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Gates Foundation Funds "Altruistic Vaccine"

QuantumG writes "The Bill and Melinda Gates Foundation has awarded a $100,000 grant to the University of Queensland, Australia to develop a vaccine against dengue fever, a disease spread by mosquitoes. Unlike other vaccines, the 'altruistic vaccine' doesn't specifically protect the individual being bitten, but instead protects the community by stopping the transmission of the pathogen from one susceptible individual to another. The hope is to do this by effectively making their blood poisonous to mosquitoes, either killing them or at least preventing them from feeding on other individuals. Professor Paul Young explained how his work fell outside current scientific traditions and might lead to significant advances in global health — he said he could envision the vaccine being used around the world within 10 years, and it would be designed to be cheap and easy to implement."

32 of 259 comments (clear)

  1. A vaccine? by Anonymous Coward · · Score: 4, Funny

    Is this a vaccine that prevent you from getting infected with that anti-captialist altruistism?

    Is this yet another attempt for Microsoft to destroy the Free Software movement?

  2. Is that really enough? by jasonmanley · · Score: 5, Insightful

    I don't want to sound ungrateful or anything but is $100K really all that much considering how expensive it must be to do this kind of research?

    --
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    1. Re:Is that really enough? by unlametheweak · · Score: 3, Informative

      I don't want to sound ungrateful or anything but is $100K really all that much considering how expensive it must be to do this kind of research?

      I could presume it is enough money to pay for the salary of the one researcher that was awarded this grant. It's not a lot of money, but Microsoft has spread their grants to other researchers working on other projects as well.

    2. Re:Is that really enough? by KibibyteBrain · · Score: 4, Interesting

      The Gates foundation tends to give results-driven grants, so they will probably get more if they come up with something promising.

    3. Re:Is that really enough? by Anonymous Coward · · Score: 5, Insightful

      Bill Gates != Microsoft

    4. Re:Is that really enough? by jellomizer · · Score: 3, Informative

      Exactly,
      Unlike other grants such as the NFS, the Gates foundation is very results driven. In essence Bill Gates is using the money just like in a business with the only exception the goal isn't to make more money to to have the best effect on humanity. So 100k grant to do some research (And this guy probably has other money, Money from the university that pays his salary and facilities) The 100k pays for tools and grad students (Who work cheap) to help with his research. Now with further study if it shows more of a success then he may get more. But if it is a dead end research the Gates Foundation is only down 100k vs. More.

      --
      If something is so important that you feel the need to post it on the internet... It probably isn't that important.
    5. Re:Is that really enough? by techess · · Score: 4, Funny

      Really he should up this to 640K. That should be enough for anybody.

      --
      Don't anthropomorphize computers. They *hate* that.
  3. And 20 years from now... by Solarhands · · Score: 4, Funny

    We will have new, super mosquitoes, who's bite is deadly to humans.

    1. Re:And 20 years from now... by eugene2k · · Score: 4, Insightful

      On a more serious note, though. Some time from now, if this vaccine is developed and becomes widespread, the mosquitos will adapt to the poison in it (this is what evolution is all about), and we'll have mosquitos that are resistant to the poison.

      Of course it is also possible that evolution will take another path and mosquitos stop feeding on humans and switch to animals, but not any more possible than the prospect of mosquitos becoming vegetarians.

      --
      Apple has "Mac vs PC", Microsoft has "Laptop Hunters", Linux has recession
    2. Re:And 20 years from now... by Carewolf · · Score: 5, Interesting

      I don't know, mosquitos has many other food sources than humans. Resistance to humans might not be important enough to give potentially immune mosquitos an evolutionary advantage.

    3. Re:And 20 years from now... by eugene2k · · Score: 4, Interesting

      Problem is, for mosquitos to stop feeding off humans would mean developing some sort of mechanism to differentiate between a human and an animal. So far they don't. So the more probable evolutionary path would be for mosquitos to feed and die until only the ones that survive after feeding off humans are left.

      --
      Apple has "Mac vs PC", Microsoft has "Laptop Hunters", Linux has recession
  4. Why a 100K would be needed from Bill to fund this? by IAR80 · · Score: 5, Insightful

    "When I give food to the poor, they call me a saint. When I ask why the poor have no food, they call me a Communist." Hélder CÃmara

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    http://ebgp.net/ccc/
  5. Will this help? by Z00L00K · · Score: 4, Insightful

    Because if it won't help against infection it's little consolation that you won't spread the fever.

    Of course - it's better than nothing, but even better would be to figure a way to take out diseases like Dengue Fever completely.

