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Researchers: Wolves Might Slow Spread of CWD

William G. Davis writes "According to this AP article, researchers are now suggesting that wolves might be able to slow the spread of chronic wasting disease (CWD) in deer. Chronic wasting disease is the name commonly given to spongiform encephalopathy (prion disease) in deer and elk (basically, mad cow disease in deer). The article explains how wolves typically look for weaknesses in their prey, and since prion disease causes that, wolves might target the sick animals. One has to wonder, though, about the potential ramifications of having dangerous predators exposed to this brain-wasting illness, and what type of 'unusual behavior' they'll start to exhibit."

72 comments

  1. hmmmm by Molina+the+Bofh · · Score: 0, Offtopic

    hmmmmmm... Exctasy-eating wolves in a techno party.

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  2. Brain wasted predators by presearch · · Score: 0, Offtopic

    One has to wonder, though, about the potential ramifications of having dangerous predators exposed to this brain-wasting illness, and what type of 'unusual behavior' they'll start to exhibit.

    No need to wonder, just look at Cheney and Rumsfeld. It's a textbook case.

  3. Dangerous? by rot26 · · Score: 5, Insightful

    Wolves aren't particularly dangerous. They rarely attack humans... rarely ENCOUNTER humans for that matter, and being at the top of the food chain, wouldn't be in much of a position to pass the virus (virii?) on to other species. I'd guess any wolf that began to have symptoms of such a serious disease would simply starve to death in fairly short order.

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    1. Re:Dangerous? by Tango42 · · Score: 3, Interesting

      Being at the top of the food chain doesn't stop your corpse being eaten by scavengers, does it?

    2. Re:Dangerous? by Anonymous Coward · · Score: 0
    3. Re:Dangerous? by Micro$will · · Score: 5, Informative

      Scavengers typically have immune systems thousands of times powerful as humans.

      Quote from Here Vultures have long been perceived as loathsome birds because of their feeding habits. We now know the important role these birds play by cleaning up dead animals. The Latin name Cathartes aura means "Golden purifier". Turkey Vultures are immune to botulism, anthrax bacteria, hog cholera virus and many, many more that would kill other animals as well as us. Vultures were once blamed for spreading diseases. Scientific research has shown that their digestive tract and immune system actually destroy all pathogens and help to control these diseases. Ongoing research in the medical field on the Turkey Vulture's amazing immune system may some day yield valuable information that could be applied to humans as well as livestock.

    4. Re:Dangerous? by jc42 · · Score: 4, Interesting

      I'd guess any wolf that began to have symptoms of such a serious disease would simply starve to death in fairly short order

      True. And there's lots of literature supporting the idea that predators and scavengers tend to have very good defenses against the diseases that affect their prey. Part of the defenses are powerful digestive systems that leave few cells intact and chop up most proteins and DNA into small pieces. They also have some of the best immune systems on the planet.

      The explanation is fairly simple. If you're a predator or scavenger, you often eat food that was weakened or killed by disease. This puts strong selective pressure on your species in favor of defenses against those diseases.

      I've read a couple of articles on the semi-exception that the top predator on the planet (Homo sap) seems to be a partial exception. This is generally explained as an artifact of our recent conversion to predation. We do have some predator adaptations, but we haven't had time to evolve them fully.

      There is a bit of debate about this, though. For example, studies of wild chimp populations haved turned up data showing that they actually do get a significant part of their protein by eating small animals. So our predatory ancestry probably goes back at least 5 million years. But still, we are primates, and it wasn't all that long ago that our ancestors were vegetarians.

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    5. Re:Dangerous? by /dev/trash · · Score: 1

      But scavengers have some of the toughest digestive tracks in the world.

    6. Re:Dangerous? by dnahelix · · Score: 1

      Hmmm, why don't they put Turkey Vulture genes in all our livestock? I'd eat 'em up! YUM YUM

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    7. Re:Dangerous? by Alsee · · Score: 3, Interesting

      There is an interesting twist on this with Komodo Dragons. Their mouth is specially designed to trap bits of rotting flesh. This breeds several dozen varieties of bacteria including some of the most virulent and deadly bacteria on earth. Flesh eating necrotizing bacteria, blood-born bacteria causing sepsis, bacteria that knock out the immune system, an entire host of different nasties.

      One bite from a Komodo and it's saliva introduces all of these infections at once. A bite victim almost inevitably dies within one to three days. No known antibiotic can cure an established infection.

      The exciting part of the story is that Komodo Dragons obviously must have evolved an amazingly powerful defense to all of these bacteria. An expedition was sent to collect some Komodo blood and work is ongoing. They have isolated multiple anti-bacterial compounds and hopefully they will be able to make incredibly powerful new antibiotics available in a few years.

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    8. Re:Dangerous? by Alsee · · Score: 1

      Why waste time mucking aroud with genetic enginering when you could simply start raising Turkey Vulture livestock?

      Turkey Vulture! It's not just for Thanksgiving anymore!

