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Japan to Allow Human-Nonhuman Mixed Cloning

Sara Chan writes: "Japan has decided to allow combined human-animal embryos to be produced through cloning, which could result in mixed-species creatures. The intended purpose is to permit transplant organs to be produced in specially-bred animals. The original story is in a Japanese newspaper, but you can get an English summary here."

36 of 659 comments (clear)

  1. My first reaction by imrdkl · · Score: 5, Funny

    We got too many trolls already.

  2. Does this mean.. by witz · · Score: 4, Funny

    That soon we'll be seeing Spiderman, Wolverine and The Thing roaming the streets?
    This just smells bad.

  3. It has to be said... by Johnso · · Score: 5, Funny

    Bart: "How would I go about creating a half-man, half-monkey-type creature?" Ms. Krabapple: "I'm sorry, that would be playing God..." Bart: "God schmod. I want my monkey man!"

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    1. Re:It has to be said... by mmaddox · · Score: 5, Funny

      Two words:
      vagina, sheep.

      Hellooooooooo, Dolly!

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  4. They Need to by hooded1 · · Score: 5, Funny

    How else are they gunna make all that anime into live cinema. You need animal-human hybrids.

    --
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  5. Gigantic moral issues by PoiBoy · · Score: 5, Insightful
    Whether this is scientifically feasible is a trivial question compared to the ethics of such an endeavor. If one believes that humans are different from animals in that we contain a spirit and an awareness of God, then should a cross between a human and an animal be considered an animal or a spiritual being? Moreover, as an advanced society, do we really wish to combine our gene pool with that of an animal?

    Is this a step forward for mankind, or a step backward?

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    1. Re:Gigantic moral issues by Chasuk · · Score: 5, Insightful
      If one believes that humans are different from animals in that we contain a spirit and an awareness of God,

      Religious belief doesn't deserve a special category, and should not be confused with ethics. I can think of several ethical objections to this type of research, and none of them involve a belief in God(s) or ensoulment.

      Moreover, as an advanced society, do we really wish to combine our gene pool with that of an animal?

      As we are animals, this question could almost be considered facetious, but I doubt that was your intent. The question should perhaps be:

      As a society, advanced or otherwise, should we engage in research which mixes human and non-human gene pools?

      My ethics ascribe nothing special to the state of being human (or nothing which would be pertinent to this debate), so the question, for me, becomes:

      Should we engage in research which involves the mixing of interspecies gene pools?

      Yes, we should, or at least we should not restrict ourselves from such research without solid, logical reasons. This reasons may also be ethical reasons, as logic and ethics are not necessarily mutually exclusive.

    2. Re:Gigantic moral issues by Bi()hazard · · Score: 4, Troll
      Consider for a moment that the chimpanzee shares more than 99% of its DNA with humans. Your first reaction may be, "Phew, I suppose adding human DNA to animal embryos won't have such a drastic effect overall." However, that would be missing the point: miniscule changes in DNA are capable of creating drastic and unpredictable mutations in the resulting organism. Having interned in a biotech lab, I can tell you scientists are well aware of this. Current bioengineered organisms are created using the most conservative methods available. For example, the GE corn is modified only with a single well known and fully documented gene at a time. That's why we don't have true designer foods yet-scientists know that they can only control simple processes they've observed occurring naturally. Anything more would be completely unpredictable-a drastically mutated corn could even be poisonous, due to extensions of the same biological processes they prize as natural pesticides now.

      We can only hope the scientists in Japan are as cautious. Adding carefully selected human genes to replace closely related animal counterparts could result in a source of transplantable organs, and a huge supply of failed test subjects. However, reckless experimentation could create monsters. We wouldn't see catgirls, we'd see the sort of deformed, unrecognizable things I'm sure a few of the trolls are going to link to. (Don't worry, I'm going to spare you the sources for all of these) A pig with one and a half heads, a calf with organs on the outside of its body, and retarded mice with skulls too thin to protect their brains from being damaged by wind have all been documented in nature, but they are extrememely rare and immediately culled by natural selection. A laboratory environment makes these disasters very likely, and allows for propagation of their genetic lines.

