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First Digital Simulation of an Entire Life Form

An anonymous reader writes "LiveScience is reporting on what appears to be the first digital simulation of an entire life form. Researchers created more than a million digital atoms to reverse engineer the satellite tobacco mosaic virus, a relatively simple organism. But is it really a life form? From the article: 'Viruses are tiny bundles of protein and genetic material that straddle the line between life and non-life. Many scientists prefer to call them "particles" because even though they contain RNA or DNA like other lifeforms, they can only replicate inside other living cells.'"

37 of 271 comments (clear)

  1. First Digital Simulation of an Entire Slashdot DUP by TripMaster+Monkey · · Score: 2, Informative


    Story is a dupe...original story can be found here.

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    ____

    ~ |rip/\/\aster /\/\onkey

  2. Life is not a binary distinction by wsherman · · Score: 5, Interesting
    But is it really a life form?

    Language is digital (as opposed to analog) in the sense that you either use a word in a sentence or you don't. You can either use the word "life" in a sentence or not but you can't use a fraction of the word ("li" or "fe" don't mean fractional life - or anything at all for that matter). This creates (willful?) confusion in the minds of people who are very focused on a literal interprtation of language based laws and moral codes that "life" is a binary distinction.

    The reality, however, is that the word "life" refers to a whole variety of concepts. There are all different ways of being alive and there are all different levels of being alive. Certainly we can find examples of things that are very "alive" just as we can find examples of colors that are very "blue" - but that doesn't mean every color is either pure blue not blue at all and it doesn't mean that something is either completely alive or not alive at all.

    Going way off topic, the whole "life begins at conception" is what we in the sciences refer to as "not even wrong". After all, it's kind of hard for dead people to have children. If you really want to talk about when life began it would be at the big bang when matter developed the properties that cause it to form into complex self-replicating patterns over very long time scales.

    1. Re:Life is not a binary distinction by Red+Flayer · · Score: 5, Insightful

      "You can either use the word "life" in a sentence or not but you can't use a fraction of the word ("li" or "fe" don't mean fractional life - or anything at all for that matter)."

      Oh, without capital letters, they mean nothing -- but I know quite a few chemists who'd dispute that Li and Fe are meaningless. :)

      To get on-topic, I think that humans constantly categorize and assign labels to things as either a member of a group or outside it, which IS binary.

      That creature is a fish|not a fish. That creature is a mammal; or it lays eggs and has a bill, so it is a bird (ummm, bad example, on second thought). That rock is igneous; or it is not. That tree is deciduous|not deciduous.

      What is the point of defining something if the definition does not allow us to use it to categorize? Things like this virus, and viruses in general, raise the debate over what is life|not life. And that debate can stimulate greater knowledge, and greater understanding, by challenging our assumptions and our definitions... so I'm all for making distinctions when we can.

      --
      "Trolls they were, but filled with the evil will of their master: a fell race..." -- J.R.R. Tolkien on Olog-hai
  3. Simulating intelligence? by 4D6963 · · Score: 5, Insightful

    If they can simulate something else than a virus (because I don't think viruses are intelligent) could they by this way obtain intelligence by simulating an intelligent animal?

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    You just got troll'd!
    1. Re:Simulating intelligence? by Paraplex · · Score: 3, Insightful

      I think the real difficulty here is that an intelligence (or any life form really) isn't really alive without input & output. You can't just simulate (based on any physical model) an isolated life form because it would just sit there. You need to simulate the environment it inhabits.

      The line between the organism and the environment is very blurred. I tried to write a cellular autonoma of a weather/ecology system at once stage and was overwhelmed with the sheer number of variables which would have to be included to make it complete. You essentially can't leave anything out.

      Don't mean to sound like a buddhist or anything, but everything is inextricably connected. You'd need to start by making a 500 million atom small environment or some such.

    2. Re:Simulating intelligence? by egomaniac · · Score: 5, Insightful

      If they can simulate something else than a virus (because I don't think viruses are intelligent) could they by this way obtain intelligence by simulating an intelligent animal?

      Of course. It would take an absolutely colossal amount of computing power, but given sufficient resources and a complete understanding of the basic physics and chemistry involved (neither of which we have yet) you could absolutely simulate a living creature, and the simulation would be intelligent. There have been many sci-fi stories that have used this basic concept. In fact I expect the first intelligent machine will attain its intelligence by simulating a living brain (although at a much higher level than individual atoms).

      If we assume that all physical processes can be simulated by a computer (given complete knowledge of the laws of physics), which seems to be a safe assumption, the question boils down to "is intelligence a physical process?" Everything we know about the brain's operation says that the answer is a resounding "yes" -- and if intelligence is merely a manifestation of the physical operation of the human brain, then there is nothing about it that can't, at least in theory, be simulated.

