M-Saunders, please ignore the hate and thanks for your enlightened views on publishing. I was disappointed when you guys "forked" LinuxFormat but I have enjoyed what I have consumed of the new magazine and podcast. I hope your business model is sustainable and look forward to catching up with the issues I've missed.
I doubt there will be any "legitimate" uses of this particular technology.
However, it may be a model on which we can base future online retail. The existing model is utterly broken: I really don't want databases all over the world holding my username, password, credit card details and billing address waiting for the next SQL or SSL vulnerability to vomit the information into the hands of criminals. Nor do I want to trust, use or respect services like paypal.
View this as an iteration towards a more secure and decentralised system for legitimate commerce which keeps credit card and escrow companies out of the equation. Surely that is a good thing?
In my limited experience, MP3 decoding under Linux sounds more pleasing than under other operating systems on the same hardware. I have mentioned my experiences with Rockbox on a 3G iPod previously.
You are aware that the correct spelling is "fetus"? "Foetus" would be derived from the Latin for "stench" - which tends to be a post-partum phenomenon!
Moral objections aside, the pictured device looks reasonably similar to several dry powder inhaler devices (e.g. http://www.serevent.com/how_to_use_serevent.html) used for the treatment of asthma. Patients get confused about their medications and devices on a frequent basis, and it won't be long before someone tries to inhale a lump of lead.
First of all, I am by no means an audiophile. I have a 3rd generation iPod and a computer with onboard sound and 2 tinny speakers on either side of my monitor.
I quite like the standard iPod interface. I can find tracks quickly using the database and scrollwheel. I've had some issues transferring files with amarok, but gtkPod works well.
Most of my collection sounds fine on the iPod, but I was never very satisfied with orchestral music with a large dynamic range. I'd ripped some Arvo Part CDs to MP3 at increasingly high bitrates using lame. Despite that, the quiet bits (such as the closing bell harmonic at the end of "Cantus") sounded awful: some sort of bubbling distortion. It seemed fine playing through my PC, but I put that down to my dodgy hardware blotting out the bubbling noise. In the end, I resurrected my old windows partition and ripped to AAC in iTunes. It was a bit better. My conclusion at the time? AAC was a better music format than MP3.
Then I installed Rockbox. I didn't like the interface much, and preferred browsing a database of artists rather than reorganising my whole collection into folders. At the time, browsing on a 3G iPod was painful. It would take about 60 seconds to scroll through a moderate sized list of artists. (I submitted a patch to speed this up but it was rejected. In any case it works much better now.) Battery life was poor, and crashes were frequent. I considered wiping it from the machine, but then I listened to those quiet MP3 tracks again.
The difference was stunning.
Crystal clear and without distortion, they sounded as good as the original CDs (and at least as good as the AACs).
My conclusion now? Apple's MP3 decoder on the 3G iPod is appalling. Being a bit of a cynic, I suspect it has been crippled or underdeveloped to push DRM-leaden formats.
Rockbox has come a long way since I tried it. It now seems as stable as the default firmware and I'd recommend it highly.
I'm afraid the grandparent post is the correct one. In the setting of anti-cancer therapy, most Phase I trials are carried out on patients with advanced disease and no further evidence-based treatment options.
Phase I trials are essentially "dose finding" studies. The drugs will have been tested on animals giving an indication of likely doses and toxicities in humans. Volunteers on a Phase I protocol will be exposed to serially increasing doses of a drug, until toxicity prevents the dose being escalated further (the maximum tolerated dose or MTD). After ascertaining the MTD, it becomes possible to plan a Phase II trial using the drug in a "safe" dosing band.
Phase I trials are not about identifying the side effects of a drug. They are not about finding out whether a drug works or not. They are about finding the MTD. In many cases you can get hints about toxicities and efficacy, but this information has a high probability of being misleading. Phase II and III trials address this issue.
