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Living Photos Use Bacteria as Pixels

BrainBlogger writes "Scientists at UC San Francisco have engineered bacteria to create living photographs that weigh in at 100 megapixels per square inch. The photos were created by projecting light on "biological film" -- billions of genetically engineered E. coli growing in dishes of agar."

156 comments

  1. Students discovery? by dada21 · · Score: 4, Interesting

    Obligatory Coral Cache Link

    Pretty detailed tiny image of the Flying Spaghetti Monster. How many noodly appendage comments will we see?

    With the growing number of sequenced microbes, we can search through nature's large trove of tools to find ones that fit the job," Levskaya said. "In our case, searching for light-sensing domains led us to use a photosynthetic bacterium." The students produced ghostlike, living photos of many things, including themselves and their advisors

    I wonder how far they are from being able to take a huge image of a processor chip pathway and use these microbes to lay out an eating path for another microbe to create cheaper chips. I'm guessing it isn't realistic in the near future, but as the progression builds towards more "consistent" bacteria, maybe we'll see more aggressive use of these discoveries for profitable reasons.

    That's my biggest question -- is anyone seeing private R&D scientists investing time and money in engineered bacteria that will be protected by patents or other IP protections? It's pretty amazing that TFA's discovery was by students.

    1. Re:Students discovery? by Anonymous Coward · · Score: 1, Interesting

      It's not that amazing to see discoveries come from students in Academia.

      I would be more amazed to see a company develop something like this. These days, it seems bio-business works by putting a protection of patents around academic discoveries.

    2. Re:Students discovery? by haluness · · Score: 1

      It's pretty amazing that TFA's discovery

      Its more engineering a feature than discovering a feature

    3. Re:Students discovery? by websaber · · Score: 4, Funny

      The Flying Spaghetti Monster http://en.wikipedia.org/wiki/Flying_Spaghetti_Mons ter appears in living material and you attribute it to "Science" and "Bio-business". He is talking to us and we are just to cynical to listen. For shame. We must fight for the minds of tommorow or there is no hope.

      --
      "A good friend will bail you out of jail. A true friend will be sitting next to you saying, 'damn....that was fun!'"
    4. Re:Students discovery? by ottffssent · · Score: 2, Interesting

      These bacteria are way too big to be of any use in modern photolithography. Assuming each one's square, and there's 1 per pixel, each bacterium takes up an area of about 6.5 square microns (1 100-millionth of a square inch). For comparison, the smallest production SRAM cell I can find is .25 square microns, and contains 6 transistors. That makes these bacteria 150x as big as a transistor, and even larger when compared to the features that make up the transistors and connect them together.

      Now, in situations where you want a physically large product, such as the circuitry to drive an LCD, biology holds huge promise.

    5. Re:Students discovery? by Anonymous Coward · · Score: 0

      Pretty detailed tiny image of the Flying Spaghetti Monster. How many noodly appendage comments will we see?

      You must be new here. We will see none, because nobody RTFA!

    6. Re:Students discovery? by macklin01 · · Score: 1

      It's pretty amazing that TFA's discovery was by students.

      Actually, that's pretty normal in graduate school. Professors have the breadth and depth of understanding that allows them to select promising projects and to know which have the greatest current value. (i.e., they know how to select a project that's currently important / interesting with a good likelihood of getting grant funding.) This also allows them to direct a large group of graduate students. But generally, once the graduate students receive the problem, it's up to them to find the solutions and any new discoveries to finish the job.

      An example: A student is told to implement a mathematical model for tissue growth in a collagen scaffolding. The professor says that a level set method is probably the best way to model the boundary of the growing tissue / colony of cells and hands off several research papers to the graduate student. The student tries those things and find that some methods work well and others don't. The student does a literature search and finds out that this is the best that exists. At that point, the student confers with the advisor as necessary and develops whatever new techniques are necessary to get the job done. Then, the advisor and student get to write two papers: one on their new numerical techniques, and another on the science findings that were made possible by their new numerical techniques.

      The key is that the graduate students are responsible for filling in the fine details of a larger project. This means that it's only natural that they'll discover new things along the way. (That's what they write their dissertation on.) The professors of course have a major role in this, too, but in a certain sense, they're (extremely competent) managers, but not of the pointy-haired variety. :-) -- Paul

      --
      OpenSource.MathCancer.org: open source comp bio
  2. Not surprising by roman_mir · · Score: 3, Funny

    Living Photos Use Bacteria as Pixels ...
    Nothing for you to see here. Please move along.
    ---
    Can't see nothing with those bacteria sized pixels!

    1. Re:Not surprising by Bananatree3 · · Score: 1
      Nothing for you to see here. Please move along.

      That is, unless you have really good eyesight.

    2. Re:Not surprising by Anonymous Coward · · Score: 0

      Well... here is my AC deep thought for the day...

      Kind of makes you wonder if the being/beings that put us here are discussing these images in a similar manner....
      http://www.peru-explorer.com/nasca.htm

  3. Respect life by Anonymous Coward · · Score: 5, Funny

    That bacteria has every much of a right to life as you! Boycott anti-bacteria soap and walking!

    Who do some people think they are--the pinnacle of creation, or something?

    1. Re:Respect life by Anonymous Coward · · Score: 0

      Who do some people think they are--the pinnacle of creation, or something?

      Only the christians. The others are superfluous scum.

  4. Hmmm. by cocoamix · · Score: 5, Funny

    So that's what an intelligently designed life-form looks like.

    1. Re:Hmmm. by Anonymous Coward · · Score: 0

      I'm not so sure Jesus would approve.

    2. Re:Hmmm. by Anonymous Coward · · Score: 0

      Of course. The lifeforms were made in His image. His Noodly image.

    3. Re:Hmmm. by Anonymous Coward · · Score: 0

      Actually you are what an inteligently designed life form looks like.

      This bacteria is what a humanly designed life form looks like.

      Just because someone who was inteligent designed you, doesn't mean you inherited that intelligence.

      Just a thought...

