New 'Mighty Mouse' Formula Found

mystyc writes to tell us that scientists at Johns Hopkins have improved upon their original "mighty mice" discovery. Teamed with the biotech firm MetaMorphix and pharmaceutical company Wyeth, they have found a new agent that interacts with the muscle-limiting protein myostatin that was able to trigger a 60% increase in muscle size after just two weekly injections.

Comments

Gotta love the scroll wheel.

[PopeOptimusPrime]

Please move this to the Apple section :P

Keeping Score

[Nerdposeur]

So, for the obligatory recap, we're looking forward to: Mice that are really strong, don't age (http://science.slashdot.org/article.pl?sid=05/11/ 18/2133229&tid=214&tid=14), can regrow damaged limbs (http://science.slashdot.org/article.pl?sid=05/09/ 01/0035245&tid=99&tid=14), and have no fear (http://science.slashdot.org/article.pl?sid=05/11/ 18/0644240&tid=191&tid=14).

I, for one, am investing in explosive mousetraps.

Abstract / free full paper link

[Frangible]

ABSTRACT: Myostatin is a secreted protein that normally functions as a negative regulator of muscle growth. Agents capable of blocking the myostatin signaling pathway could have important applications for treating human muscle degenerative diseases as well as for enhancing livestock production. Here we describe a potent myostatin inhibitor, a soluble form of the activin type IIB receptor (ACVR2B), which can cause dramatic increases in muscle mass (up to 60% in 2 weeks) when injected into wild-type mice. Furthermore, we show that the effect of the soluble receptor is attenuated but not eliminated in Mstn(-/-) mice, suggesting that at least one other ligand in addition to myostatin normally functions to limit muscle growth. Finally, we provide genetic evidence that these ligands signal through both activin type II receptors, ACVR2 and ACVR2B, to regulate muscle growth in vivo.

Full journal article (PDF)

normal people

[rayde]

so my question is this... if something like this is proven to be safe in humans, allowing large increases in muscle growth, will it ever be available to the public? if not... why not?

Steroids have long been banned in sports because they can have catastrauphic side-effects, and pro atheletes are often seen as role models. however, if a product came out that could dramatically strengthen humans, without nasty side-effects, for what reason shouldn't the average person be able to go out and in two weeks have significantly larger muscles? should it be regulated? and if so, why?

there are ethical implications here... the haves vs. the have-nots... those who can afford to increase their muscle mass using the products would perhaps become a superior segment of the human race. imagine a scenario where western countries and their super-citizens gain a distinct physical advantage over the less wealthy countries.

yet think of the productivity gains that would be possible in manufacturing, construction, or other physically intensive occupations. strengthening your workers could bring huge advantages.

it's a very interesting issue, i'm sure one that we'll see popping up again in the future.