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Ginkgo Doesn't Improve Memory Or Cognitive Skills

JumperCable writes "Ginkgo biloba has failed — again — to live up to its reputation for boosting memory and brain function. Just over a year after a study showed that the herb doesn't prevent dementia and Alzheimer's disease, a new study from the same team of researchers has found no evidence that ginkgo reduces the normal cognitive decline that comes with aging. In the new study, the largest of its kind to date, DeKosky and his colleagues followed more than 3,000 people between the ages of 72 and 96 for an average of six years. Half of the participants took two 120-milligram capsules of ginkgo a day during the study period, and the other half took a placebo. The people who took ginkgo showed no differences in attention, memory, and other cognitive measures compared to those who took the placebo, according to the study, which was published in this week's Journal of the American Medical Association."

59 of 403 comments (clear)

  1. That's just Western prejudice by For+a+Free+Internet · · Score: 5, Funny

    These euro-centric "scientists" can't see pas their narrow-minded blinders to tap into the millenia of cultural experience embodied in Eastern medical and spiritual traditions. The point is, Gingko Baloba has a very potent effect when added to the labels of alternative medical products, causing them to fly off the shelves in exchange for cash. Western medicine is just jealous and probably racist and sexist against peoples like me.

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    1. Re:That's just Western prejudice by Hatta · · Score: 5, Funny

      Sounds like they should do some tests on this "placebo" stuff to see what makes it as good as ginkgo.

      --
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    2. Re:That's just Western prejudice by Phreakiture · · Score: 4, Interesting

      I know you're joking, but I actually would have thought it really cool if they had a second control group who took nothing, just to see if there is a psychosomatic element in play.

      --
      www.wavefront-av.com
    3. Re:That's just Western prejudice by lorenlal · · Score: 2, Insightful

      I read this a while back, and it's been noted that placebos are becoming even more effective... so the manufacturers are making even more potent ones.

    4. Re:That's just Western prejudice by natehoy · · Score: 2, Insightful

      Actually, if they wanted to check psychosomatic elements, the ideal would be to have subgroups who "know" what they are taking, but lie to some of them. So you have a group that "knows" they are taking the real thing (some of them actually are, some of them are taking the placebo), and a group that "knows" they are taking the placebo (some are, some aren't). Arrange it so the people appear to have learned accidentally about their faked status, so they feel certain they know the truth.

      If a significant percentage of those who "know" they are taking a placebo get a real benefit from the drug anyway, then you've probably eliminated psychosomatic bias and have a winner.

      Especially if that exceeds the number who "know" they are taking the real drug but are actually taking a placebo, because you've demonstrated that the real benefits of the drug are better than the placebo effect can even generate. :)

      --
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    5. Re:That's just Western prejudice by nasch · · Score: 2, Funny

      I think you should probably just get a new sarcasm detector. Yours may be beyond repair.

    6. Re:That's just Western prejudice by sdpuppy · · Score: 2, Funny
      Yeah yeah.

      But the problem with Ginko (and stuff like it) is that the people who really need it

      forget to take it

      Thank you, I'll be here all day.

      Now what were we talking about? (dang)

    7. Re:That's just Western prejudice by tgatliff · · Score: 2, Interesting

      Tests like these are flawed from the beginning, and I am sure that these scientists know this. The trick that is always played by supplement manufactures are to set the dosages much lower than what is required to reduce side effects. Meaning, for any "drug" to work, there will always be side effects.

      For Ginko, the effective dosage is around 600mg per day, and I can tell you from years of experience that it works quite well at this dosage. There are many side effects in some people at this dosage, however. Also, it is a very powerful blood thinner as well, however, so this side effect can be quite dangerous for some people as well. None of this is a problem at 120mg, however, which is why it showed no improvement.

    8. Re:That's just Western prejudice by TheCarp · · Score: 2, Interesting

      Another thing is, we shouldn't expect it to be able to do anything.

