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The Future of the Most Important Human Brain

mattnyc99 writes "About a year ago, we watched live as neuroanatomist Jacopo Annese sliced the brain of Memento-style patient Henry Molaison (aka H.M.) into 2,401 pieces. Since even before then, writer Luke Dittrich — whose grandfather happened to be the surgeon to accidentally slice open the H.M. skull in the first place — has been tracking Annese and a new revolution in brain science. From the article in Esquire: 'If Korbinian Brodmann created the mind's Rand McNally, Jacopo Annese is creating its Google Maps. ... With his Brain Observatory, Annese is setting out to create not the world's largest but the world's most useful collection of brains. ... For the first time, we'll be able to meaningfully and easily compare large numbers of brains, perhaps finally understanding why one brain might be less empathetic or better at calculus or likelier to develop Alzheimer's than another. The Brain Observatory promises to revolutionize our understanding of how these three-pound hunks of tissue inside our skulls do what they do, which means, of course, that it promises to revolutionize our understanding of ourselves.'"

252 comments

  1. An odd approach... by Rival · · Score: 3, Interesting

    While I have no wish to demean their efforts, this approach still seems somewhat brutal to me. I'm no neurologist, but isn't this still a rather macro-level view of things, with the cutting process still causing damage to the fine structures they want to study?

    It seems likely to me that future scientists will look back at this in not too long with stifled laugher and perhaps a little shock at the approach.

    1. Re:An odd approach... by Raenex · · Score: 3, Insightful

      There are lots of ways to image and study the brain. This is just one more. Sure, in a hypothetical future they might be able to scan it down to the finest detail, but for now we do what we can.

    2. Re:An odd approach... by fuzzyfuzzyfungus · · Score: 5, Insightful

      It almost certainly is disrupting fine structures or details of network connections that future neurologists might want to study; but I suspect that this is one of those situations where they don't really have a choice.

      The brain is extremely complex, and nondestructive imaging methods are either expensive, low-resolution, or both. Good old slice-n-stain, with a dash of modern robotics, is cheap and high resolution.

      Since we know so little about how brains actually work, it isn't a bad idea to just build a giant dataset, using an economic and high-resolution technique, and hope that that dataset allows future researchers to pinpoint more closely what they should actually be looking for.

      Given that the supply of brains donated to science, while not huge, can be reasonably expected to continue into the indefinite future, starting with destructive; but quick, reverse engineering steps, and then gradually progressing down to finer, more focused ones, seems pretty sensible.

      A lot of the brains thus sliced will, it is true, be destroyed as far as the researchers of the future are concerned; but slicing them may be the only way to get the researchers of the future to a position of sufficient knowledge.

    3. Re:An odd approach... by TapeCutter · · Score: 4, Funny

      Or as Douglas Adams put it - "If you try and take a cat apart to see how it works, the first thing you have on your hands is a non-working cat."

      --
      And did you exchange a walk on part in the war for a lead role in a cage? - Pink Floyd.
    4. Re:An odd approach... by DerekLyons · · Score: 2, Insightful

      While I have no wish to demean their efforts, this approach still seems somewhat brutal to me. I'm no neurologist, but isn't this still a rather macro-level view of things, with the cutting process still causing damage to the fine structures they want to study?

      Do you have a better way? Seriously, it's not like they haven't spent the better part of a century working out the sectioning techniques and steadily improving them.
       

      It seems likely to me that future scientists will look back at this in not too long with stifled laugher and perhaps a little shock at the approach.

      The same way we react in shock to those who operated without anesthesia. Or laugh at the Greeks who tried to cure tuberculosis with leeches and a poultice of wine must and sea urchin gonads. (I don't know if they did exactly that, but it's typical of the medicine of the era.) They didn't have a better way, neither do we. We do the best we can with what we know.

    5. Re:An odd approach... by interkin3tic · · Score: 5, Informative

      but isn't this still a rather macro-level view of things, with the cutting process still causing damage to the fine structures they want to study?

      No, the cryostat is designed to preserve things down to the subcellular level. Had they just cut it up with a scalpel, yeah, that would not preserve much. Fixing it with, say, paraformaldehyde, then freezing it and sectioning it, the sections do okay if you're skilled at it. You can see down to the neuron level.

