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Acquired Characteristics May Be Inheritable

A story from a week or so back in Technology Review describes research coming to the surprising conclusion that Jean-Baptiste Lamarck may have been right — that acquired characteristics can be passed on to offspring, at least in rodents. Lamarck's ideas have been controversial for 200 years, and dismissed in mainstream scientific thinking for nearly that long. "In Feig's study, mice genetically engineered to have memory problems were raised in an enriched environment — given toys, exercise, and social interaction — for two weeks during adolescence. The animals' memory improved... The mice were then returned to normal conditions, where they grew up and had offspring. This next generation of mice also had better memory, despite having the genetic defect and never having been exposed to the enriched environment."

242 comments

  1. Finally... by Anonymous Coward · · Score: 2, Funny

    something that explains religion...

    1. Re:Finally... by RuBLed · · Score: 4, Funny

      Interesting eh? So how did it explained religion?

      Is it where the first ones get all the good stuff and the offsprings only get to dream/think about it? Well I could understand that if the scenario was giving dozens of virgins to one guy, the rest would only dream about it. In that case it would be a supply and demand problem, not an inherited one. (or in our case as /.ers, it might not even matter if there's an abundance in the supply anyway.)

    2. Re:Finally... by goombah99 · · Score: 2, Insightful

      Interesting eh? So how did it explained religion?

      Well it appears that proclivity for social interaction is acquired. PLus it is somthing you can pass on to others without genetics.

      What's not quite clear to me here is if the children mice were separated from the adults at birth. if not then perhaps the adult mice just are passign on behaviours. if so then maybe there is some extra genetic means of passing things on at the cellualr level or perhaps mice in the womb can experience the behaviours of their parents.

      For example, if the preacher droning or the choir singing somehow releases endorphins in the mother that increase blood flow to the fetus, perhaps an association with certain sensory input can be learned at the fetal level.

      --
      Some drink at the fountain of knowledge. Others just gargle.
    3. Re:Finally... by Pescar · · Score: 2, Interesting

      I read about this (or something very similar) in new scientist a few weeks ago. If it's what I'm thinking of, the offspring were separated from their parents at birth.

      --
      so.... you're a girl, huh?
    4. Re:Finally... by LingNoi · · Score: 1

      There is no evidence that music being played to babies in the womb does anything. In fact the guy that did the original research did it on college students and no one really understands how this correlation to babies ever materialized.

    5. Re:Finally... by madcow_bg · · Score: 1

      There is no evidence that music being played to babies in the womb does anything. In fact the guy that did the original research did it on college students and no one really understands how this correlation to babies ever materialized.

      This might be it, then :). NEW evidence, not seen on the previous experiments.

    6. Re:Finally... by khanyisa · · Score: 1

      In the article it said that they had some of the mice raised by mice who hadn't been exposed to the better environment and had the same genetic defect as the parents - these offspring also experienced a memory benefit from their biological parents

    7. Re:Finally... by Chrisje · · Score: 1

      If you had read the article, you would have read that abused rats were raised by "normal" mothers and their problems were not solved by that measure, thus proving that the "home experience" doesn't account for the behaviour witnessed.

    8. Re:Finally... by Hatta · · Score: 1

      Religion is already explained by evolutionary thinking. The brain is a sophisticated correlation detector. Some of these correlations might be real, but some might just be coincidences. Missing a real correlation can have some pretty negative consequences. But falsely accepting a coincidence as a correlation carries very little selective penalty.

      Consider Cargo Cults. That's some really strange behavior based on a false correlation. It really didn't cost them much of anything though, in evolution no harm is no foul. Now consider the payoff if they had been right.

      Another idea worth considering is that close knit communities may have a selective advantage over loose groups of individuals. Working together helps everyone survive. Having a common mythology that brings the community together would there for be selected for, whether the mythology represents reality or not.

      --
      Give me Classic Slashdot or give me death!
    9. Re:Finally... by Anonymous Coward · · Score: 0

      ...right. Because all people with religious parents grow up and stay religious, and all people with non-religious parents grow up and never become religious.

      I just absolutely love horrible assumptions with such an arrogant pompous attitude. I'm glad you know it all.

    10. Re:Finally... by spiralx · · Score: 1

      It doesn't even need that much - religion is a perfect social and cultural fit for both the genetic inter-tribe/family bond and the xenophobia that's instinctive to those outside our group... at least back before the march of civilisation. As we expand our boundaries of what we consider our "in-group" religion has to redefine itself to fit, something its finding increasingly difficult to do.

  2. DNA Learning by mfh · · Score: 2, Insightful

    It could be one day possible to create a kind of device that harmonizes human beings early on in childhood development, increasing their awareness and understandings.

    --
    The dangers of knowledge trigger emotional distress in human beings.
    1. Re:DNA Learning by DigiShaman · · Score: 1

      Sure, why not? It would have to be provided by male side though as a female's eggs are fixed in numbers from birth.

      --
      Life is not for the lazy.
    2. Re:DNA Learning by Anthony_Cargile · · Score: 0, Troll

      It could be one day possible to create a kind of device that harmonizes human beings early on in childhood development, increasing their awareness and understandings.

      Nah, too easy to invade privacy or get hacked that way (see: big brother). On an unrelated note, its good to see some old^H^H^Hlow UIDs out and about!

    3. Re:DNA Learning by zappepcs · · Score: 2, Interesting

      That is actually the point. To learn to teach ourselves and our children in the best possible way. Unfortunately, there are those that would have us taught certain things regardless of their merits or value or truth.

      Recently, researchers found that there might be a manner to attach the brain to limbs that have no function due to nerve damage. Apparently there are parts of the brain that can learn to do any function with some training. This means that neuropathways in our brains can be altered through training and remain fixed in this position for many years. There is no magic to suppose that this alters biochemistry to suit the new use. If you ask me (and I know you didn't) this is part of how evolution works. Once monkeys start using tools I doubt they will ever magically 'forget' how to use them. It won't be but a generation or two before this is part of normal brain function. If you've ever watched a new foal learn to walk within hours of birth, then learn to run in the same morning, you will no doubt wonder what is in the horses brain that makes them capable of this? Humans and other mammals have a long learning cycle for this.

      As mentioned, this might explain religion however tenuously. There are studies happening as we speak about how the brain is hardwired for religion, or more specifically accept that magic is responsible for things outside our current ability to understand them.

      The important next point would be showing altered biochemistry and/or genetic change due to learning/experience. The studies like the one that hints that engineering types are more likely to have boys than girls is important. It means that or hints that brain chemistry has biochemical effects on us and our offspring via genetics. Animal husbandry would tell us this if we listened, but we need to see it in humans to fully 'get it'... I don't want to say that this is more evidence for the support of eugenics, but... well, it seems likely.

      Truly, we are not yet done learning about the human condition. Perhaps one day we will be able to engender and recognize many more folk like Einstein or Newton et al. Unfortunately that will only come at the price of recognizing others as second class citizens or some form of Gattica etc.

      I hope that it is used to improve the condition of all, not simply the best or those most able to pay. Genetic change/mutation comes to all, just as rain does not fall only on the unjust. Eugenics would limit the gene pool and that would be bad for all of us ... in the long run.

      Hopefully this will turn out to be a good thing and not leave the human race with the regrets Nobel died with.

    4. Re:DNA Learning by Forrest+Kyle · · Score: 3, Insightful

      How about books? I know that parents barely try that anymore, but reading does that.

    5. Re:DNA Learning by Anonymous Coward · · Score: 0

      too long, didn't read (see below.

    6. Re:DNA Learning by MrNaz · · Score: 2, Funny

      Or we could create environments where children are encouraged to learn and behave in a mutually co-operative manner! These institutions could perhaps replace schools...

      --
      I hate printers.
    7. Re:DNA Learning by lostmongoose · · Score: 0, Offtopic

      or more specifically accept that magic is responsible for things outside our current ability to understand them.

      A wizard did it.

    8. Re:DNA Learning by gardyloo · · Score: 3, Funny

      It could be one day possible to create a kind of device that harmonizes human beings early on in childhood development, increasing their awareness and understandings.

            Beer.

    9. Re:DNA Learning by ultranova · · Score: 1

      It could be one day possible to create a kind of device that harmonizes human beings early on in childhood development, increasing their awareness and understandings.

      Maybe, but this study doesn't indicate that. It's far more likely that the parent rodents, who's behaviour had been altered by their conditioning (how else could the scientists know their memory had been altered?) simply altered the childhood conditions their offspring. That is, of course, passing on an acquired trait, but so is culture.

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    10. Re:DNA Learning by mfh · · Score: 1

      Think of the future. It takes so long to read a book. With a special device you could directly alter the physical molecules into new configurations!

      Every time I hear of someone suggest some out of date technology to go back to the way it used to be, it reminds me of the chariots in Rome. Perhaps we'll have to go back to chariots too, but we won't have the money for the horse feed, unfortunately.

      Progress moves in one direction; forward.

      --
      The dangers of knowledge trigger emotional distress in human beings.
    11. Re:DNA Learning by nizo · · Score: 1

      Forget that; I think we should genetically engineer people to grow a second brain, filled with memories (maybe switched on after adolescence). Imagine figuring out how to grow a brain that is filled with facts; if we understood how memories work and could manipulate dna, this seems like it would be possible.

    12. Re:DNA Learning by warsql · · Score: 2, Insightful

      *upload ...* I know Kung Fu!

      --
      878659 - yep its prime.
    13. Re:DNA Learning by Forrest+Kyle · · Score: 1

      Books are not an "out of date" technology.

    14. Re:DNA Learning by Metasquares · · Score: 2, Insightful

      Awareness and understanding of what, exactly? Human suffering? Religion? Politics? Culture? Do we really want a population designed to universally uphold the ethics that society dictates as 'proper' at any moment in time?

      Not only would it clash with the ideals of free will and self-determination, but the consequences of many popular ethics would be disastrous if universally applied. Society is not built upon the categorical imperative.

      Let's not muck with people's morals (or the awareness and understanding that causes them to form these morals). Moral diversity is necessary for individual health and a functional society.

    15. Re:DNA Learning by Main+Gauche · · Score: 1

      And I, for one, will welcome our new Borg overlords.

    16. Re:DNA Learning by FatdogHaiku · · Score: 2, Funny

      Every time I hear of someone suggest some out of date technology to go back to the way it used to be, it reminds me of the chariots in Rome. Perhaps we'll have to go back to chariots too, but we won't have the money for the horse feed, unfortunately.

      That's in the future, but the chariots will hover, and be pulled by large (also hovering) jet engines... http://www.youtube.com/watch?v=j6Jyq0cWntY&feature=related

      --
      You have the right to remain sentient. If you give up the right to remain sentient, you will be elected to public office
    17. Re:DNA Learning by Anonymous Coward · · Score: 0

      Not so sure about that. Did the Low UID see it's shadow? Wouldn't that mean we get 6 more weeks of GNAA trolls?

    18. Re:DNA Learning by Anthony_Cargile · · Score: 1

      I think so - some mod's been digging through my history and modding every post I've made recently "troll", except for the +5 posts. Somebody's out to get me, because apparently I've pissed off the karma gods somehow...

    19. Re:DNA Learning by Anonymous Coward · · Score: 0

      "Facts" are abstractions, and your brain is no more "filled" with them than a bird is filled with feathers.

      If you understood how memory works, through brainwave interference patterns and not something so primitively rigid as storage, you would not have suggested something so ridiculous. And that's not even getting into the "why" of it, which I'm sure would be as entertaining as your last post.

    20. Re:DNA Learning by Anonymous Coward · · Score: 0

      The physical portions of your brain do indeed store memories. As proof, I will poke portions of my brain until I forget about your post.

    21. Re:DNA Learning by Anonymous Coward · · Score: 0

      I can't wait 'til they invent Ow My Balls!*

      *brought to you by Carl's Jr.

    22. Re:DNA Learning by Hatta · · Score: 1

      Think of the future. It takes so long to read a book. With a special device you could directly alter the physical molecules into new configurations!

      Yes, this invention will allow parents to spend even less quality time with their children! Will the wonders of technology never cease?

      --
      Give me Classic Slashdot or give me death!
    23. Re:DNA Learning by Xenographic · · Score: 1

      > If you've ever watched a new foal learn to walk within hours of birth, then learn to run in the same morning, you will no doubt wonder what is in the horses brain that makes them capable of this? Humans and other mammals have a long learning cycle for this.

      I thought it was more a matter of us lacking the muscles to do this. Newborn humans aren't exactly strong. (Though if there was evolutionary pressure for us to develop that kind of strength right off the bat, like there would seem to be for foals, I'm sure the musculature would evolve in due time.)

    24. Re:DNA Learning by shutdown+-p+now · · Score: 1

      I hate beer!

      So much for harmony...

    25. Re:DNA Learning by SnowZero · · Score: 1

      I think so - some mod's been digging through my history and modding every post I've made recently "troll", except for the +5 posts. Somebody's out to get me, because apparently I've pissed off the karma gods somehow...

      It's the Legion of Extraordinary Low User Ids.

      I crossed them once... it took 5 years for my karma to recover. Make sure you always wear your tinfoil hat tilted back a bit, since the people out to get you might be sneaking up from behind.

  3. Brain plasticity by elashish14 · · Score: 1

    Of course. The brain is quite plastic at such an early stage of development. This is why people that lose vision have great hearing and smelling, etc. My question is whether these effects can occur when the brain isn't the problematic organ.

    In any case, the problem is making sure that we can identify these problems while there's still time to nurture someone to overcome it. The brain is far more plastic in early stages of life than it is in older ones.

    --
    I have left slashdot and am now on Soylent News. FUCK YOU DICE.
  4. Interesting... by drosboro · · Score: 5, Informative

    Lamarck is one of those guys who's name is generally synonymous with bad science (he's about as villified as Darwin is deified). I'm actually a bit (pleasantly) surprised that someone would invest the time into this sort of study.

