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Organ Damage In Rats From Monsanto GMO Corn
jenningsthecat writes "A study published in December 2009 in the International Journal of Biological Sciences found that three varieties of Monsanto genetically-modified corn caused damage to the liver, kidneys, and other organs of rats. One of the corn varieties was designed to tolerate broad-spectrum herbicides, (so-called 'Roundup-ready' corn), while the other two contain bacteria-derived proteins that have insecticide properties. The study made use of Monsanto's own raw data. Quoting from the study's 'Conclusions' section: 'Our analysis highlights that the kidneys and liver as particularly important on which to focus such research as there was a clear negative impact on the function of these organs in rats consuming GM maize varieties for just 90 days.' Given the very high prevalence of corn in processed foods, this could be a real ticking time bomb. And with food manufacturers not being required by law to declare GMO content, I think I'll do my best to avoid corn altogether. Pass the puffed rice and pour me a glass of fizzy water!"
If it's going to damage my liver, I'm switching to scotch. I'm sorry, Jack, but I just can't take the chance...
what's most disturbing about this is forbes magazine just named monsanto company of the year.
When you recognize love in another and realize how precious it is, everything else seems so insignificant.
Monsanto did the research in 2000 and 2001, and obviously knew the outcome. So how did they manage to suppress the data and results for 8 years?
John
The invisible hand of the free market made the data and research invisible.
You are welcome on my lawn.
From their conclusions:
This can be due to the new pesticides (herbicide or insecticide) present specifically in each type of GM maize, although unintended metabolic effects due to the mutagenic properties of the GM transformation process cannot be excluded. All three GM maize varieties contain a distinctly different pesticide residue associated with their particular GM event (glyphosate and AMPA in NK 603, modified Cry1Ab in MON 810, modified Cry3Bb1 in MON 863). These substances have never before been an integral part of the human or animal diet and therefore their health consequences for those who consume them, especially over long time periods are currently unknown
It sounds to me like the issue isn't the GM itself, but the over-use of novel pesticides that it permits.
No kidding!!! What do you say at this point?
I think the majority of "high prevalence of corn in processed foods" is HFCS - does this contain significant fractions of the proteins involved.
Not that I think HFCS is a health food. I'm so glad that Iowa corn lobby influence can't reach over here to the UK.
I have no idea.
All you "free market" enthusiasts out there, answer this question for me:
How would the unencumbered "free market" handle a problem like this? Especially since none of us who eat corn are actually direct customers of Monsanto's GM corn?
Tell us how getting government out of business is going to prevent a little thing like people dying from organ failure for eating Monsanto's frankencorn?
You are welcome on my lawn.
There may be others, but those spring to mind...
Monsanto did the research in 2000 and 2001, and obviously knew the outcome.
You can't say "and obviously knew the outcome" unless you're Monsanto. I believe that GMO crops undergo far fewer tests for safety than pesticides. From the Wikipedia page on one of the three crops in question (MON 863):
In 1989 a 90-day rat-feeding trial done by the FDA, 40 rats that were fed the Bt corn developed multiple reactions typically found in response to allergies, infections, toxins and diseases. Gilles-Eric Seralini reviewed the study as part of the French Commission for Biomolecular Genetics and said that the response by the rats were similar to reactions caused by pesticides. Although the Bt-toxin is a pesticide, he points out that animal research on pesticide-producing corn is nowhere as thorough as that required for approval of pesticides. Follow-up studies on these serious findings were demanded from organisations worldwide. None were conducted and the corn was approved.
MON 863 is even approved for use in the EU which is surprising considering the long history of European countries denying crops imported from other countries like the US where GMO crops are allowed on the off chance that said crops were cross pollinated with GMO plants in other fields. Very recently I believe Germany banned cultivation of GMO plants. If you want your data don't look toward Monsanto or even the underfunded FDA. Look to the European Union, I hope more studies follow in the path of this research but unfortunately it's hard to think of a source for major funding if it's not our tax dollars.
My work here is dung.
as a scientist, it has two things I dislike listed on its webpage... 1. In a prominent position its "unofficial IMPACT FACTOR" ... ugh.