      Even if we put aside the moral implications of creating and sustaining these creatures, there are practical dangers. Such organisms would likely possess immune systems too weak to defend against the sort of pathogens normal organisms never notice. Look at what happens to late stage AIDS patients-they often contract rare diseases doctors have never seen before. They fall prey to bacteria assumed to be harmless, or fungal infections that have never been observed growing in living things before. These diseases could use a large supply of debilitated mutants as incubators to develop until natural selection produces strains capable of surviving in healthy organisms. We could see the emergence of a virus as unexpected and deadly as ebola. This is only one of the dangers posed by genetic experimentation. However, the potential benefits are too good to resist. There is no choice but to experiment, and we can only hope the experiments are done responsibly.

    3. Re:Gigantic moral issues by aozilla · · Score: 5, Insightful

      Whether this is scientifically feasible is a trivial question compared to the ethics of such an endeavor. If one believes that humans are different from animals in that we contain a spirit and an awareness of God, then should a cross between a human and an animal be considered an animal or a spiritual being?

      Sounds like a good way to find out. Create one and ask it.

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  6. Differences in American and Japanese cultures by bigdreamer · · Score: 4, Insightful

    I find it fascinating that in America, people freak out when they hear about human cells being cloned. But in Japan, they're discussing mixing animal cells with human cells. I wonder how Americans would react to such a combination? I don't think the Religious Right would handle this issue very well.

    1. Re:Differences in American and Japanese cultures by Knunov · · Score: 5, Interesting

      Which is exactly why we should get our legislature off its stupid ass and pound some sense into them. If we don't do it, someone else will, and profit greatly from it. We should be leading the way in genetic engineering technology, not following.

      The next worldwide industrial boom will be Bioengineering. If people are willing to pay $1000 for a CPU upgrade, imagine what they would pay for blue eyes. Or broad shoulders. Or a high IQ. Or thick hair that will never fall out. Or straight teeth. The list goes on and on.

      We need to be positioned well in this industry.

      Knunov

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    2. Re:Differences in American and Japanese cultures by Velox_SwiftFox · · Score: 4, Interesting
      To fix a defect is one thing, but to create a race of super-humans is another.

      So those who make up the left hand edge of the IQ spectrum, or are below average in strength, and maybe other arbitrary categories should live with their disadvantages - but we raise the bar for "normal" 20/20 eyesight, immunity against diseases, and other categories?

      What do you think happens when we eliminate those on the low side of the average, we all become above average?

      Besides, who died and made you God?

  7. Wow, that's a hell of a step. by autopr0n · · Score: 5, Interesting

    I find this disturbing. And I'm one of the people who can't understand at all why people are bothered by the idea of 'regular' cloning; I mean it really makes no sense to me. But allowing chimeras to be created? That's just something I never thought anyone would do.

    Or am I misunderstanding what's actually going on. Are they simply doing things like creating human hearts in monkeys and the like? As with the tobacco plants we rigged up to create hemoglobin or insulin or whatever? I don't really see a problem with that, I guess.

    I do see that they plan to ban 'regular' cloning, so I guess they don't want the whole 'mad scientist' thing going on. If it could really be used to ultimately cure sick people and make people more healthy then really (imo) it would be unethical to disallow it.

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    1. Re:Wow, that's a hell of a step. by MulluskO · · Score: 3, Insightful

      Really.

      I'm just worried that all this new life-prolonging technology will belong the wealthy alone. As it is now, it is already difficult enough to transcend one's class. What will happen when the wealthy really are smarter than average folk? I worry that children born without the technology won't be able to compete.

      Assuming they maintain their stand, does this mean Christians and other moral types will one day live shorter lives and be less intelligent than people without such scruples?

      Just a thought.

      --

      Too busy staying alive... ~ R.A.
  8. Cat Girls by Apreche · · Score: 5, Interesting

    My roomate has a thing for cat-girls and he's pretty excited right now. I however don't like this idea one bit. I mean most wild animals can kick a human's ass. Imagine a lion/man or and elephant/man. Smart and powerful. They'll take over. Just like exo squad, if you've ever seen it.

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  9. Re:Mother In Laws?? by rjamestaylor · · Score: 3, Funny
    the prospect of growing pigs with fully compatible organs for humans could be VERY usefull indeed.

    *grunt* Yes, *snort* I agree *squeal*

    Pig Organs: squeal when you say that.

