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Happiness Is A Warm Electrode

sufijazz writes "A story by Gregory Mone on the Popular Science website talks about trials to use deep brain stimulation to cure chronic depression. It's a deeper exploration of the 'brain pacemaker' discussed here on the site before, and a practical application of research discussed even earlier. Why the pulses affect mood is still unclear, but scientists believe that they may facilitate chemical communication between brain cells, possibly by forcing ions through nerve fibers called axons. In turn, this may trigger the release of mood-regulating chemicals like serotonin and norepinephrine. Similar trials are being conducted in other places. Exact numbers are hard to ascertain, but it's estimated that fewer than 50 patients in North America are walking around with wires in their brain."

30 of 199 comments (clear)

  1. Eye-Friendly by Anonymous Coward · · Score: 3, Informative

    Here without the ads and annoying background.

  2. sounds familiar by User+956 · · Score: 2, Funny

    Why the pulses affect mood is still unclear, but scientists believe that they may facilitate chemical communication between brain cells, possibly by forcing ions through nerve fibers called axons.

    Isn't that the same way World of Warcraft works?

    --
    The theory of relativity doesn't work right in Arkansas.
  3. it's both by User+956 · · Score: 4, Funny

    Happiness Is A Warm Electrode

    Hmm, I always thought that happiness was a warm gun.

    It's actually both, which means, logically, that happiness is a taser.

    --
    The theory of relativity doesn't work right in Arkansas.
  4. heh. by apodyopsis · · Score: 4, Funny

    the rise of the wirehead!

    http://en.wikipedia.org/wiki/Wirehead

  5. I used to take anti-depressants by Das+Modell · · Score: 4, Insightful

    When I was on anti-depressants I acted in a way that, in retrospect, wasn't natural for me. I did some very weird things and occasionally embarrased myself, which is something that I don't like to do. What the fuck was I thinking back then? And was it really caused by anti-depressants, or have I simply changed? I don't know, but I'm now very wary of any artificial means of making yourself happy or less depressed. Besides, this technology doesn't address the root cause of why someone is depressed. I suppose it's useful to someone who's really badly depressed, but personally I wouldn't want to try it.

    1. Re:I used to take anti-depressants by Sunburnt · · Score: 4, Insightful

      this technology doesn't address the root cause of why someone is depressed.

      It may, if the root cause of the depression is genetic.

      I generally agree with your sentiment, though. A great deal of depression is comorbid with personality disorder, or can be strongly correlated to environmental factors.

      In the former instance, there is probably little to be done in the clinical sense. Changing this person's emotional reactivity is likely to just bring different aspects of their disordered personality to light, and the chaos and alienation this can induce in the patient and their social group is probably no healthier than the depression. There's much more to this, but a discussion of therapy for personality disorders would be long and outside the scope of this discussion.

      It is the second instance, I believe, where you hit the nail on the head. If a patient gets depressed by their own self-defeating thoughts and patterns of abuse in their life, then it is the role of the therapist to facilitate change in those thoughts and behaviors within the context of everyday life, not to recommend tinkering directly with the patient's neurons.

      It is, of course, quite possible that some folks genes provide them with an abnormal system of emotional regulation, and that "rewiring" this system is the best way to enable them to participate in the full range of human experience. Given what I know of ethics review boards, it is likely that the few dozen folks who've undergone this procedure had not responded positively to the normal range of treatment, and that they have not been diagnosed as PD'd. I'll bet that getting cerebral electrodes implanted for depression probably requires at least as much review and investigation as bilateral cingulotomy, for example.

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    2. Re:I used to take anti-depressants by suv4x4 · · Score: 2, Interesting

      When I was on anti-depressants I acted in a way that, in retrospect, wasn't natural for me. I did some very weird things and occasionally embarrased myself, which is something that I don't like to do. What the fuck was I thinking back then? And was it really caused by anti-depressants, or have I simply changed? I don't know, but I'm now very wary of any artificial means of making yourself happy or less depressed.

