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Domain: neurosciencenews.com
Stories and comments across the archive that link to neurosciencenews.com.
Stories · 8
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First Evidence For Higher State of Consciousness Found (neurosciencenews.com)
New submitter baalcat quotes a report from Neuroscience News: Neuroscientists observed a sustained increase in neural signal diversity -- a measure of the complexity of brain activity -- of people under the influence of psychedelic drugs, compared with when they were in a normal waking state. The diversity of brain signals provides a mathematical index of the level of consciousness. For example, people who are awake have been shown to have more diverse neural activity using this scale than those who are asleep. This, however, is the first study to show brain-signal diversity that is higher than baseline, that is higher than in someone who is simply "awake and aware." Previous studies have tended to focus on lowered states of consciousness, such as sleep, anesthesia, or the so-called "vegetative" state. For the study, Michael Schartner, Dr Adam Barrett and Professor Seth of the Sackler Center reanalyzed data that had previously been collected by Imperial College London and the University of Cardiff in which healthy volunteers were given one of three drugs known to induce a psychedelic state: psilocybin, ketamine and LSD. Using brain imaging technology, they measured the tiny magnetic fields produced in the brain and found that, across all three drugs, this measure of conscious level -- the neural signal diversity -- was reliably higher. The findings have been published in Scientific Reports. -
Brain Aging Gene Discovered (neurosciencenews.com)
New submitter baalcat quotes a report from Neuroscience News: Columbia University Medical Center (CUMC) researchers have discovered a common genetic variant that greatly impacts normal brain aging, starting at around age 65, and may modify the risk for neurodegenerative diseases. The findings could point toward a novel biomarker for the evaluation of anti-aging interventions and highlight potential new targets for the prevention or treatment of age-associated brain disorders such as Alzheimer's disease. In the current study, Drs. Abeliovich and Rhinn analyzed genetic data from autopsied human brain samples taken from 1,904 people without neurodegenerative disease. First, the researchers looked at the subjects' transcriptomes (the initial products of gene expression), compiling an average picture of the brain biology of people at a given age. Next, each person's transcriptome was compared to the average transcriptome of people at the same age, looking specifically at about 100 genes whose expression was found to increase or decrease with aging. From this comparison, the researchers derived a measure that they call differential aging: the difference between an individual's apparent (biological) age and his or her true (chronological) age. "This told us whether an individual's frontal cortex looked older or younger than expected," said Dr. Abeliovich. The researchers then searched the genome of each individual, looking for genetic variants that were associated with an increase in differential age. "One variant stood out: TMEM106B," said Dr. Rhinn. "It's very common. About one-third of people have two copies and another third have one copy." "TMEM106B begins to exert its effect once people reach age 65," said Dr. Abeliovich. "Until then, everybody's in the same boat, and then there's some yet-to-be-defined stress that kicks in. If you have two good copies of the gene, you respond well to that stress. If you have two bad copies, your brain ages quickly." The study has been published in the journal Cell Systems. -
New Study In Mice Shows That Increasing Serotonin Affects Motivation, But Only In Certain Circumstances (neurosciencenews.com)
New submitter baalcat quotes a report from Neuroscience News: A new study in mice shows that increasing serotonin, one of the major mediators of brain communication, affects motivation -- but only in certain circumstances. Furthermore, the study revealed that the short and long term effects of increased serotonin levels are opposed -- a completely unforeseen property of this neurotransmitter's functional system. A surprising behavioral effect, discovered in mice by neuroscientists at the Champalimaud Centre for the Unknown (CCU), in Lisbon, Portugal, strongly suggests that serotonin is involved in a biological mechanism which affects the animals' motivation. The study has now been published in the online open access journal eLife. Serotonin, one of the chemical "messengers," or neurotransmitters, in the brain, is used by neurons to communicate with each other. It plays an important role in the regulation of sleep, movement and other behaviors which are essential for animal survival. But for motivation in particular, it was unclear whether serotonin was involved. Using optogenetics, the team stimulated the release of serotonin from neurons in the raphe nuclei. They first induced "peaks" of serotonin by stimulating these neurons with pulses of light, lasting three seconds every ten seconds, over three five-minute time periods. The mice, placed in a box, were left free to explore their environment. In these conditions, their most frequent spontaneous behaviors are walking around, rearing, grooming, digging holes or keeping relatively still, but nevertheless alert. The only difference the scientists saw was that stimulation caused the mice to reduce their locomotive speed by about 50%. In general, this stimulation of serotonin-producing neurons did not affect other behaviors. The effect of these serotonin "peaks" on locomotion was almost instantaneous (speed reduction manifested one second after stimulation) and transient, with things going back to normal after five seconds. But during this short period of time, "the animals acted as if they weren't motivated," says Zach Mainen, who led the study. -
Personality Traits Are Linked To Differences In Brain Structure, Says Researchers (neurosciencenews.com)
