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Digital Microfluidics

herrd0kt0r writes "A brilliant team of researches at Duke University have been working on digital microfluidics, with potential applications in biotech labs-on-a-chip, optical routers/switches, wavelength division multiplexers and the like. Essentially, this team has developed a solid state device capable of moving very small drops of fluid over very small distances with very little power. From their website they remark that "[m]icrofluidic processing is performed on unit-sized packets of fluid which are transported, stored, mixed, reacted, or analyzed in a discrete manner using a standard set of basic instructions." Their site includes eight .mpgs demonstrating their microfluidics tech in real-time. Be sure to take a gander at this video showing programmable flow of droplets as well as this one showing droplet splitting and formation."

96 comments

  1. WOW by dalurka · · Score: 0

    When I thougth I have heard everything

    --
    If it was hard to write it should be hard to read.
    1. Re:WOW by scalis · · Score: 0

      But surely you have seen this before... It's nothing new, I saw it all on DVD coz' the video store had a complete motion picture about this. I think it was called "Flubber" and starred Robin Williams. Although they seemed to be a bit more advanced than this project.

      ** OMG ** They have invented Flubber!!

      --

      True ravers don't need drugs
  2. Hmmm by Weffs11 · · Score: 1

    Interesting concept, but what uses?

    1. Re:Hmmm by Anonymous Coward · · Score: 0

      Did you even read the article or just look at the pretty videos??

    2. Re:Hmmm by mikewas · · Score: 4, Insightful

      What good is the electric light. You need a gas light to see the dim glow!

      Cars! You need a mechanic to ride along to keep it running. Just toys for rich playboys.

      ATT gave up the right to enter the computer business in exchange for keeping the monopoly on phone service for a few more years. What possible use could there be for C & UNIX outside of a few research instituions?

      IBM let the PC industry slip through their fingers because they viewed them as toys, nothing there that should distract them from their mainframe business.

      I doubt that anybody will really know the answer to your question, no matter what it's asked about, except in hindsight.

      --

      "Glory is fleeting, but obscurity is forever." --Napoleon Bonaparte
    3. Re:Hmmm by eyepeepackets · · Score: 3, Insightful

      Some applications might be:

      - chemical analyzers for bonb detection, drug detection, polutant detection, purity analysis, etc.

      - hydraulic applications such as you see in full scale in real life (a nano bulldozer, heh)

      - steam engine applications maybe? Turn that AMD heat pig of yours into a small, closed-system electical generator

      Anyway, I'm sure there are many more potential applications, but you get the idea.

      --
      Everything in the Universe sucks: It's the law!
    4. Re:Hmmm by Mercaptan · · Score: 5, Insightful

      W00t! No more pipetting.

      This has some very useful applications. I work in a genetics lab doing a lot of molecular biology work with primate genomes.

      It's still a needle in a haystack issue. We deal with nanograms of DNA suspended in microliters of liquids. The microliter is pretty much the limit of what we can manually manipulate, anything less and it gets damn expensive. As it is, there's a lot of suspending, centrifuging, and shaking going on in the lab; a lot of work and time to manipulate a very small amount of material.

      If I could just load my sample onto a microfluidics device and 'manipulate' everything by executing commands, life would be much easier. You'd probably avoid a lot of loss and contamination issues with this type of technology. The amounts of expensive reagents used could be reduced significantly. It'd be like a tiny tiny molecular biology lab in a box.

      Those are just some of the research possiblities. I'm sure you could have a 'farm' of these microfluidics devices to do production level work.

      --
      -- "Sucks to your ass-mar"
    5. Re:Hmmm by VValdo · · Score: 2

      Let me be the first to predict that this technology will be used to manufacture the most precision-shaken or stirred martinis science can create.

      --
      -------------------
      This is my SIG. There are many like it, but this one is mine.
    6. Re:Hmmm by Anonymous Coward · · Score: 0

      Realtime mixing of aromatic substances for remote smell playback. And undoubtly, the pr0n industry will offer the first applications. Yuk.