    --
    -- @rjamestaylor on Ello
  10. Aren't they doing this already? by shanek · · Score: 5, Interesting

    IANAGeneticist, but my understanding is that insulin for diabetics is produced by injecting human genes into e. coli bacteria. So, aren't we already making human-nonhuman (in this case, bacteria) hybrids?

    1. Re:Aren't they doing this already? by dondelelcaro · · Score: 5, Informative

      Yes. Typically it's not done with human genes, as it's easier to get non-human cells and non-human genes, but alot of experiments involve rescueing null mutants (where a protein of importance has been disabled in the mutant) with exogenous or xenobiotic protein or DNA. This is typically used as a demonstration of the ability of a specific model to be used as an abstraction of the equivalent human system (or higher organism). [I haven't done this work in my lab, as we don't deal with whole cells, but there are researchers around me who have...]

      In the near future, the most likely thing that is going to happen is the cloning of pigs with exact copies of human immunospecific proteins for the human who needs an organ transplant. Then the donor animal will have an exact match immunologically with the human patient, and the human patient will not have to be subjected to an arduous immunosuppressent regimin. So you'll have a chimeric pig expressing the patient's immunological markers, and won't have to wait for a compatible human donor to die or sign consent forms.

      Beyond that is mere conjecture, but I don't expect we'll be seeing anything resembling the mythical chimeras of olde, as a work like that would involve a gargantuan effort and (in my mind at least) would have little to no scientific validity and usefullness.

      --
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  11. Xenotransplantation already happening in US and UK by btb · · Score: 3, Informative

    I think this is the scariest frontline documentary I've ever seen:

    Organ Farm

  12. Re:Terrible idea by tps12 · · Score: 3, Offtopic
    The people who promote these schemes in the name of science should not be allowed to claim (as they usually do) that opposition is due to ignorance and superstition.

    Should not be allowed to? Don't you think it is remotely possible that opposition to a given technology may be based on ignorance and superstition? A great example of this might be your mentioning Three Mile Island. You may not be aware of this, but Three Mile Island was not a disaster. The safety systems worked as designed, and very little radiation was leaked. The Chernobyl accident has been shown to have been caused by incompetency on the parts of the plant operators. This is far from any "intrinsic" danger in nuclear power. In fact, nuclear power is economical. It is also the most environmentally clean power source in places where space limitations prevent things like hydroelectric and wind power. Further, the irrational fear of nuclear-anything means that most Americans miss out on some important technologies: for example, all of the E coli outbreaks of the last decade could have been prevented through irradiation. Restaurants could serve medium rare burgers again.

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  13. Human to human transplants are taboo in Japan. by alphaseven · · Score: 5, Interesting
    It doesn't surprise me that Japan would be so eager to use animals to supply organs, organ transplants from humans was illegal until 1997.

    Japan's first transplant procedure in 1968 resulted with the doctor being charged with murder because it wasn't clear if the donor was brain dead.

    Aparently the taboo has something to do with Japan's Shinto and Buddhist beliefs. Here's a link: Japan Legalized Organ Transplants from Brain-dead.

  14. Bad reporting by cosmicaug · · Score: 5, Interesting

    Superficial reading of the Ananova article would give one the impression that they are talking about a partly human chimera (it is hard to read "combined human-animal embryos" any other way); which would be a horribly unethical monstrosity.

    What they're undoubtedly talking about (though I can't verify it since I can't read Japanese) are transgenic animals which express human proteins which is nothing new and posses no real ethical challenges (other than those involving the safety issues of xenotransplantation such as the real posibility for introducing various pathogens into the human population).

  15. Re:Terrible idea by Velox_SwiftFox · · Score: 3, Insightful
    Transgenic implants are a terrible idea. The most credible theory on the origin of HIV is that it jumped species after a bunch of vaccinations with a trial vaccine that had been incubated in monkeys. The first known cases of AIDS turn out to map pretty well to the trial sites.

    Apocryphal.

    HIV is a chimpanzee virus, well established in wild populations, and one which apparently causes them little trouble, Well adaped to its wild hosts, it spreads among them easily while maintaining a balance between surviving in their bodies and not damaging the host which are its natural home; this is why chimpanzees experimentally infected with HIV do not develop AIDS.

