeling down, depressed, or hopeless
3. Trouble falling or staying asleep, or sleeping too much
4. Feeling tired or having little energy
5. Poor appetite or overeating
6. Feeling bad about yourself—or that you are a failure or have let yourself or your family down
7. Trouble concentrating on things, such as reading the newspaper or watching television
8. Moving or speaking so slowly that other people could have noticed? Or the opposite—being so fidgety or restless that you have been moving around a lot more than usual
9. Thoughts that you would be better off dead or of hurting yourself in some way
You may have noticed something - where are the questions asking if you had, in the last few weeks, been interested in something, excited, enjoyed a meal, felt energetic etc: all the things that strongly indicate that you are not clinically depressed? Reading through that, it seems as if it is designed to make you think more about the bad things in your life, to make you think you are depressed.
Which isn't surprising - because, like most things in medicine, this questionnaire was written by a company selling depression medication.
So while a questionnaire about depression would be a good idea, it needs to be one that is much more balanced than this.
But I doubt this will happen. The technology for electric vehicles is moving apace, will soon become less expensive than the high-level engineering required to produce an internal combustion drivetrain, and it is much more convenient and cheaper to run. The writing is on the wall for the internal combustion engine.
Cycles and circles. Unless you collect the oxygen instead for industrial use, but then you would have just burnt it with something else somewhere else - and it would replace industrial oxygen created by cooling and distilling the air.....
This study had several limitations. First, a major limitation is ascertainment bias associated with participation in this brain donation program. Although the criteria for participation were based on exposure to repetitive head trauma rather than on clinical signs of brain trauma, public awareness of a possible link between repetitive head trauma and CTE may have motivated players and their families with symptoms and signs of brain injury to participate in this research. Therefore, caution must be used in interpreting the high frequency of CTE in this sample, and estimates of prevalence cannot be concluded or implied from this sample.
It is true that all these infected male mosquitoes cannot produce offspring, but that's not the important part. They are being released to infect the female population. When infected, the female mosquitoes can breed, producing infected offspring, and infected females don't then later get infected with Dengue.
Just a little correction - while these Aedes aegypti mosquitoes do carry Dengue, Zika and West Nile, they don't spread malaria. That is left to a range of different mosquito species in the Anopheles genus.
But there are a small number of species that carry human disease. These could safely be eliminated, and their ecological niche would be filled by similar species that don't carry human diseases.
And I am more often told, by some ignorant enviromentalist, that something clearly and obviously safe is dangerous, than being told by researchers that something is safe before long experience and epidemiology find it problematic. The later is something that happens a few times a generation, the former is two-thirds of the internet
The benefit is that the existance of the Wolbachia virus in the mozquito reduces the ability of the Dengue and Zika viruses to infect the it, reducing transmission.
Now, resistance among Dengue and Zika virus strains is a different matter - but where they are largely being used, where the infections are not endemic, but imported - the virus won't be exposed to Wolbachia for long enough for that to happen. But we'll have to see how this goes in area where these viruses are endemic.