      It seems likely to me that future scientists will look back at this in not too long with stifled laugher and perhaps a little shock at the approach.

      I personally am always astounded at what past scientists were able to accomplish with the tools at hand. Ramon Y Cajal, the "father of neuroscience" had primitive microscopes and a method of staining cells that sounds exhausting, but described the brain in astonishing detail. I personally doubt I could have accomplished what he did with the tools we have now. Unless future scientists are idiots, they'll likely realize that these are the best tools we have now.

    6. Re:An odd approach... by h4rr4r · · Score: 1

      The same way we react in shock to those who operated without anesthesia.

      Are we so sure anyone ever did this on a regular basis?

      I ask because we have made alcohol for a long time, and known of plants that would have anesthetic applications possibly even longer.

    7. Re:An odd approach... by mcgrew · · Score: 1

      My brain doesn't seem to be working well (I had a few beers). I thought I'd read everything he wrote, what's that from?

    8. Re:An odd approach... by sznupi · · Score: 3, Funny

      As opposed to working cat before? What's that?

      (/me looks around...yup, the beast sleeps; on the coffer this time)

      --
      One that hath name thou can not otter
    9. Re:An odd approach... by hairyfeet · · Score: 1, Informative

      My grandmother often told stories told to her by her grandfather who was in the Civil war, and yes, in the field hospitals it was pretty much "Hold him down, and get sawing" kind of deal. She said the weapons they used on the soldiers at the time also helped to crank up the barbarism, with soldiers often loading chains, nails, and anything else they could find into cannons when they ran out of shells. Sure we already knew about anesthesia, but good luck finding any in a muddy field hospital in the middle of TN with a battle going on. Troops and doctors on both sides simply didn't realize it was gonna be such a hideous war, believing it would be a "gentlemen's conflict" like the revolutionary war.

      --
      ACs don't waste your time replying, your posts are never seen by me.
    10. Re:An odd approach... by Anonymous Coward · · Score: 1, Informative

      My brain doesn't seem to be working well (I had a few beers). I thought I'd read everything he wrote, what's that from?

      It's from a speech he gave at a conference which hasn't actually been published anywhere, but was captured on tape, and Richard Dawkins quoted it in his eulogy.

    11. Re:An odd approach... by Whomp-Ass · · Score: 2, Interesting

      The major problem is that at the point of death (or at least, brain-death) is that the dendrites of the neurons detach from the axons of the surrounding neurons at about a rate that is the square of the of the difference over time of the inverse of temperature loss...meaning, by the time you slice-and-dice, the important bit (that is, the bits, rather...the connections and pathways that make you...well, you...are gone).

    12. Re:An odd approach... by Anonymous Coward · · Score: 0

      My brain doesn't seem to be working well (I had a few beers). I thought I'd read everything he wrote, what's that from?

      if I recall correctly, The Salmon of Doubt: Hitchhiking the Galaxy One Last Time.

    13. Re:An odd approach... by Anonymous Coward · · Score: 0

      It's from an excellent speech he gave, found here.

    14. Re:An odd approach... by Sulphur · · Score: 2, Funny

      Much later: A physician was asked what course not in Med School contributed most to his career.

      Carpentry.

    15. Re:An odd approach... by CrimsonAvenger · · Score: 3, Informative

      She said the weapons they used on the soldiers at the time also helped to crank up the barbarism, with soldiers often loading chains, nails, and anything else they could find into cannons when they ran out of shells.

      This is not so likely to be historically correct as one might suppose. Fact is, what they fired out of cannons back then wasn't loose powder and shot, but a single bag containing powder and a cannonball. In other words, if you don't have any cannonballs (not shells), then you've got no powder to shoot nails and chains.

      Sure we already knew about anesthesia, but good luck finding any in a muddy field hospital in the middle of TN with a battle going on.

      Ether was used more than you might suppose in the Civil War. At least by the Union, who could afford to make the stuff and had the wherewithal to deliver it in quantity to their armies.