      --
      ZFS: because love is never having to say fsck
    3. Re:Simulating intelligence? by JesseL · · Score: 2, Insightful
      But to get back to more basic or philosophical considerations: Maybe we're simply not able to create structures more complex than ourselves...

      I read a quote somewhere related to that idea. It was somthing to the effect of "in that case Einsteins mother must have been one hell of a physicist".
      --
      "Prefiero morir de pie que vivir siempre arrodillado!"
    4. Re:Simulating intelligence? by 4D6963 · · Score: 2, Insightful
      Afterall the human brain is still by magnitudes more complex than any computer we can build nowadays

      Sure, but who talked about a human brain?

      Personally I'll content myself with a virtual genuinely intelligent simulated bug.

      --
      You just got troll'd!
    5. Re:Simulating intelligence? by infinite8s · · Score: 2, Informative

      > If we assume that all physical processes can be simulated by a computer (given complete knowledge of the laws of physics), which seems to be a safe assumption...

      Aha, but your given is anything but, and hence your asumption isn't so safe.

    6. Re:Simulating intelligence? by jackelfish · · Score: 2, Interesting

      The simple answer to your question is no. In the field of Molecular Modeling, we have a pretty good idea of how to simulate a system at the atomistic level. As the article states, we are pushing the limits of computational resources and time to complete the simulations at the level of about 1 million atoms (this is state of the art). The simulation discussed in this article is of a Satellite Virus (not even a true virus by strict definition, as it requires a cell to be previously infected by a virus) and as such is the smallest "living" organism on the planet (it has only 2 genes; 1 to synthesize its coat protein and another which we have no idea of its function). Now think of a bacteria like E.coli which has something on the order of 4500 genes, several of which are expresed in multiple copies. Don't forget all of the metabolites and water also. This takes the simulation from 1 million atoms up to at least say 5-10 orders of magnitude in size. So a simulation that took 12 days on a 256 CPU SGI cluster would now take 1.2 million to 1.2e11 days on the same cluster (you can also do the math to figure out how scaling the cluster would effect the time). So, long story short, we have no hope of doing an all atomistic model of even Ecoli any time soon. But, lets not forget that these simulations were only atomistic in the Newtonian sense of the word (we are only simulating atoms as point masses using Newtonian Physics, commonly referred to as Molecular Mechanics). If we want to simulate chemical reactions (an essential component of life), we require Quantum solutions for these simulations and we are looking at a limit of somewhere on the order of 400 to 4000 atoms for these types of simulations. So to really simulate E coli, lets add another 10 orders of magnitude to our estimates. The next order of business is to simulate a eukaryotic cell which may have 10,000 genes in it. Then lets go to multi-celled organisms...and so on. The long and the short of it is that there is no realistic hope, any time soon, of doing simulations on this order, until there is a significant leap made in either the way the simulations are done, or the power of the computers on which we do them. There may be ways of abstracting things by making assumptions that will reduce the accuracy of the models, but that is another story.

      --
      "When Nature Calls We All Shall Drown" Johan Edlund
    7. Re:Simulating intelligence? by iammaxus · · Score: 2, Insightful
      a complete understanding of the basic physics and chemistry involved (neither of which we have yet)

      I believe you are wrong and we already possess sufficient physical knowledge and have for years. As far as I understand it, the Schrödinger equation (and perhaps some other quantum mechanical theories) allows us to model the behavior of electrons completely. All the interactions involved in biochemistry are simply a result of electron behavior (nuclear reactions do not affect life significantly). This is not to say that there is not still work left to be done in the field as modelling at such a low level is probably impractical.

    8. Re:Simulating intelligence? by fnurb · · Score: 3, Informative

      As Kurzweil and many others have pointed out, we don't need to simulate every single neuron and synapse, let alone every single neurotransmitter molecule, in order to simulate the operations of an intelligent brain. Rather, research now focuses on simulating cognitive processes at a much higher symbolic level. The results, from auditory simulations of human audio processing to an artificial pancreas, show that many complex biochemical processes can be simulated to the required level of detail without bothering with simulating down to the quantum level or anywhere near it.