      If I give you a sugar pill and tell you it will cause tachycardia (and, if needed explain what that means), and give it to people, I would expect a significant number to report racing hearts. However, you can feel your heart, so there is a feedback loop, and its beat can be effected by mood, thought etc. (to some degree even consciously controlled)

      However, if I say it "increases blood flow in your calf"... I might expect you to report strange sensations in your calf... but I wouldn't really expect to see actual increased blood flow there (as opposed to anywhere else from heart rate changes).

      How needed are placebos on tests that look at physical things like, tumor size? I have yet to find any credible link between believing that your tumor will shrink and having it happen.

      On the other hand, memory and cognitive skills can be effected by mood and psychological process. So I think the placebo makes sense to rule out cognitive differences based on differences in your actions based on the belief that the pill might be helping.

      --
      "I opened my eyes, and everything went dark again"
    9. Re:That's just Western prejudice by Bigjeff5 · · Score: 3, Insightful

      The placebo effect is the same as the occasional cancer patient that goes into remission when the best medical science said there was no way to survive. It definitely exists, and there is no good explanation for it. It's like a belief that you will recover, or in the case of placebos that some drug will improve whatever function, triggers something in your body to put out a little extra effort, and it is sometimes enough to turn the tide.

      For simple things like a memory test, just believing you have a better chance of doing well allows you to do better than you would ordinarily. If you don't think it works, then it probably won't.

      You've got to remember that even cognitive processes rely on physical bodily functions - mood depends on more of one type of chemical firing off than another, so even things like a placebo anti-depressant effect is changing the physical responses in your brain. It's quite impressive, when you think about it.

      --
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    10. Re:That's just Western prejudice by Bigjeff5 · · Score: 2, Insightful

      The second portion of that is unneccessary, because if the drug really works the people who take the placebo will see less of an improvement than the ones taking the drug. There isn't any need to over-complicate it.

      If the placebo and the drug both have identical effects, then the drug is actually a placebo also.

      --
      Security is mostly a superstition... Avoiding danger is no safer in the long run than outright exposure. - Helen Keller
    11. Re:That's just Western prejudice by Bigjeff5 · · Score: 4, Insightful

      If the Ginko was doing anything, it should have shown a slight improvement over the placebo even at 120mg. If the results come back essentially the same, then it is obviously not the Ginko improving memory.

      The placebo effect is powerful on its own, and had they used another control group who took nothing you probably would have seen the Ginko and placebo groups both averaging better scores than the control group. That doesn't mean the Ginko itself actually does anything.

      Even assuming you are right that Ginko will have literally no affect whatsoever until the dosage is above a certain level (which I find ridiculous, btw), if it is unsafe to use at its effective dosage, what's the point?

      --
      Security is mostly a superstition... Avoiding danger is no safer in the long run than outright exposure. - Helen Keller
    12. Re:That's just Western prejudice by Machtyn · · Score: 2, Insightful

      This sounds like an episode of House.

  2. Ginko has a different effect on me by Green+Light · · Score: 2, Interesting

    I have noticed that when I take it, I am more "motivated". I get up out of my chair and do stuff, rather than surf, say, slashdot.

    --
    "Send an Instant Karma to me" - Yes
    1. Re:Ginko has a different effect on me by sakdoctor · · Score: 5, Insightful

      People say the same about crystal meth

    2. Re:Ginko has a different effect on me by Abcd1234 · · Score: 4, Informative

      Well, that or you just assume that's the effect it will have on you, and so you behave accordingly.

      But, hey, who am I to argue with a placebo effect that works for you?

    3. Re:Ginko has a different effect on me by Aladrin · · Score: 2, Funny

      It's true, but it's harder to get motivated enough to exercise. It's fairly easy to get motivated enough to take a pill.

      Maybe he should take the pill to get motivated to exercise...

      --
      "If you make people think they're thinking, they'll love you; But if you really make them think, they'll hate you." - DM
    4. Re:Ginko has a different effect on me by Synn · · Score: 4, Funny

      I just can't get up the energy to take a pill every day. Do you think they could make a pill that makes me motivated to take pills?

