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Brain Surgery Patient Trapped in a Mental Time Warp

diverge_s writes "BrainConnection has an interesting article about a man who lives life straight out of the movie Memento. FTA: "When twenty-seven year old Henry M. entered the hospital in 1953 for radical brain surgery that was supposed to cure his epilepsy, he was hopeful that the procedure would change his life for the better. Instead, it trapped him in a mental time warp where TV is always a new invention and Truman is forever president. The removal of large sections of his temporal lobes left Henry unable to form any new personal memories, but his tragic loss revolutionized the field of psychology and made "H.M." the most-studied individual in the history of brain research.""

37 of 338 comments (clear)

  1. On the bright side... by jd · · Score: 5, Funny

    It means he never has to put up with re-runs on television and got to escape the entire disco era unscathed.

    --
    It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
    1. Re:On the bright side... by Saven+Marek · · Score: 5, Funny

      It means he never has to put up with re-runs on television and got to escape the entire disco era unscathed.

      I'm now wondering if he's been employed as a slashdot editor, and every dupe is a fresh exciting new story.

    2. Re:On the bright side... by ePhil_One · · Score: 4, Interesting

      What does he think when doctors walk in with cell phones, digital cameras, and PDA's?

      --
      You are in a maze of twisted little posts, all alike.
    3. Re:On the bright side... by Kandenshi · · Score: 5, Informative

      The removal of his hippocampus, amygdala and bits of his temporal lobes did indeed cure his seizures. While he can hardly be said to live a "normal life" now his health is fairly good. Currently suffering from osteoporosis but that's not really a function of his surgery or his former seizures :P

      If you want to really dig into his case I'd suggest the following review paper that summarizes alot of the interesting things we've learned because of him much better than TFA does IMO:
      http://homepage.mac.com/sanagnos/corkin2002.pdf/

  2. In other news by drDugan · · Score: 5, Funny

    "BrainConnection has an interesting article about a man who lives life straight out of the movie Memento. FTA: "When twenty-seven year old Henry M. entered the ..."

    1. Re:In other news by MoogMan · · Score: 3, Funny

      Hey, I must be new here!

  3. Clive Wearing... by RustNeverSleeps · · Score: 5, Informative

    This case reminded me of another case I learned about in a psychology class several years ago. There is a British man named Clive Wearing who has a similar condition caused by disease. A video of Wearing showed him greeting his wife as if for the first time in months or years, even if she had only just stepped out of the room for a minute, writing in his journal every couple minutes etc. They did say that he had some vague recollection of major events like the fall of the Berlin wall and the Soviet Union, but not much beyond that. He was also shown playing the piano very fluently, although he went into a seizure as soon as he stopped playing, supposedly because of the "shock" from the music stopping.

  4. A bit more about him by Lord+Byron+II · · Score: 4, Interesting

    Okay, I started typing this based only on the title of the /. article when it was still in the mysterious future. It looks like I'm talking about the same guy that the article is. Anyway, this guy is truly fascinating. It's good to hear that he's still alive and kicking! Here's what I typed before reading the article: I was doing video conversions (VHS->VCD) for a Pyschology professor a while back and he had this most amazing video of a man through some sort of illness had lost the ability to make new memories (a la, Memento, although this was before the release of that movie). He was happy as a clam, although kind of dazed and confused. What was interesting though, was that as he got older (the video followed him over something like twenty years), he started to adapt. I say adapt, because he wasn't making new memories, but was learning patterns. Let me explain: the nurses always came into his room hoping that he would recognize them, but of course he wouldn't, because he met them after the brain injury, but he started to pick up on that anticipation and started to fake knowing them, as best he could.

    1. Re:A bit more about him by cgenman · · Score: 4, Interesting

      My grandmother is going through this exact same process, and it is interesting to watch. She has gone from thinking that she just got to her new home, to "I think I've been here a few weeks." (years, actually) She's stopped recognizing a lot of people, but she's learned to pretend to know everyone. She learned to walk over to the calendar to see if people were there yesterday, even though she doesn't recognize the calendar or know why she's going to that part of the room.

      She even learned how to sneak out and buy beer, and did so repeatedly. We were all impressed by that one. Of course, she pled innocent, and as far as she knows she was.

    2. Re:A bit more about him by Sycraft-fu · · Score: 4, Informative

      What is happening, at least as was explained to us psych majors, is that he can learn skills, but not facts. Those parts of the brain are apparantly seperate, which is one of the major discoveries his case has lead to. So you cannot teach him facts about a bicycle that he doesn't know, but he could learn to ride a bycicle, if he doesn't know how.