2. In a prominent position its "UNOFFICIAL impact factor" ... well, if TR/ISI can't find it important enough to tabulate (assuming this is what unofficial indicates), why should we care :(
in fact, this is the first time I have heard of the journal ... if the work is more widely useful, we not publish in a more widely-read journal?
You have a food that kills rats. How can you possibly get angry about a food that kills rats? I mean, do you know how many people are starving because rats eat the food? This is absolutely a great thing.
This is my sig.
You know what? I don't believe this research is right. It may be correct and we're gonna learn of an interesting mechanism whereby this implementation actually allows a protein to avoid the digestive system and make it's way straight into the bloodstream. That would really be cool. But from what I know of the mechanisms of digestion and what types of molecules get through the whole process, I just don't believe this conclusion is correct. I suspect that it's bogus or a statistical fluke. As I said, there may be something here but my first inclination is to suspect something is wrong. Research has shown many mutually exclusive things to be "true" and so one has to have a mechanism that throws up a "bogus flag". This article does.
So I'm gonna call bogus for now.
During the 19th century the issue was contaminated food produced by the new breed of large processed food manufacturers: in the early 20th it was the meat packing industry. Now it's Monsanto. In the first two cases it turned out industry was unfit to regulate itself, and bribery of Government officials was rife. But nowadays we regard processed food manufacturers as mostly benign (well, except for the junk food industry), and nobody worries about tinned meat. Regulation in the end was good for the industry. Monsanto needs to stop pissing on anyone who suggests it isn't perfect, and start to come clean. It would be in its long term benefit.
From scarped cliff or quarried stone she cries "A thousand types are gone, I care for nothing, no not one."
OK, I haven't read the paper in detail, but my initial impression is that, if academic researchers have found evidence that GM food damages your health, why haven't they put it in a really major journal--Nature, Science, PNAS, or something like PlosONE if the whole publication really had to be open access? I've got a degree in biology, and this is the first time I've ever come across the 'International Journal of Biological Sciences'.
Glancing at their results table, it doesn't seem clear cut overall. E.g. there are cases where rats fed 11% GM corn show a response, but rats fed 33% GM corn don't, cases where male rats are apparently affected, but not females, and vice versa. They also don't name the maize they used as a control, so we don't know how accurate it is.
All in all, it looks like they did a rather unconvincing study that prominent journals weren't prepared to accept, so they stuck it out there in this way. That doesn't mean it's wrong, but take it with a pinch of salt.
It doesn't look like the 'impact factor' relates to anything. Its in the header whether you're looking at an article or their contact information. No explanation there.
This note on the front page: This Journal is ranked among the top 2.1% of journals (29/1380) according to SCImago in the area of Agricultural and Biological Sciences ...details
Indexed/covered by MEDLINE, PubMed, Science Citation Index (SCI) Expanded, Current Contents®/Life Sciences, EMBASE, CAS, CABI, Scopus
Plus there isn't much anti-GM crapvertising elsewhere on the website. I'm normally among the first to call bs, but this could very well be the ideal journal for the paper as it seems specifically dedicated to issues in the biological/agricultural sciences.
Anyone familiar with the journal or practices in submitting in the field?
The study shows no organ damage. This is a lie by the esteemed Slashdot editor.
The study shows slight changes in some parameters which could be signs of damage. It could also not be. Eating sausages will give you different kidney readings from eating chicken, yet neither sausages nor chicken has been banned. Correspondingly the study says these are "signs of toxicity and not proof of toxicity". I would have expected KDawsons "organ damage" to imply that organ damage had been found.
Some data seems surprising - there is a significant effect for female rats consuming 11% Monsanto corn, but not male rats or female rats consuming 33%?
Although I agree that multiple year teasts should be performed, and organ damage checked for. Though it would be extremely surprising if this has not already been done by anyone.
Of course, since I write this I must be paid by Monsanto or just be evil, since all good-thinking progressives would never question criticism of an evil megacorp like Monsanto.