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    9. Re:Dangerous? by Urkki · · Score: 2, Insightful
      • I've read a couple of articles on the semi-exception that the top predator on the planet (Homo sap) seems to be a partial exception. This is generally explained as an artifact of our recent conversion to predation. We do have some predator adaptations, but we haven't had time to evolve them fully.

      There's a much more simple explanation.

      Our immune systems are poor because they don't get enough stimuli when we are in childhood. Modern medicine takes care of most of our illnesses so our own immune system doesn't have to, and therefore modern medicine needs to take care of those illnesses through our lives. Of course the plus-side of modern medicine is that we don't have a 50% child death rate... ;-)

      I wouldn't be surprised in the slightest if also human immune system could learn to deal with almost any bacteria, if they just would get the chance in childhood. So I wonder if we'll ever have sort of "general vaccines" given to children yearly or something, to teach their immune system to deal with all common bacteria and virus types that are now practically missing in our "over-hygienic" urban lifestyles.
    10. Re:Dangerous? by mrogers · · Score: 2, Interesting
      ...studies of wild chimp populations haved turned up data showing that they actually do get a significant part of their protein by eating small animals. So our predatory ancestry probably goes back at least 5 million years.

      That estimate is based on the false assumption that any trait present in modern chimps was also present in the common ancestor of chimps and humans. Chimps have evolved as much in the last 5 million years as we have. They may have discovered hunting as recently as we did - it's even possible that they learned to hunt by imitating humans.

    11. Re:Dangerous? by The+Cydonian · · Score: 1

      As I recall, the City of Cologne had actually introduced a wolf population into one of its parks to try and stem the burgeoning rabbit population there.

    12. Re:Dangerous? by dnahelix · · Score: 1

      I can't wait to DEEP FRY one!

      Although a glow-in-the-dark Turkey Vulture would be the ultimate.

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    13. Re:Dangerous? by drox · · Score: 1

      I've read a couple of articles on the semi-exception that the top predator on the planet (Homo sap) seems to be a partial exception. This is generally explained as an artifact of our recent conversion to predation.

      It might also be explained by the fact that, alone (AFAIK) among the predators/omnivores, humans cook most of the meat that they eat. Cooking effectively kills most food-borne pathogens. This would go a long way toward preventing food-borne illnesses, and might explain the relatively poor defenses human have against such illnesses.

  4. Pure FUD by Drakin · · Score: 5, Informative
    One has to wonder, though, about the potential ramifications of having dangerous predators exposed to this brain-wasting illness, and what type of 'unusual behavior' they'll start to exhibit."



    Had the submitter actually read up on CWD, they'd have learned that it's already present in areas where there are wild wolves, and that there's no sign of the wolf population contracting it.

    As well, in tests that involved feeding infected brains to live stock, none of the livestock showed any signs of contracting CWD. The only time they've had sucess with transmitting the disease outside of deer and elk is by atricicial means, as in, directly injecting it into the brain.

    So the wolves should be safe enough.

    1. Re:Pure FUD by elmegil · · Score: 1
      Seems to me pretty clear: the sick animals are going to be more easily caught by the wolves long before they're at the falling down, massive amounts of whatever it is causing the disease in their body stage. Which should reduce the risk to the wolves, eh?

      As for not figuring out how it's transmitted, that's kinda worrisome, don't you think? This disease is hitting herds of animals and even after a few years of observation we can't tell how it's transmitted?

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    2. Re:Pure FUD by Feztaa · · Score: 1

      As for not figuring out how it's transmitted, that's kinda worrisome, don't you think? This disease is hitting herds of animals and even after a few years of observation we can't tell how it's transmitted?

      What are you talking about? Your parent poster told you how it's transmitted: the deer are injecting each other's brains directly with syringes.

    3. Re:Pure FUD by Syrrh · · Score: 1

      Safe enough, though it'll hardly make a dent in the disease. CWD is NOT a virus, it's a hell of a lot worse little bugger. There's really only two ways to counteract the disease, and neither gives warm fuzzies to self-labeled environmentalists.

      1-Kill the potential carriers. ALL of them, as many as can be found, reducing populations so drastically that it'll take 30-40 years for numbers to come back up, giving plenty of time for the disease to run its course in the one or two surviving carriers. Naturally, this means that wolves will starve to death, and is a potentially nasty setback in the gene pool of affected species.

      2-Cure it. Not a bad solution, but it's a medical breakthrough on par with curing cancer. Still, researchers should get to work on fighting prions anyway. If anything similar to CWD ever came to affect humans it'd be a catastrophic plague. Near as we can tell it's 100% lethal, irreversible once contracted, incubates for months or years before symptoms show, about as contagious as mononucleosis, and the pathogen isn't harmed by most disinfecting techniques. The only relief about prions is that it seems to take multiple exposures of significant volume before the full effect is reached, much like low-level carcinogens.