    The most credible theory for transfer of the virus to humans involves a person hunting chimpanzees for food who had a cut or sore which came in contact with the blood of an infected chimp they killed.

    Of course, this does nevertheless support your conclusion.

  16. Limited change in cloning regulations by DaoudaW · · Score: 3, Insightful

    Here is the English version of the same newspaper article.

    From the article:
    The hope is that human organs could be grown in other species and later transplanted into humans.

    However, some said the decision opens the door to the risk of creating mixed-species organs, or possibly even creatures.


    The article is about the publication of guidelines on research into human cloning. While allowing the cloning of aggregate embryos, the Wednesday announcement bars all other embryo cloning, citing insufficient debate about the ramifications of such cloning.

    The research hasn't even begun yet. Maybe its possible to grow aggregate embryos, maybe its not. Maybe it will result in mixed-species, maybe not.

  17. Re:Terrible idea by Rutulian · · Score: 3, Troll

    What the hell are you talking about? Oh wait, you don't know either.

    Developing and testing vaccinations in animals is and has been a very common practice in medical research. It also has absolutely nothing to do with cloning.

    All nuclear reactors in the US were built with negative temperature coefficients. They are the safest reactor designs in the world. Chernobyl had a positive temperature coeffecient, this is true, but the meltdown was due to operator error, not poor reactor design. And the US reactors, even with their failsafe designs are not completely immune to accidents.

    It is also important to note that it is cheaper to build reactors with positive temperature coefficients. Reactors are built this way because of politics, not because scientists don't know what they are doing. BTW, there was plenty of anti-nuke propaganda in the 50's and 60's.

    As for the bit about geneticists not knowing what they are doing... how do you think science works? Pop culture tends to lead people to believe that scientists sit around blackboards with nonsense mathematical equations surrounding them until they come to some epiphany and boom, we have a warp drive. That is not how science works people! Science is a lot of experimentation, trial-and-error, and guesswork. A lot of things are discovered by accident. Mapping of the human genome doesn't suddenly mean that we know everything about human genetics. There is a lot of stuff we don't know, and we are only going to be able to further our knowledge if we experiment and try new things.

    You say that opposition should not be allowed to be disregarded as ignorance and superstition. Well, all I have to say is that maybe the opposition should come up with some intelligent and coherent arguments. It is easy to be disregarded as reactionary if you don't sound like you know what you are talking about.

  18. Whatever created us wants us to do this by HanzoSan · · Score: 3, Interesting


    You see, Whatever created us gave us the ability to create life, and gave us the abilities we have by evolving us.

    So anyone here who believes in god but isnt blinded by the bibles description of god, can understand that.

    If we program a computer to do something the computer does what its created to do, whatever created us obviously created us to create and to destroy.

    Thats basically our job.I belive theres supposed to be a balance in creation and destruction but right now we destroy more than we create due to greed.

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  19. Nekomimi Complex... by Kenshin · · Score: 3, Interesting

    Oh hell... now this is going to give all those greasy Otaku one more thing to fantacize about: real-life catgirls.

    (Catgirls, a.k.a. "Nekomimi", are a popular fetish amongst Otaku. If you hadn't noticed, of course.)

    --

    Does it make you happy you're so strange?

  20. Re:Repeat after me... by bwalling · · Score: 3, Interesting

    "I tell you the truth, this generation will certainly not pass away until all these things [end of the world, etc.] have happened." - Jesus, Luke 21:32, c. 2000 YEARS AGO

    This is one of the hardest verses in the gospels to interpret. Various views exist for what generation means.

    Some take it as meaning "race" and thus as an assurance that the Jewish race (nation) will not pass away. But it is very questionable that the Greek term geneav (genea) can have this meaning.

    Two other options are possible:

    Generation might mean "this type of generation" and refer to the generation of wicked humanity. Then the point is that humanity will not perish, because God will redeem it.

    Or generation may refer to "the generation that sees the signs of the end" (vv. 25-26), who will also see the end itself. In other words, once the movement to the return of Christ starts, all the events connected with it happen very quickly, in rapid succession.

    All of the above commentary was taken from Bible.org.

  21. Re:Terrible idea by Zeinfeld · · Score: 5, Informative
    A great example of this might be your mentioning Three Mile Island. You may not be aware of this, but Three Mile Island was not a disaster.