    That being said, the article is rather short in one important area: a suggested mechanism for this sort of inheritance. Without that, it's bound to be mired in controversy for some time.

    1. Re:Interesting... by MoellerPlesset2 · · Score: 5, Informative

      Lamarck is one of those guys who's name is generally synonymous with bad science (he's about as villified as Darwin is deified).

      What? I've heard Larmarck's evolutionary ideas ridiculed but villified?
      He wasn't that unscientific. He was just wrong.

      Or are you thinking of Lysenko? Now that particular advocate of inherited-acquired-characteristics was indeed a villain, a lousy scientist and a political tool.

    2. Re:Interesting... by cryptoluddite · · Score: 5, Insightful

      Article doesn't say what interactions the adult mice had with their offspring. The benefit may have just been passed to the next generation through regular learning, modeling, etc.

      I don't know about lab mice, but rat packs have a pretty complicated social structure (for example nominating food tasters to try new sources of food) so I'd bet that mice can teach their young a lot more than researchers might suppose.

    3. Re:Interesting... by Kandenshi · · Score: 5, Insightful

      Here's my personal suggested mechanism.

      Enriched environments have long been known to make mice 'happier' in addition to being better at solving various tests, and having larger brains, etc. This stress-reducing effect has been known to be maintained long after the rats are removed from the enriched environment.

      The change in the mother rats should fully be expected to be partially shared with the pups. The womb is not a completely separate environment that just happens to exist inside the mother, her experiences shape what sort of chemicals(beneficial or detrimental) are delivered to the baby.

      A healthier, less stressed out mother is likely to nurture her babies properly while they're in utero, and uterine environment that's not bathed in stress hormones is generally a preferable one for the baby's neurological development.
      TFA also mentions that an opposite effect occurs, where highly stressed mothers had babies that then also abused their pups tend to have pups that themselves are poorer mothers. They don't mention if problem solving tests were given to these rats, but I'd fully expect that they'd show deficits in tests of memory and intelligence.

      The researchers in the article say that this is a completely shocking discovery, I'd be shocked if it didn't happen. The stress response affects not only the mother, but also the baby, and those changes can be noticed in their later lives. Quel surprise.

    4. Re:Interesting... by drosboro · · Score: 5, Informative

      Actually, I've just taken a peek at the original article in J. Neuroscience, as posted in the comments below.

      The interesting thing is that this seems to be passed on at embryogenesis - so it's quite distinct from learning. It's also quite distinct from other epigenetic inheritance studies, which have demonstrated that some of mom's behaviour can result in changes in the offspring's tissues. If this is in fact happening at the embryo stage, it is a whole different pathway.

    5. Re:Interesting... by williamhb · · Score: 4, Insightful

      That being said, the article is rather short in one important area: a suggested mechanism for this sort of inheritance. Without that, it's bound to be mired in controversy for some time.

      This is an unfortunate shortcoming of science at the moment. A tested result is rejected until there is a suggested mechanism; as soon as a mechanism is suggested, it is all too often treated as "true" even if the mechanism itself has never been experimentally tested at all but was just plucked out of the air. The one that instantly springs to mind is the 2005 result that being cold can after all make you susceptible to catching a cold. The paper is reasonable and itself admits that its "suggested mechanism" (that capillaries in the nose constrict, reducing access by the immune system) was not itself tested by the authors, but was just an idea they came up with when their actual experiment -- do people sitting around with their feet in bowls of icy water catch colds more often -- gave a positive result. Nonetheless, that mechanism very quickly started getting bandied around as if it were gospel.

    6. Re:Interesting... by ceoyoyo · · Score: 4, Informative

      Yes, it does. The article says that the changes are still evident even when the pups are raised by control rats, NOT their mother.

      It also says the change is not permanent - it only lasts a few months. I didn't notice any mention of whether the mother rat still functions at a high level when she's pregnant. If she does, the change could be due to the environment in utero, which would be consistent with the effect fading over time.

    7. Re:Interesting... by mapkinase · · Score: 1

      General molecular mechanism that could explain inheritance of acquired characteristics is epigenomic environment of the mother's cell. All cells in our bodies have the same DNA, yet they are drastically different in the function, structure, etc.. The reason for that is that persistent self-sustained combination of concentrations of all biomolecules is different in different cells. This environment dictates which genes are silent and which are not.

      In short, DNA determines "what" but does not say how much of each.

      That includes gametes of the mother: same genetic material could play differently depending on the differences in the chemical composition that were present in the mother's egg at the moment of consumption.

      --
      I do not believe in karma. "Funny"=-6. Do good and forbid evil. Yours, Oft-Offtopic Flamebaiting Troll.
    8. Re:Interesting... by Tubal-Cain · · Score: 3, Informative

      a suggested mechanism for this sort of inheritance

      Epigenetics?

    9. Re:Interesting... by dunelin · · Score: 3, Informative

      There is a mechanism for this kind of inheritance and it is part of a growing field called epigenetics. Whether genes are present are not as important as how they are expressed. Are they switched on or off? Experiments show that gene expression can be altered by environment and that epigentic information can be passed down to the next generation. There was a great Nova episode about it.

      http://www.pbs.org/wgbh/nova/sciencenow/3411/02.html

      I'm not sure if this is the exact mechanism involved in this study, but it is a possibility.

    10. Re:Interesting... by Anonymous Coward · · Score: 1, Insightful

      This is a crock of BS.

      First, no one "deifies Darwin". Second, Lamarck is widely respected in France as the father of evolution, and that's exactly what he was. Ideas about evolution were bouncing around for a long time before Lamarck, but he was the first one to lay down an actually scientific theory of evolution. No educated biologist would "vilify Lamarck".

      But the fact remains that he simply didn't get it right. He didn't figure out the branching tree of life, and he didn't figure out natural selection. "Inheritance of acquired characters" wasn't even an original Lamarckian contribution, he merely endorsed it as part of his theory, as did Darwin.

    11. Re:Interesting... by buchner.johannes · · Score: 2, Informative

      Actually, if you read his wikipedia entry, it turns out that Lamarck wasn't extraordinary in the view of inheriting features. Darwins opinion was similar.

      Only the next generation (Neolamarckism) extremed the point of view (giraffes, etc) and Lamarck got held responsible. Luckily he died first :-)

      http://en.wikipedia.org/wiki/Lamarckism#Neo-Lamarckism

      --
      NB: The message above might reflect my opinion right now, but not necessarily tomorrow or next year.
    12. Re:Interesting... by im_thatoneguy · · Score: 1

      And exposing a mother to alcohol has effects on the baby as well.

      This test is pretty rediculous. Feed a human mother alcohol and the baby can turn out mal-adjusted. Have a human mother smoke a pack of cigarettes every day and the baby might turn out different.

      Yes human and mouse mothers, what you're exposed to during preganancy can have an effect on your child outside of genetics.

      It should also be noted that darwin proposed "Survival of the Fittest" without any knowledge of genetics. Whether or not changes can occur before or after conception is irrellevant. It's still survival of the fittest. If a finch aquires the ability to eat a nut a day before mating or the day it was conceived is irellevant. The point is you genetically/chemically/spiritually/intellectually transfered an important survival trait to another animal which then out gunned its competition and managed top ass along that same trait genetically/chemically/spiritually/intellectually.

    13. Re:Interesting... by yog · · Score: 2, Informative

      One can hypothesize that certain actions lead to genomic changes that will be replicated in the germ line (oocytes or spermatocytes).

      We already know that mutations can introduce genomic changes that are propagated to the offspring. It could be as simple as a replication error in the spermatocyte.

      We also know that hormones activate parts of the genome that may be inactive. Depending on the type of hormone, they enter the cell or effect a change in the cell that causes activation of a segment of DNA in the nucleus that will induce the production of a protein or enzyme. It's possible (but I am not sure--perhaps a biologist here can confirm) that some of the activation mechanisms are actual mutations rather than the removal of inhibitory substances on the chain.

      Given the huge amount of stuff we don't know, it's reasonable to suppose that mutations that propagate to the offspring might be caused by the development of traits in the parent such as enhanced learning. After studying some genetics, I have come to believe that almost any of these things is possible, and we have a ton left to learn.

      The theory some are offering here that behavior is passed on via non-genetic pathways is of course also plausible but would not be necessarily a permanent alteration in the population. Have they looked at the 3rd and 4th generations yet?

      Obviously, an improvement in intellectual abilities that results in a permanent germline change would have huge ramifications for humans. Yet, smart people don't necessarily have smart offspring. A mediocre person who manages to uplift themselves to a high level of intellectual achievement might be expected to have smarter kids, but this doesn't seem to be a trend. Then again, a massive study might confirm or disconfirm this.

      Luckily, we have a more science-friendly administration and hopefully they will start throwing more money at this kind of basic research, our general national bankruptcy notwithstanding. Friends at NIH and NIST have told me their budgets are going up, so something new is happening, at least. I'm not a fan of big government, but (depoliticized) science funding is definitely a good thing that benefits the country and the entire world.

      --
      it's = "it is"; its = possessive. E.g., it's flapping its wings.
    14. Re:Interesting... by buchner.johannes · · Score: 2, Funny

      Did you test this on mice or on humans. How many died? Someone think of the children!!1

      --
      NB: The message above might reflect my opinion right now, but not necessarily tomorrow or next year.
    15. Re:Interesting... by im_thatoneguy · · Score: 5, Insightful

      How is that a shortcoming of science?

      1) The researches found a result.
      2) Proposed a possible mechanism.
      3) Stated the mechanism was untested and might just be bullshit they cooked up at the pub.

      4) People misreport guess of researchers as "Fact!" ...
      6) "Shortcoming of science!" (and profit?)

      It's sort of like saying that the urban legand "People think we only use 10% of our brain even though research has shown this to be almost certainly false." is a shortcoming of science.

      People talk. People like to have "all the answers". The problem is with gossip not science. 'Science' hasn't ruled on the subject yet. The official stance of 'science' is that the mechanism is unknown.

      Just as 'science' has only found that mouse mothers subjected to certain conditions can pass along the effects to their children even after the conditions have ceased. The mechanism should be discovered before any other conclusions can be reached. The summary is attempting to assign far more consequence to the study than study can provide. The shortcoming is with vague and speculative reporting not science. /rant

    16. Re:Interesting... by interkin3tic · · Score: 1

      Not too long ago there was a study in which bisphenol A, a component of plastics, eaten by mice caused epigenetic changes in the next generation.

      (http://www.environmentalhealthnews.org/newscience/2007/2007-0730dolinoyetal.html)

      I'm not sure how far these epigenetic changes were observed to last though, but there is the implication that these could be acquired traits which are heritable.

    17. Re:Interesting... by interkin3tic · · Score: 1

      Second, Lamarck is widely respected in France as the father of evolution, and that's exactly what he was.

      It's rather telling that he is only really considered the father of evolution in france, his home country. He did contribute very important points that Darwin built on, but it's hard to say that he's the father of evolution when did not get natural selection or the origin of variation correct.

      Vilified is overstating it though. The theory was incomplete, but it is diminished only by the magnitude of Darwin's work. Had the typical incremental process of scientific theories happened (instead of Darwin laying so much out by himself) Lamark could easily have been the giant in the field.

    18. Re:Interesting... by dasunt · · Score: 1

      The researchers in the article say that this is a completely shocking discovery, I'd be shocked if it didn't happen. The stress response affects not only the mother, but also the baby, and those changes can be noticed in their later lives. Quel surprise.

      I always figured that was realistic as well. Mothers and fetus share many of the same chemicals. Isn't it evolutionary adventageous for the offspring to adapt itself to the environment (the chemicals) it causes? Does the mother seem to have low stress and plenty of food? Time to grow into a large healthy offspring. Mother under high stress and less food? Smaller offspring will survive on less food, and perhaps faster maturation as well, since it seems that they could be at risk of dying before being able to breed.

    19. Re:Interesting... by ultranova · · Score: 0, Redundant

      What? I've heard Larmarck's evolutionary ideas ridiculed but villified?
      He wasn't that unscientific. He was just wrong.

      Actually he was right. You inherited your native language from your parents and will pass it on to your children, but don't have any English/Spanish/Mandarin/whatever genes. Language is an inheritable acquired trait, as is all culture.

      Or are you thinking of Lysenko? Now that particular advocate of inherited-acquired-characteristics was indeed a villain, a lousy scientist and a political tool.

      From what I've heard of him, it seems likely that he was simply insane in the sees-things way, and used as a tool by Stalin's regime.

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    20. Re:Interesting... by Anonymous Coward · · Score: 0

      > Enriched environments have long been known to make *mice* 'happier' in addition to being better at solving various tests, and having larger brains, etc. This stress-reducing effect has been known to be maintained long after the *rats* are removed from the enriched environment.

      Enriched environments turn mice into rats? AWESOME!

    21. Re:Interesting... by GravityStar · · Score: 1

      So human mothers-to-be are genetically selected to want a strong, genetically healthy man to be the father of their children? And then to get a smart/skilled/knowledgeable man to raise them? Which will result in that has a bigger chance to be strong, genetically healthy and skilled?

      Natural selection is a bitch.

    22. Re:Interesting... by ciderVisor · · Score: 2, Insightful

      Isn't it evolutionary advantageous for the offspring to adapt itself to the environment (the chemicals) it causes?

      Individuals don't adapt, populations do.

      --
      Squirrel!
    23. Re:Interesting... by Anonymous Coward · · Score: 0

      Aha, interesting!
      Along these lines, I could imagine that while the mother rat has a baby rat in utero, her brain is being stimulated by the experimenters into forming nice strong neuro networks.
      Just imagine a group of genes being switched on during neuro growth stimulation, wouldn't it be viable that the offspring's brain also would be affected by the same proteins/hormones/whatever?