In the setting of therapy for non-malignant disease (hypertension etc), the compounds tested in Phase I trials are expected to be relatively non-toxic. As such, they are tested in healthy volunteers for the reasons explained by the parent. Conversely, anti-cancer therapies are expected to be extremely toxic in the short, intermediate and long term. They are often associated with profound myelotoxicity and resultant sepsis, and can increase lifetime cancer risk. It is not sensible to expose healthy volunteers to these risks for the sake of a dose-finding experiment.
Using ODF is not an answer to your typesetting conundrum. Applying styles sensibly in a wordprocessor like OpenOffice Writer is a difficult skill. The format you store the document in has little influence on this.
I'd suggest using LyX to produce formal documents. It handles the typesetting for you, can manage bibliographies and create contents pages, references etc. The built in documentation will guide you through.
I was 6 when 3d Monster Maze came out. It was the first "1st person 3d" game I'd ever played. For the first 10 minutes I sat staring at the screen, randomly pressing buttons and trying to work out what the hell I was looking at. When Rex came running down the corridor towards me, however, it became clear...
I can confirm that pressing '7' harder made it more likely you would escape from the dinosaur's jaws: by making the RAM pack wobble and crashing the machine!
I played the game on a ZX81 emulator a few years ago. I got away from Rex every time. Maybe in another 20 years I'll be able to complete Quake 2?
"The situation could be improved somewhat by sshd tracking failed logins by IP address, and disallowing that IP address from logging in for a while."
The DenyHosts script mentioned above does exactly this, updating/etc/hosts.deny as appropriate. When I installed it, I set it as a cron job to run every 20 minutes. Looking at the logs I was astonished to see how many login attempts were made between scans. Now I run the script in --daemon mode which helps.
Slashdot Mirror
M-Saunders, please ignore the hate and thanks for your enlightened views on publishing. I was disappointed when you guys "forked" LinuxFormat but I have enjoyed what I have consumed of the new magazine and podcast. I hope your business model is sustainable and look forward to catching up with the issues I've missed.
I doubt there will be any "legitimate" uses of this particular technology.
However, it may be a model on which we can base future online retail. The existing model is utterly broken: I really don't want databases all over the world holding my username, password, credit card details and billing address waiting for the next SQL or SSL vulnerability to vomit the information into the hands of criminals. Nor do I want to trust, use or respect services like paypal.
View this as an iteration towards a more secure and decentralised system for legitimate commerce which keeps credit card and escrow companies out of the equation. Surely that is a good thing?
The line which tends to ruin my software is: /* Copyright (c) 2013 Neil McPhail */
(Sigh)
Far too much prior art in that little corner of the world, I'm afraid.
In my limited experience, MP3 decoding under Linux sounds more pleasing than under other operating systems on the same hardware. I have mentioned my experiences with Rockbox on a 3G iPod previously.
You are aware that the correct spelling is "fetus"? "Foetus" would be derived from the Latin for "stench" - which tends to be a post-partum phenomenon!
Moral objections aside, the pictured device looks reasonably similar to several dry powder inhaler devices (e.g. http://www.serevent.com/how_to_use_serevent.html) used for the treatment of asthma. Patients get confused about their medications and devices on a frequent basis, and it won't be long before someone tries to inhale a lump of lead.
First of all, I am by no means an audiophile. I have a 3rd generation iPod and a computer with onboard sound and 2 tinny speakers on either side of my monitor.
I quite like the standard iPod interface. I can find tracks quickly using the database and scrollwheel. I've had some issues transferring files with amarok, but gtkPod works well.
Most of my collection sounds fine on the iPod, but I was never very satisfied with orchestral music with a large dynamic range. I'd ripped some Arvo Part CDs to MP3 at increasingly high bitrates using lame. Despite that, the quiet bits (such as the closing bell harmonic at the end of "Cantus") sounded awful: some sort of bubbling distortion. It seemed fine playing through my PC, but I put that down to my dodgy hardware blotting out the bubbling noise. In the end, I resurrected my old windows partition and ripped to AAC in iTunes. It was a bit better. My conclusion at the time? AAC was a better music format than MP3.