    3. Re:A bit more about him by Slashcrap · · Score: 3, Interesting

      What smoking and having those "bad" habits only do is make the last few years of your life miserable, not simply end it.

      I'm really sorry to break this to you, but the last few years of your life are likely to be miserable and painful anyway.

      I know it is very comforting to believe that you can avoid this by living healthily, but you are still going to degenerate and die. And that process is not necessarily going to be more comfortable just because you ate tofu all the time and never passed up an opportunity to whine about someone smoking a cigarette 50 feet away from you.

      If there is a God, I strongly suspect that He has a very dark sense of humour. Leading an excessively healthy life probably counts as provocation.

    4. Re:A bit more about him by Mad_Rain · · Score: 4, Informative

      I would recommend to anybody who is interested Oliver Sacks, a neurologist who wrote a great book called The Man Who Mistook His Wife For a Hat for other intriguing and amusing tales from the fringes of psychology and medicine. As I recall (eek!) it did a fair job of explaining our understanding of the brain (even as the book is 20 years old).

      --
      "What do you think?" "I think 'What, do you think?!'"
  5. That man today... by Carpe+PM · · Score: 5, Funny

    ...is better known as Cowboy Neal.

  6. Ah, come in. Now what seems to be the matter? by Anonymous Coward · · Score: 5, Funny

    (Caption on the screen: 'IT'S THE MIND -- A WEEKLY MAGAZINE OF THINGS PSYCHIATRIC' Cut to montage of photographs again with captions and music. Cut to a man sitting at usual desk. He is Mr Boniface.)

    Boniface: Good evening. Tonight on 'It's the Mind', we examine the phenomenon of déjà vu. That strange feeling we sometimes get that we've lived through something before, that what is happening now has already happened. Tonight on 'It's the Mind' we examine the phenomenon of déjà vu, that strange feeling we sometimes get that we've ... (looks puzzled fir a moment) Anyway, tonight on 'It's the Mind' we examine the phenomenon of déjà vu, that strange...

    (Cut to opening title sequence with montage of psychiatric photos and the two captions and music over. Cut back to Mr Boniface at desk, shaken. Caption on screen: 'IT'S THE MIND')

    Boniface: Good evening. Tonight on 'It's the Mind' we examine the phenomenon of déjà vu, that strange feeling we someti... mes get ... that ... we've lived through something...

    (Cut to opening titles again. Back then to Boniface, now very shaken. Caption on screen: 'IT'S THE MIND')

  7. Not news... by xitshsif · · Score: 3, Insightful

    "entered the hospital in 1953 for radical brain surgery"

    If the most recent development was in 1953, is it still news?

    1. Re:Not news... by mrchaotica · · Score: 5, Funny

      It is to him!

      --

      "[Regarding the 'cloud,'] ownership was what made America different than Russia." -- Woz

  8. Mirror, mirror by Baby+Duck · · Score: 4, Interesting

    The funniest and cruelest thing you can do to him is show him his own reflection. How would you feel if you woke up one morning and had tons of wrinkles on your face where none were before.

    --

    "Love heals scars love left." -- Henry Rollins

    1. Re:Mirror, mirror by greginnj · · Score: 3, Informative

      One of his doctors actually did this -- perhaps thinking it would help 'jar' his memory or something, not really thinking through the effect that suddenly seeing yourself old would have. HM's reaction was predictable -- 'Hey, Doc! What the hell is this??'

      Fortunately, the doctor realized his error quickly, took away the mirror, and said, 'It's complicated, but I can explain it to you. But first, come on over to the window'. After looking out the window for a bit, HM forgot why he was there, or even that he was upset.

      --
      Read the best of all of Slash: seenonslash.com
    2. Re:Mirror, mirror by HaydnH · · Score: 5, Informative

      "The funniest and cruelest thing you can do to him is show him his own reflection. How would you feel if you woke up one morning and had tons of wrinkles on your face where none were before."

      Errr, did you read the article? He doesn't appear too bothered by the mirror thing:

      "Mainly, though, he leads a life of quiet confusion, never knowing exactly how old he is (he guesses maybe thirty and is always surprised by his reflection in the mirror) and reliving his grief over the death of his mother every time he hears about it."