    4. Re:Pure FUD by Fnkmaster · · Score: 2, Interesting
      IANACROPS (I Am Not A Cancer Researcher Or Prion Scientist), but I strongly disagree that curing prionic diseases is on par with curing cancer. Cancer consists of a large variety of possible cellular mutations in growth control, protective and other signalling mechanisms. Curing it requires complete mastery of cellular signalling and control mechanisms taking into account all possible genetic variations in the affected person or animal, AND all the possible mutation sites that can lead to cancer.


      Curing a single kind of prionic disease requires creating a substance that catalyzes a reverse transformation from the variant (prionic) protein form to the normal protein form. Since the original transformation is possible, the reverse transformation is surely also possible, and can probably be made energetically favorable with the right kind of agents. While it may be easier to describe than to implement, I still think it sounds a lot easier than curing cancer, and not out of reach of current biotechnology research.

  5. Brain tissue? by Johnny+Mnemonic · · Score: 2, Interesting


    I had understood that "Mad Cow" is only transmitted by eating the brains of an infected animal. Ranched cattle would acquire it as they are sometimes feed the brains of previously slaughtered cattle, but how exactly do deer and other wildlife transmit it?

    Is there another transmission vector, or do deer etc in fact eat the brains of their own dead?

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    1. Re:Brain tissue? by Fnkmaster · · Score: 1
      Very good question. I just found this link which seems to indicate they think spread is either maternal (before birth or through mother's milk I guess), or "lateral", I guess meaning from other deers, and they cite saliva as a vector.


      Presumably this means it's substantially more transmissible than Mad Cow Disease because it accumulates in other tissues outside of the brain and central nervous system. Or it means they are lying to us about the possible transmission vectors for Mad Cow Disease and that BSE can possibly be transmitted through vectors besides brain tissue.


      The potentially unpleasant conclusions for the safety of our food supply are left as an exercise to the reader.

    2. Re:Brain tissue? by Johnny+Mnemonic · · Score: 1


      Or it means they are lying to us about the possible transmission vectors for Mad Cow Disease and that BSE can possibly be transmitted through vectors besides brain tissue.

      That's exactly what I'm worried about as well. And from your link:

      We know that Mad Cow Disease can be transmitted to humans. Chornic Wasting Disease is similar to Mad Cow Disease; however, there has been NO documented evidence to date that it can be transmitted to humans by ingestion of infected meat.

      That unfortunately makes it as clear as mud. The quotes says 1) some potential for transmission of CWD to humans via meat; 2) CWD is similar to Mad Cow, but 3) don't panic, because you can't get Mad Cow from eating the meat of an infected animal.

      Fucking christ, it sounds like we're being lied to, to protect the ass-stupid ranchers who made herbivores into cannibals. I don't think I'm eating beef until we get some straight answers, and I don't care what the FDA chief served for Xmas dinner.

      The fact that John Titor warned about this very thing doesn't help, either. Although that's tinfoil hat time.

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    3. Re:Brain tissue? by Alsee · · Score: 1

      do deer etc in fact eat the brains of their own dead?
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      I think we may have just figured out is triggering the outbreak.

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    4. Re:Brain tissue? by Anonymous Coward · · Score: 0

      Unfortunately they really just don't know how its transmitted in wild deer. And no I don't think deer eat the brains of the dead. Could be wrong but I've never heard anything like that (especially since they are herbivores...)

    5. Re:Brain tissue? by Smitedogg · · Score: 2, Interesting

      I live in Colorado, in an area were there are a lot of Elk Ranches (Yes, they do exist). CWD is covered fairly regularly by the local papers when they don't have enough fluff to fill the space

      Basically, no one has caught CWD as far as they can tell, yet. They really have no clue if it's possible, but there are a few cases here in Colorado where people have gotten Creutzfeldt-Jakob disease and have eaten wild elk. CJ disease is what humans get from mad cow. It is of course possible they got it from some other mean, but when all the locals infected live in the mountains and hunt for food...it's hard not to make conclutions.

      1) some potential for transmission of CWD to humans via meat; 2) CWD is similar to Mad Cow, but 3) don't panic, because you can't get Mad Cow from eating the meat of an infected animal.

      1) It might be possible, as I already mentioned. 2) Veeeery similar. 3) They were referring to getting CWD from eating meat, which they aren't really 100% sure on. At least the ranchers out here aren't

      CWD is, incidently, airborne. They have determined this because wild elk get it from going to areas near penned elk. Of course this isn't 'official', and they'll rather term it 'possible lateral transmission', but it happens.



      dogg
    6. Re:Brain tissue? by MillionthMonkey · · Score: 1

      Ranched cattle would acquire it as they are sometimes feed the brains of previously slaughtered cattle, but how exactly do deer and other wildlife transmit it?

      The stuff is persistent. It can stick around on surfaces for a long time. And it survives harsh environments. Surgical implements remain infective for prion diseases even after being autoclaved and sterilized with heat and chemicals.

      Scrapie, for example, is a prion disease of sheep. Farms in Iceland that had not had any sheep present at all for three years, in an effort to get rid of scrapie, were ravaged by it all over again as soon as they imported healthy sheep from elsewhere.