Then I installed Rockbox. I didn't like the interface much, and preferred browsing a database of artists rather than reorganising my whole collection into folders. At the time, browsing on a 3G iPod was painful. It would take about 60 seconds to scroll through a moderate sized list of artists. (I submitted a patch to speed this up but it was rejected. In any case it works much better now.) Battery life was poor, and crashes were frequent. I considered wiping it from the machine, but then I listened to those quiet MP3 tracks again.
The difference was stunning.
Crystal clear and without distortion, they sounded as good as the original CDs (and at least as good as the AACs).
My conclusion now? Apple's MP3 decoder on the 3G iPod is appalling. Being a bit of a cynic, I suspect it has been crippled or underdeveloped to push DRM-leaden formats.
Rockbox has come a long way since I tried it. It now seems as stable as the default firmware and I'd recommend it highly.
...the breaking news on the BBC website suggests that someone was about to do that very thing: http://news.bbc.co.uk/1/hi/world/americas/5261456. stm. It may be another false alarm. Time will tell.
I'm afraid the grandparent post is the correct one. In the setting of anti-cancer therapy, most Phase I trials are carried out on patients with advanced disease and no further evidence-based treatment options.
Phase I trials are essentially "dose finding" studies. The drugs will have been tested on animals giving an indication of likely doses and toxicities in humans. Volunteers on a Phase I protocol will be exposed to serially increasing doses of a drug, until toxicity prevents the dose being escalated further (the maximum tolerated dose or MTD). After ascertaining the MTD, it becomes possible to plan a Phase II trial using the drug in a "safe" dosing band.
Phase I trials are not about identifying the side effects of a drug. They are not about finding out whether a drug works or not. They are about finding the MTD. In many cases you can get hints about toxicities and efficacy, but this information has a high probability of being misleading. Phase II and III trials address this issue.
In the setting of therapy for non-malignant disease (hypertension etc), the compounds tested in Phase I trials are expected to be relatively non-toxic. As such, they are tested in healthy volunteers for the reasons explained by the parent. Conversely, anti-cancer therapies are expected to be extremely toxic in the short, intermediate and long term. They are often associated with profound myelotoxicity and resultant sepsis, and can increase lifetime cancer risk. It is not sensible to expose healthy volunteers to these risks for the sake of a dose-finding experiment.
Using ODF is not an answer to your typesetting conundrum. Applying styles sensibly in a wordprocessor like OpenOffice Writer is a difficult skill. The format you store the document in has little influence on this.
I'd suggest using LyX to produce formal documents. It handles the typesetting for you, can manage bibliographies and create contents pages, references etc. The built in documentation will guide you through.
I was 6 when 3d Monster Maze came out. It was the first "1st person 3d" game I'd ever played. For the first 10 minutes I sat staring at the screen, randomly pressing buttons and trying to work out what the hell I was looking at. When Rex came running down the corridor towards me, however, it became clear...
I can confirm that pressing '7' harder made it more likely you would escape from the dinosaur's jaws: by making the RAM pack wobble and crashing the machine!
I played the game on a ZX81 emulator a few years ago. I got away from Rex every time. Maybe in another 20 years I'll be able to complete Quake 2?
I run firefox from a 32bit chroot, and Flash works fine with this. With a little tweaking, it runs transparently from the 64bit desktop.
"The situation could be improved somewhat by sshd tracking failed logins by IP address, and disallowing that IP address from logging in for a while."
/etc/hosts.deny as appropriate. When I installed it, I set it as a cron job to run every 20 minutes. Looking at the logs I was astonished to see how many login attempts were made between scans. Now I run the script in --daemon mode which helps.
The DenyHosts script mentioned above does exactly this, updating
Give it a try.
wine wdviewer.exe
Error! Newer windows version needed