New submitter baalcat quotes a report from Neuroscience News: Our personality may be shaped by how our brain works, but in fact the shape of our brain can itself provide surprising clues about how we behave -- and our risk of developing mental health disorders -- suggests a study published today. According to psychologists, the extraordinary variety of human personality can be broken down into the so-called 'Big Five' personality traits, namely neuroticism (how moody a person is), extraversion (how enthusiastic a person is), openness (how open-minded a person is), agreeableness (a measure of altruism), and conscientiousness (a measure of self-control). In a study published today in the journal Social Cognitive and Affective Neuroscience, an international team of researchers from the UK, US, and Italy have analyzed a brain imaging dataset from over 500 individuals that has been made publicly available by the Human Connectome Project, a major US initiative funded by the National Institutes of Health. In particular, the researchers looked at differences in the brain cortical anatomy (the structure of the outer layer of the brain) as indexed by three measures -- the thickness, area, and amount of folding in the cortex -- and how these measures related to the Big Five personality traits. The study has been published in the journal Social Cognitive and Affective Neuroscience. -
How the Human Brain Decides What Is Important and What's Not (neurosciencenews.com)
New submitter baalcat writes: A new study reported by Neuroscience News sheds light on how we learn to pay attention in order to make the most of our life experiences. From the report: "The Wizard of Oz told Dorothy to 'pay no attention to that man behind the curtain' in an effort to distract her, but a new Princeton University study sheds light on how people learn and make decisions in real-world situations. The findings could eventually contribute to improved teaching and learning and the treatment of mental and addiction disorders in which people's perspectives are dysfunctional or fractured. Participants in the study performed a multidimensional trial-and-error learning task, while researchers scanned their brains using functional magnetic resonance imaging (fMRI). The researchers found that selective attention is used to determine the value of different options. The results also showed that selective attention shapes what we learn when something unexpected happens. For example, if your pizza is better or worse than expected, you attribute the learning to whatever your attention was focused on and not to features you decided to ignore. Finally, the researchers found that what we learn through this process teaches us what to pay attention to, creating a feedback cycle -- we learn about what we attend to, and we attend to what we learned high values for. 'If we want to understand learning, we can't ignore the fact that learning is almost always done in a multidimensional 'cluttered' environment,' says senior author Yael Niv, an associate professor in psychology and the Princeton Neuroscience Institute. 'We want kids to listen to the teacher, but a lot is going on in the classroom -- there is so much to look at inside it and out the window. So, it's important to understand how exactly attention and learning interact and how they shape each other.'" The study has been published in the journal Neuron. -
Study Finds Link Between Profanity and Honesty (neurosciencenews.com)
A team of researchers from the Netherlands, the UK, the U.S. and Hong Kong report in the journal Social Psychological and Personality Science that people who use profanity are less likely to be associated with lying and deception. Neuroscience News reports: Profanity is obscene language which, in some social settings is considered inappropriate and unacceptable. It often refers to language that contains sexual references, blasphemy or other vulgar terms. It's usually related to the expression of emotions such as anger, frustration or surprise. But profanity can also be used to entertain and win over audiences. As dishonesty and profanity are both considered deviant they are often viewed as evidence of low moral standards. On the other hand, profanity can be positively associated with honesty. It is often used to express unfiltered feelings and sincerity. The researchers cite the example of President-elect Donald Trump who used swear words in some of his speeches while campaigning in last year's U.S. election and was considered, by some, to be more genuine than his rivals. The international team of researchers set out to gauge people's views about this sort of language in a series of questionnaires which included interactions with social media users. In the first questionnaire 276 participants were asked to list their most commonly used and favorite swear words. They were also asked to rate their reasons for using these words and then took part in a lie test to determine whether they were being truthful or simply responding in the way they thought was socially acceptable. Those who wrote down a higher number of curse words were less likely to be lying. A second survey involved collecting data from 75,000 Facebook users to measure their use of swear words in their online social interactions. The research found that those who used more profanity were also more likely to use language patterns that have been shown in previous research to be related to honesty, such as using pronouns like "I" and "me." -
Study Finds You Can Grow Brain Cells Through Exercise
phantomfive writes: Researchers have discovered that aerobic exercise may increase neurogenesis. Based on the results, rats that were put on a treadmill grew more brain cells than rats that didn't. Resistance training seemed to have no effect. This is significant, because the neuron reserve of the hippocampus can be increased, thus preconditions for learning for humans could be improved simply through aerobic exercise. -
Researchers Are Developing Cure for Human Pain (neurosciencenews.com)
transporter_ii writes: Scientists from University College London seem to have come up with a two-pronged treatment regimen they believe would help patients suffering from chronic pain. And in a strange irony, they did it by making it possible for mice – and one human – to feel pain when they previously couldn't. From the story: "To examine if opioids were important for painlessness, the researchers gave naloxone, an opioid blocker, to mice lacking Nav1.7 and found that they became able to feel pain. They then gave naloxone to a 39-year-old woman with the rare mutation and she felt pain for the first time in her life. 'After a decade of rather disappointing drug trials, we now have confirmation that Nav1.7 really is a key element in human pain,' says senior author Professor John Wood (UCL Medicine). 'The secret ingredient turned out to be good old-fashioned opioid peptides, and we have now filed a patent for combining low dose opioids with Nav1.7 blockers. This should replicate the painlessness experienced by people with rare mutations, and we have already successfully tested this approach in unmodified mice.'"