      Until DNA is proved to be changing, this research isn't that revolutionary.

    24. Re:Interesting... by TuringTest · · Score: 2, Informative

      Individuals don't adapt, populations do.

      Individuals adapt, populations evolve.

      --
      Singularity: a belief in the "God" idea with the "demiurge" relation inverted.
    25. Re:Interesting... by TapeCutter · · Score: 4, Insightful

      "This is an unfortunate shortcoming of science at the moment."

      I agree with most of your post but disagree with your conclusion.

      Contrary to the GP's claim there is no requirement in science for a "suggested mechanisim", the results of the experiment are far more important than the explaination. For example, nobody has yet explained gravity but few doubt it exists and that we can acurately predict it's behaviour via models.

      However it is common practice for papers to offer (clearly labelled) speculation in the hope that "someone else" will look for evidence and cite your paper if they find it. A failure to understand the difference between clearly labeled speculation and repeatable experimental results is definitely a "shortcoming" but it is not a "shortcoming of science". Worse still the "shortcoming" of which you speak is often indistingushable from willfull ignorance.

      "A tested result is rejected until there is a suggested mechanism" - This is simply false.

      IMHO the "unfortunate shortcoming of science" is the apparent inability of it's philosophy to rate a mention in high school science classes. This is not due to a lack of trying, see: Sagan, Dawkins and Randi. My own SPECULATION as to why is it so, is that most people ( including the majority of educators ) simply want certainty and cannot accept a philosophy that shuns it, so the philosophy part is ignored and science becomes a library of factiods that are discovered via inspiration, rather than found via critical thinking.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    26. Re:Interesting... by Anonymous Coward · · Score: 0

      I think the GP meant it was a problem with the current "industry" of Science (i.e. the people in it), and not the Scientific Method itself as you point out.

      I know first hand that there's a sort of smell-test for results in the community. If it doesn't pass our intuition about how we currently think the world works, the results get held up to *much* greater scrutiny than if it's just parroting what we've believed all along.

      It may be beneficial, as a way to direct our time and money into the most fruitful lines of research, but it sure as hell isn't scientific (as in the Scientific Method).

    27. Re:Interesting... by Veggiesama · · Score: 1

      Lysenko is the perfect example of why mixing politics and science can be a bad thing.

      The belief in acquired characteristics was widespread through the Soviet Union. How else, the Communists argued, would progress be possible if you couldn't better yourself in life and pass on those traits to your children? If everyone just started over a blank slate at birth, wouldn't it be just a big wash where nobody ever improved?

      Of course, that model fails to take into account cultural evolution (memetics), like giving new generations more educational options than previous generations, which actually can result in generational progress.

    28. Re:Interesting... by Anonymous Coward · · Score: 0

      extremed

      Stop verbing nouns!

    29. Re:Interesting... by mcvos · · Score: 1

      This isn't the first time I've heard about developed traits being inherited. And it's obvious that this should be possible: children receive a lot more from their mother than just nuclear DNA. The ovum contains mitochondria and various other organelles and proteins. Furthermore, during pregnancy the mother provides lots of stuff to the child.

      You can inherit viruses, genetic defects caused by viruses, but in some cases apparently also anti-bodies to some diseases, and who knows what else.

      Lamarck may not have been correct, he wasn't entirely wrong either. (Although this is not exactly how he imagined it.)

    30. Re:Interesting... by mcvos · · Score: 3, Informative

      First, no one "deifies Darwin".

      Some people do, actually. Some people claim he's the greatest thinker ever, launched the most revolutionary idea ever entirely on his own, etc.

      Of course those people are wrong. Darwin didn't work in a vaccuum. Darwin's grandfather had already published the idea that all animals might have a common ancestor. Several others were working towards the exact same theory that Darwin ended up publishing. When Alfred Russell Wallace wrote Darwin about this new theory he was working on, Darwin suddenly got in a hurry to get his published first. If he hadn't we could have been celebrating a Wallace-year instead of a Darwin-year.

      Darwin was merely a good scientist who was the first to publish an important theory that turned out to be true. But a lot of people make more out of him than that.

    31. Re:Interesting... by the_womble · · Score: 1

      Lysenko has arguably given anyone who suggests the idea of inherited acquired characteristics a sort of guilt by association.

      Ridiculed is probably more accurate than villified.

    32. Re:Interesting... by Anonymous Coward · · Score: 0

      The mechanism is called epigenetics. You can read about it, for instance, in the book "Epigenetic Inheritance and Evolution: The Lamarckian Dimension" by Jablonsky and Lamb.

      (This is not to be confused with some earlier crackpot theeory also called epigenetics.)

      There was also a 2007 NOVA two-parter about it called "The Ghost In Your Genes". Fascinating stuff.

      I think we should be wary of saying that Lamarck was right, however; I'm quite sure his theory was nowhere near this nuanced. What we're talking about here is a genetic potential, which certain environmental factors will unleash to varying degrees, and which can affect the genes so that a "fuller version" of a given gene is expressed in the off-spring.

      Even though the breakthroughs in understanding the basic principles of epigenetics were made in the mid-to-late '90s, it's only now that the world is beginning to realize that we have something really important here, esp. in relation to the genes vs. environment debate. Epigenetics is going to be big. As I understand it, the so-called "epigenome" is comprised of genes or gene-like mecanisms contained in the cell but outside of the chromosomes. The epigenes can then influence the genes to varying degrees, depending on what the organism needs in its interaction with the environment. Presumably (but I'm speculating here) the epigenes comprise the secret of our true genetic baseline, meaning that if we can put the epigenes to proper use, then we can unleash our full genetic potential. But this will need to be done very carefully, because we're probably not built for all the genes to be at full expression simultaneously. But picking some strategic epigenes to activate, might indeed "harmonize" us, in the sense that it might make our true human nature manifest itself. The nature and personality that we would have if we were brought up as we were around the time when our species evolved. That would demonstrate just how social we are, and how important social networks would be. Who knows, it might even revert us to "primitive communism"! :-)

    33. Re:Interesting... by indytx · · Score: 1

      There was already a short segment on Nova about a year ago about epigenetics. http://www.pbs.org/wgbh/nova/sciencenow/video/3411/q02-220.html

      --
      Make love, not reality television.
    34. Re:Interesting... by Anonymous Coward · · Score: 0

      "A tested result is rejected until there is a suggested mechanism" - This is simply false.

      No, it certainly happens. Not all the time, but sometimes. A result's importance gets seen by some reviewers as somehow diminished if there isn't a mechanism attached. And it's not the only case where papers are rejected for non-scientific reasons. For instance, Paul Dourish spent an entire CHI paper complaining that papers about the social impact of technology have regularly been rejected from Human-Computer Interaction conferences if they haven't had an "Implications for Design" section tacked on at the end. As if science is only valuable if it includes directions for how to build a shinier toy.

    35. Re:Interesting... by Anonymous Coward · · Score: 1, Insightful

      So human mothers-to-be are genetically selected to want a strong, genetically healthy man to be the father of their children?

      Yup. And that is why the things men commonly want in women can be easily connected to giving birth or taking of the child in physical attributes (nice breasts and hips) or good genes and good sociological standing in others (how fit someone is. Some cultures appreciate being well fit while others appreciate seeing that woman has had excess food - often the latter cultures seem to connect fat women to being good at giving birth, too).

    36. Re:Interesting... by TapeCutter · · Score: 1

      Sorry I was unclear. I don't deny that these things happen, just that the philosophy of science does not condone it and it's method does not require it.

      OTOH industry confrences often blur the lines between science, technology and business. Maybe the CHI selection commitee is simply not interested in anything that does not have "Implications for Design" and considers Paul's paper "out of scope". If that is the case then Paul is banging his head against a brick wall, his time would be better spent submitting the paper to a respectable sociology journal.

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    37. Re:Interesting... by Culture20 · · Score: 1

      But are the control rats normal rats, gene-effected stupid rats, or gene-effected stupid rats with trained-better-memory (probably not the latter)? If they're normal rats, then they could teach things well too.

    38. Re:Interesting... by Anonymous Coward · · Score: 0

      How is that a shortcoming of science?

      1) The researches found a result.
      2) Proposed a possible mechanism.
      3) Stated the mechanism was untested and might just be bullshit they cooked up at the pub.

      4) People misreport guess of researchers as "Fact!" ...
      6) "Shortcoming of science!" (and profit?)

      Because sadly "people" sometimes includes other scientists, quoting the suggested mechanism from the paper as being a found result. It doesn't always get picked up in a peer review of the subsequent papers, and once enough subsequent papers have been publshed, untested mechanisms can effectly enter a sort of academic folklore.

    39. Re:Interesting... by Ed_Pinkley · · Score: 1

      Verbing weirds language.

      --
      "Long time listener, first time caller."
    40. Re:Interesting... by Anonymous Coward · · Score: 0

      This is an unfortunate shortcoming of science at the moment. A tested result is rejected until there is a suggested mechanism; as soon as a mechanism is suggested, it is all too often treated as "true" even if the mechanism itself has never been experimentally tested at all but was just plucked out of the air.

      I wouldn't say that it's a shortcoming of science itself, but a shortcoming if its practitioners. The scientific method would allow someone to pull the the idea for a mechanism out of the air, but that would be the beginning of the process, not the end of it. The "pulled from the air" idea would then be called a "hypothesis" and then you'd need to develop an experiment to test that hypothesis. Even if the experiment supports the hypothesis, it generally still wouldn't really "prove" the hypothesis. It might support the hypothesis enough to be accepted until someone can come up with an alternative explanation.

      But science does have an inherent weakness in that its practitioners are always human, and therefore prone to make mistakes, make assumptions, and jump to conclusions. Further, it has a weakness in that, once something is discovered, the idea has to be spread to other flawed humans who often make those same mistakes on top of understanding the whole idea poorly. One of the big problems right now is the way a tentative conclusion reached by a single study, and perhaps not extremely well supported, gets published by the press as, "Scientists have now discovered that..."

    41. Re:Interesting... by shaitand · · Score: 2, Informative

      I don't know about the study but this effect can be readily observed in cannabis plants. Cannabis plants have a differentiated gender, unlike most plants there is a distinct male and distinct female.

      Under stress a female plant can become a hermaphrodite by producing one or more male flowers (there are chemicals to induce this or erratic light patterns or keeping the plant alive under artificial lighting for extreme lengths of time without fertilization). That plant can self pollinate or pollinate another female.

      In the cannabis world the seeds from such a union are prized because they grow all female plants (unfertilized female flowers are the only part of the plant that is smoked)but there is a well known side effect of this process. The seeds have a significant chance of being hermaphrodites without any of the stresses that caused the condition in the mother plant.

    42. Re:Interesting... by Anonymous Coward · · Score: 0

      Just goes to show how little the peer review process really works. Good thing we are paying for so many volunteers with our subscription money.

    43. Re:Interesting... by shaitand · · Score: 1

      I don't know about humans but plants certainly pass learned traits to their seed. This can be readily observed.

    44. Re:Interesting... by mirkob · · Score: 2, Informative

      When Alfred Russell Wallace wrote Darwin about this new theory he was working on, Darwin suddenly got in a hurry to get his published first. If he hadn't we could have been celebrating a Wallace-year instead of a Darwin-year

      not exactly.

      the story goes (at least for what i remember of "the origin of the species" that i recently read)
      that darwin were working to his theory for some forty-fifty years, when he received this mail about practically identical ideas from wallace, then some friend of him insisted that he pubblish his theory before wallace do, but he insisted to clarify with wallace first, and wallace insisted that darwin pubblish his work (that contain some thousand of pages, cases and example to support his theory).

      the final result is "the origin of the species" a quick exposition of his theory with some reference to the tons of material he collected and a thoroughly detailed introductory chapter with names and ideas of all who contributed to the ideas on the field, his grand father, lamark and wallace for example.

    45. Re:Interesting... by moderatorrater · · Score: 1

      What's really funny with your criticism is that Darwin himself didn't have any mechanic for passing the traits along, all the evidence for DNA came later. There are many such discoveries in science where they're able to explain what happens long before they explain how.

    46. Re:Interesting... by Anonymous Coward · · Score: 0

      You should read "Evolution in Four Dimensions: Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life" - by Eva Jablonka. It discusses these issues and theories about the mechanisms for this kind of inheritance in reader-friendly language.

    47. Re:Interesting... by radtea · · Score: 1

      It also says the change is not permanent - it only lasts a few months. I didn't notice any mention of whether the mother rat still functions at a high level when she's pregnant. If she does, the change could be due to the environment in utero, which would be consistent with the effect fading over time.

      All of which makes the use of the term "inheritable" misleading to the point of being wrong, in a typical sensationalist /. headline that is not at all justified by the article. There have been minor violations of the central dogma known for decades, mostly in bacteria but more recently in other organisms, in which environmental conditions trigger pathways that result in alternations in DNA which can be inherited by offspring and, like all inheritable characteristics, then passed on to the next generation after that and so on.

      However, "an effect on the parent that results in an effect on the first few months of life of the first generation of descendants" is not "inheritance" in the usual biological sense of the term. The "inheritance" being described here is more plausibly explained as a change in the biochemical environment of the mother's body that results in the same kind of "inheritance" that one sees in some babies born to crack addicts.

      This is entirely different from Lamarkian theory, which posited true, multi-generational inheritance of acquired characteristics, and which IS observed in cases where the genetic material of inheritance (which includes but is not limited to DNA) is altered by the organism's evolved biochemical response to the environment.

      --
      Blasphemy is a human right. Blasphemophobia kills.
    48. Re:Interesting... by blueg3 · · Score: 1

      I don't know who you're suggesting rejects results of an experiment without a suggested mechanism, but in science, it's simply not true. Showing experimental results with no known mechanism is not only acceptable, it has historically appeared quite frequently.