    4. Re:Hmmm. by Anonymous Coward · · Score: 0

      It is amazing how circular your logic is, and yet you think you've said something meaningful. If you are an example of a designed entity, the designer must have had a few too many and forgot to go to the designated designer for guidance.

    5. Re:Hmmm. by Anonymous Coward · · Score: 0

      How does insulting god make his logic circular?

    6. Re:Hmmm. by swiftstream · · Score: 1

      It can't be coincidence that the picture produced by these intelligently-designed life-forms is that of the Flying Spaghetti Monster. They are obviously indicating who is the Great Intelligent Designer of the human race!

      --
      Be a PATRIOT--because the only thing we have to fear is the lack thereof.
    7. Re:Hmmm. by Yocto+Yotta · · Score: 2, Funny

      That, you heathen, is the image of Jesus' father. Get with the times.

      --
      A B A C A B B
    8. Re:Hmmm. by ozmanjusri · · Score: 1

      How does insulting god make his logic circular?

      It makes Him so pissed off he can't think straight.

      --
      "I've got more toys than Teruhisa Kitahara."
  5. Mmm. by dslauson · · Score: 4, Funny

    Who wants to be the first to flip through my E.coli scrapbook?

    1. Re:Mmm. by Anonymous Coward · · Score: 0

      Only if the obligatory E.coli centerfold is age appropriate.

    2. Re:Mmm. by Anonymous Coward · · Score: 0

      By chance, my cursor obscured the 's' in scrapbook, so your comment was even funnier.

    3. Re:Mmm. by Anonymous Coward · · Score: 0

      Do kids these days even know what a centerfold is?

  6. Remember.... by TeaQuaffer · · Score: 4, Funny

    To wash your hands and don't touch your face after using your camera.

    --
    Sola Deo Gloria!
  7. Gross ... by fak3r · · Score: 0, Offtopic

    Obviously they got all the germs from donated used keyboards...Dirty keyboard cause infections in hospitals

  8. Ecoli coating by Belseth · · Score: 4, Funny

    Great, now you can get Montezuma's Revenge from a photo.

    1. Re:Ecoli coating by nizo · · Score: 4, Funny

      Plus now you really can go blind from looking at naughty pictures.

    2. Re:Ecoli coating by game+kid · · Score: 1

      I can barely stomach the thought of gastroenteritis from my pictures, nevermind blindness.

      --
      You can hold down the "B" button for continuous firing.
    3. Re:Ecoli coating by Dirtside · · Score: 1
      Plus now you really can go blind from looking at naughty pictures.
      It's not so much the looking, as the masturbating after touching the pictures...
      --
      "Destroy science and religion. Science would re-emerge exactly the same; but not religion." - Penn Jillette, paraphrased
  9. dirty pictures by hosecoat · · Score: 4, Funny

    so now there is a new kind of dirty picture. The internet will thrive!

  10. Just as well these bacteria can't think for... by St0rmwarden · · Score: 1

    ... themselves, or someone who hasn't washed recently could end up with "idiot" written on their forehead.

  11. What I'd REALLY like to see... by GillBates0 · · Score: 1

    What I'd really like to see is for them to take a picture of billions of genetically engineered E. coli bacteria in a petridish of agar. Yes, that sure will be cool to see.

    --
    An Indian-American Hindu committed to non-violent thought/speech/action alarmed by the global explosion of radical Islam
  12. Wow by GmAz · · Score: 0, Redundant

    Do you get your money back if the image starts to get blurry or stretch apart? What if it dies?

    --
    Click Click Bloody Click PANCAKES!
  13. E. coli!? What happens if... by GecKo213 · · Score: 2, Funny

    ...my child gets a hold of the negatives and eats them? E. coli poisoning!? No thank you!

    --
    Generation Trance: What generation are you?
    1. Re:E. coli!? What happens if... by johnty · · Score: 1

      i'd worry if your kid ate some negatives in the first place... those corners can be sharp you know...

      --
      I am unique, just like you, and you, and you...
  14. Great... by DaedalusLogic · · Score: 1

    Now photos can be as healthy for you as a Jack in the Box hamburger.

    I don't think the hamburgers react to light though... or anything else...

  15. Hail Thy Holy Noodley Appendage! by Bananatree3 · · Score: 2, Insightful

    I have seen His Holiness himself! Bacteria in the form of Him?!? This most certainly is the work of Thy Holiness! How else could this be possible? Most certainly His own work. These students have been Touched by his Noodely Appendage! (faints)

    1. Re:Hail Thy Holy Noodley Appendage! by Anonymous Coward · · Score: 0

      His image in the bacteria cannot be an accident! The bacteria must have been intelligently designed to make it! ... oh, wait...

  16. Obligatory Jokes by thewiz · · Score: 4, Funny

    That picture of you will really grow on someone!
    Watch as the eyes of the picture really do follow you around the room!
    E. Coli never looked so beautiful!

    --
    If "disco" means "I learn" in Latin, does "discothèque" mean "I learn technology"?
  17. That's old... by Anonymous Coward · · Score: 0

    Baskin Robbins had that years ago with their photo cakes.

  18. *Ducks* by Shadow+Wrought · · Score: 1, Redundant

    That photo sure grows on you doesn't it?

    --
    If brevity is the soul of wit, then how does one explain Twitter?
    1. Re:*Ducks* by evil+agent · · Score: 4, Funny
      That photo sure grows on you doesn't it?

      Yeah, it's so life-like.

      --
      End transmission.
    2. Re:*Ducks* by Anonymous Coward · · Score: 0

      But I hear dead pixels are a big problem...

  19. and what _I_ really want to see by rsilvergun · · Score: 1

    is a picture of George Wendt eating E. coli bacteria from a petridish in a movie.

    --
    Hi! I make Firefox Plug-ins. Check 'em out @ https://addons.mozilla.org/en-US/firefox/addon/youtube-mp3-podcaster/
  20. new bacteria by Anonymous Coward · · Score: 0

    I for one welcome our new photogenic masters.

  21. why is this interesting? by penguin-collective · · Score: 5, Interesting

    E. Coli genetic engineering has been around for many years. Creating light sensitive strains, strains that make pigments, etc. is roughly appropriate for college level biology. I suppose it's kind of neat that engineers have taken notice, but it really is textbook stuff.

