Wow, and to think I wasted 8 years in grad school getting my PhD in genetics and didn't figure out the scam which is DNA testing. Thanks so much for being smarter than everyone else. If Alec Jeffreys was dead I'm sure he'd be rolling in his grave.
Even if you transplanted bone marrow from a delta-CCR5 individual into a HIV+ person the non-immune system cells which are virally infected (like important things like neurons) would still produce virus. It would be AIDS, but without the opportunistic infections. Eventually they would still die horrible deaths without antiretrovirals. Also, there's no guarantee that with a constant viral load from the other infected cells in the body that the "impenetrable" donor cells wouldn't get infected by a mutant which had less reliance on the CCR5 co-receptor.
If we assume the populations are at Hardy Weinberg equilibrium (which they will not be for all diseases as there is some negative selection on afflicted individuals) then we use the formula p^2 + 2pq + q^2 = 1. If q^2 = 1 in 2000 then p is 0.9776 and q is 0.0223. This means that the rate of carriers of the disease is 0.9776 * 0.0223 * 2 which is 0.043. If we multiply it out to see what are the chances of taking 1000 people and none of them being a carrier it is (1-0.043)^1000 which gives us the extremely low probability of 3.84 x 10^-20 or 0.0000000000000000000384, so for most diseases this is sufficient even if you don't take people known to have the disease.
I have used this video in my intro biology class, telling them it is an absolutely marvelous video and that by the time they graduate they will understand the complex processes depicted. I have spoken through it, thereby adding my own narration. Does this mean I am going to get sued too? In finding this video for my class I noticed many versions out there on youtube and other video sites, ones which had the copyright notice absent already, so does this mean I would get sued for showing those instead of the original? It's not like they posted the video on a site representing it as their own, it was part of a powerpoint presentation and I really doubt there is solid grounds to show they did anything wrong. Just because they are pushing their own agenda which the poster disagrees with does not mean they are any worse than other people making up a powerpoint presentation and not citing every graphic and video they find on the web.
Simple solution: The "fuel filter" is a glass like tube with a UV light, all fuel passes through the beam and any DNA or RNA passing through the UV light gets destroyed. I imagine this would be important for any usage (not just the threat of bioterrorism) as you are more likely to get bacterial or fungal contamination if you aren't sterilizing the fuel.
Actually, one big problem is that while instant freezing from N2(l) can easily be done, the thawing takes time. During that time the small ice crystals formed by a rapid freeze will actually grow together and make crystals which are large enough to damage the cells. Think about it this way: Most people have enjoyed a slush on hot summer days. After a while a slush left out will form one large ice chunk floating in the middle of a syrupy liquid. The large chunk is the fusing of smaller ice crystals, when this happens in cells damage results. I have had conversations at genetics society meetings with some researchers working on antifreeze proteins which bind to and block the ice crystals from fusing, it's cool stuff;)
I'm pretty sure I heard about them taking busloads of homeless people down to Las Vegas and then hauling back busloads of hookers for all the foreign visitors.
Bacteria, due to their rapid rate of replication (short generation time) are very prone to selection. There would be a fitness decrease to carry around this useless DNA, especially in redundant copies. Because of this, over time the mutants which had this "data" deleted would replicate slightly more quickly and these footprints in the sand would be washed away. This is the whole reason bacteria have compact genomes, redundancy and garbage are a waste of energy to replicate every generation making them weaker than their optimized counterparts.
Your butterfly link is to research conducted under artificial conditions which do not reflect the level of exposure at a real farm. This anti-GMO lie has long been debunked for the fabrication it really is.
See the USDA for more.
If any exploit becomes used, won't it be fairly obvious to find what key is being used and then look it up in the big list of player keys to figure out which one it came from?
Real problems? I don't think we geneticists can solve the world's real problems, so we will just try and do what little we can to help out. Making more nutritious food won't fix fucked up foreign policies that deal with food aid or make the supply chain more efficient, that's the problem of people who work in those industries.
It's like saying OLPC shouldn't exist because it doesn't solve the core problems of the third world, it will only help children get more education. It may not fix the problem, but it is the little bit that the tech industry can do to help.
Tell me, how does what YOU do save the world? I doubt that porn and world of warcraft quite make the cut.
This is about finding a stable surface protein on the surface of HIV which may be a good target for the production of an antigen which would elicit a stable immune response as a number of people have antibodies which target the same site. This has nothing to do with DNA, the submitter is just biologically illiterate.