      Few weeks ago when we talked about Singularity AI (AI that produces smarter AI and so on), I made a post and within it had ironic remark that AI's happiness level you could imagine as some sort of mood_level number. Training the AI to increase it's mood level when it meets our criteria would be a way to keep its behavior within given guidelines.

      Thing is, of course, it's the same for us. People replied that the robot would just up its mood_level with a tool or a program, and go on a killing spree.

      In the end though, AI or actual intelligence is a very complex system. If the system says you're sad, you'd rather look into why you're sad and try changing things in your environment or actions.

      The current state of psychology science would rather look at the symptom of another problem and try to "hack it". You can fool yourself you're happy by tweaking your "mood_level", but you realize the one you're lying you is yourself, it's no different that measuring your temperature with a thermometer with "it's all ok! don't look at the scale" written all over it.

      Depression is apparently a big problem. There's the argument some people are depressed because of chemical imbalance, well but is there any research going into the difference between both? Nope, instead let's prod rods in our brain, and take drugs.

      They should sell those rods and meds together with pink glasses.

  6. Oh, but it is addressing the root cause by gbutler69 · · Score: 5, Insightful

    If the root cause is that your Axons are not releasing enough neurotransmitters, then this technique is addressing the root cause.

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    Over-the-top Response Guy! Giving "Over-the-Top Responses" since 1970.
    1. Re:Oh, but it is addressing the root cause by replicant108 · · Score: 5, Insightful

      "If the root cause is that your Axons are not releasing enough neurotransmitters, then this technique is addressing the root cause."

      The problem is that modern medicine assumes that this is the root cause.

    2. Re:Oh, but it is addressing the root cause by ConceptJunkie · · Score: 3, Insightful

      Exactly. Modern psychological medicine isn't much further along than smacking your TV set to improve the reception (a metaphor that is becoming more and more archaic). They sometimes know what works. When it works, they sometimes know why. But I imagine they don't often know what caused it in the first place.

      --
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    3. Re:Oh, but it is addressing the root cause by sjames · · Score: 2, Interesting

      When it works, they sometimes know why.

      It seems that they very rarely if ever know why. It seems that practically ALL psychiatric drugs except for tranquilizers can act "paradoxically", that is, the opposite of their intended action. Furthermore, over time their effects on a given patient may flip-flop. That is, drug A used to make the condition worse, but is now helpful. B was effective for several years but now makes them worse. Meanwhile, as far as they know, A and B are in the same class, have similar actions and SHOULD have the same effect.

      So, standard procedure is to keep trying different ones until one of them seems to provide more relief tahn side effects. When it stops working, try again. It's WORSE than banging on the TV. At least with that, you learn after a while just where to bang and how hard.

      It strongly suggests that the simple model of too much or too little of a neurotransmitter is at best incomplete. That is, perhaps the natural homeostasis is thrown off rather than absolute levels of neurotransmitters. Alternatively, neurotransmitter levels have nothing to do with it, but adjusting them may sometimes compensate for the real problem (with highly variable success).

      That's not to say the current drugs don't benefit some patients greatly. It may not put things right but for many it at least leaves them better off. However, the prevailing attitude that this is the final answer and all we need is more targeted drugs is not exactly conducive to further knowledge, and it leads to both discounting patient complaints that things seem wrong somehow and failure to recognize that at best the drugs are a trade-off where some are better off with the original complaint than with the side-effects or even that treatment may not need to be lifelong to be effective.

  7. Let the probing begin! by Anonymous Coward · · Score: 5, Funny

    Now I know why I've been happier since I was abducted. Oh wait, this is about a brain probe...

  8. I love how all these brain techniques... by tjstork · · Score: 3, Insightful

    say "we don't know why this works... but we think it makes you happy..."

    Yet, somehow, a good joint and a stiff drink are evil.

    --
    This is my sig.
  9. People need exercise: by LuxMaker · · Score: 3, Insightful

    Exercise on par with drugs for aiding depression:: http://news.yahoo.com/s/nm/20070919/hl_nm/exercise_depression_dc;_ylt=AqwvsOoXYw0l3eNh11Gw1O0DW7oF

    So get unglued from your computers occasionally and get some fresh air. =)

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  10. Citizen by Colin+Smith · · Score: 4, Funny

    "You are now a class three citizen, your happiness level will be raised accordingly."