      Usually experimenters will suggest reasonable mechanisms. It is a mistake of people and the media to report these suggested mechanisms as true, not a mistake of science. People apparently fail basic logic.

    49. Re:Interesting... by _Sprocket_ · · Score: 1

      Actually he was right. You inherited your native language from your parents and will pass it on to your children, but don't have any English/Spanish/Mandarin/whatever genes. Language is an inheritable acquired trait, as is all culture.

      And here I thought language was something that was taught.

    50. Re:Interesting... by sorak · · Score: 1

      Lamarck is one of those guys who's name is generally synonymous with bad science (he's about as villified as Darwin is deified).

      What? I've heard Larmarck's evolutionary ideas ridiculed but villified?

      He wasn't that unscientific. He was just wrong.

      Or are you thinking of Lysenko? Now that particular advocate of inherited-acquired-characteristics was indeed a villain, a lousy scientist and a political tool.

      So does he work for the discovery institute?

    51. Re:Interesting... by Abreu · · Score: 4, Informative

      So does he work for the discovery institute?

      Close, he was employed by Joseph Stalin

      --
      No sig for the moment.
    52. Re:Interesting... by moylek · · Score: 1

      That being said, the article is rather short in one important area: a suggested mechanism for this sort of inheritance. Without that, it's bound to be mired in controversy for some time.

      Of course, Darwin's theories gained significant ground for decades before the discovery of Mendel's work provided a mechanism.

    53. Re:Interesting... by Jack9 · · Score: 1

      The article (did you even read the summary?) indicates this may not be strictly true. The idea that an individual animal can adapt, passing on a change to the offspring, is right there in the description. Can your kids read?

      --

      Often wrong but never in doubt.
      I am Jack9.
      Everyone knows me.
    54. Re:Interesting... by Saroset · · Score: 1

      I wish I had mod points.

    55. Re:Interesting... by tfoss · · Score: 1

      It's possible (but I am not sure--perhaps a biologist here can confirm) that some of the activation mechanisms are actual mutations rather than the removal of inhibitory substances on the chain.

      As a biochemist, I can say that this kind of pathway is one I've never heard of. Mutation (and DNA damage of all kinds) is something that a cell tends to avoid at all costs, a large amount of cellular machinery exists for the purpose of fixing such damage, or causing the cell to go into programmed cell death if need be. It *is* possible, but it seems unlikely that nature would choose such a dangerous mechanism that it spends a lot of time trying to prevent as a regulatory system.

      The best explanation I've seen is that of in utero environmental changes (prenatal experience). It's clear that environmental stimuli affect all kinds of biochemical interactions (gene activation, protein production, cytokine production, small molecule production, etc etc). That such changes occurring in a mother will also affect offspring in utero is not particularly surprising. It is also consistent with the effect being unrelated to upbringing (that having other mothers raising the 'smartened' pups still shows an effect). The observation that this effect disappears over time, also suggests a non-genetic basis. TFA doesn't mention this as an explanation, and I can't get to the original papers, so it's possible the researchers dismiss this for some unmentioned reason.

      Simply put, if you bathe an embryo in SmartJuice, then it'll develop under that influence. When you remove the SmartJuice by being born, the influence will still have an imprint, even though the mouse is not producing it's own SmartJuice.

      It's still cool, if not quite 'Lamarckian.'

      -Ted

      --
      -=-=- Quantum physics - the dreams stuff are made of.
    56. Re:Interesting... by Randle_Revar · · Score: 1

      Seriously. Geneticists have been talking about this for quite some time now, it isn't all that new.

    57. Re:Interesting... by Anonymous Coward · · Score: 0

      Darwin was merely a good scientist who was the first to publish an important theory that turned out to be true. But a lot of people make more out of him than that.

      Yeah, but most of them are creationists who want to turn him into the King of Science so they can tear him down. (In African-American studies it's known as the "head nigger" technique, which has been popular throughout the entire history of racism. Find some well-known member of the group you hate; inflate him to be the symbol of that group; finally, ridicule him and tear him down, and in that way you put all of "those people" in their place.)

        Some of them are anti-creationists who are just baiting the creationists. (Darwin fish, etc.)

        Very few of the people "deifying" Darwin are actual scientists.

    58. Re:Interesting... by AxelBoldt · · Score: 1

      Lamarck is one of those guys who's name is generally synonymous with bad science (he's about as villified as Darwin is deified).

      Let's not forget that Darwin himself believed in Lamarckism; genetics wasn't known at the time.

      That being said, the article is rather short in one important area: a suggested mechanism for this sort of inheritance. Without that, it's bound to be mired in controversy for some time.

      The whole phenomenon isn't that new; it's called epigenetics and is transmitted most likely by the methylation pattern of the DNA, histone modification, and RNA interference. It's not stable and doesn't last beyond a few generations though, so it won't give a new mechanism for natural selection.

    59. Re:Interesting... by maxume · · Score: 1

      Nutrition is also hilariously important (and something that fit parents are likely to do a superior job of providing).

      --
      Nerd rage is the funniest rage.
    60. Re:Interesting... by maxume · · Score: 1

      A fetus behaves, in many ways, like a parasite.

      There are processes in a pregnant woman's body that protect her from the fetus (a sufficiently malnourished woman won't even be fertile...).

      --
      Nerd rage is the funniest rage.
    61. Re:Interesting... by rpbird · · Score: 1

      Memory in mammals is a complex thing. Just how thorough was this "genetic crippling" of the memories of these mice? Are other genes involved in mammalian memory than just those affected by the experimenters? Where did the mice come from? If from a commercial source, maybe their creation and breeding are somehow flawed. So many questions, so few real answers from this article.

      I look forward to future experiments of this sort. Maybe something will come of it; or maybe the experiment was flawed. I'm keeping an open mind until more information is available.

    62. Re:Interesting... by sjames · · Score: 1

      The article hints at methylation as a direction for an explanation, but it's far from complete.

      That's to be expected with a finding this surprising. Naturally, the result will need to be replicated, probably a few times before anyone busts their ass looking for a mechanism.

    63. Re:Interesting... by ceoyoyo · · Score: 1

      The article states that the effect was still observed when the rat pups were raised by other rats with the bad mutation but without the enriched environment that the mother experienced.

    64. Re:Interesting... by ceoyoyo · · Score: 1

      Exactly. Aside from the sensationalism, and the completely inaccurate portrayal of Lamarck, the next step would seem to be to take eggs from these rats and use IVF to have the pups born to an unenriched mother. If THOSE pups show function over what's expected, then they've shown something really exciting. Otherwise the most likely explanation is happy mother, happy children.

    65. Re:Interesting... by baubo · · Score: 1

      Can't find my source, but I thought the idea of learned characteristics being passed on genetically was what set Soviet genetics back four decades. FTA: "Indeed, one of the studies found that a boost in the brain's ability to rewire itself and a corresponding improvement in memory could be passed on." Wow.

    66. Re:Interesting... by Anonymous Coward · · Score: 0

      [citation needed]

    67. Re:Interesting... by meringuoid · · Score: 1
      How else, the Communists argued, would progress be possible if you couldn't better yourself in life and pass on those traits to your children? If everyone just started over a blank slate at birth, wouldn't it be just a big wash where nobody ever improved?

      That sounds like a very bourgeois attitude. If the rich man passes on his riches to his son, then the rich man's son has an unearned advantage over the poor man's son. That's how it is done in the imperialist nations. Under Communism, comrades, we must abolish the inequitable capitalist ideologies of inherited wealth, and give all free workers an equal chance to achieve their Socialist goals!

      --
      Real Daleks don't climb stairs - they level the building.
    68. Re:Interesting... by alexo · · Score: 1

      Darwin didn't work in a vaccuum.

      True, but assuming a spherical Darwin in a vacuum gives a decent approximation.

    69. Re:Interesting... by shaitand · · Score: 1

      I've given examples elsewhere in the discussion. Repeating again would be redundant.

  5. Actual article by Anonymous Coward · · Score: 5, Informative

    Here's the actual article.

  6. IANAG by Nautical+Insanity · · Score: 1

    But I'm interested in how they think the trait for intelligence gets passed on. It might be important to note what causes the genetic defect. It could be a change in a site that is actively expressed, or it could be a change in whether the area of the chromosome responsible for the brain function is activated. There are still lots of gaps in our knowledge in what causes gene expression because it's based upon more than just start and stop codons, but also on the structure of the molecule. It could be possible that environmental factors changed some physical element of the gene causing it to be expressed again, though to me that sounds almost as much of a soft sci-fi nightmare as "genetic memory." Perhaps someone who is a geneticist can shed some light on possible vectors for this hereditary intelligence.

  7. Histone modifications by Rand310 · · Score: 5, Informative

    We're just learning that Histone/DNA modifications can be inherited.

    Histones (the spools around which DNA is stored) tell when the DNA source code should be 'active' vs 'inactive'. And these histones have a huge data space in the form of possible modifications (methylation, acetylation, etc.).

    When DNA is replicated, these histones too are replicated at the same time. And they seem to be replicated in a semiconserved manner similar to DNA (half go to 'old' strand, half go to 'new' strand). And that there is a whole series of touring-like proteins that can 'read' 'write' or 'erase' these modifications.

    If these modifications are made during an organism's life, they can be inherited by offspring.

    Not only is the code being copied, but the 'marks' that tell which/when/where to read the code at any given time/condition too can be passed down. And that these marks can be written in real time rather than waiting for mutations in the code itself.

    There was a recent study that XO females who inherited the X from their father had markedly different dispositions than those who inherited the X from their mother. DNA modification that is unique to how the male or female deal with their own X chromosome could be being passed down to offspring.

    1. Re:Histone modifications by zappepcs · · Score: 1, Interesting

      That answered a couple of questions that I have. I'm saying thanks, and ensuring that I can find your post again so I can look more of that information up when I have the time. That there is a possible mechanism says tons given that it does explain most of what is needed to pass the trait on.

      To me, this is one of the great mysteries of evolution. Not a physical trait, but a social trait becomes widespread. Social groupings and culture do not fully account for many things in my view. A genetic susceptibility to assuming a trait would explain many things that do not yet have a good explanation. Put simply, how do we inherit the equivalent of programming?

      They say that small children who have never seen a spider are afraid of them? How did they learn that? Perhaps the hardwired instincts we are born with are not so hardwired as inherited programming. Which of course makes them changeable, and has implications for nature vs nurture questions. All very interesting.

    2. Re:Histone modifications by wizardforce · · Score: 2, Interesting

      That is an excellent post on epigenetics. Incidentally it should be noted that methylation changes gene expression through altering the interaction between the molecular machinery responsible for synthesizing proteins and DNA in which cytosine residues are methylated. Histone proteins can be alterest as well to alter the tightness in which they are bound to DNA which also affects gene expression.

      --
      Sigs are too short to say anything truly profound so read the above post instead.
    3. Re:Histone modifications by Gorobei · · Score: 1

      Who are "they?" There are a ton of studies showing small children are not afraid of bugs (typically, give child a cup with a big fake bug on it -- little children don't care, bigger ones freak out.)

    4. Re:Histone modifications by loxosceles · · Score: 2, Interesting

      If these modifications are made during an organism's life, they can be inherited by offspring.

      Aren't you skipping over the lateral transfer step?

      It's not just about whether there are mechanisms besides DNA that can statically store data, or whether the environment (say, learning) can influence that data storage in a non-random manner.

      Even assuming DNA itself could be changed non-randomly in response to the environment, those changes still have to be transferred to gametocytes in order to be inheritable.

      I'm not a biologist but I know there are some theories about lateral gene transfer in differentiated organisms, and I thought those were still pretty sketchy. Given the novelty of histone research, I suspect they haven't gotten very far in investigating, much less demonstrating, lateral transfer of histone-encoded data.

      So... not at all saying that what you're proposing is impossible, just that it seems pretty speculative.

    5. Re:Histone modifications by zappepcs · · Score: 1

      Sorry, can't find the study report now. It was to do with instincts, or those brain programs we seem to be born with. Where you say little kids don't care about bugs but older children do, I see kids who are afraid, and kids who are not and I question: Why is that? This would explain it or at least give a possible explanation. To the point of evolution, such things could be passed to offspring supporting survival even in the absence of parents or guardians. This does not apply to all aspects of life it seems, but it does explain some fundamental issues.

      on the question of intelligence we often compare all artificial attempts at intelligence to the human mind. A process that I feel is fundamentally flawed given the nearly complete lack of scientific understanding how the human mind works. It's all very interesting.

    6. Re:Histone modifications by Gorobei · · Score: 1

      "Why is that?" has an easy answer: children learn to be afraid of bugs. It is not an innate response.

      It's easy to test:
      1. have a child
      2. repeatedly show child bugs

      Child only gets grossed out at around age 5. Investigation done.

      My kids are 6 and 4 -- the 6yro hates bugs, the 4yro finds them interesting. In a year or two, the 4yro will hate bugs, and will have learned to associate them with decay, rotting, etc. It's a simple heuristic, nothing more.

    7. Re:Histone modifications by Anonymous Coward · · Score: 0

      Remember, there is nothing to fear but fear itself... and spiders.

    8. Re:Histone modifications by Anonymous Coward · · Score: 0

      I don't know where I remember this from but I seem to recall something to the effect that infants are born with only two instinctive fears:

      Fear of loud noises
      Fear of falling

    9. Re:Histone modifications by nine-times · · Score: 1

      This might perhaps be unconnected to your post (to be honest, I don't understand your post well-- I don't know that much about genetics), and perhaps just completely off-topic, but I've had a theory for a while that I've been waiting to hear of someone developing the same theory. Maybe it's already common but I just haven't heard of it.

      So the theory is this: that we have evolved mechanisms that allow us to evolve better. I don't have any support for this theory except that it seems like it would make a lot of sense to me, and I've read that in some cases, scientists have been surprised at how quickly some inheritable traits can change.