      The math represented thus becomes quite different, and, given a simple extrapolation of accelerating returns regarding computing power per cost, show that within a decade we *will* have the processing ability to create a functional digital brain at the complexity level of a human brain. This doesn't automatically mean that model will be instantly intelligent, but, when you factor in our accelerating understanding and ability to model abstract thought processes in software on top of our ability to model the physical functions of the brain, it is not unreasonable to suppose that we will produce true digital intelligence by way of a bottom-up simulation of brain processes. Add in the accelerating returns principle, and, within a few years after that, our digital model wil have processing power thousands and then millions of time that of a single brain, which in turn, even before sentience can be used to help us refine our behavioral models of thought processes-- and the likelyhood that it will cross the threshold of intelligence approaches certainty.

      It is only a matter of time, and the surprising thing is, if one simply projects the curve outward, how soon it will likely happen.

      --


      Flout 'em and scout 'em,
      and scout 'em and flout 'em;
      Thought is free. - Shakespeare [The Tempest]
    9. Re:Simulating intelligence? by binarybum · · Score: 5, Funny

      If they can simulate something else than a virus (because I don't think viruses are intelligent) could they by this way obtain intelligence by simulating an intelligent animal?

      Of course. It would take an absolutely colossal amount of computing power, but given sufficient resources and a complete understanding of the basic physics and chemistry involved (neither of which we have yet) you could absolutely simulate a living creature, and the simulation would be intelligent. There have been many sci-fi stories that have used this basic concept. In fact I expect the first intelligent machine will attain its intelligence by simulating a living brain (although at a much higher level than individual atoms).


            Dude, this is going to blow your mind.

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      ôó
    10. Re:Simulating intelligence? by edremy · · Score: 2, Insightful

      As far as I understand it, the Schrödinger equation (and perhaps some other quantum mechanical theories) allows us to model the behavior of electrons completely

      IWAQC (I Was A Quantum Chemist), so I'll bite. In theory, this is true. All you have to do is solve the Schrodinger equation for the system and you're done. The problem is that we can only solve it exactly for a few systems, the most complex being the hydrogen atom. Even the He atom is beyond our abilities, at least in the realm of exactness.

      Now, you can get into any number of simulation methods- there's standard Hartree Fock, density functional theory, a bevy of semi-empirical methods and a host of others. The problem is that all of them are approximate, often wildly so. Even for the simplest system, they have a lot of trouble reproducing reality. Quick: which end of the CN- ion is negative? You'll get different answers with different basis sets in Gaussian, much less the changes you get from introducing correlation methods.

      Assume that you somehow manage to solve the equation "well enough". That's nice, but all of the above assumes only a single point in time. My grad work was in introducing time into the picture. Electrons move really fast. (Well, they don't really move in the way you and I think about motion, but still) You'll need to solve the above, nearly impossible set of equations every tenth of a femtosecond at the slowest if you want to have any hope of modling things accurately- really, you probably should be doing it every attosecond.

      Ten years ago I managed a crappy simulation of a few lithium and hydrogen atoms undergoing a few tens of femtoseconds of a reaction. Computers are faster, yes, but Moore's law is never going to solve this issue.

      --
      "Seven Deadly Sins? I thought it was a to-do list!"
    11. Re:Simulating intelligence? by JesseL · · Score: 2, Informative

      You're welcome. Here's the correct quotes with attributions (from a fortune file circa 1989):

        "Anything created must necessarily be inferior to the essence of the creator."
      -- Claude Shouse (shouse@macomw.ARPA)

      "Einstein's mother must have been one heck of a physicist."
      -- Joseph C. Wang (joe@athena.mit.edu)

      --
      "Prefiero morir de pie que vivir siempre arrodillado!"
  4. I Hope... by eno2001 · · Score: 4, Funny

    ...Symantec/Norton, McAfee, CommandPoint, Crudpuppy, ClamAV, Grisoft and the rest are all preparing signatures, otherwise if this thing gets in the wild it will turn your data into nothing but pond scum... ;P (Aren't there ANY moderators with quirky senses of humor anymore?)

    --
    -"...bad old ideas look confusingly fresh when they are packaged as technology" - Jaron Lanier (Digital Maoism on Edge.o
  5. Move along, nothing to see here... by PoprocksCk · · Score: 5, Funny

    ...We've been able to have viruses on computers for many years now.

  6. Re:First Digital Simulation of an Entire Slashdot by richdun · · Score: 2, Funny

    And it took 13 days...That's one slow simulation.

  7. Duplicate; here's a link to the research anyway. by tskirvin · · Score: 3, Informative

    The main research page may interest some of you. And for those that it doesn't help, perhaps you want to look at our Linux clusters instead?

  8. Its awesome by mnmn · · Score: 2, Interesting

    Simulating life is awesome. Now the next step is to simulate something like an Amoeba in water... let its DNA drive it to 'eat' a food particle, and see how accurate the digestion (and binary replication) is with the input being only the DNA and initial conditions. I wonder what kind of computers are required to simulate all that, in how much time? I'd more gladly donate cpu cycles to this than to SETI.