    5. Re:Ginko has a different effect on me by bearsinthesea · · Score: 3, Insightful
      Really? So it works for 30 year olds, probably? Are there any, say, facts you are basing this conclusion on? Any reasoning?

      Your post seems to say that drugs that work on younger people generally don't work on older people, or people with health problems. Can you give some other examples of this general rule? Maybe some other scientific studies?

    6. Re:Ginko has a different effect on me by Aladrin · · Score: 3, Funny

      I think that your father's boot is used for that. It's an anal suppository.

      --
      "If you make people think they're thinking, they'll love you; But if you really make them think, they'll hate you." - DM
    7. Re:Ginko has a different effect on me by un1xl0ser · · Score: 2, Funny

      in fact, forget the motivation ...

      --
      v4sw6PU$hw6ln6pr4F$ck 4/6$ma3+6u7LNS$w2m4l7U$i2e4+7en6a2X h
  3. Medical conspiracy! by vvaduva · · Score: 5, Funny

    Yes but was it ORGANIC Kinkgo?? That is the question! This test was obviously conducted by real doctors who don't want us to know the truth about the power of eating weeds that grow in exotic jungles.

    1. Re:Medical conspiracy! by Jason+Levine · · Score: 5, Funny

      No, first you need to grow the Ginko organically. Then you need to increase the potency by diluting it homeopathically. Next, you form it into an ear candle. Once you do that, the the Loch Ness monster and Bigfoot will contact the aliens from Vega 7 who will beam increased memory skills and ESP into you. But if any of this is attempted by "Western medicine", it will all fail.

      --
      My sci-fi novel, Ghost Thief, is now available from Amazon.com.
    2. Re:Medical conspiracy! by The+Flymaster · · Score: 3, Interesting

      Well, not to speak for ginko or non-science, but it's not like eating weeds that grow in exotic jungles hasn't helped save a life or two.

    3. Re:Medical conspiracy! by cain · · Score: 3, Insightful

      I know you're making a joke, but ginko is far from exotic and nor is it a weed (it's a tree). It is widely grown in cities as it is very hardy. If you live in NYC, you see them all over the place and come fall can't help but smell the foul odor of the pods as they fall to the ground and are crushed underfoot.

      http://www.efloras.org/florataxon.aspx?flora_id=1&taxon_id=200005235
      http://en.wikipedia.org/wiki/Ginkgo_Biloba
      &c, &c

    4. Re:Medical conspiracy! by MBGMorden · · Score: 2, Funny

      I concur. They also need to make sure that they're using ALL NATURAL ginkgo.

      I find it comical that the "ALL NATURAL" movement has any weight behind it when countless varieties of "all natural" plants are quite poisonous, whilst tons of completely chemically derived artificial medicines will save your life.

      Heck I literally remember one stupid infomercial that was on a while back where the guy (one of those typical hyped up dorks who always appears on such shows) was proclaiming that we shouldn't eat anything that had something with a "chemical sounding name" in the ingredients list. I wonder how they'd feel about sodium chloride or dihydrogen monoxide.

      --
      "People who think they know everything are very annoying to those of us who do."-Mark Twain
    5. Re:Medical conspiracy! by Dan+Ost · · Score: 2, Insightful

      This whole herbs thing doesn't make any sense to me.

      People eat "herbs" because they think some chemical in the "herb" offers some medicinal benefit. If that chemical can be extracted (or synthesized) in a more pure form and put in a pill, then why would you eat the plant instead? The plant might have the chemical you want, but it also has lots of other (possibly harmful) stuff in it that the pill is free of. Also, with the pill, you know how much of the active ingredient you're getting. There's no way to know how much you're really getting if you eat your "herb".

      If the chemical can't be extracted or isolated, that probably means that the medicinal benefit is really the placebo effect. Another possibility is that a chemical was found, but rigorous testing indicated significant side-effects.