    In fact, even more simply, since the pigment was present/absent based on whether the bacteria were growing in the light, you can repeat this experiment at home: use any organism using chlorophyll for photosynthesis and grow it in patterned light: you'll get a "photograph" in green/yellow. That's an experiment even elementary school students do.

    You've got to give it to these people, though: they are excellent salespeople. Getting away with such trivialities as "engineering" and endowing bacteria with "new skills" takes both guts and skills.

    1. Re:why is this interesting? by imsabbel · · Score: 1

      You would be surprised how many "really basic" stuff any college student could do become cutting edge stuff if you JUST make them a bit smaller/ better /ect.

      I did some lithography to create 3d-structures using multilayered resists as a basic lab course. Using REALLY old stuff like 400nm HG-vapour lamp lithography and contact masks. Things you could have done 25 years ago.

      But just do the same with an ebeamer and make 15 nm free-gaps to contact spintronic devices without annoying insulating layers, and its suddenly paper-worthy.

      Same here. 100million pixel/in^2 seem to indicate 2.5um structure size, which COULD be a breakthrough in reproducability/ miniaturisation of that kind of process... (i cant say it IS as im not very familiar with that biology stuff)

      --
      HI O WISE PRINCE. WHT TOOK U SO DAM LONG?
    2. Re:why is this interesting? by Anonymous Coward · · Score: 0

      Agreed. This is worth a Nature paper ?!??!

    3. Re:why is this interesting? by timeOday · · Score: 1

      I have to wonder if there is something more to it. My first thought was that this is awfully similar to drawing on somebody with sunblock when they fall asleep on the beach.

    4. Re:why is this interesting? by swiftstream · · Score: 2, Interesting

      Uhh, in case you didn't RTFA, this _is_ college level biology. The team that genetically engineered the bacteria was led by a grad student.

      --
      Be a PATRIOT--because the only thing we have to fear is the lack thereof.
    5. Re:why is this interesting? by Tim · · Score: 1

      It's a dirty not-so-secret of the scientific establishment that lots of crap gets published in high-quality journals. Lots of great, insightful, interesting papers get rejected, too. Frequently, the success of a publication is about its sales value, more than its scientific value (not to mention who you know, who you are, and how much money you have).

      I could go on and on about this, but it isn't worth the time. People are people everywhere, including scientists. If you do things that make people say "wow, cool hack," then it almost doesn't matter how difficult it was to do. Almost.

      --
      Let's try not to let fact interfere with our speculation here, OK?
    6. Re:why is this interesting? by Anonymous Coward · · Score: 0

      WOW. How did this parent get a rating of 5. I do this kind of work, and I assure you it is no trivial task to re-engineer a life form to do you bidding. If this is so easy, then why is it in Nature (the greatest scientific journal there is). also i know these people, so i have to stick up for them.

    7. Re:why is this interesting? by Anonymous Coward · · Score: 0

      Whatever - this is a pretty trivial genetic engineering project made cool by the shiny "synthetic biology" label, which is itself just re-marketing of what real biologists have been doing for ages.

      Oh, and it's in Nature because they were doing a special on "synthetic biology" and put the least embarrasing example they could find in as a Brief Communication. It's fairly telling that this "synthetic biology special issue" has no research Articles or Letters from the field...

    8. Re:why is this interesting? by Julian+Morrison · · Score: 1

      It's interesting, not because it's difficult or wholly new, but because they gave it the conceptual spin that might lead to real-world applications.

      Scientists knew stuff would heat in an electric current, and hot stuff would glow in a vacuum without burning, long before Edison figuired how to commercialize the light bulb.

    9. Re:why is this interesting? by Anonymous Coward · · Score: 0

      Yes, but "my college science project" doesn't usually make the press, or more importantly, Nature.

    10. Re:why is this interesting? by penguin-collective · · Score: 1

      There is no "breakthrough" here--these are just light-sensitive E coli growing on agar. It's essentially scum on top of jello and about as useful as a recording medium.

      Bacteria may well eventually become useful as a storage medium in some form (people have thought about it and tried it), but this work isn't anywhere on the path to that goal.

    11. Re:why is this interesting? by Anonymous Coward · · Score: 0

      " It's fairly telling that this "synthetic biology special issue" has no research Articles or Letters from the field "

      I think you just said it best yourself. This demonstrates the fact that field is incredibly difficult and indeed "new". And I can assure you the people in this field are not biologist but instead engineers like me and many others who read this site. The fact that I as an engineer can create something over a year that a biologist would have deemed impossible (or at least too difficult to attempt) I find to be quite an accomplishment.

      Oh yeah. And I didn't know biologists ever used transfer functions to look at genetic systems components.

  22. Looks monochrome to me by Locke2005 · · Score: 1

    Uh, why don't you get back to me when you can engineer bacteria that respond differently to different wavelengths of light, e.g. change to the same color as the light striking them. THEN I'll get excited!

    --
    I've abandoned my search for truth; now I'm just looking for some useful delusions.
    1. Re:Looks monochrome to me by philoupoussin · · Score: 1

      that could easily be done. To get most energy out of the sun, photosynthetic organisms (plants, algae mostly) must take into account the spectral properties of the light. Evolution answered with not one type of photoreceptor, but many different, each having its preferred wavelength. All the work is already done, just a matter of copy-pasting. Then generating the corresponding color would be (almost) trivial, through expression of chimeric proteins (chimera between a given photoreceptor and a given chromogenic enzyme). Voila !

  23. New Scientist by alanw · · Score: 4, Informative
    Plenty of bandwidth over at New Scientist

    Complete with a photo of His Noodly Holiness.

  24. Using E.Coli as pixels? by Stonent1 · · Score: 2, Funny

    That's pretty shitty.

    1. Re:Using E.Coli as pixels? by yellowjacket03 · · Score: 1

      True. But now I have an excuse not to look at photo albums anymore. The terrible diarrhea.