All they have proven is that turning the gene back on can alleviate the disease. This is no closer to a cure than any other single gene disease that could be fixed by putting a good copy in. Not only that but most autism has nothing to do with this mutation, most autistics are male and only females get Rett syndrome. The title and summary are the biggest load of non-biologists trying to write about biology I've read in months.
A terrorist, A scientologist, and a donkey walk into a bar....
The terrorist says to the scientologist,"Stay away from the donkey, I've packed him full of explosives." The scientologist says to the terrorist,"You can't blow up the donkey, I've packed him full of thetans!" Finally the donkey says,"Actually, I'm fine. You filled each other up, you Asses."
They used a truncated portion of the steroid receptor that makes the cells divide, it would competitively inhibit the real receptors from triggering cell division.
They managed to test against human tumors which had been xenografted into mice, they packaged their new therapeutic transgene into a modified lentivirus then injected the virus directly into the tumor site.
While this result is promising, it suffers from the same drawbacks as many gene therapies: we can figure out what to put into the cell to fix it, but the big problem is finding a very effective vehicle (virus) to target a high proportion of the required cells.
Yes, the longest undefended border in the world. If you go to a remote enough area you can walk across, but anything you could drive across would probably at least have a remote sensor (with anti-terror killer lasers coming soon).
You can teach a TEN year old not to play with your phone, but a TWO year old isn't going to listen to your explanation about not playing with it to dial 911 by accident.
A phone is not a razor blade, grenade or flame thrower. I let my kids play with my phone (when locked), the remote, the mouse and keyboard on the computer (with Toddlerkeys enabled). They see their parents hitting buttons and doing things and they want to emulate us to some extent and see what the big deal is about and their curiosity should be encouraged. The problem here is entirely with RIM, any keypress which can accidentally happen just by shoving the phone in your pocket and dial 911 is not a feature, it's a bug.
If I was one of the corporations that Apple tried to extort by buying this patent I would just form a nice alliance of lawyers with the other "infringers" and fight the thing tooth and nail. There is probably a better chance of spending 100 million getting the patent voided than giving Apple a billion and bending over.
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But it is so much easier to cut down trees and leave letters remaining than it is to dig a very big hole in the ground.
Wow, and to think I wasted 8 years in grad school getting my PhD in genetics and didn't figure out the scam which is DNA testing. Thanks so much for being smarter than everyone else. If Alec Jeffreys was dead I'm sure he'd be rolling in his grave.
Look up AIDS related dementia, or better yet, enroll in my class where I teach 6 weeks on HIV.
Even if you transplanted bone marrow from a delta-CCR5 individual into a HIV+ person the non-immune system cells which are virally infected (like important things like neurons) would still produce virus. It would be AIDS, but without the opportunistic infections. Eventually they would still die horrible deaths without antiretrovirals. Also, there's no guarantee that with a constant viral load from the other infected cells in the body that the "impenetrable" donor cells wouldn't get infected by a mutant which had less reliance on the CCR5 co-receptor.
If we assume the populations are at Hardy Weinberg equilibrium (which they will not be for all diseases as there is some negative selection on afflicted individuals) then we use the formula p^2 + 2pq + q^2 = 1. If q^2 = 1 in 2000 then p is 0.9776 and q is 0.0223. This means that the rate of carriers of the disease is 0.9776 * 0.0223 * 2 which is 0.043. If we multiply it out to see what are the chances of taking 1000 people and none of them being a carrier it is (1-0.043)^1000 which gives us the extremely low probability of 3.84 x 10^-20 or 0.0000000000000000000384, so for most diseases this is sufficient even if you don't take people known to have the disease.
I have used this video in my intro biology class, telling them it is an absolutely marvelous video and that by the time they graduate they will understand the complex processes depicted. I have spoken through it, thereby adding my own narration. Does this mean I am going to get sued too? In finding this video for my class I noticed many versions out there on youtube and other video sites, ones which had the copyright notice absent already, so does this mean I would get sued for showing those instead of the original? It's not like they posted the video on a site representing it as their own, it was part of a powerpoint presentation and I really doubt there is solid grounds to show they did anything wrong. Just because they are pushing their own agenda which the poster disagrees with does not mean they are any worse than other people making up a powerpoint presentation and not citing every graphic and video they find on the web.
Simple solution: The "fuel filter" is a glass like tube with a UV light, all fuel passes through the beam and any DNA or RNA passing through the UV light gets destroyed. I imagine this would be important for any usage (not just the threat of bioterrorism) as you are more likely to get bacterial or fungal contamination if you aren't sterilizing the fuel.
