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Stem-Cell-Like-Cells Made Using Only Blood?

Adair writes "Newscientist.com is reporting that a UK biotech firm, TriStem has developed a technique to 'turn ordinary blood into cells capable of regenerating damaged or diseased tissues.' Their method transforms anyone's white blood cells into 'stem-cell-like-cells' which can then be coaxed into one of a myriad of healthy cells such as heart, nerve, or brain. Having made these claims for years, TriStem has recently provided proof to their claims, which some scientists who witnessed called 'stunning."' They have some more proving to do, but if the initial results pan out, the applications could be fantastic -- and without the stigma of traditional stem-cell research."

47 comments

  1. Used for cobra bite necrosis? by Bob+Cat+-+NYMPHS · · Score: 3, Interesting

    There was a guy on Motel William's show yesterday who had been bitten and had a big hole in his abdomen after debriding the killed flesh. He said a frend of his had used white blood cells 'and sumtin' and he healed in 10 days. Anyone know if this is the same process?

    1. Re:Used for cobra bite necrosis? by Holi · · Score: 0, Offtopic

      Your sig: Shouldn't it be "i" as "Pi" is not an irrational number.

      --
      Sorry, teleporters just kill you and then make a copy. A perfect, soul-less copy.
    2. Re:Used for cobra bite necrosis? by Dreadlord · · Score: 4, Insightful

      TriStem claims in the article that the technique can be used to regenerate many kinds of cells, including smooth muscle cells, on the other hand, I wonder if regenerating cells is all what the body needs to recover lost parts, because randomly generating cells isn't going to recreate the same organ after all, so there should be another technique to control how cells are regenerated.

      --
      The IT section color scheme sucks.
    3. Re:Used for cobra bite necrosis? by Jesrad · · Score: 3, Informative

      randomly generating cells isn't going to recreate the same organ after all

      IANACellBiologist, but from my knowledge on the subject, replacing randomly the cells of a dying organ DOES replace it efficiently. It'd take a continuous, regular treatment over a few years but it would most probably work. From the article, TriStem managed to cure diabetic and immunodeficient mice with this method, ergo they managed to replace pancreas and bone marrow.

      --
      Maybe we deserve this world ?
    4. Re:Used for cobra bite necrosis? by Anonymous Coward · · Score: 1, Funny

      So, could they replace a foreskin?

    5. Re:Used for cobra bite necrosis? by Jesrad · · Score: 1

      I'm afraid it wouldn't help with decayed teeth either :/

      --
      Maybe we deserve this world ?
    6. Re:Used for cobra bite necrosis? by Anonymous Coward · · Score: 0

      "Your sig: Shouldn't it be "i" as "Pi" is not an irrational number."

      'i' is imaginary, "Pi" is irrational, unless you've discovered some new proof.

  2. Awesome! by bobo+the+hobo · · Score: 1, Funny

    So I could like, inject this stuff into my arm and I'd have a super-arm that could like shoot laser beams and pick up mack trucks full of pianos?

    1. Re:Awesome! by Anonymous Coward · · Score: 1, Funny

      Yes.

  3. Something sounds suspicious by Anonymous Coward · · Score: 3, Funny

    I would check to see if these TriStem people have recently returned from Antarctica or a husky was doing the presentation.

    1. Re:Something sounds suspicious by altmiket · · Score: 0

      I'm picturing MacReady and Childs sharing a drink at TriStem headquarters now...

  4. Wow by tsa · · Score: 5, Informative

    If this is true these guys can make insane amounts of money. They patented their technique in 1996 in the UK and in 2000 in the US so we are left with a monopoly. Hopefully they won't exploit it too much.

    --

    -- Cheers!

    1. Re:Wow by Callan · · Score: 3, Insightful

      Only for a bit. Patents don't last forever (just longer than some would like).

      Now, if they left it a 'trade secret', then it'd be different ;)

    2. Re:Wow by Jesrad · · Score: 4, Insightful

      It cannot be kept a trade secret if it is hard to believe technology. There's the same problem with "free energy" devices and antigravity devices, they require repeated reproduced experiments to be taken seriously, which can't happen if they won't tell you how to do it.