    2. Re:Using E.Coli as pixels? by Hirsto · · Score: 1

      Support bacteria! It's the only culture some people have!

  25. Hellooooo blogvertisement by SuperBanana · · Score: 3, Interesting
    "Adapted from a press release" indeed. WHOIS for brainblog.com:
    Administrative Contact: Elabridi:, Mounir mounir@yahoo.com Maroc Internet SARL 221 Boulevard Zerktouni Casablanca, 20010 Morocco 17202492499 Fax --

    Third google hit on Mr. Elabridi's name is:

    "Maroc Internet - Management Mounir Elabridi, a globally recognized innovator in Internet marketing, founded Maroc Internet in 2002. Mr Elabridi brings to this venture a proven track ...

    Well, now how about that.

    The domain name servers for the domain are NS1/NS2.BENSULLIVAN.COM. Mr. Sullivan lives at 4404 Price St, Los Angeles, CA 90027- about a 15 minute drive from University California Los Angeles. It's a stretch, but also an interesting coincidence.

    1. Re:Hellooooo blogvertisement by dokebi · · Score: 1

      Yeah, but UCSF is about 300 miles away from UCLA. I'd say that's some stretch.

      --
      In Soviet Russia, articles before post read *you*!
    2. Re:Hellooooo blogvertisement by k98sven · · Score: 1

      That's one of the stupidest things I've seen with a +5 moderation in some time.

      Blogvertisement? Okay. What exactly are they advertising here? What product are they selling?

      Website advertisments - and how does that make 'em different from 95% of other sites Slashdot links to?

      And Brainblog is apparently run out of Morocco. Oh, well that connection is obvious then? Nope. Oh, but their DNS servers are run by a guy in Los Angeles! That makes it all clear - only 15 minutes away from UCLA! (Nevermind that a few tens of thousands of people must live in a 15-minute radius of UCLA)

      And UCLA is only 6 hours away from UCSF where the research was done! And they're both in the UC system! (Nevermind that it's one of the world's largest.)

      Calling things "interesting coincidences" is not an excuse to not employ critical thinking.

  26. Just in time for Christmas... by Anonymous Coward · · Score: 0, Funny

    In A.D. 1, Christianity was beginning...
    Roman Commander: What Happen?
    Centurion: Somebody set up us the cross.
    Centurion: We get new religion.
    Roman Commander: What!
    Roman Commander: It's Jesus!
    JC: How are you children?
    JC: All your cross are belong to Jesus.
    JC: You are on your way to political upheaval.
    Roman Commander: What you say?
    JC: You have no chance to survive make your Empirical Dominion.
    JC: Ha Ha Ha Ha...
    Centurion: Commander!
    Roman Commander: Move Executions!
    Roman Commander: For Great Rome!

  27. This gives.... by wpiman · · Score: 1

    new meaning to the term live porn.

  28. flying speghetti monster? by GoatPigSheep · · Score: 0, Flamebait

    How am I supposed to believe this is real if there is a pic of the flying speghetti monster in the corner (FSM). Looks like slashdot got duped by a joke article again...

    --
    GoatPigSheep, the 3 most important food groups
  29. Angry E. Coli by RootsLINUX · · Score: 1

    I initially read the post as -- billions of genetically engineered E. coli growing in dishes of anger , and I couldn't for the life of me imagine how the scientists were able to know that the E. Coli were angry. I thought maybe they were working together to form insulting pictures to project at the researchers, like goatse or something to that effect. E Coli with attitude: now that's news for nerds! :D

    --
    Hero of Allacrost, a FOSS RPG for *NIX/*BSD/OS X/Win
    1. Re:Angry E. Coli by Anonymous Coward · · Score: 0

      current mood: bacteriay

    2. Re:Angry E. Coli by Anonymous Coward · · Score: 0

      Wouldn't it be the dish that was angry? Wouldn't you be?

  30. Warning Label... by __aaclcg7560 · · Score: 1

    ... billions of genetically engineered E. coli ...

    Why would anyone want to buy a camera that has a warning label that the product is not only hazardous to your health but is also a biological agenet if exported outside of the USA? Should be a hot Christmas item for kiddies and terrorists.

  31. Ah! by setirw · · Score: 1

    So that's how those neat photographs of the Avian Flu virus were taken!

    --
    This message printed on 100% post-consumer recycled electrons.
  32. Ya wanna know what's really interesting? by TrebleJunkie · · Score: 0, Offtopic

    All this neat stuff we can do, and we *still* dismiss intelligent design as a possibility.

    *chuckle* That's really interesting. Sad and funny, but interesting.

    --

    Ed R.Zahurak

    You know, oblivion keeps looking better every day.

    1. Re:Ya wanna know what's really interesting? by Anonymous Coward · · Score: 0

      You can't seriously think that people believing that their imaginary friend created them is a basis for science, do you?

  33. Re:In Soviet Russia... by Zey · · Score: 1

    The mid-1980s want their humour back.

  34. e coli by Quiet_Desperation · · Score: 0, Redundant

    I hear the pictures turned out like shit, though.

  35. E.coli by FidelCatsro · · Score: 1

    Do not eat iPic

    --
    The only things certain in war are Propaganda and Death. You can never be sure which is which though
  36. Slow Film by Rob+Riggs · · Score: 1

    Exposure took 12-15 HOURS? What does that equate to as far as film speed? You're going to need to get that down quite a few orders of magnitude to be useful for imaging anything.

    --
    the growth in cynicism and rebellion has not been without cause
    1. Re:Slow Film by SnarfQuest · · Score: 1

      Now, imagine using it to make porn. Are you up to it?

      --
      Who would win this election: Andrew Weiner vs Andrew Weiner's weiner.
    2. Re:Slow Film by Anonymous Coward · · Score: 0

      Wrong.

      This is the best news ever for people doing still image photography.

      If this project ever gets anywhere, we could have another space telescope with images hundreds of times clearer than Hubble... without needing a huge and risky mirror system.