    I have a PhD in Nuclear physics and I am a chartered engineer.

    Three mile island came within seconds of a melt down. It demonstrates conclusively that the nuclear industry was nowhere near as safe as it had claimed. I don't accept the spin from the PR flaks of the nuclear industry that we have to trust them until they kill 5,000 people for real.

    If the dice had rolled only slightly differently, the operators at Cherobyl might have succeeded in shutting down the reactor, had the three mile island operators not been lucky the reactor might have gone. The design flaw at Chernobyl was one that could not have been predicted with the design tools available in the USSR or the US when the plants were built. It was an area of positive feedback in the control regime that could only be detected using 3d modelling. That did not become possible until the introduction of the first CRAY series - and even then it took quite a long time for the simulation software to appear.

    Moreover, the placement of any potentially hazardous industrial complex on three mile island should never have been allowed, let alone a nuclear plant. The bridges to the island simply cannot support an evacuation in an acceptable time. Building a nuclear plant that close to manhattan was gross negligence.

    I used the term 'intrinsicaly safe' in a technical sense, no light water design is intrinsically safe, there is a critical mass that is damped down to prevent runnaway. If the safety systems fail and do not fail safe as planned you get a heck of a bang.

    The Canadian CANDU heavy water system is intrinsically safe. It employs heavy water as the moderator, if there is a failure of the pressure vessel etc, etc the glass containers shatter and the moderator drains away shutting down the reaction. In pebble bed each fuel element is encapsulated in a moderator shell, again no critical mass, no chance of a big bang.

    Do not assume that because there are some ignorant critics of nuclear power that all critics are ignorant. If the nuclear industry had not told so many blatant and deliberate lies in the 60s and 70s there might have been fewer ignorant critics today.

    Jim Cramer (The Street.com) has a rule - financial irregularities means sell. Basically when ypou have been lied to by the management of a company it is time to take the exit door (e.g. Enron). In the UK the Thatcher govt. discovered during their privatization of the electricity industry that far from being low cost, the nuclear stations were barely economic on an operating basis - there was no possibility of paying of the original capital costs or eventual decommissioning costs. As a result a government that started ideologically committed to nuclear power discovered that the books had been cooked and they could not sell the plants to anyone at any price.

    Further, the irrational fear of nuclear-anything means that most Americans miss out on some important technologies: for example, all of the E coli outbreaks of the last decade could have been prevented through irradiation.

    Irradiation is banned for good reason. If you irradiate food you kill off the bugs but not the toxins they create. If technology allows food that is unfit for human consumption to be passed of as fresh you can be 100% sure that it will happen in the US.

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  22. Re:won't fly in the USA by Yorrike · · Score: 5, Insightful
    All I can say is, FINALLY!

    A country has the guts (and yes, I'm not surprised it's Japan), to go about ignoring the stupid religious morals set by the US in regard to cloning animals/humans with the specific end of using them for organ harvesting.

    I'm one step closer to being able to have a genetically perfect pancreas transplant, which means I'm a step closer to being able cease these stupid insulin injections 4-8 times a day.

    --

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  23. Yeh, and by autopr0n · · Score: 3, Informative

    here's a link saying why that's crap. Basically, the vaccine makers never used chimps in their research (there's no chimp DNA in the results). There is no SIV in the results.

    The most telling line is this one though: Hooper argues that that theory lacks scientific proof and that no one has as yet produced scientific evidence to contradict his theory

    In other words, "no one can disprove this, so it must be true!", or, in other words "It's total crap!". No legitimate scientist would ever say that, Its the same kind of crap spouted by people who don't believe in evolution or global warming.

    --
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  24. in related news by RestiffBard · · Score: 3, Funny

    Japan today voted to change the official name of the island to "The Island of Dr. Moreau"

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  25. Human-animal work has been going on for years by primenerd · · Score: 3, Informative

    In genetics we use somatic cell hybridization for genetic analysis and chromosome mapping. It is the process of fusing human mouse cells and culturing them in a lab.
    Transgenic animals have already been created in many countries. Pigs with human genes to prevent rejection of heart valves come to mind.
    In my opinion, the article was poorly translated and the initial post was misleading. People are having images of werewolves and such. At this point in time it would be impossible to successfully create a hybrid of this type. In 10 or 20 years this might actually be a problem. Until then, it's science fiction.

