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Breakthrough In Human Genetics

Many readers have submitted this story about a breakthrough in our understanding of human DNA: in particular, how much variation can exist between peoples' genes and how genes are involved with certain diseases. "One person's DNA code can be as much as 10 percent different from another's, researchers said on Wednesday in a finding that questions the idea that everyone on Earth is 99.9 percent identical genetically. They said their new version of the human genetic map, or 'book of life,' fills in many missing pages and chapters to explain how genes are involved in common diseases. The Human Genome Project mapped the billions of letters that make up the human genetic code. Scientists later refined the map by looking for single variations called SNPs or single nucleotide polymorphisms. The CNV map gives researchers a different way to look for genes linked to diseases by identifying gains, losses, and alterations in the genome."

13 of 240 comments (clear)

  1. Spelling on Slashdot by Harmonious+Botch · · Score: 5, Funny

    One person's genetic code can be 10% different from another's, and chimps are 98% the same as humans.
    No wonder so many of you can't spell.

  2. Good Science meet bad math by DrKyle · · Score: 5, Informative

    Looking at the writeup from Nature. They clearly state that these results point to maybe a 0.5% difference among individuals, or 99.5% identical. That's 20X less variation than this crap article would have you believe. The actual research deals with CNV's = copy number variants. So for a given stretch of DNA, different people in a population might have that region duplicated or triplicated which does not really allow them to make anything different, but it might alter the levels of expression of those genes. As this DNA is found in multiple copies it had largely been believed to have a low number of genes, as is the case of most highly repeated DNA, but the researchers have evidence that these repeated domains do contain a large number of unique genes. In a short summary/analogy:
    Some people are 8 feet tall.
    Some people are 4 feet tall.
    Therefore, people vary in height by 200%.

    It's obvious to see the failed logic in that case, that's the same thing here, just because 10% might potentially be variable, that doesn't mean any single person even exists at each extreme.

  3. Misunderstanding by Anonymous Coward · · Score: 5, Funny

    No, no, no, no, no... this is all just a misunderstanding of scientifical facts. You see, it's only the darker folks, whom we are 10% different from, that are 2% different from monkeys. The world was made this way intentionally, presumably by some Great, Omnipotent Designer... whatever you want to call him. I know this to be true because I learned it in a museum. In Kentucky. It was right next to the exhibit with humans and dinosaurs living together.

    Honestly folks, get it together already.

  4. Um... not quite. by Punchcardz · · Score: 5, Interesting

    "One person's DNA code can be as much as 10 percent different from another's, researchers said on Wednesday in a finding that questions the idea that everyone on Earth is 99.9 percent identical genetically." It doesn't call it into question at all. The simple matter is that how you define "different" and measure the percentages makes a big difference. The human genome is ~3 billion base pairs. You can have a singe nucleotide change in a gene of say 5000 base pairs. When you compare a given gene between individuals, do you count the whole gene as being entirely different? Or do you say that it is 99.98% (4999/5000) the same?

  5. more examples of fuzzy math by circletimessquare · · Score: 5, Funny

    1 million monkeys randomly typing typewriters = 1 shakespeare manuscript created

    monkeys and humans 98% the same, and this new genetic analysis indicates human up to 10% different, or, only 90% the same

    therefore, 98%-90% = 8% difference in monkey versus human random shakespeare manuscript creation

    8% of 1 million is 8,000

    therefore, 8,000 more monkeys than humans are required to produce one shakespeare manuscript

    it's a scientific fact folks

    (as well as all other "facts" gleaned from this 10% number in the article)

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  6. Re:God vs Man by timmarhy · · Score: 5, Funny

    picture someone sticking they hands over their ears and yelling LALALALALA I CANT HEAR YOU, and you will know the religous stance

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  7. Re:chimpanzees=98% human by RetroRichie · · Score: 5, Funny

    We already found him. And we elected him President!

  8. On The Origin of Slashies... by Anonymous Coward · · Score: 5, Funny
    Creationists on slashdot? I thought this place only had smart people.
    And where do you think these smart people came from? Unless you seriously believe that they spontaneously appeared on slashdot fully-formed, they must have evolved from something ;)

  9. Re:Actually by nacturation · · Score: 5, Insightful

    So how is parent Offtopic?

    Because it's a creationist site whose tagline is "Upholding the authority of the bible from the very first verse." While the source generally shouldn't be taken into consideration when considering the argument, in this case it's similar to asking the KKK for informed research on black people.

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  10. Re:Actually by mrRay720 · · Score: 5, Insightful

    Very true.

    Whenever I hear people talk about how we're "99% like a chimp", "45% like a fern", "76% like a catfish", etc. I just point out that we are not DNA. DNA is just the intruction manual on how to make us.

    A more accurate analogy would be that the user manuals for a chimp and a human are 99% similar. Considering that the first 950,000 of 1,000,000 pages are about basic body structure, chemicals, etc, that's hardly surprising.

  11. Re:Natural Selection no longer applies to humans by Burnhard · · Score: 5, Insightful

    Humans have escaped the phenomenon of Natural Selection, for the most part. All of us who wear glasses? We should have been culled. All these people developing diabetes from eating too much sugar? Selected against. Asthma? You get the picture. Running with the idea that there is a higher power that created the world, I would say that Natural Selection is the method that higher power uses to figure out what works. But now with health care and a strong sense of altruism, errors in the genetic code are propagating throughout our species and wrecking havoc. In other words, we're playing god by saving lives that should have been selected against and allowing them to pass on their flawed genes.Sorry if my first post here is highly naïve, but you are making the assumption that caring for the sick or less fortunate is not itself a trait that has been selected for in previous generations. You mention a strong sense of altruism. This trait remains in the population because it is selected for, especially as Human (and primate) populations survive as groups, not as individuals.

  12. Re:Natural Selection no longer applies to humans by oliverthered · · Score: 5, Funny

    Unfortunatally it seems to be just the kind of humans you wouldn't want running around the place that are having lots of children nowadays.

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  13. Re:Natural Selection no longer applies to humans by Almost-Retired · · Score: 5, Insightful

    And now your kid is born with a gene that means they're 80% likely to die from some horrible disease by the age of 30. If I were that kid, I would be pissed at my parents for not choosing the screening option.

    Sorry, I can't agree with that last statement, having been a step-parent to 2 of "Jerry's" kids for 17 years. Regardless of the physical problems and the fact that one has already died at age 34 of MMD, they were, and are glad to be alive. So don't try to put words in a hypothetical childs mouth, thats not what comes out when they make their wishes known.

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