  37. webcast of the lecture is here! by dokebi · · Score: 3, Informative

    He gave a talk at the Synthetic Biology seminar at UC Berkeley two weeks ago. The web cast is located here:
    http://webcast.berkeley.edu/courses/archive.php?se riesid=1906978261
    It's titled "Programming Dynamic Function into Bacteria"

    --
    In Soviet Russia, articles before post read *you*!
  38. Done before.... kinda by EmbeddedJanitor · · Score: 1

    In the 60s or 70s someone did something similar using photosynthesis on regular leaves. The bacteria are probably better (finer grained and faster).

    --
    Engineering is the art of compromise.
    1. Re:Done before.... kinda by modest+apricot · · Score: 1

      Actually, I did a science experiment somewhere in middle school to the same effect to demonstrate photosynthesis. you can imprint photo negatives onto leaves using tobacco and photosynthesis.

  39. calculating the resolution of bacteria... by fanblade · · Score: 1

    100 megapixels per square inch with bacteria?

    By the same logic, a photograph developed from a negative has as many pixels as molecules on the surface of the paper. Anyone care to calculate that resolution?

    1. Re:calculating the resolution of bacteria... by Anonymous Coward · · Score: 0

      No... The resolution of a negative is governed by the size and density of the photosensitive grains in the emulsion.

    2. Re:calculating the resolution of bacteria... by fanblade · · Score: 1

      Sheesh. My point was that their logic is flawed. No matter how dense the bacteria, the printed resolution is governed by the negative (in turn governed by the size and density of the grains). The idea that the paper determines the resolution is silly.

  40. yuck! by 6pak · · Score: 0

    if only that stuff in my bathroom could do this...

  41. WHAT !!! Oh Man... by MajorDick · · Score: 1

    Now I gotta worry about getting DISEASES like e-Coli from my PORN ?!?!

  42. Ben Sullivan by SuperBanana · · Score: 1, Informative
    Ben Sullivan is a busy blogger bee and socialite (that photo was taken rather close by to the Price Street address- at King King, on Hollywood Boulevard.)

    Seems to also be involved in scienceblog.com, among other things. Which has the exact same address in whois- 4404-1/2 Price Street (sorry- first comment, I omitted the "1/2" by mistake.) Scienceblog.com also happens to feature the same story. He's pretty cheap about hosting, too- flickr seems to host a lot of the images he uses on his blog entries.

    DNS servers for that domain are ns1/ns2.themachineworks.com, and it has an address in France: 7 impasse toufixe de la mort, F-75025, Paris. Kind of a dead end there for me.

    Visiting www.themachineworks.com, there is what appears to be a generic hosting help page. Click through one, and you can see that the page was last modified by "h-68-164-115-163.lsanca54.dynamic.covad.net". "lsanca" looks like "Los Angeles, CA", and a traceroute confirmed it- one of the last hops was through a router with a hostname containing "losangeles1".

    Call me crazy, but why is an "internet marketing specialist" working with Mr. Sullivan? And what is with the super-ritzy address? Hmmmmm.

  43. Beware by Profcrab · · Score: 5, Funny

    "Mooooom, the picture of Billy is eating Billy."

  44. Just like the game! by Dasher42 · · Score: 1
    Remember, everyone, this is stable:
    OOO
    This isn't:
    OOOO
    And I can draw a mean cannonball pattern.
    1. Re:Just like the game! by Zphbeeblbrox · · Score: 1

      0
      0
      0

      lol I wonder how many will get the reference?

      --
      If you see spelling or grammatical errors don't blame me. I tried to preview but IE here at work borked the CSS
    2. Re:Just like the game! by thebudgie · · Score: 1

      Well, I certainly don't. What game are you referring to? (I'm going on a wild assumption that it is a game, but on /. it could be anything... (also I'm quite drunk.))

    3. Re:Just like the game! by Zphbeeblbrox · · Score: 1

      Why The Game of Life of course!

      --
      If you see spelling or grammatical errors don't blame me. I tried to preview but IE here at work borked the CSS
    4. Re:Just like the game! by thebudgie · · Score: 1

      aaaah, now i see. I remember having a game of life thing on my parent's first computer (a Packard Bell) and playing around with the patterns to see what worked, but never on the scale the website you linked to did. I played Darwinia recently which would occasionally show a game of life type intro with randomly generated start populations. Brought back good memories, and would often reach higher numbers of different generations of 'darwinians' (instead of dots) than I could in my youth, with the Packard Bell program...

    5. Re:Just like the game! by Zphbeeblbrox · · Score: 1

      I was first introduced to the game by an andre norton book. I used to spend hours laboriously working out patterns on paper. It helped break up the monotony of long car rides. My first program ever written was a Life Game simulator. You had to enter in your patterns as program arguments.

      Ahhh those were the days.

      --
      If you see spelling or grammatical errors don't blame me. I tried to preview but IE here at work borked the CSS
  45. oh gross! by shokk · · Score: 1

    I thought goatse.cx was bad, but these new photos really make me sick! (rimshot, please) Thank you, thank you. I'll be here all week. Try the veal and don't forget to tip your waiters.

    --
    "Beware of he who would deny you access to information, for in his heart, he dreams himself your master."
  46. Prior art already exists... by MTO_B. · · Score: 1

    This technology has been used for many years by the the wizards.
    I recall Harry Potter seeing many of these pictures.

    If I recall correctly there were some pictures that even came with candy, these had this "ancient" technology, that's why those pics moved only once... they used bacteria, and bacteria like all life forms have only one life to live. The pictures at Hogwarts walls used more modern technology, where bacteria would reproduce, hence making the pictures live forever.

    http://www.google.es/search?q=living+picture+harry +potter

  47. Original link please by caseih · · Score: 2, Insightful

    Where I can I find the original story? This is interesting to me, but I'd rather not be maniupulated into driving traffic to some blog site like Mr. Roland Piquepaille likes to do (haven't seen any of his posts in a while, thank goodness). Not trying to troll here.

    1. Re:Original link please by Anonymous Coward · · Score: 0

      Original Story from Nature (might require login)
      <URL:http://www.nature.com/nature/journal/v438/n70 67/suppinfo/nature04405.html>

    2. Re:Original link please by spage · · Score: 3, Informative

      The lab's home page is http://www.voigtlab.ucsf.edu/ , but they don't have a news item for this yet. The work seems to be Engineering E. coli to see light and will be in Nature according to their Papers section.