      One theory went like this. The placenta left over from the birthing process was shown to be highly infectious. So the infected ewe would contaminate the grass and soil, and then the grass was eaten by other sheep (maybe years later, even) on the same farm.

      The mechanism of horizontal transmission of CWD in deer is unknown but contact via saliva, urine, and feces are the prime suspects as usual. Of course, given the durability of the agent, there are plenty of conceivable ways it could happen.

  6. Chronic Wasting vs Mad Cow Disease by TykeClone · · Score: 2, Informative

    Was just talking about this with a coworker (who keeps track of this kind of thing - he's more of a "commodities geek")on Wednesday.

    Sounded like people link these two diseases is that the end result looks the same. Chronic wasting disease is a muscle problem, Mad Cow disease is a deterioration of the brain. Both end up the same with a weak animal that can't walk.

    Chronic Wasting disease is probably more of a problem brought on by the overpopulation of deer in the upper midwest than anything. Wolves (and other predators) will benefit until the deer are brought into a more sane population - then they'll turn on people.

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    1. Re:Chronic Wasting vs Mad Cow Disease by jabberjaw · · Score: 1

      First I would like to state that IANAB (I am not a biologist). That said, from what I have gathered CWD is a form of transmissible spongiform encephalopathies (which include mad cow diesease). Diseases such as these result in the formation of lesions on the brain via deformed prions. As a result of this, animals motor skills are impared. Learn more here and here

    2. Re:Chronic Wasting vs Mad Cow Disease by the+argonaut · · Score: 1

      Was with you all the way up to:

      Wolves (and other predators) will benefit until the deer are brought into a more sane population - then they'll turn on people.

      Has somebody been reading too much Little Red Riding Hood? Wolves pose little to no danger to humans and if given the opportunity and not harassed will go out of their way to avoid us. The vast majority of wildlife encounters result from people hiking and camping doing stupid things like feeding wild animals, leaving out food, toothpaste, human waste, or other such items that attract wildlife, harassing animals, etc. The remainder are a result of humans further encroaching on wildlife habitat, often repeating the above mistakes. Sorry for my lack of sympathy, but people doing shit like this probably deserve to be attacked if they can't learn a little bit of common sense.

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  7. Enough Speculation! by -stax · · Score: 1

    Whoever posted this is an idiot.

    Fact: Any Predator will zero in on weak prey.
    Fact: Wolves are not particularly dangerous to humans.
    Fact: Wolves have been exposed to more mind altering diseases than CWD, ie. Rabies for much longer than we have even known about CWD, much less tracked it.
    Fact: CWD does not cause the animals to go "MAD" or attack others.


    David Mech, a biologist with the U.S. Geologic Survey and a wolf expert, cautioned that until wolves and wasting disease actually interact, theories about wolves controlling the spread of the disease are just speculation.

    1. Re:Enough Speculation! by Anonymous Coward · · Score: 0

      There's no need to personally attack the submitter. It's understandable to link mad cow and chronic wasting disease. They both show similar end result symptoms. So there's a few facts wrong... point them out respectfully.

    2. Re:Enough Speculation! by William+G.+Davis · · Score: 1

      Fact: Any Predator will zero in on weak prey.

      When did I say anything to the contrary? Did you actually read my synopsis?

      Fact: Wolves are not particularly dangerous to humans.

      And neither are black bears, mountain lions, and many other predators indigenous to this continent. What's your point? Would you walk up to them and pet them? They're still dangerous none the less.

      Fact: Wolves have been exposed to more mind altering diseases than CWD, ie. Rabies for much longer than we have even known about CWD, much less tracked it.

      How many of them invoke no immune system response whatsoever, can't be conclusively diagnosed without a post-mortem autopsy, have the apparent potential to jump from species to specious, and are transmitted in from animal-to-animal in ways still not entirely understood?

      Fact: CWD does not cause the animals to go "MAD" or attack others

      No, it causes a rapidly progressing dementia in many animals, robbing them of their cognitive function and often changing their personality and behavior drastically. Cats with feline spongiform encephalopathy (mad cat disease), for example, often become violent or withdrawn. No one knows for sure how wolves will be/are being (if at all) affected by prions.

    3. Re:Enough Speculation! by William+G.+Davis · · Score: 1
      from species to specious

      Should be "from species to species".

    4. Re:Enough Speculation! by -stax · · Score: 1
      One has to wonder, though, about the potential ramifications of having dangerous predators exposed to this brain-wasting illness, and what type of 'unusual behavior' they'll start to exhibit.

      My point is that the above phrasing was incredibly sensational. It implies that suddenly we will have packs of "mad wolves" ravaging the countryside.

      As you already stated wolves are no more "dangerous" than the black bears, mountain lions, and many other predators indigenous to this continent. What's your point?

      There has been NO research to indicate that "dangerous predators" will become a threat to humans because of CWD infection.

      Your synopsis was (IMO) overly sensational and speculative. My apologies for calling you an idiot, it was not necessary for the discussion, nor was I correct.