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    Deleted
  11. When antidepressants work, they aren't "artificial by sirwired · · Score: 4, Informative

    While I am not depressed, I am very close to some who are, and they universally describe the feeling of getting on the proper drug regimen as "having a curtain lifted from my eyes", or "feeling a great weight off of my shoulders". Not high, not weird, just no longer crushingly depressed most of the time. On a properly tuned, working, medication regimen, anti-depressants enable the patient to again experience a "normal" range of emotion. Working, properly tuned, anti-depressants don't make you feel happy; instead they enable you to be happy under circumstances that most folks would be happy in, and you feel normal on normal days. You still feel like crap on crappy days.

    That said, everyone does react differently, and some can have the side-effect of sending you into a manic state (which can include the symptoms you described). Usually a dosage or timing adjustment can fix this.

    Drug tuning is still more art than science. A new drug to treat depression is considered a great success if 50% of the users experience a 50% improvement. Many successful regimens involve combinations of drugs, and it can take a year or more to find the right combination. (It doesn't help that many common drugs take over a month to have any effect.)

    SirWired

  12. Only 50 wired brains? Count again by Antique+Geekmeister · · Score: 4, Informative

    Take a look at the cochlear implant wearers in the US. The auditory nerve is considered part of the brain in the paper I read a few years ago. There are 10,000 children in the US alone wearing them, according to Wikipedia. Then there are the implants for epilepsy, Parkinson's, and attempts to provide them for balance disorders.

    It's interesting work: they're apparently much more effective for transmitting a signal than picking up signals, so the idea of using them for artificial limbs or thought-control of aircraft has never really worked well.

  13. Re:Wireheads by pla · · Score: 2, Insightful

    It won't be long until we know if Larry Niven was right about brain stimulation. If the current makes you feel better, will you be less likely to switch it off?

    Niven didn't pull that idea out of nowhere - He based in on experiments on rats and chimps contemporary with his writing that found they would rather zap their brains than eat, sleep, have sex, or take favored drugs such as cocaine and heroin.

    So yes, it would almost certainly have the exact same effect on people. Imagine the best orgasm you've ever had, while eating your favorite meal, while high on your favorite intoxicant, then quadruple that. The most restrained willful human alive would turn into a drooling zap-junkie, no question at all.

  14. Re:Happiness is a Warm Gun by dkleinsc · · Score: 4, Funny

    Well, I've always liked the Russian answer to happiness:
    "You come home from work, are sitting in your broken-down chair reading Pravda, when three men in badly-fitting suits knock on your door.
    'Mr Voyslatovich?'
    'No, he lives 3 floors up.'"

    --
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  15. Re:Stupid symptom fighting by mattpalmer1086 · · Score: 2, Informative

    depression != unhappy

    Unhappy is what normal people feel when something exists to make them unhappy.
    Depression is what depressed people feel all, or most of, the time, for no apparent reason.

    Anti depressants allow a depressed person to feel normal - i.e. they can feel unhappy again, as well as happy and everything in between. It reconnects their emotional response to everything, rather than being permanently, well, literally depressed.

  16. Well, if we're just limiting it to reality... by unitron · · Score: 2, Funny

    ...it's estimated that fewer than 50 patients in North America are walking around with wires in their brain."

    Yeah, but I bet there's a much bigger number who think that they are!

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  17. Re:Stupid symptom fighting by VanessaE · · Score: 2, Interesting
    As someone who suffers from both chronic depression and the more acute or short-term version of it (yes, there are two different diagnoses), I can say with complete confidence that you have absolutely no idea what you're talking about. Yes, changing your situation can sometimes help, but the root cause is not environmental, it's something physical in the brain. Unlike a lot of medicines, anti-depressants actually try to treat the cause of the problem rather than just the symptoms. It's just that this is the brain we're talking about, and we all know the brain is a tricky bastard to tinker with.