      The most recent presentation slides (PDF) are a hoot, that talk must have been fun.

      Go UCSF!

      --
      =S
    3. Re:Original link please by AeroIllini · · Score: 1

      In response to the PDF of the PowerPoint presentation:

      On page 7, there's a graph with the y-axis labeled, "Miller Units", with bars representing "Dark" and "Light". "Light" I get, but I didn't realize Miller made a stout....

      --
      For security, the MD5 hash of this message and sig is 09f911029d74e35bd84156c5635688c0.
  48. I have a cold by Linker3000 · · Score: 4, Funny

    AAAAAaaaaaTTTTCHHHHHHHHHHHOOOO

    Hey, my 24 exposure roll of 35mm film just became 26 exposures!!

    --
    AT&ROFLMAO
    1. Re:I have a cold by Anonymous Coward · · Score: 0

      AAAAAaaaaaTTTTCHHHHHHHHHHHOOOO

      Hey, my 24 exposure roll of 35mm film just became 26 exposures!!


      You don't know where this E. coli stuff comes from, do you?

    2. Re:I have a cold by Linker3000 · · Score: 1

      Yes...

      "The bacteria is shed...in the fecal material as well as nasal and or ocular secretions."

      Meh!

      --
      AT&ROFLMAO
  49. pr0n applications by Randall_Jones · · Score: 0, Offtopic

    Maybe now there will finally be pornographic images of high enough resolution to meet my refined tastes.

  50. Interesting. by jd · · Score: 4, Informative

    For images that are essentially monochromatic, this is fine. Actually, a Russian photographer did some ingenious colour photography using monochrome film, but that was sensitive to all frequencies not just one.

    --
    It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
  51. Cool... by chrstphrb · · Score: 0

    I wonder when will scratch-n-sniff stickers begin using this technology?

  52. Scientists create "chemical image" with molecules by GrahamCox · · Score: 4, Funny

    Scientists have announced that they have managed to create a gigapixel per square inch "light sensor" using only silver halide molecules coated onto a transparent plastic substrate. On exposure to light, some molecules change state by dissociating into pure silver. Exposure times of just a few milliseconds were all that were needed. This image is not visible to the naked eye, but can be "developed" using chemical processing to amplify the image to make it visible. The final image can be then fixed and rendered no longer light sensitive by bleaching out the remaining halides. The image is then rendered permanent. With its vastly higher resolution than ordinary digital CCD sensors, scientists are hailing the discovery as a breakthrough for creating ultra-high resolution images. They have also speculated that by creating a sandwich of light sensitive layers and colour filters, colour images could be recorded by the same process. The only question is, is the usual digital imaging that we have all grown used to doomed by this new process?

  53. He thought of it first... by sokweman · · Score: 2, Interesting

    Interestingly, the idea of using microbes to create an image is not new. Alexander Fleming, the discoverer of penicillin, was a member of the Chelsea Arts Club by virtue of paintings he made by growing different colored bacteria. http://en.wikipedia.org/wiki/Alexander_Fleming

  54. Engineering e-coli uh? by Scrameustache · · Score: 1

    Where did I park my Zodiac?

    --

    You can't take the sky from me...

  55. More interesting information by SuperBanana · · Score: 1, Informative

    Previously mentioned sites: www.scienceblog.com www.bensullivan.com www.themachineworks.com.

    Guess what? Scienceblog and themachineworks are both hosted out of an EV1servers hosting facility in Houston, Texas. They're so close to each other, they share the second-to-last router in a traceroute.

    Second- brainblog and bensullivan.com are hosted from exactly the same server (or behind the same firewall) at theplanet.com. Again- in Houston. Ben Sullivan seems awfully cozy with Mounir Elabridi.

  56. 100 Megapixels per inch? I've got a better idea: by Anonymous Coward · · Score: 0

    Megabytes per inch.

  57. BBC radio story by Anonymous Coward · · Score: 1, Informative

    I heard about this just over an hour ago on the BBC's radio 4:
    http://www.bbc.co.uk/radio4/science/frontiers.shtm l

    real audio stream of the program, until it gets replaced in a weeks time by the next program:
    http://www.bbc.co.uk/radio4/science/rams/frontiers .ram

    It talks about various projects around the topic of engineering microorganisms. Light-sensitive engineered E. Coli, "bacterial photography" starts around 8 minutes in if you want to fastforward...

  58. Synthetic Biology & iGEM by Anonymous Coward · · Score: 0

    The photosensitive E.coli were just one of several entries in last year's Intercollegiate Genetically Engineered Machines (iGEM) competition, which is an annual synthetic biology contest that takes place over the summer at participating institutions. With the help of a few professors and TAs, small teams of students propose, design, and "implement" actual genetically modified organisms.

    Check out this week's Nature as well as the iGEM wiki for more information about synthetic biology and iGEM, respectively. Biology is definitely getting more and more interesting for engineering-minded students.

    I highly recommend taking some biology, bioinformatics, or biotechnology classes if you are an undergraduate in CS/EE... exciting times, especially compared to the regular "IT" universe.

  59. The penicillin photo loses popularity... by radiotyler · · Score: 1

    "Hey! I made one too, out of penicillin!"
    "Dude, it's eating my e. coli photograph! C'mon man... all that time wasted."
    "Weird, it looks like the Virgin Mary now..."

    VIRGIN MARY E. COLI PHOTOGRAPH - NO RESERVE - FREE SHIPPING

    --
    hi mom!
  60. Ducks? by Anonymous Coward · · Score: 0

    Honestly, after a joke that bad, ducking isn't enough. You should be diving into a bomb shelter.

  61. on-demand engineering by spage · · Score: 1

    Read the slides (PDF), they acknowledge photosynthesis. Yes, it's just college students engineering new functionality as part of a competition, but that itself is pretty cool. I didn't know there is already a registry of standard biological parts for this sort of hacking. They add photosensitivity to the bacterium membrane, add pigmentation change, and hook them up.