      It just seems somewhat natural to me that something like this should happen as a life form becomes more advanced. Whenever humans are refining their methods, it usually occurs to them at some point to refine the process of refining their process. What might start off as trial and error becomes more systematic, and as the whole thing becomes more refined, the way in which new changes are considered also changes.

      It seems obvious to me that sufficiently advanced organisms would protect themselves against drastic changes, and I've read about several ways that DNA replication is regulated (details escape me) and things that happen in the womb that might abort drastic mutations. But I've never read any suggestions that there are mechanisms specifically to create/support other mutations, perhaps in a controlled way, so as to foster evolution. Everyone seems to still think that mutations are the result of random chance, which seems unlikely to me.

    10. Re:Histone modifications by shaitand · · Score: 1

      This makes perfect sense and explains the ability of cannabis plants (which are normally gendered) to pass on hermaphroditism to their offspring. The plants begin as male, female, or hermaphrodite (like almost all other plants). Exposed to conditions which do not occur in nature, either male or female plants will produce a flower of the opposite gender under stress. Usually a female is observed since cannabis is generally cultivated for unpollinated female flowers. The seeds produced by pollinating a female flower with the male flower of such a plant have a greatly increased liklihood of producing naturally hermaphrodite offspring.

      From what I have read the DNA to produce either gender of flower is present in both sexes and the opposite gender flower simply isn't an active gene. When a plant like this becomes a hermaphrodite it activates these characteristics in its DNA.

      Of course cannabis cultivators have known this since at least the 60's and there had to be a few researchers among them. They likely just forgot to publish it. ;)

    11. Re:Histone modifications by Anonymous Coward · · Score: 0

      No, you're misunderstanding the post. These epigenetic changes (methylation states, etc.) can change within the life of the parent. These are not the same as changes to the DNA. They are changes relating to the regulation of gene expression. If the methylation states of genic regions are passed from mother to offspring, then this is a completely different mechanism of heritability than changes to the coding regions of genes in the DNA.

      Also, you don't completely understand lateral gene transfer. And research on histones isn't that new.

    12. Re:Histone modifications by Bob-taro · · Score: 1

      Couldn't that just as easily mean that your children inherited a fear of bugs that doesn't "kick in" until age 5?

      --
      Prov 9:8 Do not rebuke mockers or they will hate you; rebuke the wise and they will love you.
    13. Re:Histone modifications by sjames · · Score: 1

      The question is, how does a change in methylation in the brain come to be expressed in the gametes?

    14. Re:Histone modifications by chris.evans · · Score: 1

      bullshit, how are these special molecules that encode environment learning then transmitted to the fetus?

  8. Memetics? by Anonymous Coward · · Score: 1, Interesting

    My first thought is that it could be a meme. Somehow, the environment caused mice acquire a (subtle) behavior which their offspring acquired (mice can learn by observation) and stimulated their brains resulting in better memory...

    Can anyone else comment?

    1. Re:Memetics? by Hal_Porter · · Score: 2, Funny

      From my internet knowledge I know that cancerous memes are passed from newfags to oldfags (e.g. Boxxy! U RAF U RUSE). This would appear to be the opposite direction to parents passing useful knowledge to their children.

      --
      echo -e 'global _start\n _start:\n mov eax, 2\n int 80h\n jmp _start' > a.asm; nasm a.asm -f elf; ld a.o -o a;
  9. Lack of control? by noidentity · · Score: 2, Insightful

    mice genetically engineered to have memory problems were raised in an enriched environment [...] The mice were then returned to normal conditions, where they grew up and had offspring. This next generation of mice also had better memory, despite having the genetic defect and never having been exposed to the enriched environment.

    Who's to say the enrichment caused this, lacking a control whose parents were NOT raised in an enriched environment? And if they did do a control (RTFA, yeah right), the explanation could simply be that the enriched environment resulted in a more healthy womb that the offspring grew in. Parents pass a lot more than just DNA to their offspring.

    1. Re:Lack of control? by drosboro · · Score: 2, Informative

      There was certainly no shortage of control groups (they did several controls, apparently following standard protocol for this type of research, according to the original journal article).

      As for the "healthy womb" hypothesis, I think that the interesting thing is the specificity of the effect - the offspring show the same changes in a specific biochemical pathway (that compensated for a genetic defect) that the mother had as a result of the enriched environment. Not to say that it couldn't be just a healthy womb effect, but the specificity of the whole thing seems to point elsewhere.

    2. Re:Lack of control? by Telvin_3d · · Score: 2, Interesting

      So the obvious follow-up would be to get mice with a different genetic defect that is related to learning. Do the same thing with them and see what pathways are affected. Depending on results, it could really shake things up.

    3. Re:Lack of control? by Angostura · · Score: 1

      Of course, they were specifically looking for that specific effect. It would be interesting to see how many *other* beneficial effects there were from the "healthy womb" (if any)

  10. Mice parents? by Anonymous Coward · · Score: 1, Insightful

    I'm sorry, so the offspring of these mice stayed with the general population and their parents?

    Couldn't this be an argument for nurture? Heck, just competing with other mice.

    Like the youngest learning to eat first in some families...

    I'm not convinced that there is anything even remotely of interest here.

    1. Re:Mice parents? by drosboro · · Score: 1

      There doesn't seem to be anything in the original article (J. Neuroscience) to suggest that the offspring were kept with the parents. It's a bit short on methodology, because they're using standard protocols that are just referenced from other papers, but it seems like the offspring are "whisked off" to their own cages.

  11. I wants a giraffe neck by beefsprocket · · Score: 0, Offtopic

    I always thought my neck was too short, watch me and my progeny evolve bitches!

    1. Re:I wants a giraffe neck by ardle · · Score: 1

      Mods: it's not offtopic, just difficult to read!
      Have you ever broken a limb and had it in a plaster cast? Notice how the limb has lost muscle (maybe even bone) when the cast comes off?
      Have you heard that thinking about exercise imporves muscle tone?
      Ever re-learnt something? Or re-re-learnt seomthing? Each time, it's quicker.
      "Use it or you lose it"
      Epigenetics is a feedback mechanism, just like all the others. It must be a good one because it has been around for a long time.
      The case of the Irish Elk is a good example of a feedback mechanism that failed.
      Be careful with that giraffe neck - it might be bad for your kids!

  12. RTFA by Gorobei · · Score: 1

    The article says nothing about DNA "modifications."

    When a mommy mouse makes a baby mouse, the baby mouse depends on:
    1. The DNA it gets from the mom and dad mice.
    2. The chemical/hormonal environment during development in the womb.

    The article says point 2 is more important than expected (although there is a lot of folk wisdom that implies it, so it may be more that scientists dismissed/ignored/couldn't test a fairly obvious hypothesis.)

    No DNA modification/Lamarkian inheritance is going on: beyond raw DNA, happy mommy mice give birth to happy baby mice, etc.

    1. Re:RTFA by Cyberax · · Score: 2, Insightful

      Read what grandparent says.

      It's actually quite possible that epigenetic DNA modifications DO happen in these mice.

    2. Re:RTFA by Gorobei · · Score: 1

      The grandparent post was gibberish about histones.

      No one is claiming epigenetics is false. You just don't need to invent a bunch of random ideas to explain what is observed.

    3. Re:RTFA by Rand310 · · Score: 1

      How do you expect that the 'chemical/hormonal environment' affects the progeny in a heritable manner?

      It is quite possible that under certain environments certain sections of the DNA can be activated - and that these activations (in memory or elsewhere) can be heritable.

      This is not necessarily what is going on in the article, but it is an interesting and tested if unknown means by which non-genetic heritability can take place.

    4. Re:RTFA by Gorobei · · Score: 1

      Numerous studies have observed that desire-to-explore vs desire-to-hide in offspring is affected by the stress of the mother during pregnancy. From an evolutionary point of view, it's a no-brainer, and needs no genetic explanation. It's about the most basic non-genetic survival mechanism you could have: if mom is stressed, get born in keep-your-head-downl mode, else, get born in exploit-the-environment mode.

    5. Re:RTFA by Rand310 · · Score: 1

      How though?

      Through what mechanism?

      It does make sense. But how do you get there?

      Histone modifications and other such epigenetic effects give a tested and possible avenue for exploration. An avenue that is currently being studied in the scientific community.

      What biological mechanisms would create 'conditions' with such affects?

    6. Re:RTFA by Gorobei · · Score: 1

      Given that the entire physical offspring is constructed from chemical inputs from the mother (save for 1 sperm,) the most parsimonious explanation is that if, during this bootstrapping process, stressor molecules (e.g. adrenaline-type compounds) are encountered, the offspring selectively activates its stress-related systems.

      The whole "growing from a cell into a live-birth animal" thing is a really complex process. It's why, for example, given the complete elephant DNA, you *can't* make an elephant: you also need the interaction between the mommy elephant and the developing baby elephant. Growing from 1 cell into a billion cells is not a totally programmed process: there is tons of feedback/decision points based on the interaction between the host parent and the progeny. It's probably accurate to describe the process as "chemical warfare:" the progeny is trying to suck every resource it can out of the mother, and the mother's body is fighting back to avoid dying. Is it really so surprising that the offspring is born with traits that are influenced by the mother's state? The converse would be more surprising.

    7. Re:RTFA by TheLink · · Score: 1

      What I'd like to see tested is whether the mice's grandchildren inherit the improved memory.

      --
    8. Re:RTFA by flitty · · Score: 1

      There was an article in Newsweek a few weeks back about bugs that had a spiny helmet when a mother encountered a certain predator, and when the mother never encountered that predator, the children did not have the helmet. This is not "lamarkian" evolution at all. The genes had the "code" for displaying one of the two traits already, and the chemicals present in the mother when pregnant (the stress vs. non-stress idea) is all that influences which trait is displayed.

      If, however, the same bug had never had such a spiny helmet, and in 1 generation (mother to child) sprouted this spiny helmet after the threat of a head removal by a predator, THAT is what Lamark suggested, which is entirely disproven.

      I think what this study potentially shows, rather than questioning the fundementals of Evolution, is that there are hormones that a body produces that influences the plasticity of the brain when exposed to a learning environment, which also seems to influence the development of a child's brain plasticity. Given the knowledge that brain plasticity is a relatively new idea scientifically, such a hormone/chemical is going to be relatively groundbreaking if found/identified.

      --
      Whether or not there is some sort of god, I'm not supposed to say/god is a word and the argument ends there-Smog
  13. So true, we still have much to learn too. by Anonymous Coward · · Score: 0

    Genetics is a rather young science. We have made huge gains since Watson and Crick, but we really don't understand what the bulk of our DNA does.

  14. This doesn't rule out... by gandhi_2 · · Score: 1

    ...that these mice used practiced good parenting.

    1. Re:This doesn't rule out... by blueg3 · · Score: 1

      If you'd read the study, you'd know that it does!

  15. Simpsons Did It by devnullkac · · Score: 1

    Actually, it was Newsweek, a month ago. There was even a follow-up online-only piece on the same experiment as TFA that was out one day earlier.

    To comment on the topic at hand, though, it's no surprise that there are elements beyond genetics that contribute to evolutionary success. Embryology is extraordinarily complicated and there's plenty of room in there for the environment supplied by the mother to affect the form of the child, especially in species that gestate internally as long as most mammals do.

    --
    What do you mean they cut the power? How can they cut the power, man? They're animals!
  16. Wait, how does it get passed? by Richard.Tao · · Score: 4, Insightful

    Females have all the eggs made before they're born, so how could the genetic material in them be affect by the conditions that the mother grew up in? Sperm DNA seems like it could be modified by the father according to living conditions, but it seems odd to think that environmental information in the brain would be passed down to the testes and such... It seems more plausible to think it's just the mice had a better mother.

    1. Re:Wait, how does it get passed? by im_thatoneguy · · Score: 1

      DNA is only part of the equation. Put a frog egg in mildly radioactive water and see what happens.

      This study essentially just says "The environment of the pregnant mother can have an effect on the offspring." To which I say ... "Duh". Push down a 6 pack of budlight every day while preganant and I can disprove mendelson as well. No genetic manipulation!

    2. Re:Wait, how does it get passed? by Zerth · · Score: 3, Informative

      Many genes are only activated in the presence of certain helper chemicals. Similarly, some proteins can only fold properly with the assistance of helper enzymes. Some of these helper systems form a loop and are kickstarted by the uterine environment.

      If you disrupt one of those loops by injecting hormones or other methods of altering body chemistry, like scaring the living shit of a mouse at an early age, the cycle will break and thus affect the uterine environment and not kickstart the next mouse's production of those chemicals.

      I could've sworn it had already been shown that pumping adrenaline into young female mice caused them to be adrenaline-sensitive and their progeny to be maternal inheritably adrenaline sensitive, but I can't find a link for it.

    3. Re:Wait, how does it get passed? by DarkProphet · · Score: 1

      I suppose its possible that immature eggs can still be affected by the mother's body chemistry prior to and/or at fertilization. The question is what is the mechanism in which body chemistry can influence gene expression? My guess is that the particular chemistry of the ova (and likewise sperm) may impact which sections of DNA are "flagged" as active or not (junk DNA). It makes sense that cellular chemical composition would play heavily into the development of a fertilized egg the same way a pregnant mother's chemistry can dramatically affect the baby's development (e.g. crack babies). DNA itself is not solely responsible for making us who and what we are, but it would be worthwhile to know in what ways (if at all) we could pass on positive traits to our offspring aside from gene manipulation.

