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Cheap Blood Clot Detection Device

Gearoid_Murphy writes "The BBC details the news of a cheap handheld device to detect blood clots on the surface of the brain. The device uses infrared light to penetrate 3 cm into the body; light that has passed through clotted blood changes detectably. A doctor who is testing the device in India said, 'We found a 98% accuracy for showing blood clots or haematomas.'"

26 of 103 comments (clear)

  1. Woah.. by Thyrteen · · Score: 4, Insightful

    I have a feeling that some surgeons will be sleeping alot better post-operation when they can monitor something like this more effectively.

    1. Re:Woah.. by ScrewMaster · · Score: 2, Insightful

      Surgeons will go for the CT scan every time. It costs more.

      And provides a lot more information than this handheld gadget can. Given a choice, I'd opt for some real imaging rather than a high-tech studfinder.

      --
      The higher the technology, the sharper that two-edged sword.
    2. Re:Woah.. by Thyrteen · · Score: 5, Insightful

      Although the CT Scan would be useful, you need to remember. Your friend has a brain tumor. They operate, and remove it successfully, and close the opening. At this point, you wait, and pray that there's no clotting. Perhaps if this probe could be attached (I don't see why not), for a night after surgery, if clotting starts, the surgeon could get a much faster start on the patient, rather than waiting for "symptoms" to occur. A CT Scan can be useful in determining a problem, but the constant monitoring is useful for a separate scenario.

    3. Re:Woah.. by TheLink · · Score: 3, Insightful

      The wait for a CT scan could be too long. There can be far more of these devices than CT scanners.

      This will help determine if patients need immediate attention.

      As long as the false positive rates aren't high and this device is sensitive enough to detect the common cases, it will be useful.

      --
    4. Re:Woah.. by Silver+Gryphon · · Score: 3, Insightful

      Since the CT scan is expensive, time consuming and often has an hour-long wait even in emergency rooms, they now use the CT scan only if they are fairly certain there's a problem and are often discouraged from doing more than one a day on a single patient. A device like this could be used like the O2 Saturation monitors or cardiac monitors: preventative, non-invasive and don't require scheduling of the million-dollar equipment.

      I can see this tech being used some day to detect clots in legs, arms, etc.

    5. Re:Woah.. by clickclickdrone · · Score: 3, Interesting

      Well, India, rather than England but if it does the job... Heck in the UK they still use leeches c/o the NHS and it's not uncommon to use maggots on badly infected wounds because they eat the bad stuff and leave the good stuff far better than any other treatments. Just because something sounds medieval, don't write it off.

      --
      I want a list of atrocities done in your name - Recoil
  2. To stem the statistical comments: by cgenman · · Score: 4, Interesting

    Inevitably someone is going to say "Well yeah, that means 2% died. Rough lot of good that did them."

    Before that person is you, think of the 98% that lived. I bet they're pretty happy that their chances of detection and survival went way up. And if you were sitting on an operating table in rural India with a poorly underfunded doctor wondering what's going wrong with you, wouldn't you like to take those odds too?

    1. Re:To stem the statistical comments: by pytheron · · Score: 5, Insightful

      To put statistics into perspective, you need to consider the following (for arguments sake).
      Say 98% lived with this new tech. What percentage lived without it ? Maybe 94%. You can't infer that the previous methods of detection/avoidance were mediocre just because the new method has a high success rate. The article certainly gives no comparisons.

      --
      "I am not bound to please thee with my answers" [William Shakespeare]
    2. Re:To stem the statistical comments: by Anonymous Coward · · Score: 3, Informative

      In fact, they are using CTs to confirm the diagnosis...so the implication is that the hand held device is missing 2% of the cases that the CT is catching...at a great cost savings (what was that speech from fightclub about the recall formula?)...that might be the reason why the device isn't cleared for use in the states.

    3. Re:To stem the statistical comments: by Repton · · Score: 4, Interesting

      I'd also be interested in the false positive / false negative rates, and the overall rate of blood clots.

      Eg, suppose 1 in 10 patients develop blood clots under some circumstances. You could get a 90% accuracy by making a device that just reports "No clots" every time. If you're classifying 98% of clots as clots and 98% of nonclots as nonclots, over 1000 tests you'll have 98 blood clots correctly identified, 2 missed, and 18 nonclots misclassified as clots..

      (obviously I have no idea what the true rate of blood clots is)

      Of course, the engineers who made the device and the scientists who test it almost certainly know all this, so I'm not being particularly insightful. If they call it a breakthrough or think it will be useful, then they're probably right. We just can't tell either way from the article...