    7. Re:Hmmm by Anonymous Coward · · Score: 0

      I read the article and am still asking the same question.

    8. Re:Hmmm by slickwillie · · Score: 5, Funny

      Maybe it could be used to write your name in yellow on a single snowflake.

    9. Re:Hmmm by Anonymous Coward · · Score: 0

      Speaking of steam engines...
      That reminds me of a Tesla patent of a system where one turbine was powered by combustion, and another powered by water (steam) heated by the excess heat of combustion. Or something to that effect. It seemed more useful than just dissipating the heat with a fan, heat sink, or whatever.

      I wonder, how much useful energy could a small steam engine attached to an AMD yield? 10% of the input? 50%? (Wild-ass-guess.)

    10. Re:Hmmm by Anonymous Coward · · Score: 0

      YOU = FAILURE :D

    11. Re:Hmmm by packeteer · · Score: 1

      you could have tanks of different chemicals that are all touched by this device... the device could mix the chemials together in a precise way and output it into another tank... basically it wouyld take the work out of mixing chemicals making production easier/cheaper

      --
      unzip; strip; touch; finger; mount; fsck; more; yes; unmount; sleep
    12. Re:Hmmm by Anonymous Coward · · Score: 0

      I'm sure you could have a 'farm' of these microfluidics devices to do production level work.


      I believe the correct phrasing would be:

      Imagine a beowulf cluster of these...

    13. Re:Hmmm by Anonymous Coward · · Score: 0

      YOU: SUCK MY BALLS

    14. Re:Hmmm by marciot · · Score: 1
      Well, imagine a PCI card with a handful of fragrances and one of those chips for mixing...

      Anyone care for a NoseBlaster card?

      Marcio Luis Teixeira

    15. Re:Hmmm by Anonymous Coward · · Score: 0

      The Application I think that they are doing the research under grant for (DARPA) is to detect extremely small concentrations of say the nerve agent VX or a bio agent since we would usually take a sample and then mix it with a compound that will change color if the agent is present this would be many times more sensitive.

      hope that helps
      Xanadu

    16. Re:Hmmm by Anonymous Coward · · Score: 0

      Ah, but you could crash the entire system by simply asking for a "Shaken AND Stirred" martini.

      The joys of computing.

  3. What to drink? by rcs2 · · Score: 2, Funny

    Vodka Martini.... microprocessed, not stirred.

    --
    This is not a signature.
    1. Re:What to drink? by MADCOWbeserk · · Score: 1

      Stole my joke... Nuts

  4. fancy kitchen device by Anonymous Coward · · Score: 0

    As seen on tv...

  5. Yoyager? by NetNinja · · Score: 0

    Beam me over.

  6. Down already... by Duncan3 · · Score: 2, Funny

    Sure, direct links to .mpg files on slashdot, what the heck were they thinking?

    --
    - Adam L. Beberg - The Cosm Project - http://www.mithral.com/
  7. Now I've seen it all by JPriest · · Score: 1

    [m]icrofluidic processing? I was going to enroll in the "vapoware 101" class that Duke was offering but for some reason the web site is down.

    --
    Saying Java is nice because it works on all OS's is like saying that anal sex is nice because it works on all genders.
    1. Re:Now I've seen it all by Anonymous Coward · · Score: 0

      I work at the University of Illinois and there are a bunch of people working on the subject here. What exactly makes microfluidics vaporware?

      Sincerely,
      Kevin Christie
      crispiewm@hotmail.com

  8. pardon my ignorance by faeryman · · Score: 3, Funny

    Thus a wide range of established chemistries and protocols can be seamlessly transferred to a nanoliter droplet format.

    Can it be used for TCP/IP? If so I would like to electrowet those mpegs to my computer. Stupid /. effect..

    --


    ,
    faeryman
    1. Re:pardon my ignorance by SoupIsGoodFood_42 · · Score: 2
      Stupid /. effect..

      Shouldn't that be the splashdot effect?