It is poorly done science, which makes it junk science / bad science.
Actually, one big problem is that while instant freezing from N2(l) can easily be done, the thawing takes time. During that time the small ice crystals formed by a rapid freeze will actually grow together and make crystals which are large enough to damage the cells. Think about it this way: Most people have enjoyed a slush on hot summer days. After a while a slush left out will form one large ice chunk floating in the middle of a syrupy liquid. The large chunk is the fusing of smaller ice crystals, when this happens in cells damage results. I have had conversations at genetics society meetings with some researchers working on antifreeze proteins which bind to and block the ice crystals from fusing, it's cool stuff ;)
I'm pretty sure I heard about them taking busloads of homeless people down to Las Vegas and then hauling back busloads of hookers for all the foreign visitors.
This table would seem to support the #3 status.
Bacteria, due to their rapid rate of replication (short generation time) are very prone to selection. There would be a fitness decrease to carry around this useless DNA, especially in redundant copies. Because of this, over time the mutants which had this "data" deleted would replicate slightly more quickly and these footprints in the sand would be washed away. This is the whole reason bacteria have compact genomes, redundancy and garbage are a waste of energy to replicate every generation making them weaker than their optimized counterparts.
Your butterfly link is to research conducted under artificial conditions which do not reflect the level of exposure at a real farm. This anti-GMO lie has long been debunked for the fabrication it really is. See the USDA for more.
If any exploit becomes used, won't it be fairly obvious to find what key is being used and then look it up in the big list of player keys to figure out which one it came from?
Wasn't there a time (back in this win95 era) that USB was the wacky new proprietary format?
Real problems? I don't think we geneticists can solve the world's real problems, so we will just try and do what little we can to help out. Making more nutritious food won't fix fucked up foreign policies that deal with food aid or make the supply chain more efficient, that's the problem of people who work in those industries.
It's like saying OLPC shouldn't exist because it doesn't solve the core problems of the third world, it will only help children get more education. It may not fix the problem, but it is the little bit that the tech industry can do to help.
Tell me, how does what YOU do save the world? I doubt that porn and world of warcraft quite make the cut.
This is about finding a stable surface protein on the surface of HIV which may be a good target for the production of an antigen which would elicit a stable immune response as a number of people have antibodies which target the same site. This has nothing to do with DNA, the submitter is just biologically illiterate.
All they have proven is that turning the gene back on can alleviate the disease. This is no closer to a cure than any other single gene disease that could be fixed by putting a good copy in. Not only that but most autism has nothing to do with this mutation, most autistics are male and only females get Rett syndrome. The title and summary are the biggest load of non-biologists trying to write about biology I've read in months.
The terrorist says to the scientologist,"Stay away from the donkey, I've packed him full of explosives."
The scientologist says to the terrorist,"You can't blow up the donkey, I've packed him full of thetans!"
Finally the donkey says,"Actually, I'm fine. You filled each other up, you Asses."
They used a truncated portion of the steroid receptor that makes the cells divide, it would competitively inhibit the real receptors from triggering cell division.
They managed to test against human tumors which had been xenografted into mice, they packaged their new therapeutic transgene into a modified lentivirus then injected the virus directly into the tumor site.
While this result is promising, it suffers from the same drawbacks as many gene therapies: we can figure out what to put into the cell to fix it, but the big problem is finding a very effective vehicle (virus) to target a high proportion of the required cells.
It says you can't be more than 250 pounds, doesn't that rule out like half the US population? That can't be good for marketing.
I would have preferred calling the mission "The Solar Windsock" but I guess that just blows.
Yes, the longest undefended border in the world. If you go to a remote enough area you can walk across, but anything you could drive across would probably at least have a remote sensor (with anti-terror killer lasers coming soon).
You can teach a TEN year old not to play with your phone, but a TWO year old isn't going to listen to your explanation about not playing with it to dial 911 by accident.
A phone is not a razor blade, grenade or flame thrower. I let my kids play with my phone (when locked), the remote, the mouse and keyboard on the computer (with Toddlerkeys enabled). They see their parents hitting buttons and doing things and they want to emulate us to some extent and see what the big deal is about and their curiosity should be encouraged. The problem here is entirely with RIM, any keypress which can accidentally happen just by shoving the phone in your pocket and dial 911 is not a feature, it's a bug.
If I was one of the corporations that Apple tried to extort by buying this patent I would just form a nice alliance of lawyers with the other "infringers" and fight the thing tooth and nail. There is probably a better chance of spending 100 million getting the patent voided than giving Apple a billion and bending over.