This is exactly right. The reason GMO corn exists and is widespread is that the gov't has incentivized corn production so much that it is practical to grow huge fields of it. This crop monoculture results in the excessive need of pesticides, hence the requirement of "Roundup-ready" crops in the first place.
but WTF Monsanto, FDA. This is bad for EVERYBODY. Especially considering Americans eat more corn than anyone on Earth, ever(except maybe the Hopi).
This is why you can't let lobbying continue as is. I don't think this out-and-out corruption through bribery, but I'd bet my bottom dollar Monsanto spent a lot of money wispering into ears that GMO posed no health risk and was a forgone conclusion. Hell, they didn't even need to check their own data, what could possibly go wrong? Besides that's the FDA's job right? Meanwhile the FDA hears all about how Monsanto wouldn't let any GMO through that would hurt their consumers. Of course they know the technology better, and their own analysis should be thorough enough to allow for FDA approval.
I'll take a Department of Redundancy Department that does its goddamn job over a regulatory body that doesn't.
I don't know enough about toxicity studies to analyze this too closely but then as I read it, there is some "fishy" stuff going on.. First off, though - these researchers did not set up these studies. They used lawyers to get data from some of these companies or something like that- it's kind of vague. I have NEVER seen a study where you report like you did the research but you actually didn't. You are just trying to take the numbers and draw your own conclusion.
They say in one part: "The most fundamental point to bear in mind from the outset is that a sample size of 10 for biochemical parameters measured two times in 90 days is largely insufficient to ensure an acceptable degree of power to the statistical analysis performed and presented by Monsanto. " They say that because they think Monsanto shouldn't say the corn is safe - but then they (these researchers) are using that same "Insufficient" data to say it's unsafe. That's the way this whole paper is- it just doesn't jive together.
They also note that the control corn fed the rats in these studies was not similar enough to the GM variety to be good controls.
OK - then why are they using these data at all - why not do their OWN study???!!! I"ll tell you why - because they found a way to skew this data for their own purposes. How can you pick apart an experimental design and then use that data and say YOUR conclusions are valid. This is insulting and I still do not believe this can be a legitimate journal (although I can't find much on it online).
Correct, GM is truly a wonderful thing. But I do wonder if spot checks on produce wouldn't be advisable. Processed foods get spot checked, perhaps produce should as well. You can get a DNA sequencer on ebay for two grand now. Grabbing the sequence that produces abrin, or ricin from the rosary pea or castor bean respectively, and putting it in a couple corn plants, is within the ability of an undergrad certainly. The lab procedures are published out there, I saw them on the kindle store even. Corn is wind pollinated, so planting a few modified malcious plants upwind of a field could be really nasty. It is only going to get easier to do, and restricting the technology is the wrong way to try and prevent it. Spot checks of produce for common pathogens and dangerous chemicals would add to the price of food, so I wouldn't suggest they be mandatory. Might work kind of like an organic stamp, "Non-deadly GM" or somesuch.
refactor the law, its bloated, confusing and unmaintainable.
They do it through lawsuits. They are a very litigious company as they sue their own customers for failing to disclose harvest data and seed information. Since they patended certain varieties of soybeans and corn, you cannot keep seed from one year to the next. Also, a neighboring farmer who has his own non-Monstanto crops contaminated by Monstanto crops are also being sued and asked to prove themselves innocent.
It's a travesty. I am not opposed to GM foods by any means, but this company's approach to solving problems with their products is completely unreasonable. A class-action suit seems to be the only answer.
Wait...so the president's actions in 2009 is responsible for information remaining hidden from 2000 through 2008? For crying out loud, he didn't even make US Senate until 2004. But yes, I suppose the corruption of a member of the Illionois Senate has its reach all the way down into the state of Missouri (where Monsanto is based). Or maybe Obama has a time machine.
Are you sure about that? I'm not a farmer, and I don't know anyone who has had anything to do with Monsanto corn, but I wouldn't be surprised if there was a contract that you need to sign before buying Monsanto GM corn.