    Many diseases are spread by mosquitoes and if you can take out them from the equation it may help against several diseases. Pheromones are one important factor when the mosquitoes are mating and if you can attract the males to a trap you can either kill them or replace them with genetically modified ones that are less able to spread diseases. The modification may range from sterile offspring to offspring that aren't able to work as a carrier or even offspring that are shunning humans as blood source.

    --
    If builders built buildings the way programmers wrote programs, then the first woodpecker would destroy civilization.
    1. Re:Will this help? by IAR80 · · Score: 4, Informative

      Mosquitoes certainly have their role in the ecosystem and killing them will certainly have unforeseen consequences. More like in the Mao and sparrows story http://en.wikipedia.org/wiki/Great_Sparrow_Campaign

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    2. Re:Will this help? by unlametheweak · · Score: 3, Funny

      Mosquitoes certainly have their role in the ecosystem and killing them will certainly have unforeseen consequences. More like in the Mao and sparrows story http://en.wikipedia.org/wiki/Great_Sparrow_Campaign

      And besides, Sparrows are too cute to kill.

    3. Re:Will this help? by MjDelves · · Score: 5, Informative

      Well actually yes this strategy is very sensible. I think you're not quite understanding the research. The vaccine doesn't stop you being bitten by mosquitoes, but would be designed to stop the virus infecting the mosquitoes. This breaks the cycle of infection and prevents many other people being infected. Yes that's little consolation for you, but in the long run, less people being infected does have a direct benefit for you.

    4. Re:Will this help? by unlametheweak · · Score: 4, Insightful

      Mosquitoes certainly have their role in the ecosystem and killing them will certainly have unforeseen consequences. More like in the Mao and sparrows story http://en.wikipedia.org/wiki/Great_Sparrow_Campaign [wikipedia.org]

      Humans are part of the ecosystem, and not allowing natural checks and balances to occur on the human population also has devastating effects on the environment. I'm not advocating culling humans however.

    5. Re:Will this help? by Ralph+Spoilsport · · Score: 3, Interesting
      oh bullshit.

      I don't live in the USA, and I don't live in Israel. If they "got ahold" of some nukes, how many does Pakistan have? Last I read, about 60, and they aren't all on missiles, and the military people in PAK have enough sense to no let these lunkheads get access to the codes. So, they would have to use them as something put on a boat and floated into a harbour. Let's pretend that they do get some missiles with nukes, do you think they're going after Western Civ first? No. They'll go after Western Civ's proxy, India (IND). Let's further pretend that they get as many as 20 (roughly 1/3 of the stockpile) in usuable order on missiles, which AFAIK, is extremely unlikely even for PAK today.

      So, they use some nukes on IND first. Bombay, New Dehli, a few other big cities disappear. Grossly wounded, there are still hundreds of millions of Angry Indians left, and they collectively march across the border and commence slaughter, with the approval and sanction of the UN. Game over. Did Western Civ end? No.

      So, let's say they go for another Western Proxy, Israel. Let's say they dump all 20 on Israel, somehow (even though they don't have a delivery system). What happens? A devastated Israel responds with its own nukes and it has dozens more than PAK and PAK is reduced to a glowing parking lot. Game over. Did Western Civ end? No.

      So, let's say they go for the gusto, and somehow get all twenty - fuck it - ALL SIXTY nukes into the USA and set them off. The USA military responds and with one submarine turns PAK into a glowing parking lot. Millions die, in the USA and PAK. But not in Europe or Japan, or Germany or France or Italy or Finland or Russia. Did Western Civ end? No.

      So, kindly quit with the fear mongering bullshit.

      The apocalypse is NOT a year away. There will be no apocalypse. There is way too much money to be made and too much power to grab for something as self-absorbed and self-indulgent as an apocalypse to occur.

      The USA is bankrupt, and will have to retreat from unipolar status fairly soon. When that happens, it will become less of a target.

      --
      Shoes for Industry. Shoes for the Dead.
  6. Useless by matria · · Score: 4, Interesting

    This won't do much good unless all warm-blooded suppliers of the mosquitoes are so treated. A handful of humans killing/disabling a few thousand mosquitoes every year won't put a dent in the total population. This kind of thing tends to have unfortunate side effects as well. A similar treatment for dogs and cats to kill fleas has been around for years, and I don't see any reduction in the flea population. I have had a couple of really sick animals as a result of the treatment before I gave it up, though.

    1. Re:Useless by flonker · · Score: 3, Insightful

      If every human with dengue fever is so treated, the mosquitoes will not have a chance to spread the fever any further if they do bite you. I don't understand the disease, and the article itself was light on detail, but if the disease spreads from ...mosquito->human->mosquito->human..., you would be removing the human->mosquito leg of the cycle.