    I feel more "stable" when I take my meds than I do otherwise, and if you were to ask my husband, he would tell you that it's like night and day. No, I don't walk around all smiles, but I'm not exactly crying all the time either. Depression sucks as bad as any other major disease. If I could get some kind of implant put in that could fix the depression in a permanent manner, I'd jump on it in a heartbeat, if only to be able to give up the pills (I have problems remembering to take them).

    What makes matters the worst for a depression sufferer is if their triggers happen to be something that themselves are either long-term or essentially unsolveable problems which the sufferer is stuck with. In those cases, pills simply aren't enough, and so you're back to feeling like hell all the time. That's where I stand (two such conditions), and I hate it worse than the most rabid Linux user hates Microsoft.

  18. Forbidden in Alabama? by kanweg · · Score: 2, Funny

    I presume that women are not allowed to have such wires in Alabama.

    http://sexinthepublicsquare.wordpress.com/2007/02/15/q-when-is-a-vibrator-more-dangerous-than-a-gun/

    Bert
    Who still wonders how Americans can sing about "home of the free"

  19. Re:Happiness is a frontal lobotomy by Anonymous Coward · · Score: 2, Informative

    Isn't this basically an electrical frontal lobotomy.

    Great question! If you mean "electrical frontal lobotomy" as in "a way to use electricity to separate the frontal lobes of the brain from the rest of the brain", then no I don't think it is. Then again, I'm no doctor, but I did read the article!

    On the other hand, if you mean "electrical procedure that is supposed to cure mental illness and that a lot of people really want to believe in to the degree that they may be willing to overlook gruesome consequences for several decades", then maybe. Who knows? Once upon a time, people thought sliced brains were the best thing since sliced bread.

    For a great story on the topic, check out http://www.npr.org/templates/story/story.php?storyId=5014080

  20. Re:shag carpet by Sunburnt · · Score: 2, Insightful

    Pseudo programming sigs != going to change people's modding/tagging behaviour.

    Well, first off, it's not a "pseudo-programming" sig. It's a sig that's been abbreviated using logical operators so that it doesn't run over the character limit. I'm a science and philosophy nerd, not a programming nerd, and it wouldn't even occur to me that my sig looks like a fake computer program.

    Secondly, I disagree with your contention. True, it is highly unlikely that one person's sig will effect lasting changes in the uses and misuses of /. features. However, I certainly believe that an individual moderator, with no consistent behavior towards conscientiousness or abuse, could be reminded by my sig to side with the former after disagreeing with one of my posts. I have no way to test this hypothesis, but it makes sense given what I know of decision-making, and it costs me nothing to implement. So, I believe that my sig can change people's behavior, although certainly not in a widespread or meaningful way. This belief is not the motivator for my sig choice, though.

    Let me point out that it's pretty presumptuous to even assume that a sig is meant to change behavior. Most sigs are just expressions of some tiny fraction of the author's opinion, frequently given indirectly through quotes or cultural references, that indicate a little something about the author's personality. So's mine: it points to my personal distaste for tag and mod abuse. On another level, it lets the reader know that I am the kind of stickler who cares enough about such things to make them the focus of my sig (which is every /.er's privilege, being a legitimized form of comment spam.) I previously had a Schopenhauer quote about the abuse of anonymity - not because I thought it would stop posters from abusing anonymity, but because I wanted to let the abusers know that I think they're cowardly assholes, and because I figured (correctly) that I might get e-mails from people who shared my interest in Schopenhauer.

    I hope this helps, and I thank you for your concern.

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    Tags != Comments, and -1 (Troll) != -1 (I Would Respond Angrily To This Poster So They Must Be Trolling)
  21. Re:When antidepressants work, they aren't "artific by speaker+of+the+truth · · Score: 4, Insightful

    If the brain isn't producing enough chemicals to allow you to experience happiness then no amount of luxury is going to lift you from depression. A common comment from people who have no clue about depression is "what do they have to be depressed about?" The answer to this is typically nothing, except for a brain that isn't working correctly.