If the GMO corn has been bred for high sugar, as we know that's the main focus, then the rats more than likely consumed more calories which I would expect to have a detrimental effect on most systems in the body. From the study: We note that these unrelated, different non-GM maize types were not shown to be substantially equivalent to the GMOs. The quantity of some sugars, ions, salts, and pesticide residues, do in fact differ from line to line, for example in the non-GM reference groups. This not only introduced unnecessary sources of variability but also increased considerably the number of rats fed a normal non-GM diet (320) compared to the GM-fed groups (80) per transformation event, which considerably unbalances the experimental design. A group consisting of the same number of animals fed a mixture of these test diets would have been a better and more appropriate control.
Yes. We need less "government regulation". That way anyone that feels that they have been wronged by Monsanto can just form a nice lynch mob and start hanging senior executives.
A Pirate and a Puritan look the same on a balance sheet.
They want to own food and the IPs for any GMOs they make and them force them into countries an markets. While i usually try to avoid hype documentaries, I do recommend watching "Food, Inc." as a starting insight into the evil of Monsanto (as well as the meat industry) - maybe biased but still a GOOD watch. The find a French documentary (usually it is subtitled or dubbed) called "The World According to Monsanto" for more details on the companies practices. Remember, before food, they created Agent Orange (as well as all the other "rainbow" Agent herbicides). Because of these shows, I have tried to buy my food from local source, and try to buy (unsuccessfully) in season (when i do buy out of season, I try Whole Foods, dunno if they are THAT better, but the one in Tulsa is good) - all my meat comes from a local butcher now and local livestock feed in conventional ways.
Yes you can, you actually have to put forth effort.
Dont buy products with it in it. My lettuce and fresh veggies dont have it, my meat does not have it, The flour I bake with does not have it.
It means switching from Insta-fake-food they sell in a box to actually getting off your butt and cooking.
Your general health will increase nearly 3 fold if you do.
Do not look at laser with remaining good eye.
You are actually claiming that the US government is small and toothless.....
Unbelievable.....
Remember when you ask the big government to do what you want, that may be great for you, until they start doing what you don't want.
Nothing that Monsanto does comes as a surprise to anyone who has seen "Food, Inc.". http://www.imdb.com/title/tt1286537/
the problem with GMO crops is that they can't be contained. a farmer doesn't have to plant monsanto's corn or soy beans for them to start growing in their fields.
and to anyone who says "i will just avoid eating corn and corn products".... good luck. almost every product in the grocery store either contains corn or ate corn.
stephen
GM is an accelerated version of what happens in nature.
No it's not. It's the artificial manipulation of a genotype to get a desired trait by means that are not very well understood but that mostly work although their consequences are not very well grasped.
We need it to feed our billions.
No we don't. Crop rotation and the use of better seeds works much better and with far less pesticides and other toxic chemicals, notably in emerging markets.
However, a certain company won't get as rich if we go that way...
May contain traces of nut.
Made from the freshest electrons.
If you actually read the journal article, all you will find is a LOT of criticism of Monsanto's statistical methodology (which may be valid), but very little (if any) of any actual evidence of toxicity.
Basically , they claim (which may be correct): Monsanto didn't do their studies properly! They should've used more rats, for longer, and with more measured parameters !
And THEN they turn around and claim... even though the study is statistically unsound (according to their own argument), we're going to draw some conclusions that are weak to begin with, even within the weak frame of this supposedly faulty study !
It just doesn't make much sense.... from a professional scientists' standpoint (mine), this amounts to a lot of hemming and hawing about experimental methods, but absolutely nothing in the way of conclusions !
My concern, which doesn't appear to have been raised yet, is this shit blows around in the wind and cross-breeds with non-GMO corn. I'm guessing nobody has any idea how badly this has happened yet. This stuff could be ending up in our food, making the most important and second largest cash crop (after marijuana) in the US poisonous to consumers. I wonder why that doesn't sit well with me.
No, it's not. With selective breeding you can never go outside of the scope of the accumulation of genetical variety available in the species your breeding with. You cannot breed dogs that produce poisonous bites by just interbreeding different type of dogs, the genetical material needed to be able to allow for a poisonous bite just isn't there. Theoretically dogs could in the long run, through spontaneous genetical mutation acquire such features, but that's outside the scope of breeding of dogs.