      --
      Maybe we deserve this world ?
    3. Re:Wow by vidnet · · Score: 2, Insightful
      If you invent something like this, you have every right to exploit it and indeed you should. They've spent a conciderable amount of money, and the patent ensures they can make that money back plus hefty bonuses if the idea is good (which this certainly seems to be).

      If there were no patents, you'd either have to keep it hidden from everyone forever (bad for science), or let everyone know and likely undercut you in selling it since they don't have the huge debt of research behind them (bad for innovation).

      There's nothing wrong with getting filthy rich when you've worked for it.

  5. south park reference... by standsolid · · Score: 0, Offtopic

    Oh please! Okay, you tell me where you can get aborted fetuses for seventy cents on the dollar? You tell me, Chuck? Yeah, I didn't think so -- you know, I'm just like the fetuses, Chuck. I wasn't born yesterday, either. Uh huh... so are you gonna talk to me, or are we just gonna keep bullshitting each other? Breakin' my balls, Chuck.

    [[slashdot posts story about stemcells without using aborted baby fetus]]

    Yes, hello, is this Captain Bly's Seafood Restaurant? Yeah, hi, I've got a shipment of about thrity-one of the most succulent shrimp from the West Indies. These are killer shrimp, Gary, your customers are gonna love 'em. What kind of price you payin' for shrimp? Oh, Gary, you're breakin' my balls, Gary. How about ten and a quarter? ...Balls, Gary. Breakin' 'em. Alright, I'll call you back

    --
    WTPOUAWYHTTOTWPA
    What's the point of using acronyms when you have to type out the whole phrase anyways?
    1. Re:south park reference... by Anonymous Coward · · Score: 0

      hahah, that was a hillarious episode. Cartman rules.

  6. Next step in longevity treatments? by Smidge204 · · Score: 4, Insightful

    Since we have some people looking into how sea urchins are practically immortal, I'm curious if there will be some way to mix and cross-reference the two veins of research to come up with a longevity treatment...

    =Smidge=

    1. Re:Next step in longevity treatments? by Anonymous Coward · · Score: 0

      insightful my ass. You think it's all that simple? Moderators do, they're a bunch of ignorant geeks, knowing nothing about gene-therapy.

    2. Re:Next step in longevity treatments? by Anonymous Coward · · Score: 0

      This has little to do with gene-therapy. Multipotent stem cells can replace any organ and reset their telomeres' division counter, hence extended longevity.

    3. Re:Next step in longevity treatments? by Anonymous Coward · · Score: 0

      Telomers *are* a division counter. To "reset them" would mean adding more, which is a cause of cancer.

  7. If this is true... by Jesrad · · Score: 2, Interesting

    If this is true then we very well may be the last generation to have to die.

    --
    Maybe we deserve this world ?
    1. Re:If this is true... by Anonymous Coward · · Score: 0

      .. AND THIS IS A GOOD THING!?!? MASS IMMORTALITY IS A BAD PLAN!!

      Let's here it for MORE population then this planet and our societies can deal with.

      *sigh* Don't do it!!

      (Um.. do as I say, not as I do)

      Pass me the Lazurus Juice?

    2. Re:If this is true... by memco · · Score: 1

      Isn't it kind of a societal law, that the longer people live, the later in life they wait to have, and the fewer children they have? Not exactly scientific, but it correlates well.

      --
      Get me a meat pie floater!
  8. This is Slashdot, after all. by Scoria · · Score: 2, Funny

    I'd have a super-arm

    Many of the subscribers already do...

    --
    Do you like German cars?
  9. Luddite opposition by Anonymous Coward · · Score: 0

    How long before the luddites start screeching about it and demanding that these scientists stop playing God. Sure, they can't use the abortion angle as an excuse, but surely something so "un-natch-er-ull" has to be against the "buy-bull"!

    1. Re:Luddite opposition by Anonymous Coward · · Score: 2, Insightful

      There's a reason God let mankind have intelligence.

      So we can use it.

      Ever see a Christian go to the doctor? Then your whole point is invalidated. If we were so picky about things "un-natch-er-ull", we would just pray. And die, as a result of being stupid. And then there would be no more Christians.

      Maybe you need to start using your God-given intelligence.