    5. Re:Enough Speculation! by William+G.+Davis · · Score: 1

      My point is that the above phrasing was incredibly sensational. It implies that suddenly we will have packs of "mad wolves" ravaging the countryside.

      As you already stated wolves are no more "dangerous" than the black bears, mountain lions, and many other predators indigenous to this continent. What's your point?

      That perhaps repopulating wolves for the sole purpose of exposing them to this neurodegenerative disease will have some unfortunate consequences. The article never addressed the possibility that wolves might be able to contract this infectious disease, so I thought it bared mentioning.

    6. Re:Enough Speculation! by -stax · · Score: 1

      no need to reinvent the wheel, this post about sums it up.

  8. Wolves as Dangerous Predators by Snowspinner · · Score: 4, Insightful

    Wolves aren't really so much "dangerous predators" as "your basic carnivores in the wild." They're not going to attack humans unless their other food options are totally depleted and they're starving.

    Mad Wolf Disease would not cause this situation so much as make the wolf infirm and eventually dead. You're not going to have sudden blood-lusted and violent wolves. You're going to have very dead wolves who can't function.

    Meanwhile, absurd paranoia like this will lead to an incrase in programs like the one they're trying really hard to put into place in Alaska, whereby they will slaughter all wolves in a given area with a 100 mile radius. By shooting them from helicopters. And sometimes, by chasing them via helicopter to the point of exhaustion, and then shooting them. Because apparently the helicopter and machine gun aren't enough on their own.

    Short form - the "wolves are dangerous" myth is both ignorant and destructive, and whoever submitted this article (As well as whoever approved it) should be ashamed - spreading crap like this on as widely read a site as /. is just wrong, and I'd encourage whoever is responsible to go to a site like www.defenders.org and donate a but of money to try to push the tide of public opinion back away from myth and towards truth.

    1. Re:Wolves as Dangerous Predators by happyDave · · Score: 3, Informative

      Hear, hear! I also recommend reading Farley Mowatt's "Never Cry Wolf." Don't hold against it that it was made into a Disney movie, please. Farley Mowatt was sent into a section of Northern wilderness by the Canadian government to investigate the "wolf problem," as hunters were complaining to the government about the scarcity of Caribou, and how the wolves were killing them all.

      His findings, in short: Human beings were responsible for the enormous drop in Caribou numbers by indiscriminate hunting. The number of myths about wolves and lupine behavior that are still around is absoultely inexcusable.

    2. Re:Wolves as Dangerous Predators by Anonymous Coward · · Score: 0

      I know some moron hunters who kill any wild dog they see, because "they are bad" and "kill all the deer". They also like to talk about how great they are for helping to reduce the population of deer, who are overpopulated because the real predators are rotting with bullet holes in them. Makes me sick.

    3. Re:Wolves as Dangerous Predators by William+G.+Davis · · Score: 1

      Wow. I never suggested that wolves were extremely dangerous, baby-eating monsters that needed to be eradicated. I used one word, "dangerous," to accurately describe an animal that can hurt humans, as opposed to, say, a Caribou or a Pronghorn or a Squirrel.

      You suggest that a mad wolf disease would not really result in unusually violent behavior, but this is not the case in other animals. Animals suffering from some kind of spongiform encephalopathy often undergo dramatic changes in their personality and disposition, often before any other symptoms significantly manifest themselves. Animals may become withdrawn, frightened, depressed, violent, etc., etc.--no one knows for sure how wolves in general or how each individual one would, if at all, be affected by the disease. I only mentioned it because the article never addressed the possibility that wolves might be able to contract this infectious disease. In no way was I implying that that the wolf population needed further eradication.

      I'm sorry Alaska is embarking on the program you described. I sometimes visit a house in an area populated by an abundance of whitetail deer and black bears and it always amazes me that many people here are terrified by wolves but aren't the least bit concerned about the black bears, which are much more likely to attack humans and much more likely to do much more damage; all because movies and TV portray them as harmless, gentle giants.

  9. However... by tsanth · · Score: 2, Informative

    -from what I remember reading in some not-so-recent Scientific American, a scavenger's immune system wouldn't help protect against rogue prions, because they're neither virus nor bacteria. A scavenger, if it incorporated these same prions into their own bodies, could possibly also be at risk for mad foo disease.

    1. Re:However... by Tango42 · · Score: 1

      I'd forgotten about savenger's immune systems, but now you mention it, i do recall hearing it before. You make a good point. As for prions, they are out of my field of knowledge, so i can't really say, but i would expect they are similar to viruses in detection, they are both sub-cellular organisms.

    2. Re:However... by jasno · · Score: 2, Informative
      From About.com:

      Definition: A protein particle that is capable of causing an infection or disease. Like viruses, prions are not capable of reproduction by themselves. Unlike viruses, prions do not contain genetic material (DNA or RNA).