  9. Mirrored Website by Anonymous Coward · · Score: 0

    the webpage got slashdotted, but a mirror can be found at:

    http://www.duke.edu/~pyp/microfluidics/

  10. One more application by KPU · · Score: 0, Offtopic

    Although we're probably not going to see microfludic processors any time soon, printers are all about moving small quantities of ink.

  11. Now I understand why my transfer slowed down... by Critical_ · · Score: 1

    You guys are hammering the duke site and I was trying to mirror their stuff for a project I am working on. Very neat stuff, hope to have my mirror up soon.

  12. go outside by Anonymous Coward · · Score: 0

    Quit reading slashdot. It's saturday. Ever wonder why the ladies aren't exactly flocking to you? It's because you're the kind of guy that posts to slashdot on saturday.

    Why not hop up off your fat, sweaty ass and see what's going on outdoors? Go to a bar or something. Meet women. Live a little, you fucking loser.

    1. Re:go outside by mikewas · · Score: 1
      Don't need no bars anymore. Got a wife that /.s too!

      Eat your heart out!

      --

      "Glory is fleeting, but obscurity is forever." --Napoleon Bonaparte
    2. Re:go outside by ProofOfConcept · · Score: 1

      Oh, the irony.

    3. Re:go outside by Anonymous Coward · · Score: 0

      you appear to be reading slashdot... and i BET with an attitude like yours your single or it doesnt last long if you arent

    4. Re:go outside by eviljolly · · Score: 1

      I can't figure out whether to call him a hypocrit or a moron....I guess either works...

    5. Re:go outside by Anonymous Coward · · Score: 0

      You are also posting on slashdot.
      so all those go for you too.
      but you already knew that.

    6. Re:go outside by mtec · · Score: 1

      Lucky bastard.

      --
      Cake or Death? Cake Please!
  13. this sounds cool by Anonymous Coward · · Score: 0

    well fuck me in the ass, this sounds cool

    1. Re:this sounds cool by Anonymous Coward · · Score: 0

      check out the videos too, they look pretty sweet.

  14. Mirror... by Huge+Pi+Removal · · Score: 4, Informative

    Programmable flow

    Droplet splitting and formation

    HTH.

    Oliver.

    (I reserve the right to take them down if you kill my web server too :) )

    --
    - Oliver

    The right to bear arms is only slightly less stupid than the right to arm bears...
    1. Re:Mirror... by Saint+Aardvark · · Score: 3, Informative
      Share and enjoy:

      2d_flow.mpg
      form_rotate_3.mpg

    2. Re:Mirror... by Anonymous Coward · · Score: 0

      I can't believe that domain was not taken.

    3. Re:Mirror... by Anonymous Coward · · Score: 0

      That rotation vid is damn cool.

    4. Re:Mirror... by gargle · · Score: 2

      http://www.solutionsgo.com/nanolytics/technology.a sp

    5. Re:Mirror... by hplasm · · Score: 1
      Programmable flow

      oooh!

      Droplet splitting and formation

      slow motion shower scene...

      Next! Next!

      --
      ...and he grinned, like a fox eating shit out of a wire brush.
  15. T2 Here we go by Bytal · · Score: 1

    Does anyone else get an eerie Terminator feeling from those dancing droplets?

    1. Re:T2 Here we go by scalis · · Score: 0

      Nopes, I was thinking Flubber actually.

      --

      True ravers don't need drugs
  16. casemod! by pixitha · · Score: 2, Interesting

    im thinking, some blacklight reflective liquid, on the top of the case, moving around in different patterns. Or coat the top of the whole case with a mapped out electirc grid, and you make it so whatever shape you want it to draw (controlled by the computer) it does! it could look pretty bad ass if you did a good job...oh and you didn't move your case.

    --
    "an eye for an eye only makes the whole world blind"
    1. Re:casemod! by Fembot · · Score: 1

      like winamp visulisations :-)

      now that would be neat

    2. Re:casemod! by Anonymous Coward · · Score: 0

      Man , i see a new generation generation of printers using this tech , think hiiiiigh rez .

  17. biophotovoltics by t0qer · · Score: 2

    I had a weird vision of things to come the other day...