    Next I wonder if the computer can be used to run regression tests to create the ideal bacteria or virii for a given situation. Virii can be built to repair human DNA in various ways... a particularly disadvantageous gene can be switched off throughout the body once infected with the virus.

    Of course this only allows Cybernet to have more destroying power once it 'wakes up'.

    --
    "Give orange me give eat orange me eat orange give me eat orange give me you." -Nim Chimpsky
  9. Simulation of an entire lifeform, my ass! by Expert+Determination · · Score: 5, Informative
    This is such a misleading headline. It's a simulation of the dynamics of the proteins forming the outer case of the virus to understand how it maintains its structure. It's purely about studying the structure - like an engineer's finite element simulation of a bridge. It's great work from this point of view. But it's not a simulation of any kind of biological process because the time scale is something like nanoseconds. So yes, it's a simulation, but it's not a simulation of a lifeform qua a lifeform.

    And that word 'lifeform' - it brings the quality of the reporting down to the level of Star Trek psychobabble. Try 'organsim', or even 'virus', next time.

    --
    "The White House is not an intelligence-gathering agency," -- Scott McClellan, Whitehouse spokesman.
  10. You are not a life form, then? by Roadkills-R-Us · · Score: 2, Interesting

    But is it really a life form? From the article: 'Viruses are tiny bundles of protein and genetic material that straddle the line between life and non-life. Many scientists prefer to call them "particles" because even though they contain RNA or DNA like other lifeforms, they can only replicate inside other living cells.'"

    The same could be same for most species of animals; they ``contain RNA or DNA like other lifeforms, they can only replicate inside other living organisms''.

  11. Cigar Store Indian by Doc+Ruby · · Score: 4, Funny

    "satellite tobacco mosaic virus"

    That sounds like the greatest hits of American products, all in one convenient album.

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    --
    make install -not war

  12. Hey . . . by karnifex · · Score: 2, Funny

    This might make a cool game. Someone get Will Wright on the phone.

  13. "life" is a lousy line to draw by smellsofbikes · · Score: 2, Interesting

    I think we can agree that bacteria are alive. But there are types of bacteria, the ones that cause leprosy and chlamydia, frinstance, that cannot reproduce outside of a living cell. (They, unlike most bacteria, invade and live inside cells.) It's fairly difficult to draw a hard line between them and some viruses that have lipid bilayers full of receptors on their outsides. Even prions self-amplify, so where do you draw the lines on what's alive?

    --
    Nostalgia's not what it used to be.
    1. Re:"life" is a lousy line to draw by supertsaar · · Score: 2, Informative
      As far as I recall the critiria would be:
      Can reproduce
      Has a metabolism
      Viruses do not have a metabolism.....
      --
      The Bigger The Headache The Bigger the Pill
    2. Re:"life" is a lousy line to draw by supertsaar · · Score: 2, Informative

      Virusses _never_ have a metabolism at any stage.

      --
      The Bigger The Headache The Bigger the Pill
  14. Re:I don't get it by shawb · · Score: 3, Insightful

    I personally just put viruses firmly in the "gray area between living and not living" because those are arbitrary distinctions: nature always finds a way to find exceptions to the niches that man creates. Not to say that our classifications are pointless, we just have to realize that there are always going to be things in that gray area. This can be shown more dramatically in other biological definitions as well: when is a fetus "alive?" What is the exact point where two diverging groups are no longer the same species? All questions that have legal ramifications which essentially require a precise definition in order to make decisions as impartial as possible, but some things will straddle the line no matter how precise you try to make your definitions.

    --
    I'll never make that mistake again, reading the experts' opinions. - Feynman
  15. Re:Life vs. Non-life by pomo+monster · · Score: 3, Interesting

    Human beings do nothing outside a very specific environment tailored to their needs, where temperature, pressure, oxygen content of air, gravity, radiation, &c., all lie within specific bounds. How is this different from a virus needing an environment that includes cellular structures in order to replicate?

    Me, I subscribe to structuralism.

  16. Re:Old news by mgabrys_sf · · Score: 2, Funny

    Very much so - I blow up life forms every day on RTCW.

  17. Re:I don't get it by shaitand · · Score: 5, Insightful

    Perhaps the better solution to this dillema is to realize the debate can not be settled because "life" is not a thing. It is a label. Humans invented the label and since it is an artificial construction its scope is equally artificial.

    There is no such thing as "life" we invented a classification without defining it and therefore we have a debate. The only reason we even find it to be important is that we are still trying to come up with excuses to think of ourselves as something more than a random cluster of protein soup.