      Actually he seems quite upbeat about the whole thing, the highlight of the article for me (as it looks like you probably missed it) has to be the following:

      When walking down the corridor at M.I.T. with Henry, Dr. Suzanne Corkin made the usual kind of small talk. "Do you know where you are, Henry?"

      Henry grinned. "Why, of course. I'm at M.I.T.!"

      Dr. Corkin was a bit surprised. "How do you know that?"

      Henry laughed. He pointed to a student nearby with a large M.I.T. emblazoned on his sweatshirt. "Got ya that time!" Henry said.

      Haydn.

      --
      Time is an illusion. Lunchtime doubly so. - Douglas Adams
  9. I never considered surgery by FuturePastNow · · Score: 4, Interesting

    I have epilepsy, specifically partial complex seizures of the temporal lobe. No neurosurgeon ever suggested surgery as a solution, but based on cases like this, I think I would have declined the offer had it been made. I can't imagine actually having part of my brain removed, and because everyone is different, results like this man's can never be 100% avoided.

    The brain has a fantastic ability to route around damage, but 53 years after this man's surgery, we still don't know enough about the way it works to reliably fix problems that the brain itself cannot handle.

    (Then again, my seizure episodes aren't nearly as frequent as described in the article.)

    --
    Give a man fire, and you warm him for the night. Set a man on fire, and you warm him for the rest of his life.
    1. Re:I never considered surgery by bloodredsun · · Score: 5, Insightful
      Actually as someone who has just finished a PhD in Neurophysiology I feel I may be a little better placed to comment than your average /. reader

      Complex partial seizures originating in the temporal lobe have one of the best success rates in epilepsy surgery, but surgery is only offered to patients whos epilepsy is medically refractive (cannot be controlled by drugs) and affects their life in such as way that they would strongly benefit from surgery. Temporal lobe epilepsy is most often caused by mesial temporal or hippocampal sclerosis, this means that that part of the brain has become scarred and shrunk and this damage is causing the seizures. So this part of the brain supports a minimal amount of function. As your seizures are probably well controlled by drugs, you would never have been offered a surgical option.

      we still don't know enough about the way it works to reliably fix problems that the brain itself cannot handle.
      That's correct to a certain extent, but we do know a lot more and one of them is how to avoid causing the sort of condition that HM suffers.

  10. first dates by vlad30 · · Score: 4, Funny

    he could meet this girl http://imdb.com/title/tt0343660/

    --
    Your'e all thinking it, I just said it for you
  11. Crueler still... by Errandboy+of+Doom · · Score: 4, Funny

    I think hitting over the head with a chair would be pretty cruel, because man, that would have to hurt.

  12. Experimental brain surgery by jd · · Score: 4, Interesting
    Around that time, theory was a lot more advanced than practice. For example, there was a theory around that time that stated that seizures and some forms of mental illness were caused by malformed connections between brain cells - that all you needed to do was sever the connections and let them regrow. As theories went, that wasn't too bad.


    Apparently what happened in practice is that doctors would use coat hangers or any other bits of wire they could find, and slash at the brain until the symptoms stopped.


    Arguably, though, severe brain damage (through cutting chunks out or prodding them wildly with steel rods) was probably a better fate than those in Victorian asylums, which combined all the home comforts of a Soviet-era Siberian prison camp with the theraputic properties of a medieval torture chamber. At least the victims of the medical experiments were often incapable of suffering much. (Some, just not as much.)


    Modern therapies for brain disorders are often highly dangerous, extremely toxic to the rest of the body, notorious for side-effects, often addictive, and many are poorly studied with completely unknown long-term consequences. That is many thousands of times better again than those who underwent the surgery.


    With the newer discoveries being produced through fMRI and other next-generation scanning equiptment, I fully expect the next thirty to fourty years to produce as many radical changes to neurological treatments as the past thirty to fourty have. It'll be interesting to see how things change.

    --
    It's a small world and it smells funny; I'd buy another if it wasn't for the money; Take back what I paid (SoM)
    1. Re:Experimental brain surgery by Vellmont · · Score: 3, Interesting


      Around that time, theory was a lot more advanced than practice.


      Boy is that an understatement. There was also little in the area of medical ethics. A lot of those doctors should have gone to jail for what they did. This is the same era where insulin shock and electro-shock were standard practices for several mental illnesses. What a sick and sad time.