    The same UCSF lab is also working on an AND gate to combine two sensors, which gets us closer to bacteria delivering lethal payloads to tumors.

    --
    =S
  62. So .? by Snaller · · Score: 1

    E. Coli? That means shitty pictures?

    --
    If Google really cared they would fix Android Chrome to reflow text, instead of discriminating
  63. Great... by JeremyALogan · · Score: 1

    Great... So now not only do they want to kills us, but they know what we look like.

  64. Yes. Fascinating. by It's+Impossible · · Score: 1



    "All this neat stuff we can do, and we *still* dismiss intelligent design as a possibility.

    *chuckle* That's really interesting. Sad and funny, but interesting."



    I'll bite.

    This particular "neat stuff" was creating using the principles and techniques of contemporary genetic science, which in turn wouldn't be possible without a solid foundation in the theory of evolution.

    Let's put that another way: much of biology, including the manipulation of tiny bacterial genes, no longer makes any sense and wouldn't be possible if you replace evolution with the Book of Genesis. Which is also exactly why evolution is so widely accepted by legitimate biologists: it predicts stuff (like the existence of DNA, for example)! And lo and behold, we continually find that those predictions were right! And then we make funny pictures using genetically-engineered phototropic E. Coli!

    Imagine if someone tried to convince you that, instead of a CPU, Gordon Moore himself was inside your computer doing math with a slide rule. Even if your computer was glued shut, might you reasonably dismiss Gordon Mooreism as a possibility, given everything else you know about computers? Given what you're capable of doing with a computer right now?

    That, Chuckles, is why people dismiss "Intelligent Design."

    At any rate, are you really philosophically prepared to argue that, if Man can do it, so can God? To me, that always sounds like a great way to diminish your creator. Unless you really want us to think of God as a grad student at UCSF? :-)

    1. Re:Yes. Fascinating. by TrebleJunkie · · Score: 1

      The day we actually get life fired up in a petri dish, the debate all becomes moot. At that point, intelligent design is not only plausible, it's possible, because we'll have done it. And it'll happen. The second we create a mini-universe inside of an electromagnetic bubble it is not only plausible, it's possible, because we'll have done it. And it'll happen. Man's no slouch. :) But that doesn't necessarily mean he'll be the first to do it. And it doesn't mean he couldn't have been a product of the last folks to do it, either, if such folks actually existed.

      But let's talk for a minute about the misconceptions you hold.

      First, that intelligent design seeks to replace "replace evolution with the Book of Genesis." It doesn't. Intelligent design -- the rational version of it, anyhow -- seeks only to explore the possibility of an intelligence behind the design of life, the universe and everything. The best way I've ever seen it presented was this way: "Imagine you're walking down the beach and you see a sandcastle. You know by looking at it that someone built it, it just didn't come to be." It doesn't call it God, nor does it call for identifying that intelligence. Nor does it then beg the question of, well, who created that intelligence, and then that one, and then that one, turtles all the way down. It doesn't grant that intelligence any moral authority. It doesn't dismiss evolution, at all. Evolution as a mechanism of further development could certainly have been an essential part of the design -- one we humans have already begun to play with in terms of software design, selective breeding, etc.

      Second, what makes you think we have a creator? Sounds like you're too closely stuck on scripture, yourself. A direct creation of human beings by some intelligence did not have to happen -- only a mechanism and/or some initial state that, once set in motion, might one day have led to our development. (Sound a bit like evolution, maybe?)

      Third, yes, if we have been created -- either directly or indirectly, I fully wish to diminish the stature of that creator. I want to take the mystery out of it. I want to take the faith out of it, and replace it with fact, evidence, and reason. I'm a rare bird -- an objectivist who can accept the possibility of the existence of God, but frankly doesn't think the existence of a God matters one way or the other. That doesn't change the fact that morality wouldn't and couldn't be mandated by that God, that God is subject to the universe's moral law, as we are. That we should, frankly, quit bugging him with every fucking request for all kinds of things we're too lazy or scared to do for ourselves and expecting him to do something about all of them and start taking control of our own lives, and leave him/her/it to his/her/its own pursuits, great achievements and happiness. I also think that God should be allowed to Shrug, too.

      Has intelligent design been coopted by the religious for their own purposes? Absolutely. And they should, frankly, shut the fuck up about it and leave their unreasonable faith and dogma out of it. And frankly, so should scientists. There's plenty of faith and dogma in science, too, and it doesn't belong there. Real scientists would explore the possibilty of intelligent design with curiosity and fervor, and not dismiss it out of hand, especially not in light of what humans have already been able to achieve while toying around with the gene, the quark, and who knows what other fun, elementary stuff.

      --

      Ed R.Zahurak

      You know, oblivion keeps looking better every day.

  65. Strangely enough... by mikael · · Score: 1

    ...I feel as if a million eyes are watching me, silently...

    --
    Vintage computer adverts: http://www.vintageadbrowser.com/computers-and-software-ads
  66. units by Anonymous Coward · · Score: 0

    So, what is the weight of 1 square inch bacteria? Do you use fluid ounces, solid ounces, UK, US or tombstones? There is something sick here and it is not the E. coli.
    New Science classes in Kansas schools use a new unit for the smell of bacteria. It is measured in cpf (cheese per foot).

  67. Dammit by 3TimeLoser · · Score: 1

    Great. Now you can actually get infected with something just by looking at porn.

    What's this world coming to.

  68. Re:Scientists create "chemical image" with molecul by TropicalCoder · · Score: 0

    It would be so cool to have images that we could zoom into like they do in the movies, where they might have a picture of a street scene, then 'computer enhance' so they can zoom into a single window in a single building, then zoom throught that to indentify the face of the occupant. Of course that's just si fi because we are lucky to get much more than 2X enlargement before the resolution becomes too poor to see much more.

    I think the "breakthrough for creating ultra-high resolution images" you speak of would come down to the capabilities of lenses, which have various limitations. It would be interesting to know, though, what the theoretical limits of resolution are.