    I dreamt in the future, man will have developed his skills of genetic engineering and stem cell research to the point where he can make things that are only science fiction now..

    For example, I started thinking about genetically engineered photovoltic algea. I saw big gigantic pools of green liquid converting sunlight to electricity using completely enviromentally friendly and biodegradeable algea.

    I also thought about genetically engineered eyeballs that could do the same thing. Imagine 100 foot eyeballs looking up at the sky in the desert. Or genetically engineered eyeballs for space observation.

    Just another one of those weird topics, on a weird day. Just to humor myself, does anyone know of any research being done into this field?

    --toq

    1. Re:biophotovoltics by joshtimmons · · Score: 2

      Yeah, I'll second that.

      Somewhere, somebody must be doing research on 100 foot eyeballs looking up at the sky in the desert.

      I mean, what's government spending for if not for projects like that.

      (Actually, I feel like those 100 ft eyes are looking down at me)

    2. Re:biophotovoltics by pixitha · · Score: 1

      isn't that pools of alge converting light into energy in some book? cuz i swear ive seen/heard that b4, if its not, then damn. creepy dreams

      --
      "an eye for an eye only makes the whole world blind"
    3. Re:biophotovoltics by jeff's+cape+shop · · Score: 1

      i was thinking about this sort of thing a few days ago - how long till we have genetica(?)lly modified creatures who's sole purpose in life is to eat our waste and run really fast on treadmills to make us electricity?

      is biological engineering ever likely to be more productive than machines?

      well if not it would be pretty cool [cruel] anyway!

      like the affront in Excession (iain m banks)

      specialising soley in the sale of capes

    4. Re:biophotovoltics by kromeke · · Score: 1

      you could use pools of alge to make biodiesel.

  18. The real question is... by Anonymous Coward · · Score: 0

    ... how can this be applied to acquiring or consuming more porn?

  19. Cyberdyne by frankie · · Score: 1

    Fluids that compute, eh? How far is it from here to mimetic polyalloys?

  20. some additional comments: by herrd0kt0r · · Score: 5, Interesting

    this whole shebang about microdroplet formation and movement is especially incredible when considering lab-on-a-chip applications for the biotech industry.

    one of the biggest problems with current solutions is the difficulty in utilizing small samples of blood/fluid. the solid-state approach of this team is great in that there are, by definition, NO MOVING PARTS! nothin to break down, and nothin to shrink down either. so you can keep things puny. the fluid volume in these experiments are in the _nanoliter_ range. and they have demonstrated their ability to split and reform droplets.

    so imagine this: you have a limited quantity of blood to analyze, and wanna run a bazillion tests. no sweat. with this tech, you can suck off puny portions at a time! you can move them around however you'd like as well, to whatever assays you'd like to run.

    the team has also demonstrated excellent droplet mixing results as well. why is this important? well, with fluid volumes that small, it is difficult to mix solutions. their electrowetting approach has yielded results that show excellent mixing. this is good for labs-on-a-chip as well, as you may need to mix different things together for certain assays.

    the potential for this kind of technology is pretty staggering. very small. very little power. no moving parts. use em for switches of many sorts! or hell, did you check out the video where they move the drop at over 200 hertz?!

    HOLY SHIZNIT!

    that's fast! eesh! but screw all this serious stuff. i think we can _all_ enjoy the first video showing the droplet performing humping maneuvers. aww jeah.

    1. Re:some additional comments: by TarrVetus · · Score: 1

      I agree--this technology will easily replace small tube systems once it catches on. And, with advancement in the tech, who knows what else it might replace. Digital plumbing may not be too far off. ;)

    2. Re:some additional comments: by Dratman · · Score: 4, Interesting

      To put those "bazillion tests" and "puny portions" into perspective, note that most of the movies show droplet sizes of 700 nl.

      Thus a typical blood tube of about 7 ml would yield 7.0E-3 / 7.0E-7 = 1.0E4 = 10,000 droplets! If the blood were diluted (likely), the number of droplets per tube would be correspondingly increased.