      --

      *sigh* back to work...
    6. Re:Medical conspiracy! by vvaduva · · Score: 2, Insightful

      That's the problem with crowds listening to someone like that on TV. They will say "we only eat natural stuff." My response is: mercury occurs naturally, so why don't eat it? Or why are you opposed to smoking "natural" tobacco? There are many things that occur naturally that will kill you or harm you.

      It's madness out there. People go insane over the Bovine Growth Hormone (BVH) but they don't understand that it's produced naturally in the cow's pituitary gland. We could go on forever with ridiculous examples like this. They don't listen. In fact, they call people like you and I uninformed!

    7. Re:Medical conspiracy! by hey! · · Score: 2, Insightful

      Seriously, you have *no* idea what you're getting when you buy a "nutritional supplement".

      Let's suppose there is some clinical evidence for a supplement's effectiveness. If you buy it in "herbal" form, it might not contain the same parts of the plant that were studied. If you buy the compound, you might not get the same enantiomer studied.

      In fact, in the United States you might not be getting what the label says at all. There was a study cited in Science News a few years back which showed that "dietary supplements" often contained *none* of the headline ingredients, and often had ingredient that weren't listed. I've had this problem with herbal *tea*; I once drank a cup of chamomile tea and had an unmistakable pseudophed reaction -- probably due to contamination with ephedra.

      Next year, the FDA will put into effect rules that will require supplement labels to be accurate and for the supplement not to be contaminated with other substances. Believe it or not, this is the first time the FDA has had a policy of enforcing those things. It's no wonder that research support for supplement claims is wanting. Even if the supplement has value, if they are using commercial supplements who knows what they are giving the test subjects. In fact, I'd say it's probably ethically questionable to conduct human research with commercial supplements, until the FDA gets its act together.

      --
      Post may contain irony: discontinue use if experiencing mood swings, nausea or elevated blood pressure.
    8. Re:Medical conspiracy! by SoupIsGoodFood_42 · · Score: 2, Insightful

      Because people might not know which things they need to extract. Cannabis is a good example. Most people focus on THC, yet there are many other similar chemicals that have not been studied to the same extend THC has. In other words, the whole idea of taking plants with benefits and exacting the single chemical that makes them useful to us, then putting it into a pill, may be a waste of time in some cases. Not to mention the complex chemical processes that take place inside a plant that don't happen inside a capsules of extracted plant matter.

      As for knowing how much herb you are getting, you can take samples, then you just need some good scales and a bit of maths. This problem has more to do with personal practices and the black market than any problems with plants vs. extracted pills.

  4. "Americans spent $107 million on it" by sakdoctor · · Score: 2, Funny

    Holy shit, that's a lot of placebo.
    But just wait until I convince everyone to eat my lawn. I'll be rich!

    Oh wait ... http://www.hollandandbarrett.com/pages/product_detail.asp?pid=138

  5. Actually works to their advantage by jarocho · · Score: 5, Funny

    I bet the herbal supplements industry is hoping its customers will forget all about this report eventually... :)

    1. Re:Actually works to their advantage by thetoadwarrior · · Score: 2, Informative

      They don't need to. Herbal health people are like religious extremists, any sort of logic won't get absorbed by their brain.

    2. Re:Actually works to their advantage by mcgrew · · Score: 5, Interesting

      On the other hand, St. John's Wort has been proven as effective at treating depression as Paxil. So you can't lump all the herbals together. Just because Ginko doesn't work doesn't mean no herbs work.

    3. Re:Actually works to their advantage by Chris+Daniel · · Score: 4, Interesting

      Yes, St. John's Wort is effective. However, you should always consult with your doctor before taking it, as it can interfere with other drugs (specifically, I have read that it prevents or retards the mechanism of absorbing drugs into the bloodstream).

      However, do keep in mind that the effectiveness of a single herbal medicine does not change the effectiveness of other herbal medicines.

      --
      Don't blame me -- I voted for Roslin.
    4. Re:Actually works to their advantage by Joe+Snipe · · Score: 2, Funny

      any sort of logic won't get absorbed by their brain.