      ("Mainstream news article lacks useful details: film at 11!")

      --
      Repton.
      They say that only an experienced wizard can do the tengu shuffle.
    4. Re:To stem the statistical comments: by Anonymous Coward · · Score: 2, Informative

      In developing a new technology, it's common to compare it's performance to the current 'gold standard'. Also, the device doesn't have to be perfect to be useful. It could be used as a first pass, and then a subsequent CT scan could be done on the patients that get a negative test result. It would be nice if the article gave the sensitivity and specificity so we would know what makes up its '98% accuracy'.

    5. Re:To stem the statistical comments: by fukitznukin · · Score: 5, Informative

      The other way to look at it is to compare infrared to the current modalities. For example, MRI which provides very sophisticated images, picks up 96% of brain injuries including blood clots. However, this is a very expensive test and is time consuming. In my hospital, I can get a STAT MRI and a radiologist's report in 1-2 hours. If it's after hours, a team has to be called in to do the test and then you can add at least another 45 minutes. Infrared testing on the other hand is a bedside test that can be done very quickly and inexpensively. From a general perspective, 98% is not just adequate it is much better than most tests used in medicine. An EKG that is done for heart attacks for example can miss up to 50% and most people are relieved when they are told that the EKG is normal. 98% accuracy is almost unheard of in medical testing. The term accuracy includes the effects of false negatives and false positives so 98% accurate does not necessarily mean that 2% of the true positives are missed, the test could be picking up all the true positives but also some false positives (it overcalls the number of abnormal test results). Additionally, a test that is 98% accurate does not mean that 2% of the people die unless of course you are referring to a uniformally fatal disease of which blood clots on the brain do not belong. A subdural hematoma is one type of blood clot on the brain and its mortality is about 60%. Additionally, if you think about it, the 2% of blood clots that are going to be missed (let's say the miss rate is 2%) will be the smallest 2% of the blood clots and therefore the least lethal. Yes, size does matter when it comes to blood clots on the brain.

  3. Company Website... by appleguru · · Score: 4, Informative

    http://www.infrascanner.com/

    Looks like they're based in PA, USA... But due to US regulations, they aren't allowed to test the device on patients in the US, and have outsourced such clinical testing to India.

    1. Re:Company Website... by Reader+X · · Score: 3, Insightful

      One wonders what other such testing is 'outsourced'...

    2. Re:Company Website... by fuego451 · · Score: 2, Interesting

      You really have to wonder what the FDA's motivation is for not allowing at least experimental use of this device in emergency settings, along with other accepted practices, to measure its effectiveness. Is there a genuine concern for the patients safety? The device certainly seems harmless enough.

      Ever the cynic, I would guess that the device and the procedure are relatively inexpensive and all parties involved are working out how best to monetize (god I hate that word).

    3. Re:Company Website... by maxume · · Score: 4, Funny

      The bastards, sending a device they believe will work to hospitals with no alternative just because there is less government interference. I bet they kick puppies too.

      --
      Nerd rage is the funniest rage.
  4. I wonder by Disharmony2012 · · Score: 2, Funny

    If this thing will be common I HATE MRIs but, I've been having massive headaches during and after sex. and yes I will wait, because I know the MRI tubes read my mind everytime go into one, and they won't let you bring a tin foil hat.

    1. Re:I wonder by j79zlr · · Score: 5, Funny

      I've been having massive headaches during and after sex.
      Its called guilt, you shouldn't masturbate that many times a day.
      --
      I'm not not licking toads.
  5. A marvelous invention! by Cathoderoytube · · Score: 4, Funny

    I have to say as a blood clot sufferer this invention sounds great. For those of you who don't know the previous means for checking for blood clots was to drain out all the patients blood and let it settle, then the doctors would count the blood clots floating on the surface. On one occasion my doctor accidently dropped his pen in the vat, then he tried to fish it out. I went completely spare and told him if he expected to put that blood back in me after he'd been sloshing around in it he had another thing coming.

    --
    I have nothing compelling to say
  6. The Slashdot blood test by Anonymous Coward · · Score: 5, Funny

    for your insensitive clots.