      --
      What could possibly hurt the security of the American people more than giving our own government the ability to hide its
    4. Re:Wait, how does it get passed? by V!NCENT · · Score: 1

      Like father like son

      --
      Here be signatures
    5. Re:Wait, how does it get passed? by Anonymous Coward · · Score: 0

      and I vaguely recall reading that there is a correlation between a high level of stress in a pregnant human (resulting in lots of cortisol) and diabetes in her children as adults...anybody? My guess is that what is in the 'fetal soup' in utero has been ignored far too long.

      BTW - you are an awesome group of posters - I have enjoyed reading all of your posts -thankyou!

  17. Not a surprising result ..... by bcwright · · Score: 3, Insightful

    Really, this is hardly a surprising result. There are many possible mechanisms that suggest themselves, operating either on the embryo or on the newborn - parents who are more intelligent are likely to be able to pass on more of what they've learned and/or provide a "richer" environment for their offspring, even if we're only talking about mice. The mammalian brain is remarkably plastic.

    The real problem for the Lamarckian paradigm is that once you've optimized the environment, socialization, and gene expression for the animals in question, it's hard to propose a mechanism for making more radical changes through "acquired characteristics" - and in fact no such changes have been observed. This study does not change that fact.

    The original article sounds to me to be altogether too credulous and sensationalistic.

    1. Re:Not a surprising result ..... by osu-neko · · Score: 2, Informative

      Really, this is hardly a surprising result.

      o.O

      There are many possible mechanisms that suggest themselves, operating either on the embryo or on the newborn - parents who are more intelligent are likely to be able to pass on more of what they've learned and/or provide a "richer" environment for their offspring, even if we're only talking about mice.

      "The findings held true even when pups were raised by memory-deficient mice that had never had the benefits of toys and social interaction."

      So, tell us, how are the more intelligent parents passing this on to their children when their children are being raised by the less intelligent "control mothers"? Are you suggesting some sort of psychic connection of between these mice and their real, more intelligent mothers? Or did you just not read the article in question, and are basing the criticism on the summary alone? I know, it's /., but still...

      --
      "Convictions are more dangerous enemies of truth than lies."
    2. Re:Not a surprising result ..... by bcwright · · Score: 1

      It's hard to be sure since the original article is not a proper journal article, but if I understand it correctly, the pups were swapped between the mothers at birth. This clearly allows for considerable influence of the birth mother, even though it would not be as strong as it would be if she had raised the pups as well. Various nutritional and hormonal influences might be at work here - in fact this struck me as a major weakness in the study: they should have swapped the embryos at a very early stage in development, but that's less convenient. In any case I do not think it is necessary to posit either some kind of "psychic connection" or full-blown Lamarckianism.

      And yes, I did read the article in question before I posted. And FWIW, my degree is in evolutionary biology. I know it's /., where flames are the order of the day, but I think your comments are uncalled-for.

  18. This Just In... by Anonymous Coward · · Score: 0

    Freud Confirms the Theory of Genetic Memory!
    As it so happens, all of those men that wanted to sleep with their mothers were simply recalling the last memory inherited from their fathers' just prior to conception.

    Coming up: President Bush recollects his vine-swinging days. Story at 11.

  19. professor of stating the bleeding obvious by Anonymous Coward · · Score: 0
    From the journalist's article

    "If the findings can be conveyed to human, it means that girls' education is important not just to their generation but to the next one," says Moshe Szyf of McGill University, in Montreal, who was not involved in the research.

    It strikes me that this is a stunningly redundant observation -- that a girl's education has an effect on her offspring. Move the mother to France and teach her French, and it doesn't require complex genetics to unravel why her offspring also speak French.

    1. Re:professor of stating the bleeding obvious by aqk · · Score: 0

      I say we move the mother to Afghanistan (Taliban-controlled section) and we shall see how her daughters grow up.
      -

  20. "Inheritable?" by Dr.+Spork · · Score: 2, Funny

    Doh, why didn't someone tell me that "inheritable" means "heritable"?

    1. Re:"Inheritable?" by Anonymous Coward · · Score: 0

      LOL. English can be such a confusing language. :-)

      Sort of analogous to "flammable" and "inflammable": There are a number of such word pairs where what look like they ought to be opposites are in fact synonyms.

    2. Re:"Inheritable?" by Anonymous Coward · · Score: 0

      US English: flammable :: British English: inflammable

    3. Re:"Inheritable?" by Anonymous Coward · · Score: 0

      What a country!

    4. Re:"Inheritable?" by Anonymous Coward · · Score: 0

      I think what you mean is, "Inheritable means heritable? What a country!"

    5. Re:"Inheritable?" by Anonymous Coward · · Score: 1, Insightful

      That's only part of the story. The word "flammable" was introduced into American English, essentially by the government, specifically because safety regulators worried that the "in" prefix could confuse people. Etymologically speaking, "inflammable" means "capable of being inflamed". Of course, this relates to fire, but also bad tempers, and so on.

      "Flammable" comes from the Latin verb "flamare" -- to set on fire. It was used by the English, but was basically abandoned until after WW2, when it gained acceptance in America.

      http://www.write101.com/W.Tips215.htm

  21. Wake me when... by Slur · · Score: 1

    ...they cut off a mouse's leg and the offspring are shown to walk funny.

    --
    -- thinkyhead software and media
  22. Looks like... by brettz9 · · Score: 1

    he was right-on Lamarck...

  23. Species Specific Behaviors by DynaSoar · · Score: 1

    That's what a good deal of what "instincts" are better called. Such behaviors occur sometimes in animals that do not learn from their parents or other functioning adults. In order for these to exist, they had to have been incorporated genetically. Since the species did not exist at some time in the past, the species and the behavior had to have evolved concurrently. Surgical excision of the part of the brain known to relate to a behavior disrupts the behavior. If there were no pathway for acquired behaviors to be passed along genetically we'd all still be oozing around in a pool of slime mold. This is yet another 'science' article about a minor aspect of a known phenomenon, written in such a way as to make it seem this recent contribution discovered and/or explains it. If this occurs in 9 out of 10 articles on /. it's because that's how often it occurs in what now passes as science writing in the media.

    --
    "I may be synthetic, but I'm not stupid." -- Bishop 341-B
  24. Wouldn't you need by vlad_petric · · Score: 1

    the histones within the reproductive cells to be modified though?

    I can totally picture how this could happen for conventional non-reproductive cell division, but that generally doesn't affect at all offsprings.

    I'm not saying that you're wrong, I'm just really wondering how that's happening.

    --

    The Raven

  25. Occam's razor? by martin-boundary · · Score: 1

    In Feig's study, mice genetically engineered to have memory problems were raised in an enriched environment

    I'm not a biologist, but this raises my Occam's razorblade.

    Why wouldn't the simplest explanation be that the genetic engineering didn't "take" across the generations, ie that the "normal" characteristics reasserted themselves in the offspring due to standard DNA redundancy mechanisms? Another simple explanation would be that the researchers didn't fully understand just what exactly their genetic engineering actually accomplished.

    It's one thing to observe an improvement from a normal baseline, it's another to observe a reversion to the normal baseline from an artificially induced abnormality.

    1. Re:Occam's razor? by Anonymous Coward · · Score: 0

      Read: Control Group.

      It's called science. Occam's razor applies where there are multiple interpretations but science tries to reduce that as far as possible. your question is very easily tested against by including the genetic alterations in a control group.

    2. Re:Occam's razor? by martin-boundary · · Score: 1
      Duh, don't be such a flippant coward. Testing against a control group alone does not help you choose an explanation for a statistical observation. Correlation is not causation and all that.

      It's the framing of their experiment that is suspicious. Generally, one tests for deviations *away* from a population with normal baseline characteristics, because those characteristics are naturally stable.

      It doesn't make sense to test an abnormal population for deviations *toward* normality, as the potential causes for the deviation include all the general, natural mechanisms that lead to the normal characteristics in the first place. To prove their theory, the researchers would have to enumerate and exclude all those natural mechanisms, assuming that they are in fact known exhaustively, which is unlikely both in principle and given the controversial nature of the claims.

      Which brings me to the reason why Occam is relevant: it is simpler to postulate that some unrelated general mechanism is causing the convergence to normal characteristics rather than a specific Lamarckian one.

  26. Not a joke... by chill · · Score: 4, Interesting

    In Soviet Russia, Lamarckism as interpreted by Lysenko in agriculture, was the state mandated approach and genetics was essentially outlawed until the 1960s. Geneticists were fired from jobs, sent to work camps, prison or just executed.

    --
    Learning HOW to think is more important than learning WHAT to think.
    1. Re:Not a joke... by veldor · · Score: 1

      In Soviet Russia, Lamarck interprets Lysenko!

  27. Useful results for treatment by SpeleoNut · · Score: 1

    The inheritance mechanism is interesting but for practical purposes is not necessary to understand to start applying this knowledge. This holds great promise for those who suffer from neurological disorders where there appears to be both a genetic and environmental component to the phenotype (eg. bipolar). An equivalent "enriched" environment (eg. improved socio-economic conditions, tailored primary education programmes, etc. rather than say institutionalisation) might help families with a history of these disorders reduce the severity of symptoms over successive generations.

    --
    rnadom txet for a sngrutaie
  28. I can think of about 20 ways by Jane+Q.+Public · · Score: 1

    or more that external factors could have influenced this experiment. I strongly suggest taking it with a grain of salt.

  29. Odd timing by cjfs · · Score: 1
    Just read part of the Blind Watchmaker by Richard Dawkins. Paragraph I left off on starts with

    It is not possible to prove that acquired characteristics are never inherited. For the same reason we can never prove that fairies do not exist. All we can say is that no sightings of fairies have ever been confirmed and that such alleged photographs of them as have been produced are palpable fakes.

    The article does seem to be a bit of stretch, especially ending with "However, he cautions, there is no direct evidence of this, and no specific evidence that the behaviors are transmitted through epigenetic mechanisms."

    1. Re:Odd timing by bcwright · · Score: 1

      This is a standard result of classical epistemology - it's certainly not original with Dawkins, it was already ancient generations before he was born. Proving a negative (any negative) is very difficult and usually impossible in just about any subject other than mathematics and logic and the like. Similarly we can't prove that flying saucers don't exist - but if anyone were to exhibit an example of any of these things, then that's all that's needed to prove that it does exist.

      It's an amusing coincidence that you were reading that at the same time but I'm not quite sure what it's supposed to prove.

  30. Does it mean that now we can raise a Posleen Army? by Pepebuho · · Score: 1

    We are becoming the Aldenata!

  31. Article mentioning poss. instinct re: spiders by zooblethorpe · · Score: 2, Interesting

    This might be something like what zappepcs was remembering. I dimly recall reading similar research several years ago -- basically, the findings are that babies appear to be more aware of or interested in snake and spider shapes, but do not fear them until they've seen an adult express fear at them. A choice excerpt (emphasis mine):

    Even though the babies pay special attention to spiders and snakes, they do not innately fear them, Dr. Rakison said.

    "If you put a baby in a tank with a snake," he said, "they would show no fear whatsoever."

    Instead, babies seem to have a "perceptual template" for the creatures that primes them to be scared of them once they see an adult showing such fear.

    All of this could be rooted in our evolutionary history, Dr. Rakison said, and could even explain why we might fear spiders and snakes more than lions and cheetahs, for instance.

    "It's thought our ancestors spent a great deal of time on the savannas in Africa, so you could see lions coming from a distance," he said.

    "Spiders and snakes tend to be hidden from view, though, and you tend to see them close up. Our ancestors, particularly the women, spent a lot of time gathering food, on their knees with their infant close by, so you can imagine you're picking plants out of the ground and all of a sudden there's a snake or a spider right there."

    Dr. Rakison's baby studies build on earlier work with monkeys done by Susan Mineka at Northwestern University.

    Cheers,

    --
    "What in the name of Fats Waller is that?"
    "A four-foot prune."
    1. Re:Article mentioning poss. instinct re: spiders by cosmicwave · · Score: 1
      Err, I'm not so sure. Babies may not fear them because their fear mechanism has not been developed yet, or they are not cognitively aware enough to know what the spider/snake is apart from any other object or animal. Sure, they can be conditioned to fear, but what about those like me who were conditioned to NOT fear those things but still do?

      I have always been scared of spiders even though my grandma would try to get me to not be afraid of them at a young age. She used to tend to her large garden and did not mind them. In that sense, I was never taught to fear insects, but I believe I inherited a gene that tells me to stay away from them, which explains my irrational fear.

    2. Re:Article mentioning poss. instinct re: spiders by zooblethorpe · · Score: 1

      Interesting anecdote. The linked article (and what else I dimly remember) suggests that babies actually *are* congnitively aware enough to identify spider and snake shapes as somehow more interesting (or at least worth spending more time looking at), which suggests that something is going on in visual processing at the pre-learned stage that flags spider and snake shapes for special consideration. Where the fear fits into the picture, I do not pretend to know.

      Cheers,

      --
      "What in the name of Fats Waller is that?"
      "A four-foot prune."
    3. Re:Article mentioning poss. instinct re: spiders by Draconius42 · · Score: 1

      This must be why my one-year-old finds my keyboard and mice cables so fascinating, and constantly pulls them down.

  32. say it aint so... Re:Interesting... by bukuman · · Score: 3, Insightful

    I really hope it's not the case that results can be rejected due to the lack of a mechanism to explain them.

    Darwin had no mechanism to back his theory of 'origin of species by natural selection'. The mechanisms people had theorized at the time were not really compatible with Darwin's ideas. It wasn't till Mendel's work was appreciated that people had a viable mechanism for the inheritance that fit with Darwin's evolutionary theory.

    1. Re:say it aint so... Re:Interesting... by CrimsonAvenger · · Score: 1

      I really hope it's not the case that results can be rejected due to the lack of a mechanism to explain them.

      Read some history of geology. Happened all the time.

      --

      "I do not agree with what you say, but I will defend to the death your right to say it"
  33. not news by jipn4 · · Score: 1

    This has been known for quite a while. However, only fairly little information can be transmitted this way, and that information lives on a DNA substrate.