      Prolly because they don't take enough Ginko Biloba...

      --
      Sometimes, life itself is sarcasm...
    5. Re:Actually works to their advantage by Onymous+Coward · · Score: 2, Insightful

      I'm an advocate of herbal remedies. Well, the ones that work. Plants can be pretty potent, and to think otherwise is shockingly naive. Not every herb is going to be a cure-all, but there's a gamut of plants that effectively address an array of health problems. Or recreational desires.

      Over-reliance on synthetics created by for-profit organizations is itself basically a disease. If, say, your first choice for addressing depression is an SSRI prescription, you've been infected by advertising.

    6. Re:Actually works to their advantage by TubeSteak · · Score: 4, Insightful

      You could consider this as evidence that depression is overdiagnosed and a prognosis of "light-moderate" depression is most likely bullshit.

      I don't see how this is insightful.
      It's like saying that since a band-aid can't staunch a bullet wound, that trauma is overdiagnosed and a prognosis of "paper-cut" is most likely bullshit. /. has a cadre of people who seem to deny/downplay the existence of mental disorders.
      They contribute nothing to the discussion other than to shit on decades of medical science.

      --
      [Fuck Beta]
      o0t!
    7. Re:Actually works to their advantage by fbjon · · Score: 2, Informative

      Here's two that show what St. John's Wort is about. First, not effective for major depression, but significantly better than placebo for mild depression. Comparisons seem harder to find, I can't access the ones I find on Google scholar.

      --
      True confidence comes not from realising you are as good as your peers, but that your peers are as bad as you are.
    8. Re:Actually works to their advantage by Dan+Ost · · Score: 3, Insightful

      What herbal remedies do you recommend?

      Why do you believe that these remedies are effective?

      How do these remedies compare to the drugs that target the same complaints in both cost and effectiveness?

      What qualifies you to be making medicinal recommendations to others? Do you have relevant training?

      Over-reliance on synthetics created by for-profit organizations is itself basically a disease. If, say, your first choice for addressing depression is an SSRI prescription, you've been infected by advertising.

      What would your first choice be for treating depression? And what, exactly, is your decision based on?

      --

      *sigh* back to work...
  6. memory no... blood flow very much so by McNihil · · Score: 3, Informative

    Aspirin or Ginko?

    http://www.umm.edu/altmed/articles/ginkgo-biloba-000247.htm

    Better concentration (some subjects thinking that that is one of the memory functions) could be a side effect of them not having headaches due to hypertension. Sample set yadi yada and so on.... statistics and damned lies.

  7. Untested drug found useless... wonders never cease by jeffmeden · · Score: 3, Insightful

    Or perhaps it's best put, wonders often never materialize in the first place. Is anyone really surprised that something sold with a big "these claims have not been evaluated by the FDA" on the bottle has, in fact, been found to do nothing close to the claim?

    Hopefully herbal viagra is next, and some day spammers will be emailing about things people actually can use...*

    *(warning the claims in this post have not been evaluated by the FDA)

  8. Back to the real thang by oldhack · · Score: 2, Funny

    Smoke and coffee.

    --
    Fuck systemd. Fuck Redhat. Fuck Soylent, too. Wait, scratch the last one.
  9. Re:So what exactly then... by nschubach · · Score: 3, Insightful

    The same thing that the color black is good for. Selling stuff to people.

    --
    Every time I start to have faith in humanity, I ruin it by driving to work between 7 and 8 am.
  10. Re:Untested drug found useless... wonders never ce by fuzzyfuzzyfungus · · Score: 5, Informative

    The "These claims have not been evaluated by the FDA" and its close friend "This product is not intended to diagnose, treat, cure, or prevent any disease." are generally a signal that the product is sold as a "dietary supplement" or "nutritional supplement".

    Thanks to DSHEA, the FDA legally can't do jack about it unless they have direct evidence of a given product causing serious harm(and their budget for going on epidemiological expeditions for that sort of thing isn't much to write home about).