      --
      AccountKiller
  13. I've read about this before by Mitaphane · · Score: 4, Informative

    I thought this story covered the term but apparently it doesn't. Anyway, the medical term for Henry's condition is called anterograde amnesia. And if it hasn't already been mentioned here, it's also the same ailment that the protagonist Leonard has in the movie Memento. And if you liked that movie I reccommend reading the short story it was based on. It's an excellent piece of prose.

  14. When my mother had a stroke... by shotgunefx · · Score: 5, Interesting

    When my mother had a stroke when she was dying of cancer, a very odd thing happened.

    I rushed to the hospital, she seemed ok, but weak. We talked for hours, everything seemed fine. I still don't know what prompted me to ask the question as our converstation was pretty much normal. I asked her "Do you know you who I am?"

    She said "No, should I?". Pretty much the worst moment of my life. As it turned out, she though it was 1968 and she was in there to give birth to what would be my brother Kevin.

    Thankfully, over the next few weeks, most of it came back, but it all came back in chronological order.

    She was back to the 1980's within a few hours, but the next 12 years came back much slower. She thought I was still with my first girlfriend circa 1990, that we had our old pets. The last few years were the only thing that remained somewhat little fuzzy.

    I always thought that was very telling about the mind. Not sure exactly what it says, but it definitely says something. Maybe memory is stored tree-like. The other thing that was odd, was the closer to the present it got, the slower it came back.

    --

    -William Shatner can be neither created nor destroyed.
    1. Re:When my mother had a stroke... by ObsessiveMathsFreak · · Score: 4, Funny

      The other thing that was odd, was the closer to the present it got, the slower it came back.

      That's easily explained through general relitivity. As she travelled through time her "speed" in time increased, thus leading to a temporal dialation effect, slowing her down.

      --
      May the Maths Be with you!
  15. Is there a name for what *I* have? by Hosiah · · Score: 4, Interesting
    While we're all taking about memory defects...

    I've have one that's very specific, but only been a minor nuisance. I blow people's names. Especially in a work environment, where I'm constantly meeting new people. A new person will have to remind me of their name anywhere from six to twelve times before it sinks in. Some people I know for awhile, then start calling them by the wrong name for a while. Then I stop that and get back to calling them by their right name again. Most people are understanding (I have to explain myself), but some get quite offended.

    Mind you, it's the only memory defect I have. I can remember a face after meeting a person once and not seeing them for years. In conversation with a co-worker on a day-to-day basis, I can tell them what we talked about yesterday, what they were wearing last week, everything they've told me about themselves down to the most minute detail. Just not their name! But in most cases, I finally get them straight after a few months.

    I was just wondering, with all the psych buffs in here...(PS it works this way online, too. I'm more likely to remember posters by their sig, or even just by their writing style, or on other forums by their icons...I'll even place people by their ID-number before their names!)

    1. Re:Is there a name for what *I* have? by GloomE · · Score: 3, Funny

      Luckily I live in Australia.
      I can get away with calling everyone "mate".

    2. Re:Is there a name for what *I* have? by aug24 · · Score: 4, Informative
      Me too. It's called Anomia

      Curable/copable for most people using mnemonics. I can do a few people at a time now, by imagining them in a hug with someone else with the same name. I hold the pictures better than the words. Still can't cope in a new contract when I have ten people to remember: I won't be able to hold any of them.

      Only works for first names, and only names I've come across before, so not a perfect solution!

      Justin.

      --
      You're only jealous cos the little penguins are talking to me.
  16. I had this problem... by Jafafa+Hots · · Score: 4, Interesting
    ... after a head injury, I was unable to form new memories. That mechanism was not working. I was totally conscious and talking to people, and yet from my perspective I didn't even exist. It is NOT like the movie Memento, because its simply impossible to have any self-awareness of your condition.

    For the weeks that I was like this, I was essentially dead. I was lucky enough that for me it was temporary, though I still have some problems, but even if I weren't already an atheist it would have been total confirmation that there is no afterlife, because with that small part of my brain not working I was literally no longer a person, I didn't exist as a mind - I was just some pile of animated meat.

    The process of regaining the memory "stickiness" was strange - that time feels like my birth.

    --
    This space available.
  17. This is fantastic by Placebo+Messiah · · Score: 5, Funny

    I just wanna say, you are a really smart buncha nerdy people. How you ended up on my TV isn't even relevant right now. I'm truly inspired by your fresh approach to scientific criticism and humour. kudos to you all and let the show go on!

  18. This is fantastic by Placebo+Messiah · · Score: 5, Funny

    I just wanna say, you are a really smart buncha nerdy people. How you ended up on my TV isn't even relevant right now. I'm truly inspired by your fresh approach to scientific criticism and humour. praise to you all and let the show go on!