      I think they're an example of a self sustaining molecule - one that catalyzes the creation of itself from another molecule.
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    3. Re:However... by Tango42 · · Score: 1

      That would make sense. I don't know how that would effect immune systems though... i would think it would be easy to the WBCs to "eat" the prions, but obviously it is more complicated than that. If they effect the brain they must be able to get through the barriers, which means they are very small (as you would expect for a single protein molecule), which would probably cause the immune system problems.

    4. Re:However... by Alsee · · Score: 1
      at risk for mad foo disease.

      ::shudder::


      I don't know what I'd ever do with my Friday nights if they ever discovered a case of mad bar disease :)

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    5. Re:However... by Anonymous Coward · · Score: 0

      Not really...when viruses get into a cell and start making trouble, they make a variety of proteins that aren't supposed to be there. Since the cell usually displays the various proteins it's making, this is what often tips off the immune system.

      Since a prion is a protein folded into the wrong *shape* but with the same *composition*, it's not clear it would elicit the same response.

    6. Re:However... by MillionthMonkey · · Score: 1

      I think they're an example of a self sustaining molecule - one that catalyzes the creation of itself from another molecule.

      That's probably the best way to look at it. It's just like Vonnegut's ice-nine, except it works on a particular mammalian brain protein instead of water.

      Infective particles pass through 30 nm filters and survive immersion for long periods of time in formaldehyde. They are relatively impervious to radiation and can survive the heat of a rendering plant. Unlike the normal protein, the prion form is not attacked by proteases such as those present in a mammalian digestive system.

      When the protein mutates to form a prion, a small beta pleated sheet region near the protein's N-terminus nucleates a much larger one that consumes an alpha helix and almost the entire N-terminal half of the protein. Apparently this can happen two ways. A non-mutant form can spontaneously mutate to the prion form. Since the prion's conformational energy appears to be lower from all the beta-pleating, this is thermodynamically possible and there must be high kinetic barriers in the way to prevent it from happening all the time. (While spontaneous cases are extremely rare, they do imply that we will never see these diseases completely eradicated.) The more likely mechanism is exposure to an already-mutant prion particle, which overcomes the kinetic barrier by acting as a catalyst.

      The prion's beta pleated sheets apparently give it structural integrity against heat, chemical, and protease attack. They are also what imparts the self-replication ability of the prion to induce the same alpha-helix to beta-pleated-sheet conformational changes in neighboring proteins, in a mechanism that is probably similar to crystal growth. The beta sheet forming peptides aggregate to form amyloid fibrils, and this kills neurons through apoptosis.

      See this page on transmissable spongiform encephalopathies for more info. There is a decent animation of the folding event here.

  10. Mad cow book by Anonymous Coward · · Score: 1, Informative

    The book Mad Cow USA is now a free download (PDF). It's the entire book with 245 pages.

  11. BS by hummassa · · Score: 1

    No primates are vegetarians. Don't do that.

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    1. Re:BS by jc42 · · Score: 2, Informative

      No primates are vegetarians.

      Well, strictly speaking, you're right. Most primates get a small amount of their protein by eating small animals, mostly insects. But this doesn't make them predators. In general, primates get most of their calories from plants, and have few if any adaptations for predation. They're more properly classified as omnivores.

      Similarly, cattle and other grazing animals inevitably eat a small quantity of insect, snails, etc that are mixed in with the herbs. But this doesn't make a cow into a predator.

      In addition to humans and chimps, there are a number of other primates that actively hunt prey. Baboons come to mind. There's also the fish-eating monkey in southern Asia. All four of these species get a significant amount of protein and calories by eating small animals. But most primate species get maybe 1% of their calories by predation, so they don't really qualify as predators.

      --
      Those who do study history are doomed to stand helplessly by while everyone else repeats it.
    2. Re:BS by s0l0m0n · · Score: 1

      [i]Similarly, cattle and other grazing animals inevitably eat a small quantity of insect, snails, etc that are mixed in with the herbs. But this doesn't make a cow into a predator.[/i]

      Sure does, if you are a snail.

  12. Sorry TykeClone.. From the article by RandomInAction · · Score: 1

    "Wasting disease makes its victims distracted and unwary as it eats tiny holes in their brains, the Denver Post reported"

    I think that clears that up.

  13. Mod Parent down - Bad info. by maysonl · · Score: 1
    To quote from the Chronic Wasting Disease Foundation website:

    Chronic Wasting Disease (CWD) is a transmissible neurological disease of deer and elk that produces small lesions in brains of infected animals. It is characterized by loss of body condition, behavioral abnormalities and death. CWD is classified as a transmissible spongiform encephalopathy (TSE), and is similar to mad cow disease in cattle and scrapie in sheep.

    1. Re:Mod Parent down - Bad info. by valkraider · · Score: 1

      I always thought "Chronic Wasting Disease" had more to do with Video Games, Junk Food, Pot, Junk Food, Soft cushy chairs, Pot, and I forget what else...

      I sure could go for a burrito right now...