    Whether you consider this a shining beacon of freedom, or an ignoble nest of quacks, it seems likely to remain so for the foreseeable future.

  11. Interesting fact by static416 · · Score: 5, Insightful

    You know what they call alternative medicine that works?.... Medicine.

  12. Supplements industry group replies with BS by noidentity · · Score: 5, Informative
    I love the bullshit reply from the supplements industry group:

    A supplements industry group, Council for Responsible Nutrition, said other studies suggest the herbal supplement can be effective in improving cognitive function.

    "In an area where there are few other safe, affordable options, I would hate to see this study send the wrong message to consumers," Douglas MacKay, CRN vice president said in an email. "I would continue to recommend Ginkgo biloba to older adults as a safe, effective option for supporting cognitive health."

    Cue the "but it worked in my case" replies...

  13. Re:So what exactly then... by fuzzyfuzzyfungus · · Score: 4, Funny

    Ginkgo Balboa is clinically proven to improve your boxing skills...

  14. Re:You know what else it's good for though, right? by BarryJacobsen · · Score: 3, Funny

    "Our bear makes other people more beautiful to you"

    Is that a Care Bear, or what kind of bear, exactly?

  15. Re:So what exactly then... by SecurityGuy · · Score: 2

    Made me lol @work. Wish I had mod points. :)

  16. regardless of its medicinal value by circletimessquare · · Score: 2, Interesting

    the ginkgo tree itself is pretty amazing: its the coelacanth of trees

    known only from the ancient fossil record, having aspects of a missing link between major plant classifications, and with no other living relatives by a long shot (at least from the perspective of western science). until isolated specimens were located, to western expert's amazed awe, in 1690. it was cultivated in the east, and this probably led to its survival, since the only populations anyone can consider wild are only in a tiny mountain reserve in eastern china... but even this group of trees might only exist because it was tended by monks for millenia, ironically for this story, probably because of medicinal value

    in other words, the coelacanth of trees may only continue to exist in this world due to the efforts of ancient man, the inverse relationship between extinction and mankind. either way, if you've ever looked at a ginkgo leaf, you can readily appreciate how ancient and alien the plant is. its like a tiny fan, a completely unique morphology unlike any other leaf you have ever seen on any other plant

    Ginkgo (Ginkgo biloba; in Chinese and Japanese , pinyin romanization: yín xìng, Hepburn romanization: ich or ginnan), also spelled gingko, also known as the Maidenhair Tree after Adiantum, is a unique species of tree with no close living relatives. The ginkgo is classified in its own division, the Ginkgophyta, comprising the single class Ginkgoopsida, order Ginkgoales, family Ginkgoaceae, genus Ginkgo and is the only extant species within this group. It is one of the best-known examples of a living fossil, because Ginkgoales other than G. biloba are not known from the fossil record after the Pliocene.[1][3]
    For centuries it was thought to be extinct in the wild, but is now known to grow in at least two small areas in Zhejiang province in Eastern China, in the Tian Mu Shan Reserve. However, recent studies indicate high genetic uniformity among ginkgo trees from these areas, arguing against a natural origin of these populations and suggesting that the ginkgo trees in these areas may have been planted and preserved by Chinese monks over a period of about 1000 years.[4] Whether native ginkgo populations still exist has not been demonstrated unequivocally.
    The relationship of Ginkgo to other plant groups remains uncertain. It has been placed loosely in the divisions Spermatophyta and Pinophyta, but no consensus has been reached. Since Ginkgo seeds are not protected by an ovary wall, it can morphologically be considered a gymnosperm. The apricot-like structures produced by female ginkgo trees are technically not fruits, but are seeds that have a shell that consists of a soft and fleshy section (the sarcotesta), and a hard section (the sclerotesta).

    http://en.wikipedia.org/wiki/Ginkgo_biloba

    --
    intellectual property law is philosophically incoherent. it is your moral duty to ignore it or sabotage it
  17. Disclosures: Dr DeKosky Gets Big Pharma Money by Ron+Bennett · · Score: 3, Insightful

    Financial Disclosures: ... Dr DeKosky reports receiving grants or research support from Elan, Myriad, Neurochem, and GlaxoSmithKline and serving on the advisory boards of or consulting for AstraZeneca, Abbott, Baxter, Daichi, Eisai, Forest, Genentech, GlaxoSmithKline, Lilly, Medivation, Merck, NeuroPharma, Neuroptix, Pfizer, Myriad, and Servier. No other disclosures were reported.