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  26. Please don't mix cells and animals! by Exmet+Paff+Daxx · · Score: 4, Interesting

    Human cloning? Far from being the "Attack of the Clones", nothing is more misunderstood than medicinal human cloning. Please, don't confuse the goals of The Human Cloning Foundation, the federation of misanthropes bent on finding a country willing to host their young Frankenstein adventures, with Medicinal Human Cloning.

    The idea behind Medicinal Human Cloning (MHC) is to clone human cells at the cellular level, before cell differentiation. Cell differentiation occurs 2 weeks into the life of an embryo, when all the cells in the embryo stop being homogenous and, all at once, establish their own identities. Some become hand cells, some feet cells, some brain cells, some blood cells. This "magic" event is the point at which human life begins. MHC is the process of cloning human cells before this event.

    The point of being able to harvest unlimited quantities of undifferentiated human cells is that these cells can become any cell in the body; they are "undecided", yet genetically matched to the recipient. The applications here are as numerous as you can imagine: tissue replacement, skin replacement for burn victims, manufactured organs custom-matched to the recipient. This is the promise we are debating; the lives of millions who could be saved by this procedure, from burn victims to heart attack victims.

    This advance promises to revolutionize medicine. Not just technically, but from a societal perspective as well. If we understand anything about MHC, it is that it will be prohibitively expensive to apply to an entire population. An order of magnitude costlier than even heart transplantation, we are dealing with sums of millions of dollars per regenerated organ. And unlike transplantation, this technique will be able to prolong the life of anyone, indefinitely. As a society, we will soon be in the position of deciding the lifespan(s) of each of our citizens. Not because we control death; not euthenasia, but because we control life.

    We've already seen this paradigm emerge with the "list" for heart transplants. The pathetic attempt at a "meritocracy" for deciding who receives a new heart has been a total failure, as evidenced by the case of David Crosby. The system is weighted in favor of the rich, against the poor. Will this paradigm dominate the field of Medicinal Human Cloning? Will only the rich live forever? Will money become the force of life? Not if we can help it. We will need to act decisively as events are set in motion.

    We must establish a true meritocracy for the Immortality Revolution ushered in by advances in Medicinal Human Cloning. Like the Slashdot Moderation system, we could create a system of random "Moderators", if you will, who are picked secretly and randomly and given the ability to tag their fellow citizens as deserving or undeserving of the scarce asset of Organ Regeneration, financed by the state. You could rate your neighbor (-1 Stupid) for abusing his spouse, or your coworker (+1 Insightful) for fixing your printer connection. Those with the highest scores would receive the greatest medical benefit: Immortality.

    Imagine a world where we never lost an Einstein, never killed a Bohr. Where great leaders like George Bush could advise us forever; where people like Noam Chomsky were but a temporary nuisance. This is the promise of cloning: not reproducing the husks of people but giving the gift of life to the greatest among us.

    We must act swiftly when the time comes.

    --
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  27. The most dangerous animal by hey! · · Score: 5, Interesting

    I don't know. This idea that men are the wimps of the animal world is a bit overdone, I think. Pre-human North America was chock full of huge critters that would make the Serengeti look like a suburban park. Then people got here and wiped 'em all out in a geologic wink of an eye. Let's face it -- even armed with weapons made from sticks and flint chips man is the most dangerous animal on Earth.

    Of course it's the giant brain, opposble thumb and social cooperation that makes man really formidable, but it's hard to imagine a chimera that takes full advantage of human and, say lion capabilities. Can you have the lion's formidable claws and still keep dexterity? Or its powerful killing jaws and a mouth capable of articulating language?

    Even some characteristics that at first seem like liabilities aren't. Our lack fur, scales, and general light build for example. On one hand, it leaves us relatively defenseless. On the other hand, it makes us offensively more formidable. A well trained runner can chase most game animals until they collapse of heat prostration.

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  28. Japan Rules by bmajik · · Score: 3, Informative

    Genetically Engineered...

    Bansai Anime Pleasure Drones.

    I bet there's some species of animal where the female copulates and then leaves immediately. (without killing the mate, if you please)

    Once again, I'm looking to the porn industry to lead the way into this new technological realm.

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