    2. Re:Luddite opposition by Anonymous Coward · · Score: 0

      There's the saying: Pray to God but row for shore.

      I don't know who says it because I'm a filthy heathen athiest, but it's a nice saying that fits with your view (I think).

    3. Re:Luddite opposition by Daniel+Dvorkin · · Score: 3, Funny

      No, the fanatical Christians' whole point is invalidated; but the grandparent poster's point is right on the money.

      Just about major medical advance in history -- dissection of corpses to learn anatomy, sterilization of instruments, immunization, anesthesia, antibiotics, x-rays, blood transfusions -- has met religious opposition when it first came out*. And over time, as the obvious benefits added up, these advances became part of "just the way things are" and almost everyone** stopped complaining about them. But new advances still set off the same alarm bells in the minds of the Luddites, who don't have the grasp of history to see what fools and hypocrites they are.

      Plenty of True Believers will happily go to the doctor, take advantage of whatever the latest technology is that's available at that moment to cure what ails them, and then go home and bitch about Those Damn Scientists Interfering With The Will By Meddling With Things Man Was Not Meant To Know. And because of this behavior, unfortunately, there's no selective pressure for that kind of idiocy to die out.

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      * I heartily recommend Jonathan Miller's The Body in Question for an overview of this, as well as other fascinating aspects of medical history.

      * With the exception of, e.g., Jehovah's Witnesses and blood transfusions. They may be fanatics, but at least they're consistent fanatics.

      --
      The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
    4. Re:Luddite opposition by A+Bugg · · Score: 1

      its "pray to God but row away from the rocks"
      A Bugg

    5. Re:Luddite opposition by memco · · Score: 1

      To be fair, not all of us believers feel that any new technology will help disprove God's existence and send the world into apocalypse. With this article I may point to references in the Bible of an era called the millenium where people will live for extended periods of time (almost a thousand years)

      --
      Get me a meat pie floater!
    6. Re:Luddite opposition by Daniel+Dvorkin · · Score: 1

      Oh, I'm not saying that all religious believers are Luddites, at all. Simply that most of the Luddism, especially w.r.t. biology and medicine, seems to use religious justifications for its absurd claims.

      --
      The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
    7. Re:Luddite opposition by Anonymous Coward · · Score: 0

      The existence of the christian god is non-disprovable. It's just plain unscientific since it's untestable by definition.

      In scientific terms, notions of god are irrelevant. They're just meaningless. You can't form a testable hypothesis.

      Religion hates science not just because science means people sometimes behave a bit less like idiot sheep, but because science looks at religion and goes "you are just irrelevant, except perhaps for studies of human psychology".

  10. New neurons? by ihtagik · · Score: 2

    Among other things, it would be interesting to see whether they can actually grow new neuron cells.

    1. Re:New neurons? by Jesrad · · Score: 2, Informative

      From the article, they claim the cells did change into neural cells (among other types of cells). This could mean the end of Alzheimer syndromes and sclerosis, and a cure for paralysed people.

      --
      Maybe we deserve this world ?
    2. Re:New neurons? by ihtagik · · Score: 1

      My thoughts exactly, but where will it stop. What's to stop us from "enhancing" ourselves say, to preempt senility? Better still, are we obligated not to? In no time one'll be able to walk into McDnld's and order a stem cell health shake...

    3. Re:New neurons? by ckaminski · · Score: 1

      Hey, if it works, and you also buy a $5 dead-cow burger and fries, that Stem-Cell shake might just be a loss-leader for McD's...

  11. Peer review? by jdiggans · · Score: 3, Insightful

    Wait until they publish a controlled study in a peer-reviewed journal. Until then, this is all science-by-press-release and not worth the paper on which it's printed.

    That said, I hope they're successful and manage to strike a healthy balance between profit and humanity.
    -j

    1. Re:Peer review? by XenonChloride · · Score: 3, Interesting

      Thanks, that was exactly what I missed in the whole thing. So far, their claim to "retrodifferentiate" blood cells to pluripotent stem cells (= similar to embryonal stem cells in the 8-cell-stadium) is questionable. It seems they simply went for profit and propaganda rather than for proof-reading by the scientific community.