    --
    Using openSUSE instead of Windows since 9th of October, 2007 and liking it.
  22. Re:When antidepressants work, they aren't "artific by Dachannien · · Score: 2, Insightful

    If we weren't supposed to eat those 4000 animals, they wouldn't taste so good.

  23. Re:Hah! Selective reading. by Sunburnt · · Score: 2, Insightful

    Defending Janov by pointing to an anecdote and encouraging the reader to "try it and see what you feel like," instead of linking to an empirical study of his clinical results, only adds credence to the GP's allegations of pesudoscience, since those are the typical rhetorical methods of its defenders. I'm sure at least one of this site's intrepid Googlers can find some actual research on either side, assuming it exists. Of course, if it doesn't exist, that's a statement in itself.

    His technique certainly goes against my understanding of healing. What Janov calls a "release of suppressed emotion," I call "rehearsing anxiety states," and I question the psychodynamic concepts that underlie his explanation of the technique. Unless Janov can show better results than the cognitive therapies, there's probably a better use of an hour than reading his book. Do you have any links to these results?

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  24. Re:When antidepressants work, they aren't "artific by ScrewMaster · · Score: 4, Insightful

    Do you have any idea what you're talking about? I will rephrase that. You do not have an idea what you're talking about. I'm not even going to debate with you about suffering: I put human beings first and animals second. If it comes down to a choice between a human being and 4,000 animals, I know which way I'd choose. Period. End-of-statement.

    When you've finished dealing with the fact that I disagree with you on every point, go read this. After you've educated yourself on how wrong you are, come back tell me that what you said is even slightly relevant. Like the GP, I've had two family members suffer from severe clinical depression, suicide was narrowly averted multiple times. In one case the onset was before the age of antidepressants: he drank to mask the effects of the depression, but overall alcohol simply worsens the problem. When one of the early drugs became available we got him on it (Elevil in the late seventies, I think ... it's been a long time) and the difference was like night and day. "I have my life back" he said, and stopped drinking ... he didn't need it anymore, just to feel normal for a while. It was astonishing, and the relief we all felt was palpable. He still suffered from the effects of his condition 'til he died, but at least he had a life. If that drug hadn't come out when it did he wouldn't have lasted another six months, a year tops. He switched to different drugs over time, as better ones became available, but he got an extra twenty five years because of them.

    People who claim that no-one needs antidepressants ("Tom Cruise, are you listening?") are fools. Ignorant assholes who would cheerfully consign other human beings to a living hell contained within their own skulls. I still don't understand how it must feel to suffer from this disease, and yet I had to deal with the consequences of it for almost thirty years. All of us did, and it was ... very difficult. I'm not saying that antidepressants (like virtually all drugs) aren't capable of being abused, but to claim that people suffering from clinical depression should just "get over themselves" is a preposterous falsehood. Period. End of statement.

    If there is a God, I hope He delivers people like you a sample of what you say doesn't exist. For just a few years: I wouldn't want you to get so depressed that you actually off yourself. Maybe then you'll understand why what you just said offended me to the core.

    --
    The higher the technology, the sharper that two-edged sword.
  25. "Modify your opinions"? It doesn't work by sirwired · · Score: 2, Insightful

    You are confusing clinical depression with pessimism. Telling somebody who is suffering from clinical depression to "modify their opinions" or "control their emotional state" is mostly useless. Somebody suffering from clinical depression is simply unable to feel happy. It doesn't matter at all what their circumstances are, or how a normally functioning person would feel about them. Yes, psychotherapy is at least partially effective for some forms of depression, but it is totally ineffective for others. (And usually psychotherapy is far more expensive than drugs.)

    Real life isn't as neat and clean as 10-minute therapy on "Dr. Phil". Telling a depressed person that they should just be happier is about as effective as telling somebody who is drunk off their ass to "think sober".

    It is silly to argue against anti-depressants because they "create a dangerous dependency on the supplier". You could say that about medication for just about any chronic medical condition. Anti-depressants are not like narcotics, you do not need to continually increase your dosage to maintain effectiveness. Most anti-depressants on the market today are not particularly expensive either, as most are available in generic form.

    SirWired