      Under these circumstances, blood could be automatically mixed with many different assay reagents, perhaps in widely varying concentrations. Each reagent would be used in such miniscule quantities that the total cost per test would be negligible. Colorimetric analysis of the results would be trivially accomplished by directing the mixed droplets past sensing stations.

      Some droplets could be sent to storage areas for timed incubation, while others moved through faster test procedures elsewhere on the chip.

      If the droplets contained bacteria in suspension, they could be systematically exposed to a huge variety of prospective antibiotic compounds in parallel at extremely low cost without the need for cumbersome slides, vials, and so forth.

      --
      Sigmund
  21. Down already??? by SkipToMyLou · · Score: 1

    Sure, direct links to .mpg files on slashdot. What the heck were they thinking?

  22. Re:It won't save /. by Mr2cents · · Score: 0, Offtopic

    Maybe the .com implosion caused a lot of people to do other things than reading /. at work? :)

    --
    "It's too bad that stupidity isn't painful." - Anton LaVey
  23. NO !!! by manabadman · · Score: 0, Offtopic

    I was pondering the relatively uninteresting nature of some of the posts today and then WHAMMO !!! It hit me ...

    Digital Microfluidics
    michael
    Ricardo Montalban Recalls Khan Movies
    chrisd
    The Bulova Accutron
    michael
    Autonomous Underwater Vehicle Competition
    michael
    New Red Hat Multimedia Oriented Distribution
    CmdrTaco
    Reclaiming the Commons
    michael
    High Definition DVD
    michael
    Boulevard of Broken .dreams
    michael
    August 2002 Daemon News Ezine Published
    michael
    HighWLAN
    michael
    Atari 2600 Hacks
    michael
    Linux 2.4.19 Released
    michael

    coincedence ... ?? methinks not ....

    MICHAEL HAS ASSASSINATED THE OTHER EDITORS !!!

    my .deb is better than your rpm !
    --Unknown Flamebaiter

    1. Re:NO !!! by Anonymous Coward · · Score: 0

      You hear that Michael!?!?!?

      U R a SUCKER!

    2. Re:NO !!! by Anonymous Coward · · Score: 0

      nice! +3 funny.

  24. Mirror: KaZaA by dav · · Score: 1

    I've mirrored the videos on KaZaA. Here's the names:

    dispenser_slow.mpg
    droplet_200hz.mpg
    electrowe tting.mpg
    form_rotate_3.mpg
    form_rotate_5.mpg
    r otary_flow.mpg
    side_moving.mpg

    And I put 'Mike Pollack' in the author field.

    There oughta be a /. channel on some P2P network for mirrored multmedia files.

  25. Anyone Besides me remember micro engines? by capo2 · · Score: 2, Insightful

    A while back Slashdot ran a story aout micro engines. If I recall correctly werent they having probles with fluid aka fuel flowing through those little suckers due to them being small etc etc dont have time to go back and read it work soon. Anyways maybe these two techs can be combied if they can make it small enough to run on the micro engines. My 2 cents.

  26. G A T C by interiot · · Score: 2

    This will just make fluids all the more important. And we know what happens when such things become put into law.

  27. Whoopie! Gasoline powered computers... by Anonymous Coward · · Score: 0

    Hmm... wait a minute, that might just work.... potential problems? Noise. (will Midas stock mufflers for my laptop?) exhaust fumes. (will my Sharper Image Ionic Breeze handle it?) Will the sucker have an electric starter or do I need too pull a rope? Pondering the questions of life.

  28. Would somebody in the know explain how this works? by citanon · · Score: 1

    No lame attempts at humor please. :p

  29. Re:Would somebody in the know explain how this wor by citanon · · Score: 1

    Actually funny stuff welcomed.

  30. Re:It won't save /. by TarrVetus · · Score: 0, Offtopic

    I doubt that /. will truly die for a very long time. Everyone wants news that's 'tailored for them,' and /. is focused on geeks and nerds. Where else will we go for news like this? CNN? _MSNBC?!_ Slashdot truly fills a niche in the media. Also, just because there are fewer posts doesn't mean that things are going downhill. Perhaps people just don't feel like posting as much as they used to. So be it.