    Not to say the results of this particular study are necessarily bogus, but sure makes one wonder.

    Big pharma dislikes "natural", as in often unpatentable, treatments; discourages their use.

    Ron

  18. Re:No surprise because of the dosage by jeffmeden · · Score: 4, Insightful

    Never mind then that Vitamin C (arguably an 'unrefined plant material') has the odd effect of making you *not get scurvy and die* as a result of a daily dosage of around 100mg.

    Relatively small doses of simple things can affect you in lots of interesting ways. Look at medication that treats thyroid disorders; it's a simple material (although it doesn't grow on trees) dosed out in *micrograms*, the slightest variation of which (less than 15 micrograms for some people, myself included) your body WILL feel the difference of.

    Most things, sure, your body sends in one end and it comes out the other relatively unchanged. Certain things, though, are profoundly influential.

  19. Re:So what exactly then... by machine321 · · Score: 2, Funny

    That sounds racist to me.

  20. 120 milligrams isn't enough for any effect by foniksonik · · Score: 2, Informative

    Herbal supplement's are not concentrated like pharmaceuticals are.... 120 mg a day won't get you anything. Take 120 mg a day of most herbs that have active drug compounds and you're likely to get no more than a trace of that drug, whereas pharmaceuticals take the active compound and synthesize it - then give you 120 mg of the concentrated compound.

    As a laugh, you could take 120 mg of marijuana - even good stuff... and smoke it. That's maybe 1/4 of a joint (you'd get about 2 joints out of a gram of weed if you were conservative). How high are you going to get on 1/4 of a joint? Not very... and THC is a fairly potent compound. Gingko is not nearly as potent.

    --
    A fool throws a stone into a well and a thousand sages can not remove it.
  21. Re:Untested drug found useless... wonders never ce by fuzzyfuzzyfungus · · Score: 2, Informative

    Interestingly, Zicam snuck in under a different loophole. Zicam was 10% Zinc Gluconate, which turns out to be pretty bloody high for intranasal use(check out what it did in animal tests). However, since Zinc Gluconate is one of the substances included in the "Homeopathic Pharmacopeia of the United States" (a collection of homeopathic "remedies" put together according to this procedure) and since 10% is equivalent to the "1D" homeopathic dilution, Zicam could be regulated and sold as a homeopathic drug rather than a conventional drug.

    Unlike "dietary supplements", homeopathic remedies are recognized as drugs under the Federal Food, Drug, and Cosmetic Act(in Section 201(g). However, unlike ordinary drugs, they are subject only to production and labeling standards, not safety or efficacy tests, and are almost always nonprescription. Normally, this isn't a big deal, because most homeopathic drugs are so diluted that the contain(on average) 0 molecules of the active ingredient, and are prepared using harmless dilutants. Zicam was unusual in that, while it arguably fell under the definition of "homeopathic", and was sold as such, it was well within the range for biological activity.

  22. Re:So what exactly then... by jollyreaper · · Score: 4, Funny

    Ginkgo Balboa is clinically proven to improve your boxing skills...

    And Ginko Bilboa is clinically proven to get you there and back again.

    --
    Kwisatz Haderach
    Sell the spice to CHOAM
    This Mahdi took Shaddam's Throne
  23. Re:No surprise because of the dosage by steelfood · · Score: 3, Insightful

    As somebody else above has said, plant extracts are not a concentrated source of anything. Which means you're probably better off comparing the effects of 120mg of freshly squeezed orange juice on scurvy than 100mg of vitamin C.