    Think of the DNA as a printed book, and the "acquired characteristics" are like little bookmarks you leave in the book: they can't alter the text, but they can direct you more quickly to different parts and change your reading experience.

  34. Might as well use it by Tablizer · · Score: 1

    It's been known for at least a few decades that breast milk carries "trainer" cells for a child's immune system. This makes sense evolution-wise: if the offspring can borrow "knowledge" from the parent, then it can help the offspring without waiting several generations for such ability to evolve genetically. The ability to use beneficial shortcuts will be passed on more often.

  35. Needs confirmation by G3ckoG33k · · Score: 1

    I am not saying this is bad science, or that they didn't find the results they did, just that the study belongs to a category where you likely need independent confirmation before accepting theur claim.

    Why? Well, in behavioral studies it is notoriously difficult have repeatable results, due to small test series and the high sensitivity of the parameters themselves, which typically are measured on very crude scales.

    It is a bit like judging contestants in chamber music in a steel plant. You need an awful lot of judges and repeated plays in order to discern the virtuosos. Bad analogy, but I hope you get the point.

  36. Such perfect research. by Anonymous Coward · · Score: 0

    What a perfect study. You take some rats. Make them retarded. Then help make them better again. Then let them have offspring. When the offspring come out normal, you come to the conclusion that it is because of the retarded parents learning to be unretarded. This really makes a whole lot of sense. Great use of millions of dollars of research money. Good thing the government is going to spend an additional 700 quadrillion dollars (of YOUR money) on additional research like this. That will stimulate the economy so much, it will have multiple orgasms. Then its offspring will be better economies.

  37. George Carlin already said it. by Anonymous Coward · · Score: 0

      That we need to stop rewarding peoples hard work because hard workers are coded for hard work, so why are we celebrating something they had no choice over. Paraphrasing from Orgy of George.
    I tend to believe that too.

  38. Comment removed by account_deleted · · Score: 1

    Comment removed based on user account deletion

  39. Does it need one? by Weaselmancer · · Score: 1

    That being said, the article is rather short in one important area: a suggested mechanism for this sort of inheritance.

    Does it really need one?

    You can do an experiment, you get results. These results suggest...something. It is able to be duplicated. It follows scientific method and rigor.

    The only problem is - most of the methods I can think of this sort of thing using are most decidedly nonscientific. Let's face it - this is closer to philosophy than science. It stands up to testing rigor, but...I just don't see a readily available purely scientific explanation. This experiment seems a little closer to Frank Herbert than modern day science.

    For now though, I think it's enough that we can observe this. It suggests interesting things.

    --
    Weaselmancer
    rediculous.
    1. Re:Does it need one? by Thiez · · Score: 2, Insightful

      > Does it really need one?

      The great thing about comming up with a mechanism for this phenomenon would be that you could make predictions and come up with new experiments. To test the mechanism. For example, do both parents need to be in the enriched environment or is one of them enough (and if one is enough, does it matter if it is the mother or the father)? What happens when we take a fertilized egg from a rat from a boring environment and put it a rat from an interesting environment (or the other way round)?

      A mechanism would make all kinds of (testable) predictions about the above questions. Once we have a mechanism we are beyond the 'we found a correlation' stage. Having said that I agree we can do without a mechanism for a little while longer. The results of a few more experiments in this area will make it much easier to come up with a mechanism.

    2. Re:Does it need one? by narcc · · Score: 2, Informative

      You're confusing a model with a mechanism.

      We have no mechanism to explain gravity, but a wonderful model that handles it well enough to land us on mars. Mendel didn't have DNA and was able to make predictions and conduct his experiments just fine.

    3. Re:Does it need one? by MrHanky · · Score: 1

      Yes, it needs one. I can think of three different ways of passing on these traits (and there may be more): 1) through hormonal influence in the womb, 2) through teaching (mouse mnemonics?) and 3) through some unknown non-DNA genetic mechanism. If it's 1), the traits will likely only last for one generation, if 2), the traits will likely mutate more from one generation to the next, if 3) it may last as long as the family tree.

  40. Re:DNA Learning ... .I wonder if the rodents they by davidsyes · · Score: 0, Offtopic

    used will be able to learn not to chew on server room wires insulation...

      How To Keep Rats From Eating My Cables?
    http://ask.slashdot.org/article.pl?sid=09/02/12/2115242

    My Bouncing Betty Tesla Coils might help...
    http://slashdot.org/comments.pl?sid=1126125&cid=26837909

    --
    Previously: "Linux... Toward the Sunrise..." Now: "Linux... Toward the-- No, now, part of Every Sunrise"
  41. Still isn't Lamarkian... by Anonymous Coward · · Score: 1, Interesting

    Heritability of acquired traits, perhaps - but in a limited framework provided for by genes. This is not a mechanism which could itself give rise to the development of new traits.

  42. ntsa... by sherifffruitfly · · Score: 1

    Not This Shit Again.

  43. Flatworms, RNA, and epigenetics by macraig · · Score: 1

    Why wasn't the legendary flatworm experiment enough to silence this debate and banish the disbelievers? Why wasn't RNA's role? Why wasn't epigenetics enough?

    I wonder if there's an emotional component to this disbelief? Too many people don't want to know or believe that their own actions and choices before they "settle down" and have children might also outlive them. All too often there are bad or foolish choices made before children are born, and even if lessons are learned later the children may still be inheriting an "instinctive" wild reckless vibe from parents that could outlast the parents and their explicit efforts to counteract it. I've also heard it said that a kitten's personality is largely predetermined by the personality and behavior of its father, regardless whether the father is even present in the environment after birth. If that is even substantially true, how much different will the story be for humans or any other higher-order mammals?

    1. Re:Flatworms, RNA, and epigenetics by smchris · · Score: 1

      I forgot about the flatworms. Came out about the time I started a psych major and I remember it being reported seriously.

  44. This is Science! by Xarvh · · Score: 2, Interesting

    So, Darwin's evolution is not the only evolution?

    Great.That's the way of Science: correcting itself and rehabilitating ideas if they get proof.

    Lamarck's theory didn't work, but it was a legit scientific theory nonetheless, in that it actually took the risk of telling us something about nature: right or wrong, nothing reduces the scientific rigor and dedication of Lamarck's work and his contribution to biology.

    This is a legit revision of mainstream evolution theory, and has nothing to do with non-falsifiable, religious crap.

    1. Re:This is Science! by SpinyNorman · · Score: 1

      This isn't evolution - there's no genetics involved.

      That's like saying that musical kids inherited their parents musicality, when in reality it's just their being raised in a musical home.

      In this case it's already shown that a better environment improves the parents memory, so why can't a better womb environment improve it in exactly the same way for the baby?!

      It could be epigenetics also (genetic expression depending on external factors), but that also isn't Lamarkism.

      Lamark didn't realize, as Darwin did, that (for example) giraffe's necks may get longer due to less competition for high up food resulting in natural selection for randomly occuring longer necked varieties. Lamark believed that one generation of giraffes would stretch it's necks reaching for food and directly pass this physical characteristic on to their young. Larmark was just plain wrong - he completely missed the basis of eveolution, and it would be beyond charitable to say that he was describing epigenetics.

    2. Re:This is Science! by Xarvh · · Score: 1

      Saying just 'Lamarck was wrong' passes a bad message about science.

      Science is not made of right or wrong, is made of ideas that are proposed and tested... Wrong ideas are often necessary to develop right ones.

      Lamarck didn't have Darwin's great intuition, but he was a great biologist and tried to give a *scientific* explanation.

      Anyway, I agree.
      I confused evolution with adaptation.

  45. Re:Does it mean that now we can raise a Posleen Ar by Anonymous Coward · · Score: 0

    This is probably the shittiest scifi/fantasy series I've ever researched on wikipedia as a result seeing it mentioned in a random slashdot comment.

  46. It's called phenotypic plasticity by Chalnoth · · Score: 1

    And it's hardly surprising, or unknown. Basically, organisms haven't just evolved to a very specific environment, but have also evolved to manage environments that change with time. The ability to pass on certain very specific acquired characteristics is still an evolved trait.

    The point with Lamarck was that he thought that all traits behaved in this way, an idea which was easily disproven. It is only a subset of non-genetic traits which are passed to offspring, and then only because specific mechanisms have been put in place by evolution to do so.

    From what I understand, many biologists are currently hard at work understanding the non-genetic paths of inheritance (called epigenetics), which include a variety of different things.

  47. Re:DNA Learning, old news by barwasp · · Score: 1

    a historical document demonstrates the usefulness of that method within human and alien species.

  48. If only... by CarpetShark · · Score: 1

    It could be one day possible to create a kind of device that harmonizes human beings early on in childhood development

    Yes indeed. If only children usually came with some sort of trainer responsible for their education, wellbeing, food, and shelter.

    You know... like those mice had, when their parents probably interacted with them in a way that requires more memory skills, since they'd learned them earlier.

  49. gb2/b/ by Alex+Belits · · Score: 1

    gb2/b/ -- this is Slashdot (not Sparta), we have an unbroken chain of crappy memes since Mae Ling Mak (not Natalie Portman) was naked and petrified, and MEEPT! (not a bunch of marketing companies' employees) was dissing Linux.

    --
    Contrary to the popular belief, there indeed is no God.
  50. Old news by Anonymous Coward · · Score: 0

    I used this same technique to breed my Golden Chocobo.

  51. Environment for the second generation? by argent · · Score: 1

    Were the second generation of mice raised with their environmentally enriched parents? Mice learn, that's obvious, that's how the first generation benefitted from their richer environment. Well, they learn from other mice, too. Like, their parents.

    Have they corrected for nurture? Have they corrected for differences in the mother's milk, even?

  52. Nothing new about this... by hesaigo999ca · · Score: 1

    We have seen regular signs of this phenomena a long time ago. Second and third generation wrestlers, musicians, etc... seems like the genes have cellular memory, and that this can be linked to "characteristics" whether involuntary or not.

    I tend to think if you lead a life of hardship, and then you bring a baby into your world,
    they are going to know hardship too. They live in the environment we ween them in. Is this really
    any big bright new flashy idea, I think someone is trying to find a way to siphon money into useless
    projects again.

  53. Females aren't born with all their eggs by PIPBoy3000 · · Score: 4, Informative

    This was a common misconception until recently. You can read about it here.

  54. Other animals do this as well by PeeAitchPee · · Score: 1

    Dogs, for example, will pace around in a circle before they lie down. Most dogs kept as pets have never had to bed down in sharp, tall grass like their wolf ancestors did, nevertheless this behavior has been passed down to them over many generations.

  55. Pokemon did it by Anonymous Coward · · Score: 0

    See here

    Now, when your egg hatches, you may notice a few things about it. For example, it is at level 5 and the stats are according to that. One interesting thing you may see is that the pokemon knows more moves than it should at level 5. For example, I bred my female Gardevoir and male Wobbuffet together and when I hatched the Ralts egg, it knew Growl, Safeguard, and Destiny Bond. But wait! Itâ(TM)s not supposed to learn Destiny Bond, and Safeguard comes as a TM! Why does this Ralts have both of those moves already?

    Breeding is a very useful technique when you want to aquire your movesets because of the fact that you can breed over two different sets of moves: Technical Machine aquired moves, and âoeEgg Movesâ. Earthquake is a very popular move used by almost every physical sweeper, but the problem with this is that you only get one TM 26. You can however chain-breed it to any pokemon you would like. Chain breeding? Some pokemon can only get a move through breeding only if you first breed two other pokemon for a male version and breed it again to the pokemon you wish for a certain move to be on. For example, say I wanted to breed Rock Slide to a Cradily. First, I would need to get a Male Relicanth and Female Corsola, breed for a Male Corsola with Rock Slide and breed that with a Female Cradily/Lileep for a Lileep with Rock Slide.

  56. Learned behaviour != hieritability by redelm · · Score: 1

    Their conclusion is only one possibility. Far more likely, the mice learned memory-improving behaviours during their enriching experience, and taught those behaviours (perhaps mostly by example) to their offspring.

    Many behaviours are learned, and they can create functional differences.

  57. Re:Does it mean that now we can raise a Posleen Ar by oracleofbargth · · Score: 1

    I've been trying to read the second book in the series, but it has an even more ridiculous overabundance of military acronyms than the first book. I don't care for the Ringo's dialog style. His descriptions of action sequences are pretty good, but slogging through the rest of the book makes it almost not worth trying to read.

    The author does seem a bit full of himself, as in the plot of the first book, the first people the military went running to when the aliens landed were the science fiction authors.....

  58. Only if they genetically modified sperm/eggs by foniksonik · · Score: 1

    It's well known that sperm and eggs develop separately at the time of conception on... the DNA in sperm and eggs is not the same as that in the host body...

    Which is to say that they could have genetically modified the host while neglecting to modify the sperm/eggs of the host and the offspring of the gen-modded mice would be 'normal' mice without the modifications at all.

    --
    A fool throws a stone into a well and a thousand sages can not remove it.
  59. Ah, "scientists"... by bussdriver · · Score: 1

    Too many people are in need of that part of religion that explains the unknown of the tangible world. Science fills this need where religion once did (for some people) and they have a tendency to act in similar irrational ways about the secure illusion provided by science as they would have before its popularity.

    Science knows nothing (metaphor, science literally is just a methodology.)

    It knows and finds truth better than any other human tool but it is still quite limited and very young (it's still run on humans.)

    We just started in this field; 150 years ago it was a big deal to even say there was some logical connection between species. We know a little bit about DNA and now we think we know everything... and are creating mutants and releasing them in the wild arrogantly thinking we are improving upon nature.

    Yet we can act like know-it-alls with the infinitely complex chaotic real world!

    There is a great deal to discover and some of it may be beyond human comprehension-- which is limited by how well we can abstract complex ideas and how fast we can learn them.