    2. Re:Useless by moj0e · · Score: 3, Interesting

      Actually, mosquito control isn't useless. I grew up in Brazil where there was a dengue outbreak in the 80's. They worked hard at making sure the mosquito didn't have an environment to grow and until this year, I hadn't heard of any dengue outbreaks. My concern with this method is that people who are infected by dengue might be transmitting the disease (through the mosquito) before they even realize that they are sick. If this is the case, the infection cycle wouldn't be completely broken. Unfortunately, this year we did have an outbreak and I got Dengue :/ (very painful). I was actually back in the US before I realized that I had dengue. Anyway, those are my 3 cents (please account for inflation)

  7. The Giving Plague by Kaseijin · · Score: 4, Interesting

    Is this a vaccine that prevent you from getting infected with that anti-captialist altruistism?

    Hey, altruism is serious business.

  8. Teh horrors! by Yeti.SSM · · Score: 4, Funny

    Won't anybody think of the mosquitoes?

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  9. Re:Problem by Your.Master · · Score: 5, Informative

    You can eliminate it if you hit the herd immunity threshold: http://en.wikipedia.org/wiki/Herd_immunity

    That requirement is essentially the same as for regular vaccines.

    As for risking mosquitoes evolving to smell the poisonous blood -- isn't that a best-case scenario? Where the immunity to spreading the disease is converted to an immunity to getting the disease because the vectors avoid the innoculated.

    The worst-case scenario basically leaves us back at square one with no loss and only a temporary gain.

  10. I hope it can be mixed in food by iamacat · · Score: 3, Interesting

    Typically there are many more animal than human hosts, since the former usually do not go to hospitals or use cloth/house/DEET to protect themselves from mosquitos. So your altruism will likely protect a chimp or an antelope rather than another human. But mass vaccination of wildlife through baits dispersed from planes can really make a difference.

  11. YIDRC by maccallr · · Score: 5, Informative
    From http://www.grandchallenges.org/Explorations/Pages/Introduction.aspx

    Initial grants of $100,000 are awarded two times a year. Successful projects have the opportunity to receive a follow-on grant of $1 million or more.

  12. More on "altruistic vaccination" by Eukariote · · Score: 3, Informative

    Watch the following video to learn more about the "altruistic vaccination" that the Gates Foundation is engaged in: http://www.youtube.com/watch?v=d7_xfUV4kSo

  13. Re:Why a 100K would be needed from Bill to fund th by DNS-and-BIND · · Score: 5, Informative

    "I am for doing good to the poor, but I differ in opinion of the means. I think the best way of doing good to the poor, is not making them easy in poverty, but leading or driving them out of it. In my youth I traveled much, and I observed in different countries, that the more public provisions were made for the poor, the less they provided for themselves, and of course became poorer. And, on the contrary, the less was done for them, the more they did for themselves, and became richer."
    -- Benjamin Franklin, On the Price of Corn and Management of the Poor, November 1766

    --
    Shutting down free speech with violence isn't fighting fascism. It IS fascism!
  14. Re:Isn't this what governor huey did.. by msimm · · Score: 3, Funny

    I'd rather they made my blood poisonous to lawyers.

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    Quack, quack.
  15. Re:Isn't this what governor huey did.. by perryizgr8 · · Score: 3, Funny

    but lawyers don't suck people's bloo...wait!

    --
    Wealth is the gift that keeps on giving.
  16. Re:Repercussions? by Thiez · · Score: 3, Informative

    > In the more immediate, what does this do to your liver?

    Well I guess that is what the research is for, right?

    > Longer term, what impact might this have on other insect populations?

    Well, since mosquitos can also feed on animals, most of them will never come in contact with the poison. I don't know how this will affect their natural predators (eating multiple poisoned mosquitos might have a negative effect on them, depending on the poison), but I assume they will investigate that too before they start handing out the stuff to everyone everywhere.

    > And will this impact negatively effect human populations?

    Well I guess that is what the research is for, right?

    > This approach is dangerous.

    Maybe. If we don't research we'll never find out. The whole thing would be dangerous if we were to give this stuff to everybody before having some idea to what the answers to your questions might be. But since thas hasn't been the way to do these things in science for some decades now, your whole post seems somewhat overrated, this last bit in particular.

  17. Re:Why a 100K would be needed from Bill to fund th by Attila+Dimedici · · Score: 4, Insightful

    You do know that Ben Franklin was a self made man. He did not inherit any wealth. He left Boston and went to Philadelphia, where he built his wealth through hard work (not by exploiting connections, except for those he made on his own). So Ben Franklin didn't "live in his own world".
    A reason that the Founding Fathers get so much credit is because there was another group around the same time with similar ideas who launched a revolution and set up a government based on those ideas as well. That group didn't work out so well (it was the group behind the French Revolution). So, the Founding Fathers of the USA obviously had some insight or something that the leaders of the French Revolution didn't.

    --
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