If you would start genetically modifying dogs with genetical material alien to dogs, say poisonous snakes, you actually could produce such poisonous dogs, given enough perseverence and research. Genetically modifying creatures is in essence engineering, working from the specfications of features of the creature up to a design. Selective Breeding is bricolage, using whatever is at hand to meet a goal that's changing along with the process.
Selective breeding is not the same thing as modern genetic modification. Mendel wasn't putting bacterial genes into corn. We've had thousands of years of testing selective breeding. We have had a decade or so of testing bacteria protein laced corn and other genetically modified foods. See the difference? The damn hippies were right: we should have tested this stuff more.
- None can love freedom heartily, but good men; the rest love not freedom, but license. -- John Milton
I've seen this a lot on this site (unfortunately). Luddite is tossed around as a swear word to ridicule those who don't understand or see any benefits of modern tech. The opposite exists but we don't have a single word for it, people who automatically trust any new tech to be safe, without any evidence that it is safe, other than the inventor's and corporation's word for it. There's a word used that is close, but doesn't specify "as regards newer tech", that is a "pollyanna". We really need a new word for those who blindly "trust" but never "verify" all new high tech advances.
This issue with some of the GM corn mods has been known for years now, and dismissed by the big business sycophants/pollyannas. The largest misconception I have seen is equating *cross species modification* with naturally occurring or man made same species hybrids. These get equated all the freaking time by alleged tech savvy people as the excuse to just "trust". The "tech pollyannas" knee jerk automatically trust, based on a starting point of falsehood belief. It's just as loony and stupid as being a luddite based on erroneous or even zero knowledge of the subject.
I am a farmer and I will say I do NOT trust corporate big ag business (nor ag college academia that relies on the same big business for funding and has tame scientists in and out of the same big business) to be self regulating as to safety concerns nor do I trust the governmental regulators because of the revolving door "jobs" aspect that occur. (exactly the same as occurs with Wall Street/Federal Reserve/Treasury/SEC revolving door jobs). There's WAY too much money involved for there not to be corruption. Just human nature. Just because some person has many letters next to their name, or some official government title, is not any guarantee they are trustworthy as to being non corrupt or "bought off". They are just as likely or not as likely as anyone else, and as the currency units involved go up in number..we should take closer and closer looks as to this trust and verify business.
It would be nice to trust the system, but I can't the way it is set up now.
Here's an interesting video on this food subject, on how much trust we should place in huge global ag business and regulations as they exist now.
http://video.google.com/videoplay?docid=6262083407501596844
Look at software code. A chunk can be written, looked at, have other people look at it, vetted..few months later they missed something and there is an 0-day.
Well, that can be patched.
Can't say the same thing for food stuff once it is planted all over. Won't be any patches once it is out in the wild and air pollination starts spreading it. We are already seeing some of the first minor examples with canola/rapeseed "superweeds". Just wait until there are major examples.
It isn't a matter of if, it is a matter of when. There will be a hugemongous "whoops..heh heh heh, guess we missed that" excuse mumbling major screwup, by guys in black suits and white lab coats at some news conference, with the global food supply. This corn might be it, who knows, but it is coming.
"Selective breeding is nothing but a very slow primitive form of genetic engineering."
The "very slow" part is what completely differentiates selective breeding and natural evolutionary processes from genetic engineering. All of the genetic differences you see in something like dogs occurred very gradually, and with some degree of harmony with the ecosystem. Introducing these GMOs is basically bypassing thousands of years of evolution, and going off on a tangent that would have a minuscule probability of ever occurring, even through selective breeding. I think that's a very important distinction when we're talking about the potential health and environmental impacts of these things.
Hmm did you hear the rest of the story on that one ?
They refused "free" gm crops seed and food, worked hand in hand with ONU to alleviate the food crisis and started sowing "normal" traditionnal seeds that were acclimated to their country.
And now they have almost reached food production independence.
Can you remind me what happened to the neighboring countries that accepted ?
They actually sowed some of the grains and now pay the "Monsanto Tax"...and even if short term they solved the problem, they now are in a problematic situation for years (possibly decades) to come.