  31. Put this in a PDA by Ironpoint · · Score: 1



    This puts us closer to handheld DNA analysis from a PDA. How soon till police in the field can check one's identity with a palm or pocketpc? (assuming you won't tell them).

    1. Re:Put this in a PDA by Planesdragon · · Score: 1


      This puts us closer to handheld DNA analysis from a PDA. How soon till police in the field can check one's identity with a palm or pocketpc? (assuming you won't tell them).


      If a police officer has a reason to talk to you (you're speeding, tresspassing, staring at everyone around you...), then you need to identify yourself. If you *don't* tell them who you are, they can just haul you in on suspicion...

      Our check against abuse of this is (judging from State Troopers having tri-copy speeding tickets, while METER MAIDS have automatic printers) making them fill out paperwork.

  32. umh.. by ittehccat · · Score: 1

    Wait.....ya lost me.

  33. or DNA security - no retinal scans required by Renaissance+Ana · · Score: 1

    Seems that in addition to being an investigational aid, it could eventually become useful for security. Or not (unless it was rigged to only take "live" samples checking for body temp, etc. -- bodily fluids aren't that hard to come by otherwise).

  34. full mirror also here: by herrd0kt0r · · Score: 2

    there was a comment above posted by anonymous coward that i'd thought i'd pass along. he just posted a full mirror of the site:

    http://www.duke.edu/~pyp/microfluidics

    apparently, you guys blew www.ee.duke.edu up.

  35. KaZaa by Erpo · · Score: 1

    I hope you're using the spyware-free KaZaa Lite rather than the infested KaZaa.

    1. Re:KaZaa by dav · · Score: 1

      Of course.

  36. And I'll be... by Anonymous Coward · · Score: 0

    ...right up at the bar sipping that drink!

  37. Gees .. fluidics is STILL going? by Evil+Pete · · Score: 4, Interesting

    Wow. I remember reading about fluidic processing in the late 1960s. Must've gone from the "valve" stage to to the IC (Integrated Conduit ?) ;-) since then. Hey, check out this fluidic amplifier ... not very micro back then eh ?

    Man that must really take persistence working on a tech bywater for 40 years waiting for it to come good. Mind you I think I remember even back then there being real world applications for this ... slow processing in hostile environments where electronics would get fried etc ... I think from memory it used the Coanda Effect or something for switching fluid streams. And there were adds in New Scientist for years afterwards selling DIY fluidics kits.

    Well maybe at last its time has come ...

    --
    Bitter and proud of it.
    1. Re:Gees .. fluidics is STILL going? by modulo · · Score: 1

      I remember there being a big writeup in the Van Norstrand Scientific Encyclopedia , around 1965 (3rd or 4th ed.?) about fluidics. IIRC, they discussed possible applications for environments inhospitable
      to electronics, like washing machines. . .

      Was a fun read. I donated my copy to Lincoln Tech in Allentown, so if you're in the area. . .

      --

      ...but the language is MUMPS, which I will not utter here

  38. Yes, But by Anonymous Coward · · Score: 0

    How long until I get to use this in my super soaker?

  39. *sigh* Obligatory. by Anonymous Coward · · Score: 0

    "Now we can enter microfluidic space and do battle with species 8274 micromachines*!"

    * Micromachines is a trademark of Galoob, if I remember right. Verily.

  40. Repairing millenium falcons comes to mind ;-) by Anonymous Coward · · Score: 0

    Wasn't Han Solo using something like this to replace broken parts in the Millenium Falcon? Seems useful enough to me, then ;-)

  41. Overclocking & Trolling by hesiod · · Score: 1

    Two obligatory points I have not seen yet... (maybe because they were modded down)...

    1) Wonder what a beowulf cluster of those would work like (bad-dum dum[b])

    2) Once this is mass-produced, overclockers could do amazing things, considering the likely heat-dissipating properties of such a product.

    (Hey, I'm here to post, not to think!)