      One (of many) more serious examples for (embryonal) stem cell research is given by D. Kaufman in PNAS 2001, 98(19), 10716-10721, for an online pdf version see Hematopoietic colony-forming cells derived from human embryonic stem cells.

      Although enthusiastic about their results, the authors are honest enough to warn in the last paragraph of the article mentioned above:

      The clinical promise of human ES cell-based therapies is great; however, because these therapies will be entirely novel, serious concerns about safety and efficacy will need to be addressed before human clinical trials can be initiated. The malignant transformation of cells that have been cultured for extended periods is a particular concern.

      This has indeed been observed by Mathias Hoehn at the Max-Planck-Institute for Neurological Research in Cologne, Germany. As far as I remember, the researchers had caused an apoplectic stroke in rats. One week later, they injected the animals with embryonal stem cells from mice. MRT scans showed that the stem cells travelled through the rat brain right to the damaged region and started to differentiate and form a network. The stem cells, originating from different specimen, had replaced damaged tissue.

      However, when the same stem cells (note: embryonal stem cells from mice) were used on mice, everything went out of control! Rather than moving to the damaged region, the stem cells started penetrating surrounding nerve cells and showed uncontrolled growth. In all mice examined, tumors were found!

      Keeping that in mind, I prefer to take all "scientific" announcements in non-peer-reviewed journals with a ton of salt.

  12. Oops by Daniel+Dvorkin · · Score: 1

    That should be "... Interfering With The Will Of God By Meddling ..." above, of course.

    --
    The correlation between ignorance of statistics and using "correlation is not causation" as an argument is close to 1.
  13. glass half full by Sean+Clifford · · Score: 1
    Hopefully they won't exploit it too much.

    They'll want to make their $ back and a handsome profit on top of it; but you're right - companies are not "fair" about it IMHO. A better system to balance that out needs to be tacked on to patent law.

    And in 17 years (depending on your country) that technology will become generic and commoditized. Inventors should be compensated for their labour; however, for the next generation the fruits of it should be ubiquitous.

    So look at it this way: in a generation, this technology will be patent-free.

    I'm as socialist and altruistic as the next guy, but I think there can be some balance with capitalism. If you defang its cannibalistic tendencies and ensure reasonable labor rights then it's not a bad way to live.

    Now, IMHO anyone who uses NIH technology or other tech developed at taxpayer expense then the taxpayer should get an even split. So if Liverium, a drug to reverse cirrhosis in alcoholics, were developed and made $50 billion for Merc then the Treasury would get half in the name of the taxpayer. Just like we should be collecting for mineral rights that mining companies get for virtually nothing (e.g. billions in gold extracted for a $30,000 fee on public land).

    What to do with this largesse? Well, everyone has their own opinion and I'll leave that to another debate.

    1. Re:glass half full by sjames · · Score: 2, Insightful

      This is a perfect example of why patents should last for a length of time that varys with the field. As a medical application, it will likely take 10 years or more just to get it on the market. If it were software it would have come out in 1997 and be obsolete by now.

      This is a lot less trivial and obvious than the patents most of /. hates as well. It sure took a lot more hard work and insight than one click shopping!

      So I don't begrudge them their patent, and hope it helps them to fund further research. At the same time, I hope they apply moderation in their pricing so that people can afford to benefit from this.

  14. Better Yet! by Lord+Kano · · Score: 3, Funny

    Everybody is Peter North!

    Mods, if you understand this joke you're just as twisted as me.

    LK

    --
    "Hi. This is my friend, Jack Shit, and you don't know him." - Lord Kano
  15. Trade Secret != Patent by dmauer · · Score: 1

    Clearly it's not a trade secret. But if it's patented, they're the only ones who are legally allowed to *use* the technology; all others must license the process from them.

    --
    === "Some people see the glass as half-empty. Others see it as half-full. I see the glass as too big." -G. Carlin.
  16. why is this amazing? by Anonymous Coward · · Score: 0
    Why do so many people think this amazing? Every cell has the same DNA so the difference between a stem cell and other cells can't be all that large...

    Probably only a difference of a few bits...

    One of those tests which shows which genes of the DNA are being expressed would probably show what the difference is...