  14. Re:Prions in brain tissue by xtermin8 · · Score: 0

    Mad Cow is transmitted by eating the brains of infected animals- in contrast to eating other parts of infected animals. Google "prions" Apparently, they are neither bacteriological nor viral. It seems prions may be active in soil, maybe even water? There's very little known about prions, but I think they remain active long after the brain tissue has decomposed.

  15. Not eating but _injecting_ ... by fygment · · Score: 1

    ... is how researchers have propagated the disease. In fact, the transmission means is unknown in part because we don't yet know the agent (as explained here). So, as in so many things, that the wolves might get and propagate the disease is just wild-assed FUD.

    --
    "Consensus" in science is _always_ a political construct.
  16. mod parent down by barakn · · Score: 1
    Had the submitter actually read up on CWD, they'd have learned that it's already present in areas where there are wild wolves, and that there's no sign of the wolf population contracting it.

    Had the parent RTFA, they'd have read that CWD has not been found in areas near wolves, and that's why nobody knows what's going to happen. To quote:

    No one has been able to study whether wolves single out CWD-infected animals because the range of predator and disease have never overlapped.

    --
    "I'm so moist I'm sticking to the leather." -Kermit the Frog on The Late Late Show
    1. Re:mod parent down by Drakin · · Score: 1

      Which is bullshit. We've got some CWD infections here where I live. This is a cause for great concern, because we also have a large number of elk ranches, and a respectable amount of white tail and mule deer.

      And guess what? We've also go wolves, who are well known to feed on the local elk.

      While I know that in the area talked about in the article the wolves have not interacted with the deer and elk, but there's other places where they have, in places where the wolf population hasn't been wiped out.

    2. Re:mod parent down by barakn · · Score: 1
      Elk ranches? Here's the problem: CWD is found in the wild less often than it is in captive populations. The ranches are fenced so that the animals (good jumpers) can't get out, and so poachers and wolves can't get in. Wolves aren't going to interact with CWD in captive populations, only with CWD in wild populations. Here's a map of CWD. The wolves haven't made it down past Yellowstone, so they haven't encountered the wild CWD spreading north yet. Looking at the wolf populations in the Great Lakes area, we note that the wolf populations are in northern Wisconsin, Michigan, and Minnesota, whereas wild CWD outbreaks are only in southern Wisconsin and northern Illinois.

      That leaves one last area: Saskatchewan, with two small wild CWD outbreaks. One CWD spot is the Manito Sand Hills (I find no mention of wolves there, though they may be) and near Saskatchewan Landing Provincial Park, where I think there are wolves. Since only 5 cases have been found in the whole huge province, though, it's impossible to study the interaction of wolves and the disease.

      Montana has shown great wisdom in outlawing game farms. CWD isn't the only reason.

      --
      "I'm so moist I'm sticking to the leather." -Kermit the Frog on The Late Late Show
  17. Dogs, horses and rabbits.... by aminorex · · Score: 1

    > One has to wonder, though, about the
    > potential ramifications of having dangerous
    > predators exposed to this brain-wasting
    > illness, and what type of 'unusual behavior'
    > they'll start to exhibit."

    Dogs (including wolves), horses, and rabbits
    are notably resistant to TSE prion diseases.
    Nobody knows why, yet.

    --
    -I like my women like I like my tea: green-
    1. Re:Dogs, horses and rabbits.... by valkraider · · Score: 1

      Condoms.

    2. Re:Dogs, horses and rabbits.... by Radical+Rad · · Score: 1

      And another important point is that even if they weren't resistant is that wolves are not in the human food chain. Better to have wasting wolves out there than wasting deer that ends up in a hunter's family's bellies.

  18. darn farmers by the_greywolf · · Score: 1

    up here in Idaho, farmers and herders generally hate wolves. they'd hunt wolves into extinction if it were up to them.

    this is one of the arguments in favor of the 7 main Idaho packs and numerous Yellowstone packs that could protect them.

    there are also a lot of hunters here that would rather have untainted game. letting the packs run wild, as they should be, could very well help hunting in this state, rather than hurt it as the farmers would have you believe.

    (sadly enough, the farmers' 3 main arguments are that wolves kill all livestock, attck humans, and destroy the game population. everyone knows wolves don't normally attack humans, that they help control the game population rather than diminish it - not to mention weeding out the sick and feeble, and rarely attack livestock - i'd hardly call 6 dead calves the end of the world. bad, yes. end of the world, no.)

    --
    grey wolf
    LET FORTRAN DIE!
  19. brain-wasted predators by ralphclark · · Score: 0
    One has to wonder, though, about the potential ramifications of having dangerous predators exposed to this brain-wasting illness, and what type of 'unusual behavior' they'll start to exhibit."

    Experience suggests that they will probably do something like launch a series of groundless IP lawsuits against the open source community.

  20. Dragon antibiotics... by dus · · Score: 1

    They have isolated multiple anti-bacterial compounds and hopefully they will be able to make incredibly powerful new antibiotics available in a few years.

    Yeah, but some incredibly powerful antibiotic that a Komodo dragon (Varanus komodoensis) can handle may be quite deadly to us humans... Komodo dragons aren't all that closely related to us, you know (for one, they're cold-blooded).