  69. These scientists were obviously... by slappyjack · · Score: 1

    ...touched by His Noodly Goodness

    Amen. Pass the Alfredo.

  70. Don't try this at home by CriminalNerd · · Score: 1


    The photos were created by projecting light on "biological film" -- billions of genetically engineered E. coli growing in dishes of agar."

    "Please keep out of reach of children's mouths. In fact, your's too."

  71. 12 to 15 hours of exposure :) by carlmenezes · · Score: 2, Funny

    smile...
    keep smiling...
    *15 mins later*
    keep smiling....
    *half an hour later*
    keep smiling...DON'T MOVE!
    *3 hours later*
    keep smiling...I SAID DON'T MOVE. I DON'T CARE IF YOU'VE GOT CRAMPS!!
    *8 hours later*
    hey! we need your eyes open! you can't fall asleep! and SMILE!
    *12 to 15 hours later*
    there! all done! Your living photograph is ready.
    Now let's start on the family portrait now that you've had some practice.

    --
    Find a job you like and you will never work a day in your life.
  72. I don't mean to be an alarmist, but... by catdevnull · · Score: 1

    OMG! I can't believe it. First we get viruses by e-mail and now you're telling me I can get a bacterial infection from from looking at naughty pictures?

    I guess the photos are very...(ahem)...life-like?

    (ducking for cover)

    --

    I might know what I'm talkin' about, but then again, this is Slashdot...
  73. In Soviet Russia.... by auspiv · · Score: 1

    Bacteria makes pictures of YOU!!!

  74. wait... by Marthirial · · Score: 0

    After Thanksgiving i will produce enough E-coli to paint the FSM's Sistine Chapel.

  75. Re:Scientists create "chemical image" with molecul by Anonymous Coward · · Score: 0

    Thank you Mr photographer for pointing out the obvious..... The trouble with geeks (myself included)is that we sometimes forget that "new technology" is not always better, or even new.....

  76. Re:Scientists create "chemical image" with molecul by Zog+The+Undeniable · · Score: 1
    About 100 line pairs per mm for Kodak Technical Pan (no longer made).

    You didn't see the "Funny" mod, did you...?

    --
    When I am king, you will be first against the wall.
  77. Incredible... by Guru84 · · Score: 1

    That's absolutely incredible that they can do it, but how long would these pictures last? Seems like they wouldn't last very long.

  78. Been there, seen that, done that by Anonymous Coward · · Score: 0

    In renowned polish SF writer Stanislaw Lem's 1981 book "Imaginary magnitude" there is a short story about this exact subject.

  79. Film still wins. by RockDoctor · · Score: 1

    That's only a factor of "several" better resolution than you routinely get from film.
    Work it out - a 35mm negative (remember those?) is also about a square inch and is on the order of 10 million pixels. That's for off-the shelf film being processed off-the-shelf, then put into a routine scanning system. If you use high-resolution film, hypered and cold-processed, possibly in a medium format camera, you'll be pushing 100 Mpx. And then you could go up to the cutting edge of photographic technology and look at half-plate or full-plate negatives (that's emulsion spread onto sheets of glass before being put into the camera) and you'd be far over 100 Mpx.
    Digital technology is approaching the capabilities of film technology, but it's not there yet. Everyone knows that digital will eventually overtake film (look at when Kodak started to push technologies like PhotoCD as an image format), but it's still not routinely beating film. Maybe another 2 years.
    (Note that the scanned images you get with your film for the price of a beer are generally not very good quality. Then again, the quality of standard processing seems to be going down as well because people are getting used to not being able to enlarge their images to the equivalent of 3x5 metres wide. Did you never wonder why your enlarger's head could be tilted to point horizontally across the darkroom?)

    --
    Birds are not dinosaur descendants;birds are dinosaurs, for all useful meanings of "birds", "are" and "dinosaurs"
  80. Re:Scientists create "chemical image" with molecul by TropicalCoder · · Score: 0

    I saw the 'funny' mod - thought it must be an error. I just didn't get it, even though I understand the principles of photography. I guess his dead pan delivery was just too much for my limited intelligence.

    100 line pairs per mm for Kodak Technical Pan is clearly a practical limitation, but it still would be interesting to know though, what the theoretical limits of resolution are. Perhaps you could supply that.

  81. I for one welcome our new bacteria pixel overlords by Anonymous Coward · · Score: 0

    Hail them.

  82. MSNBC has another prcture by PhilHibbs · · Score: 1
  83. Overlords by Astronomypete · · Score: 0

    I for one welcome our bacterial picture creating overlords

    --
    Better is the enemy of good enough. - Russian proverb.
  84. 300 by caveat · · Score: 1

    300lpm. Not official from Kodak, they don't have the specs up in the info. Shame they discontinued it, I shot a few rolls in B&W class...it's absolutely ridiculous stuff, slow as all getout (ISO25) and tricky to develop properly, but 11x14 prints from a 35mm negative have _less_ grain than a contact sheet of Delta 100 negatives when you compare them under a loupe. B&H still carries 8x10 sheets of the stuff, I'd love to see a landscape shot on that. If you're into film and you know what you're doing, I strongly suggest getting what you can find while it's still available.

    --

    Facts do not cease to exist because they are ignored. - Aldous Huxley
  85. You forget to mention by caveat · · Score: 1

    This revolutionary new chemical process, in addition to providing much higher resolution, also allows for a much greater exposure latitude than current state-of-the-art digital sensors, allowing for much greater levels of both highlight ans shadow details in high-contrast images. And this color process of which you speak should record much more accurately and vividly. All in all, I agree this breakthrough technology looks to be far superior to the current pitiful CCDs we are all used to. Perhaps a bit more inconvenient, but the results will far outweigh the drawbacks.

    (disclaimer: I have both a state-of-the-digital art Nikon D70, and a 30+-year old Nikkormat EL. I use them both a lot. Oh, but the older lenses put anything Nikon makes nowadays to shame...300mm Nikkor-H telephoto is a work of art. Anyway, I'm babbling.)

    --

    Facts do not cease to exist because they are ignored. - Aldous Huxley