Have a look at a documentary called "the world according to Monsanto" and what happened to some south american countries that are now paying millions, if not billions to Monsanto each year. Also have a look at Indian (like in India) cotton farmers and their suicide rates since they switched to GM cotton. One of the worst human tragedy of the decade, because they had to buy fertiliser and RoundUp, got more heavilly in debt and commited suicide when they couldn't repay it all.
And I'm not even a green activist. I just despise the bastards from Monsanto...
It takes 40+ muscles to frown, but only four to extend your arm and bitchslap the motherfucker
I dont eat dog, so I am not worried about any genetic modifications made to those.
The big problem with GM technology is not the actual technology - it is how it is being used.
I would have no problem eating GM foods if they were only modified to add say, additional vitamins, grow with salter water, or endure harsher environments, but the problem is they are making changes that do things like add pesticides into the food its self, or enable much higher levels of herbicides and insecticides to be used on crops without killing the plants (eg, "round up ready" strains)- so there are many more toxins actually in the food, or used on the food we eat.
The other big evil with GM crops is that it promotes monocultures, which puts all your eggs in one basket geneticalyl speaking - if there is then something that badly affects that strain of crops, it can have a devestating effect as entire harvests can be wiped out due to there being no natural bio diversity which would otherwise have allowed some plants to survive.
On top of that, the way that GM crops are licensed, so that often they are engineered to only produce a single generation from the seeds and can not breed true is just a disaster waiting to happen.
One good and relatively safe use of gene technology would be to use it to precisely Analise the natural variations produced by crossbreeding several different strains of the same type of crop, then selecting those that had the ideal characteristics.
we need to start cracking down on inappropriate genetic modifications to our food, and only allow modifications that enhance the flavour or health benefits of the food, or make it able to grow in harsher climates or with less water - not introduce genes which produce toxins or are designed to enable use of much higher concentrations of poisons.
There is - you have to sign a technology agreement.
In addition, if you don't buy Monsanto corn, you are likely to be investigated. If your field is even partially pollinated by Roundup Ready® corn, and it's probably a virtual certainty by now, they'll set the lawyers on you. Since Monsanto can afford more lawyers than you, and your farm is likely to represent your family livelihood, most people cave in and settle out of court rather than lose their family inheritance. And I'm willing to bet that some of them start buying Monsanto just to avoid it happening again... maybe it even gets written into the settlements.
That's right, Monsanto now makes money out of farmers for NOT buying Monsanto products. The best thing for them about this business model is that it spreads itself - literally, with pollen - across national borders, regardless of consent or trade agreement.
Usually pointy haired bosses are mid level though. These big decisions are made by the muckety mucks at the top.
I think that if it can be proved that research studies were obfuscated to hide the negative, or fudged..purely for economic gain, or that an official regulator used their authority position to further that shady goal, that it should be treated as a crime against humanity, like attempted genocide, along those levels. As in major criminal felony, not some white collar BS civil matter where they might get some joke fine either.
There are normal accidental mistakes, then there are deliberate decisions made to go ahead and issue some governmental stamp of approval and then produce and sell something that they know has questionable and dangerous traits. The latter non accidental occurrence should be a serious criminal violation. And repeated occurrences within the same corporation should result in a corporate death sentence, disallowal of corporate charter, declaring all outstanding stock to be worthless and untradeable. If they can do it to poor people with normal crimes, "three strikes" laws, they should apply the same thing to corporations. Three major criminal foulups-out ya go, dissolved, physical plant and other assets seized and auctioned off.
"Maximizing shareholder value" should not be the only criteria for allowing corporate charters. Just screw that and that mindset and belief. I like what the original design had, corporations had to prove to be of the public benefit to retain their charters. Now it is..they can do anything crooked sleazy or illegal they want and if they can afford to eat the fines if they are caught..they keep doing it. Nuts. Whack a few dozen of the top infringers down. Shareholders would *finally* get the message that they better be watching over their employees conduct a little better, that there's no such thing as a free lunch, and with profits come duties and responsibilities.
And with that, we need some whistleblower protections with big sharp teeth in them. It's still a joke and lower level employees in government and business are still afraid of getting the word out on malfeasance and unethical or illegal behavior they are aware of. That should just not be.