  21. Their nasty enough that... by Anonymous Coward · · Score: 0

    if you incinerate a mad foo sheep to ash, and feed the ash to other sheep you get more mad foo sheep. Moderate radiation doesn't help either. So if something has protines similar enough, and thermodynamically less stable than our nasty brain eating molecule but is unable to destroy bad copies, it's bad times as the prions just persist. Getting into water, or onto something that is suitibly tasty for another animal.

    Wolves being mammals an all, and probably closer to humans than say deer, I wouldn't call myself overly optimistic.

  22. What mystery by Camel+Pilot · · Score: 2, Interesting

    CWD is prevalent in ranching areas. I theorize that the deer and elk are eating livestock feed on occasion when the opportunity presents itself - a very common occurance.

    Keep in mind that chicken and pork feed use ground up animal protein, including brains of down animals. All approved by the USDA. It is just cattle feed that is not supposed to contain animal protein. In fact in the Washington casem, i would bet that the cow in question at one time dined on swine feed.

    Large numbers of dear and elk contact the disease simply because they live long enough for the disease to manifest itself (3 - 5 years)

    Comforting is it not?

  23. If you don't have predators, diseases fill in by hey! · · Score: 1

    A friend of my married into a rich family that owned a good sized island (somewhere in the NE us, won't be more specific).

    The deer and rodents were completely out of control. IT was great for deer hunting, but everyone in the family contracted Lyme disease. The ticks there were unbelievable.

    Then the western coyote made to that region of the country and swam to the island (an impressive feat). In one season they reduced the deer herd to a manageable size and then turned to the voles and other small rodents. Result: ticks are now in check along with Lyme disease.

    The lesson here is that without top level predators, prey populations rise until they are checked by starvation on one hand, or parasites and diseases on the other.

    --
    Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
  24. Immune system is irrelevant by MillionthMonkey · · Score: 2, Insightful

    And there's lots of literature supporting the idea that predators and scavengers tend to have very good defenses against the diseases that affect their prey. Part of the defenses are powerful digestive systems that leave few cells intact and chop up most proteins and DNA into small pieces. They also have some of the best immune systems on the planet.

    You can have the strongest immune system of any known mammal or bird and it will not protect you from prion diseases like spongiform encephalopathies. There is no foreign protein (except for the prion particle that you originally got infected from years ago), just a lot of funny-folded native protein. So what? As amyloid plaques build up in your brain, your immune system has nothing to attack. An infected animal's body can be riddled with prions at death and you will not find a single antibody to them anywhere since they pass the self/non-self test. In fact, to get antibodies, people need to inject massive quantities of prion particles into unrelated animals, whose immune systems will react in the same way they do with any foreign protein.

    A strong digestive system doesn't seem to be much help either, as the prion form of the protein is extremely resistant to attack from proteases.

    There are many versions of the prion gene, and not all of them are equally prone to malicious folding. Wolves with prion genes whose PrP proteins fold easily into the beta-pleated-sheet prion tend to die after eating lots of prions. Surviving wolves gobble prions and suffer no adverse consequences since their native protein is resistant to the altered conformation. So the wolf is probably OK, because of the selection pressure that has been applied to it.

    But you'd think the same thing about cats, and cats get the disease easily. But in fact, it is highly likely that all wolves are immune to transmissable spongiform encephalopathies judging by the mere fact that nobody has ever succeeded in infecting a dog with any sort of TSE. Even when they plonk highly infectious prion material directly into a dog's brain, no TSE develops. TSE of one flavor or another has been successfully transmitted to goats, sheep, monkeys, pigs, mink, cattle, cats, and zoo animals of all types that ate prion-contaminated feed. Never to any breed of dog (or wolf, same thing).

    When BSE broke out in England, a number of human victims (who all ate beef) came down with CJD. It was called "new variant" CJD ("nvCJD") because it turned out not to be CJD at all, which attacks the cerebral cortex, but is in fact a closely related disease: the human form of BSE, which attacks the brainstem just like it does in cattle. A prion researcher tried to transmit BSE from cows to transgenic mice which had a human prion gene, via brain injections (the foolproof way to get it- feeding is much less effective). This experiment was eventually watched closely by the British food industry as the mice survived past 300 and 400 days. But meanwhile, study of the first ten victims of nvCJD in Britain showed that all were homozygous for methionine at codon 129. About 38 percent of the human population fits this profile. The mice (which never showed any signs of illness) had a human prion gene that was homozygous for valine, not methionine, at codon 129. So while this is a transmissable disease, susceptibility is genetically determined.

  25. the first thang that came to mind.. by Roman_(ajvvs) · · Score: 1
    ...when I read:

    "One has to wonder, though, about the potential ramifications of having dangerous predators exposed to this brain-wasting illness, and what type of 'unusual behavior' they'll start to exhibit."

    was.. WEREWOLVES! Run for the hills! ;)

    --
    click-clack, front and back. I'm not moving this car otherwise.