    No doubt, you are correct. Very small dosages of certain vitamins and minerals can affect the body greatly. But very small dosages of naturally-occurring, unpurified, untreated, otherwise minimally processed things probably don't.

    --
    "If a nation expects to be ignorant and free in a state of civilization, it expects what never was and never will be."
  24. can't buy me love by Onymous+Coward · · Score: 2, Interesting

    What herbal remedies do you recommend?

    My drug recommendations all come with the serious urging that you research deeply on your own. That includes my recommendations for plant-derived or synthetic, brand-name drugs. Do you think gobbling down Tagamet and aspirin, just because you can buy them off the drug store shelf, without an understanding of drug metabolization is a good idea?

    For difficulty sleeping or resetting a sleep schedule, for antioxidant effect, plant-derived melatonin. As such a fundamental neurochemical, you'll want to be careful about your usage. A specific effect to be wary of is immunomodulation.

    Kavalactones present in the Kava plant are anxiolytics — they have anti-anxiety effects. They work on GABA receptors, similarly to alcohol, but don't have the same stupefying effects. If using the raw plant, do not take leaves and stems, only the root, macerated in water, per the traditional use. As with all drugs, take in moderation.

    For mental stimulation and performance, caffeine from green tea (or coffee). Also theobromine from cacao. Also cinnamon scent (go ahead, look it up). And again Kava. Flaxseed meal (alpha-linolenic acid, which converts to EPA and DHA — omega-3s), walnuts, etc.

    For bronchodilation, theophylline from cacao.

    For anti-emetic (nausea/vomiting, including motion sickness), ginger (active ingredient zingiberene). Perhaps marijuana.

    For mood, theobromine from cacao, kavalactones from Kava, plant-derived melatonin, caffeine. Plant-derived 5-HTP (beware interactions with MAOIs and SSRIs). I'd suggest looking into St. John's Wort, but I haven't delved deeply into it myself except to note that it's a drug metabolization inhibitor, and so requires special care regarding interaction. The first thing to do with poor mood is not to begin applying drugs anyway, plant-based or synthetic.

    For energy level, caffeine from green tea or elsewhere, theobromine (cacao), cocaine (coca).

    For anti-inflammation, depending on severity, curcumin (turmeric), eugenol (cloves), and zingiberene (ginger), bromelain (pineapple), papain (papaya), alpha-linolenic acid (flaxseeds), cinnamon. Maybe

    For digestion, ginger, pineapple, papaya.

    Surely that's a big enough list that you can find something wrong in it. I know you're looking for chinks in armor.

    Why do you believe that these remedies are effective?

    Reading. Broad-spectrum data factoring (e.g., including absence of certain kinds of information) anchored mostly by published studies (with an appropriate eye towards credibility). You? (Seriously. How do you know about your own choices?)

    How do these remedies compare to the drugs that target the same complaints in both cost and effectiveness?

    Well, gee, which ones? How about the anti-inflammatories... NSAIDs have an issue with promoting GI irritation and stomach bleeding. If you've got ulcers already, IBD or Crohn's or Coeliac Disease, NSAIDs will be pretty hard on you. On the other hand, the degree of inflammation present in autoimmune disorders is probably not the right scenario for trying to address solely with eugenol/zingiberene/curcumin. But back on the gripping hand, adding these to your diet can only help.

    Side-effects and come-down from SSRIs are pretty gnarly, especially in the suicide cases. Make sure not to miss your doses.

    Green tea can be pretty expensive, I admit. But, whatever. Ginger, turmeric, cloves... not that expensive and serve dual purpose as freakin' spices. Kava's pretty pricey, I have to say, but I quite like it. If anyone knows a good source of quality root, please chime in. I expect whole root to be less expensive than capsule or tincture preparations.

    What qualifies you to be making medicinal recommendations to others? Do you have relevant training?

    Do you have the relevant training as a consumer