  7. How it works by c_fel · · Score: 4, Informative

    Hemoglobin has a different absorption spectrum when it's oxygenated (oxyhemoglobin) or not (desoxyhemoglobin). An interesting characteristic of this spectrum is observed in the near-infrared part or light (700-850nm): http://omlc.ogi.edu/spectra/hemoglobin/index.html

    In the infrared part, oxyhemoglobin absorbs less light than desoxyhemoglobin ; it's the contrary in the red part. So if we shoot these near-infrared wavelengths (and some more, to get a good idea of the absorption spectrum) in the head and detect it somewhere else (around 5-6cm from the source), we can get information on the concentration and oxygen level of the hemoglobin in the middle of the emitter and the detector. If the hemoglobin is more present than somewhere else in the head, and it's less oxygenated than usually, we get a good idea that there's something wrong there.

    Other advantages : infrared light is non-ionizing, so it's absolutely no dangerous to use that kind of instrument continuously on a person until we are sure there's no problem.

    It's brilliant and I'm glad to see that kind of instrument emerging.

    --
    I hate all sigs, mine included.
    1. Re:How it works by nanosquid · · Score: 2, Interesting

      infrared light is non-ionizing, so it's absolutely no dangerous to use that kind of instrument continuously on a person

      A kitchen broiler is also non-ionizing radiation, but I suspect using it "continuously" on someone's brain is not such a good idea.

  8. Cheap?! by quarrel · · Score: 3, Funny

    Oi!

    Who are you to call my blood clots cheap?!

  9. Errr... by Anonymous Coward · · Score: 5, Informative

    I don't entirely agree...

    Aside from the fact that a lot of the time, we're more worried about post-op *bleeding* (which we'd see on CT) than simple clotting, I'm not sure how you'd tell appropriate clotting from dangerous clot, *except* through monitoring symptoms. Its not the clots after surgery that are dangerous, but when the clots are in areas that suffocate healthy tissue (ischemia).

    And a CT looking for new infarct would be useless. An MRI might help, but not a CT.

    And, yes, IAAD.

  10. False alarms? by edsyc · · Score: 2, Insightful

    Obviously a great development, but I wondered what the false alarm rate was. The device can detect 98% of blood clots, but how often does it say there is a blood clot when there actually isn't? False alarms could lead to costly, unnecessary surgeries that insurance (at least, insurance in the US) may not cover.

  11. Re:You don't understand, grasshopper by cgenman · · Score: 2, Insightful

    Thank you for reading the article, and for your subsequent well-informed and enlightening response. I too know that people like chief neurosurgeon professor Alok Sharma are prone to exaggerating the effectiveness of medical procedures, in a manner very similar to that of a company hawking useless anti-terrorist gear. This can be true even when clinical trials have been outsourced to them and they, therefore, have no financial stake in the marketplace success or failure of the device. Your conclusion that it should be used in conjuncture with existing tests was a brilliant masterstroke, which is only further reinforced by the fact that that is, actually, exactly what the article recommends.

    And clearly, anyone in a third world village for which the measly 400,000 dollar CT scanner cost is too much should simply be airlifted to a larger national hospital where they can be treated properly. Airlifting a should be a fast and easy solution and is done in places like that all the time. And, of course, the astronomical and rising cost of healthcare in the US ensuring that 45 million of us have no health care shouldn't stop us from thinking about the children for whom the ridiculously expensive CT scanning procedure could save, assuming they ever went to a hospital. After all, access to good medical procedures shouldn't be gated on ability to pay, so it never is, right? And having a nurse do a couple of CT scans throughout a night "just to check" is a routine procedure in most trauma cases anyway, and as such the need for a cheap, easy, handheld, and fast scanner that has basically no operating costs besides a bathroom-break worth of time and a little drain on some rechargable NiCads is gratuitous.

    This is exactly why I posted that some people would see a "98% accuracy rate" and immediately find fault. And you did, congratulations. Almost always, these are people who feel that you shouldn't use condoms because they're "only 99% effective when used correctly." Or those who decide not to take their diabetes medicines because it might only be about "95% successful" in stemming the tide of the disease. People want medicine to be black or white, good or bad, fixes you or not, but in reality medicine is a really mushy, nasty area. Certain tests may only have a 30% detection rate, but they do it anyway because detecting certain diseases at that level is better than not detecting them at all, especially to the people who get detected. Heck, CPR on cardiac arrest victims only reduces their death rate from 95% to 90%, which means that it's by and large almost useless. Almost. To those extra 5% who survive, it's very, very nice to have around.

    Having a Sociology degree, I'm well aware of just how easy it is to make percentages lie, and am happy that people seem to have developed a healthy distrust for them. What you learn to trust, if data isn't readily available, is people. If people in the field are happy with this development, and the technological basis behind it seems sound, maybe it's worthy of further examination. If they're not, like the terrorist scanners, it's probably bunk.