  18. Why virii are not alive by chrisjbuck · · Score: 5, Informative

    A (biological) virus does not eat or photosynthesize or have any metabolism at all. That's why they are virus particles, other than the slow degradation of all complex molecules if you have a tube full of virii they will just sit in the tube forever. Doing nothing. If you add sugar, protein, complex carbohydrates and sunlight to the tube of virii they will... sit there. Doing nothing. Not eating. Not metabolizing. Not replicating. Living things would either die, metabolize, or replicate, the virii do not. The virii does contain genetic information, if inserted into a cell the information is used to hijack the cell into making more copies of the virus. The virus may only encode a handful of proteins, but it uses the ribosomes and other protein building apparatus of the infected cell to make the viral proteins, and more copies of the viral genetic info (DNA or RNA) which is packaged and released from the cell (sometimes killing the cell in the process, sometimes not). Does this mean the virus is alive? All the protein synthesis, and packaging of the virus is done by the infected cell, the virus does not technically replicate itself, which is part of what we define as "life as we know it". They are not dead they just exist as a glitch. A primordial cell probably had a mutation that produced lots of particles that happened to be capable of causing the same glitch in other cells they encountered, virii are perhaps analagous to a "goto" loop that somehow copies itself to other programs, more than to actual computer viruses which imitate their biological namesake only to a certain degree. Maybe when the sony robot dogs start giving each other roborabies via bluetooth the analogy will be closer... IAABC - I am a biochemist - but genetic coding is still trickier than php scripting :P

  19. Re:I don't get it by Wizardry+Dragon · · Score: 2, Insightful

    That's possibly the most intelligent post I've read on Slashdot. I salute you!

  20. Re:Oh yes, now I get it! by shaitand · · Score: 2, Insightful

    "water" is also a noun. Water, is however a label for something real. "Life" is a label for a concept that does not exist, we made up the concept itself and not merely the label. It is not even a classification like a mammal, there is a valid definition of mammal, there has never been an agreed upon definition of life.

    There is a very substantial difference there.

  21. Life and the living by jandersen · · Score: 2, Funny

    I think we have to distinguish between 'life' as a concept and 'living organisms'. Life is an abstraction - it is the 'quality' that is common to all life processes, ie the processes that we know from living organisms.

    The only thing that is reasonably clearly defined is 'living orgnism'; and as several posts have already pointed out, viruses can't quite be called living organisms; not because the don't display life, but because they are too simply to qualify as organisms. However, they do have life proceses - eg. they reproduce.

    How can one define the concept 'life'? It is a difficult one - there are many that feel it would be too narrow to define it simply as the set of chemical processes that we know from biology; among other things, there is no sharp boundary between simple non-organic chemistry and 'life-chemistry'. There are some that define life as chemical evolution (http://en.wikipedia.org/wiki/Chemical_evolution) - this theory has the advantage that it can be generalised; all that is needed is a good generalisation of 'chemistry'.

  22. Life = Non-life by foxxo · · Score: 3, Insightful

    "Life" and "non-life" are useful, but ultimately meaningless ontological distinctions that really have no purpose at the sub-microscopic level. Any sensible person can see that ultimately there is no difference between what we deem living and what we call non-living, as the quick and the dead are still naught but particles in relationship to one another. The notion of self-identical objects larger than the fundamental particles is useful, but when dealing on such a tiny scale it's best to forget about such pointless ontological nonsense.

  23. Re:Oh yes, now I get it! by nickco3 · · Score: 2, Insightful

    Life obviously exist since we're having this debate - I doubt we could have it if we weren't alive.

    You're confusing concepts with their labels.

    He's not saying there's no such thing as life, which is easily falsified. He's saying the concept "life" is arbitrary, and that the boundaries of that concept are arbitrary: there are seven specific conditions you need to meet to be officially alive. Why those particular 7? What if we changed the list to 6 or 8?

    Having dreamt up a classification called "alive" it's easy to demonstrate there are things that meet it. But don't fall into the trap of thinking that the classification exists outside our collective heads. Because we dreamt it up it.

    Let's say we change the definition of "life", adding requirement number 8 "wings". Things that are "alive" have "wings". Therefore, you and I are not "alive" because we no longer meet the definition. BUT (this is where you got confused) we carry on exactly as we were, still reading Slashdot, still eating, moving around, excreting, etc, because we're only talking about labels, and not reality.

    See Zen and the Art of Motorcycle Maintenance if you're struggling. It took me ages to get it.

    --
    -- Nick "Hallo this is Beel Gates, und I pronounce weendows as ... WEENdows"