  19. A bit about my boyfriend by tverbeek · · Score: 4, Interesting
    In 1996 my boyfriend Andy suffered a subarachnoid hemorrhage from an aneurysm, and after surgery to repair it, had an ischemic stroke which hit his hypothalamus. End result: almost no short-term memory, like the subject of this article.

    In the weeks afterward, Andy had some fairly classic stroke symptoms, including paralysis on his right side. He couldn't talk, even to say his own name. But he could sing songs with people, because that skill is located on the right side of the brain, rather than on the left side with our language centers. And when his nasogastric feeding tube was pulled out, he spat out a very intelligible "fuck". Evidently swearing becomes a reflex.

    While he was still recovering the ability to stand and to walk, he had to be watched all the time, because he'd keep trying to get up out of his wheelchair... unsuccessfully. But the fact that he kept trying to use his right arm and leg - not remembering that they didn't work - probably helped their recovery.

    Every time I talked to Andy, I'd tell him about my new apartment; he'd usually - but not always - react with surprise. During one phone conversation (which wasn't going very well because he was distracted by the TV in front of him), I asked if I could talk to his father (with whom he was staying). Andy put down the cordless phone, saw that Dad was busy, looked up at the TV... and forgot I was there. I had to yell from the sofa cushion to get his attention, so he'd pick up the phone again. Conversations were always difficult because "what did you do today?" would elicit either shrugs or he'd just make something up, his mind grasping at any random memory that might serve as an answer. I frequently fell back on retelling him the same stories about my life lately, just to fill time and stay connected to him, and hoping that maybe they'd sink in.

    He did gradually form some new memories. His therapists accomplished some of this by chronic repetition. Living in an environment with lots of calendars and repeated quizzes about the month and year, he got fairly good at remembering that. By asking him over and over during our drive home from a restaurant what the name of it was (no, he didn't find it annoying; each time I asked he barely remembered that previous time), he was able to remember it an hour later. Once, in response to me commenting about my shitty finances, he commented about "the new apartment". After several months of telling him about the fact that I'd gone back to college for another degree, he seemed surprised when I mentioned it again, but on a hunch I asked him what the name of it was, and he remembered. But for the most part, he learned to compensate for short-term memory with habits and with a lot of clever guessing.

    I wish I could tell you about Andy's condition in the long-term, but his family won't let me see or talk to him anymore. (They say he'd get overstimulated and unmanageable after I visited or called on the phone... and I never got along that well with them to begin with.) I fought this at first, but since they're better able to care for him (they have money and a support network; I'm just me and underemployed), and since he's painlessly unaware that I'm not in his life anymore (for all he knows, he might have just seen me yesterday), I finally had to let go. More of the personal sob-story details can be found here.

    --
    http://alternatives.rzero.com/
  20. sort of common by drfireman · · Score: 3, Informative

    Memory deficits are a risk of epilepsy surgery. As yet there's no truly reliable way to predict post-surgical memory problems, but since surgery is generally a last resort, it's a risk the patients have to take. This kind of memory problem is also typical of Wernicke-Korsakoff's Syndrome, dramatized in the second chapter of Oliver Sacks's "The Man who Mistook his Wife for a Hat," which is often a consequence of long drinking binges (and an accompanying vitamin deficiency, I think). You don't always see the truly dense amnesia, but when you do it's striking.

  21. Re:Shock Therapy by Meostro · · Score: 4, Informative
    how does shocking something and causing intense and long lasting pain and anguish make them better?
    It's not supposed to cause "intense" or "long lasting pain", it's supposed to be administered under anaesthesia so you don't even know what happened. The concept of ECT is sort of like a reboot.

    Your computer (like your body) may run fine for a while, it may even go to sleep and wake back up and go on running normally. Eventually you may come across some quirky behaviour (mental disorder) that you can't fix with patches (surgery?) or subsystem resets (drugs?). When all else fails, you reboot your computer (ECT) and everything goes back to normal.

    ECT induces a seizure, and your brain sort of shuts down and resets itself. The mechanisms aren't entirely understood, but it works well to treat severe depression.

    Electro-Shock Therapy has been portrayed as horrible torture (which it was used for) and has been tried for the treatment of many mental conditions (like schizophrenia and personality disorders) where it does little to no good. It definitely has a shady past, but the modern reality is much more benign and therapeutic.