    We can't even master computer science, which is 100% man made and extremely exacting unlike the other sciences.

  60. Not even REMOTELY news by Jerry+Beasters · · Score: 1

    Once again the news media loves to misrepresent the science to make it seem like there is some "controversy." These ideas have not been controversial, and the idea that certain acquired traits can be inheritable has been accepted for a long, long time. I'm not surprised, though, ./ has no shame.

  61. This raises the question... by HTH+NE1 · · Score: 1

    Are you pondering what I'm pondering?

    --
    Oh, say does that Star-Spangled Banner entwine / The myrtle of Venus with Bacchus's vine?
  62. Comment removed by account_deleted · · Score: 1

    Comment removed based on user account deletion

  63. Darwin was not first. by Anonymous Coward · · Score: 1, Interesting

    Darwin was merely a good scientist who was the first to publish an important theory that turned out to be true. But a lot of people make more out of him than that.

    A good scientst, yes, but not the first to publish. If you actually read Darwin, which of course nobody ever does, he quite explicitly and honorably gives credit to the man who first published "a theory of the origin of species by means of natural selection" (nowadays popularly and incorrectly known as Darwin's theory of evolution).

    I freely acknowledge that Mr. [Patrick] Matthew has anticipated by many years the explanation which I have offered of the origin of species, under the name of natural selection. [...] I can do no more than offer my apologies to Mr. Matthew for my entire ignorance of his publication.
    --Charles Darwin, Down, Bromley, Kent. 13 April 1860

    I've been told several times by molecular biologists who study DNA and phylogeny that Lamarck was more correct than Darwin in most of his scientific publications, but Lysenko's corruption of Lamarck's ideas and public adoration of Darwin have caused people to emphasize Lamarck's mistakes and to ignore Darwin's.

  64. No, that does not support eugenics by itself. by Medievalist · · Score: 1

    It means that or hints that brain chemistry has biochemical effects on us and our offspring via genetics. Animal husbandry would tell us this if we listened, but we need to see it in humans to fully 'get it'... I don't want to say that this is more evidence for the support of eugenics, but... well, it seems likely.

    No, that's a logical error. You are saying that there's a process by which a population of organisms changes the characters of individual organisms over time in response to environment, and therefore members of that population should subvert that process by taking control over it and replacing the existing environmental feedback mechanisms with human planning.

    There's no good reason for that, other than hubris or o'erweening pride ("I am so smart, I am god!") and at least one good reason not to - the process by definition works, so fucking with it intentionally could destabilize the dynamic equilibrium that characterizes feedback loops.

    "It exists, and therefore I can make it better" is not reasonable or logical. There needs to be a more complex and nuanced argument if you're going to try to argue in favor of eugenics. The argument you're going to have to defeat is "it exists, and therefore is a system flexible and reliable enough to function without human management, so leave it alone and spend efforts elsewhere".

    1. Re:No, that does not support eugenics by itself. by zappepcs · · Score: 1

      I agree. The planet exists, and therefore is a system flexible and reliable enough to function without human management, so leave it alone and spend efforts elsewhere, or so the reasoning goes.

      Just because it exists and we are not yet trying to make it better does not mean we are not fucking with it already. Do you know if your food has the same nutrients as the same food did 60 years ago? Do you know if the lifestyle of the Western world countries has modified genetics/behaviors of its inhabitants? Do you know... well, you get the point.

      Research that looks like it might be useful for Eugenics may actually only be the research for preventative medicine in respect of preventing damage to the gene pool through environmental factors. It depends on your perspective. How many more generations will it take before our species REQUIRES high fructose corn syrup to fully metabolize a western diet?

    2. Re:No, that does not support eugenics by itself. by Anonymous Coward · · Score: 0

      I agree. The planet exists, and therefore is a system flexible and reliable enough to function without human management, so leave it alone and spend efforts elsewhere, or so the reasoning goes.

      Which is fine, as long as you are only concerned about the survival of the planet. If you are concerned with the survival of homo sapiens sapiens, you might want to make sure they have food and drink, among other things. The bacterial and viral parts of the ecosphere might also be worth monitoring.

      Just because it exists and we are not yet trying to make it better does not mean we are not fucking with it already. Do you know if your food has the same nutrients as the same food did 60 years ago? Do you know if the lifestyle of the Western world countries has modified genetics/behaviors of its inhabitants? Do you know... well, you get the point.

      Although I know the answers to those questions, the answers unfortunately tend to strengthen your point and weaken my own. :(

      Research that looks like it might be useful for Eugenics may actually only be the research for preventative medicine in respect of preventing damage to the gene pool through environmental factors. It depends on your perspective. How many more generations will it take before our species REQUIRES high fructose corn syrup to fully metabolize a western diet?

      That's the kind of thing I was talking about when I said a more complex and nuanced argument was needed. Also, myself, I like to study a problem a whole lot before attempting solutions, especially "solutions" like breeding for specific traits... so I prefer a perspective that is more observational and less directed towards provoking results.

      I suspect maize is a crop headed for eventual collapse, given our current agricultural and economic policies, so I sincerely hope humans won't REQUIRE high fructose corn syrup any time soon. The Irish Potato Famine would look mild compared to the US corn industry being wiped out.

    3. Re:No, that does not support eugenics by itself. by zappepcs · · Score: 1

      Well played. I believe that we agree much more than the original words led one to believe. MUCH more.

  65. Lamarckian inheritance by TempeTerra · · Score: 1

    This next generation of mice also had better memory, despite having the genetic defect and never having been exposed to the enriched environment.

    I'm going to give the researchers the benefit of the doubt here and assume they found something apart from that the second generation were raised by smarter parents.

    Lamarckian inheritance is very interesting and isn't a particularly stupid idea, apart from the fact that it doesn't match real world genetics. Because biological organisms have their phenotype largely specified by DNA, a parent would need to have their acquired characteristics transcribed back into their DNA somehow to pass it on - doesn't happen.

    But before you forget about Lamarckian inheritance as just another idea that doesn't work, consider how many non-genetic acquired characteristics are passed on from generation to generation. Language, society, and knowledge in humans, and behaviours like hunting and bird songs in animals. Acquired characteristics ARE passed on, but not genetically. Influential teachers can pass their characteristics on far more widely than the most prodigious parents.

    --
    .evom ton seod gis eht
  66. Willfull misunderstanding by wonkavader · · Score: 2, Insightful

    I have seen so many people screaming "Lamarckism! Lamarck was right!" Because they want to imply "Darwin wrong!" or "Genetics wrong!" to generate a headline. While this stuff is interesting, it's not Lamarck. It's an interesting genetically controlled chemical phenomenon. It should have been expected. You evolve to deal with issues. You have chemical controls on DNA replication and interpretation. In shorter life span animals than humans, this can be a great advantage.

    It ain't Lamarck. Lamarck says that if you cut off a tail of an animal, in generation after generation, after a while, the animal won't have a tail. Lamarck says that if a giraffe needs a longer neck to reach leaves, it will stretch upward and that act of stretching will make its children taller. And that change will go forth, generation after generation.

    This stuff is vaguely like Lamarck, but it ain't Lamarck. People bring him into the conversation to get the uneducated excited. And at base, what they really want to say is "Darwin was wrong" because that gets dumb people really excited, which in turn sells newspapers -- now Darwin didn't say anything about mechanisms, so he's not wrong. And this new stuff doesn't tell us that anything about how we generally understand mechanisms is wrong. It's just that there's more. Well, that's fine. Go study that. Yes, we'll fund you. Shut up with the Lamarck crap.

    1. Re:Willfull misunderstanding by Savantissimo · · Score: 1

      Darwinism is not synonymous with scientific evolutionary theory. Nor is neo-Darwinism. Darwin was wrong for the most part about speciation occurring gradually, for example. (Punctuated equilibrium is more the rule than the exception.) The loud dogmatists don't understand evolution or genetics; they operate on some kind of cartoon version of the theories that leading researchers have. And even the leading researchers will usually discount evidence they don't like and frequently present speculation as proven fact.

      The truth is that pseudo-scientific dogmatic Darwinists have long claimed that heritable characteristics could not be acquired, and that to say otherwise was Lamarckian heresy. They have been proven wrong repeatedly over the past decades, and even more conclusively in this latest research.

      --
      "Is life so dear, or peace so sweet, as to be purchased at the price of chains and slavery?" - Patrick Henry
    2. Re:Willfull misunderstanding by Anonymous Coward · · Score: 0

      Actually, it's little understood that Darwin WAS a lamarckian, at least in the sense he agreed that acquired characteristics could be inherited, at least in some circumstances - his "natural selection" explicitly included selection of such characterisitics. . It wasn't really until the dawn of modern genetics that Lamarck was written out of "approved" science, and it wasn't because the evidence was weak - there's always been a surprising amount of it - but that the gene-centric view could find no mechanism that could support it, so the evidence was ignored. "If my theory can't explain it, it must not happen" tends to be the rule in a lot of disiplines...

  67. Oh shit by Locke2005 · · Score: 1
    You mean Lysenko was right after all?!?

    So we should expect to see female babies being born with silicone breast implants any time now?

    --
    I've abandoned my search for truth; now I'm just looking for some useful delusions.
  68. I KNEW IT! by Anonymous Coward · · Score: 0

    I've always personally suspected (from hueristic observational conclusion) that there was a Lamarckian mechanismm to evolutionary change!

    Validation rules!

  69. "Lamarck's Signature" was published 10 years ago. by dsmatthews · · Score: 1

    Lamarck's Signature : How Retrogenes Are Changing Darwin's Natural Selection Paradigm Published Dec 1 1999 http://www.amazon.com/Lamarcks-Signature-Retrogenes-Changing-Selection/dp/0738201715

  70. weak experiment by martas · · Score: 2, Insightful

    As has probably been pointed out by slashdotters, as well as experts, concluding anything about the effect of a parent's environment to genes of the offspring is just plain dumb.

    All they did was show that parents pass on what they have learned to their offspring. Don't know about you, but I already kind of realized this, as did the entire field of developmental psychology.

    In order for me to conclude anything else, this is what the experiment must have looked like. There should be three groups of mice with the genetic defect, A B C. Group A should be the one "taught" to have better memory. Groups B and C should be left to develop normally. Fertilized eggs from group A should have been transplanted to females in group B. Group C should be left to reproduce naturally. Then, the offspring of groups B and C should be compared against each other. B's babies have any advantage over C's, then that is pretty much hard evidence that the genetic composition of the offspring of group A was somehow modified to reflect A's parents' development (without removing the original defect).

    This would be hard evidence because A's offspring's environment would have had no chance to be affected by their parents, after birth OR in the womb.

    I have to admit that I didn't make the effort to read the original article, and my comment is only a response to what some other commenters here seemed to conclude from it.

    1. Re:weak experiment by pseudonymphetamine · · Score: 1

      Mod parent up!

  71. They were genetically engineered by codewarren · · Score: 1

    It is not as if they were fed antacid and their offspring had less heartburn. These were genetically engineered. The fact that their offspring inherited the trait indicates nothing particularly remarkable except that they may have modified more than they intended. All of evolution is based on mutations being inherited. That's Darwin, not Lamarck.

  72. Re:Does it mean that now we can raise a Posleen Ar by CrimsonAvenger · · Score: 1

    The author does seem a bit full of himself, as in the plot of the first book, the first people the military went running to when the aliens landed were the science fiction authors.....

    Stealing from Niven and Pournelle (Footfall) isn't a sin.

    On the other hand, this is the only author I know of who inserted himself and another author into a book as supporting characters, and then has the other author's character kill the character representing himself. Over book sales, I might add.

    Unfortunately, Ringo is ex-military, so he's still in love with military jargon. Which is full of (mostly) incomprehensible acronyms - FEBA, anyone (which used to be called the Front, by the way)

    --

    "I do not agree with what you say, but I will defend to the death your right to say it"
  73. Bene Geserit's just aren't real. by headkase · · Score: 1

    I really don't like the idea of Lamarckian thoughts as they require a "mystic" connection. Somehow after reproduction physiological information is acquired presumably from the biological parents. I find it much more likely that a process which the biological parents could pass onto their offspring with fully understood physiological mechanisms is simpler and more possible: encoded in the organism's genome are "repair" codings. The repair codings simply run in parallel and were somehow selected from environmental cues to cybernetically (as in, auto-correction feedback methods) restore a "back-up" of "important" regions from a different part of the genome to restore functionality in areas that were undesirable to be damaged by random genetic mutation, in this case memory functions, throughout an organism's genetic-"life".

    --
    Shh.
  74. Re:Does it mean that now we can raise a Posleen Ar by BoothbyTCD · · Score: 1

    I can't even read him anymore. Ringo is the current foremost purveyor of what I like to call "...and then those hippies will be sorry!" science fiction. --Aliens will invade our defenseless, unarmed civilization...and then those liberal gun-haters will be sorry! --Evil warring factions will revert our utopian dreamworld to bronze-age barbarism...and then those limp-wristed hippies will be sorry! etc.etc. He also engages in another of my pet peeves, i.e. using the lofty vantage point of his (imaginary) future position to have his characters condescend to and ridicule us poor benighted (real) present dwellers about his pet political issues. All science fiction does this to a certain extent, but Ringo literally has characters say things like "Those poor 21st century people really believed their planet was warming, the enviro-commie schmucks...and then they were sorry."

    --
    snig
  75. Bloodsuckers! by aqk · · Score: 0

    Whatever happened to those studies of Planaria (flatworms) that when you trained them to avoid electric shocks, then chopped 'em up and fed 'em to other flatworms, the new flatworms KNEW to avoid the electric shocks?

    I say we tase a few guys, chop 'em up and...
    Oh wait... this is getting too disgusting. Let's stay with the bloodsuckers.
    -