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Virus Tamed To Attack Cancer, Cancer Drugs To Treat Alcoholism
ScienceDaily is reporting that scientists at Oxford University seem to have adapted a virus so that it attacks cancer cells but does not hurt healthy cells. "Adenovirus is a DNA virus widely used in cancer therapy but which causes hepatic disease in mice. Professor Len Seymour and colleagues found that introducing sites into the virus genome that are recognized by microRNA 122 leads to hepatic degradation of important viral mRNA, thereby diminishing the virus' ability to adversely affect the liver, while maintaining its ability to replicate in and kill tumor cells." Relatedly, cancer drugs already approved for use may be cross-functional as a treatment for alcohol addiction. "Now, the researchers show that flies and mice treated with erlotinib also grow more sensitive to alcohol. What's more, rats given the cancer-fighting drug spontaneously consumed less alcohol when it was freely available to them. Their taste for another rewarding beverage -- sugar water -- was unaffected."
Rats given the cancer-fighting drug spontaneously consumed less alcohol when it was freely available to them
I didn't know that rats "spontaneously" consume alcohol when it is freely available to them.
In any virus intended for therapeutic use in humans, allowing the virus to retain its reproductive mechanisms is just a bad idea. Viruses mutate rapidly and there's no guarantee that such a modified virus might not develop the right signals to enter and reproduce in healthy human cells. More promising efforts using engineered viruses involve the isolated production of viral structural RNA and coat proteins without the complete genome ever being copied or reproduced. This creates viral smart-particles that can be re-engineered to deliver payloads (therapeutics, contrast agents, nanoparticles etc) into targeted cell species. Nanovector is a recent start-up out of NC State University to commercialize this tech developed at a lab I used to work in as an undergrad.
"Their taste for another rewarding beverage -- sugar water -- was unaffected."
research sponsored by coke?
Well, the human body is already full of bacteria and other helpful microbes without which it wouldn't be able to survive.
We're not just "persons" we're mobile ecosystems.
Although it may sound creepy at first, if you rationally think it through a virus that "makes you better" is not such a bad idea after all.
Oh, I almost forgot, we are all injected with weakened viruses at some point of our lives so that our immune system will be able to form the right antibodies to defend itself when the real thing comes along.
Think of it like that...
So viruses can cure cancer.
Well what about all those cancer drugs we have already? They'll just sit on the shelves!
No no, we can use them to treat alcoholism.
But what about all the booze!? Pour it down the drain?
No, of course not. We're going to re-brand alcoholic beverages as medication. We're investigating is usefulness in treating social anxiety. While our trials are still in progress, the initial data looks very promising. We've also patented a time-release delivery system. With any hope, we'll have millions of people prescribed daily doses of the new wonder drug.
Excellent!
Chemists do it with moles.
Along the same lines as I Am Legend, there was that whole John Titor thing back in 2000 where the guy writing it said stuff about using viruses to attack cancer. Yay internet culture to science.
For the cancer patient could be an improvement over other alternatives.
But if you play with living things there, things that try to survive replicating, mutating, and in the case of virus, finding more hosts.
Of course, getting rid of that particular virus could be easier than getting rid of cancer, and that is something more to put into consideration.
Because we all know that movie script writers always do their homework to get their science right and never ever engage in simple-minded fearmongering.
By "alternative medical folk" do you mean quacks, or were you just misrepresenting their positions? Cancer as host cells gone awry (possibly due to an initial external influence, with the external influence not necessary for continued growth) is incontrovertible. If certain anti-fungals work on them, it's because it happens to work as an anti-cancer drug, it doesn't mean the cancer is fungus.
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Most of what we call alcoholism has been cured. The problem is that anybody who might tell alcoholics about it is either financially or emotionally invested in an existing treatment. It's like religion (see responses to this post as demonstration), and it's very frustrating.
For all the details, see the recently published book on the topic. I'm not selling the book, and if you want the details for free, I can provide you with that, too.
Wake up - the future is arriving faster than you think.
I never knew alcoholism was a big problem for mice. Nice to know we've developed a treatment. Some of Mickey's behavior was getting kinda embarrassing...
"Convictions are more dangerous enemies of truth than lies."
If I were a rat with cancer, I'd probably be drunk all the time too. Then when another rat sneezed on me and transmitted the cure like it was a cold, I imagine I wouldn't be motivated to drink so much. In fact, I'd really clean up my act trying to woo that other rat who sneezed and saved my life.
Ahh, yes. A tyrosine kinase inhibitor can play a role in alcoholism. But wait, cancer cells have tyrosine kinases, too!
I've found the connection between cancer and alcoholism: they both occur in human beings.
Although it may sound creepy at first, if you rationally think it through a virus that "makes you better" is not such a bad idea after all.
Tell that to the Xenu's loyal psychiatrists, who did something similar 70 million years ago. Oh wait, you can't; because their "happy virus", while being immediately very effective, eventually mutated and then drove every humanoid in the entire galaxy into a deep depression, ultimately causing them all to jump off the nearest bridge.
Monkeys and apes, being not completely similar to humanoids, managed to survive the 'viruscost', and they grew fat on the decaying corpses of the prior-day humans. The apes multiplied, and so now we're simply an evolution of their apish bodies, inhabited by the confused, and virus ridden thetans of yore. This is a Bad Idea.
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