      Troops and doctors on both sides simply didn't realize it was gonna be such a hideous war, believing it would be a "gentlemen's conflict" like the revolutionary war.

      Anyone who believed in 1861 that the Revolutionary War was a "gentlemen's conflict" was so deluded about history that he can be excused for thinking that the Civil War was going to be one. Alas, history doesn't agree about the nature of the Revolutionary War.

      Note, for reference, that the people who tended to think in terms of "gentelmen's war" were mostly Southern aristocrats. Most of the soldiers on both sides weren't able to kid themselves that standing on a battlefield with 30,000+ other people trying to kill you was going to be a friendly sort of affair.

      a muddy field hospital in the middle of TN with a battle going on

      Oddly enough, I had a great-great-grandfather in just such a situation. Battle of Franklin, in fact.

      --

      "I do not agree with what you say, but I will defend to the death your right to say it"
    16. Re:An odd approach... by h00manist · · Score: 0

      Nothing there to see. Whatever makes human beings tick, it is there when alive, gone when dead. You can slice and x-ray the cpu all you want, you wont figure out much about system and OS design. You need to find the right kitchen with the right lady making cookies, and the correct keymaker with the right key to the right door. I could just tell you now, but you arent ready, you wouldnt know if I were just another writer offering false cookies in a forum.

      --
      Build your own energy sources from scratch. http://otherpower.com/
    17. Re:An odd approach... by fractoid · · Score: 1

      Not a troll, IMO. I presume Rival is reading the story with an interest in understanding the fundamental functioning of the brain, and if so, the visible, physical features of the brain only tell a quarter or less of the full story, which is a complex interplay of electrical and chemical signals.

      Then again, physical features are still important for gross scale understanding of the brain's structures, especially when cross-referenced among thousands of samples. If you want to know how Alzheimers, or Parkinsons, or whatever other disease work, you could at the very least find common features between afflicted brains to suggest a direction for further research.

      --
      Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
    18. Re:An odd approach... by DerekLyons · · Score: 1

      The same way we react in shock to those who operated without anesthesia.

      Are we so sure anyone ever did this on a regular basis?

      Yes.

    19. Re:An odd approach... by ultranova · · Score: 2

      It seems likely to me that future scientists will look back at this in not too long with stifled laugher and perhaps a little shock at the approach.

      Probably. "Look at these barbarians, who didn't use tools and methods which weren't invented until later!" It's not unlike the recent story deriding Newton for being an alchemist, despite that being entirely reasonable at his time - it makes the rest of us who couldn't invent Calculus or the Laws of Motion feel better.

      It's one of the more pathetic aspects of human nature.

      --

      Forget magic. Any technology distinguishable from divine power is insufficiently advanced.

    20. Re:An odd approach... by Anonymous Coward · · Score: 0

      You've got to scribble before you can draw.

    21. Re:An odd approach... by ghmh · · Score: 1

      It appears it was referenced in his eulogy.

    22. Re:An odd approach... by uninformedLuddite · · Score: 2, Funny

      simple solution - start with a live brain and work quickly

      --
      The new right fascists are bilingual. They speak English and Bullshit.
    23. Re:An odd approach... by uninformedLuddite · · Score: 1

      What if I take it apart and no one is watching

      --
      The new right fascists are bilingual. They speak English and Bullshit.
    24. Re:An odd approach... by Veetox · · Score: 1
      In this case, "slice and stain" is appropriate, because the subject is dead tissue. I've no doubt they'll get plenty of information from it, but it's likely they won't find what they want.

      There are other useful methods for mapping the brain. MRI and PET scans can be used. (http://www.nytimes.com/2010/08/10/health/research/10spinal.html) www.nytimes.com

      Also, genechip analysis and the tried-and-true protein blot offer up a lot information. Check out the Allen Brain Atlas... (http://www.brain-map.org/)

      The mouse brain is very useful as a sort of analogy for the human brain, given the homology of genes and proteins. Of course, mice lack some of the functionality that we do, but a mouse brain can be "stopped" in vivo (using difficult techniques) or a fetal mouse brain can be dissected and its tissue actually grown live in vitro. These techniques offer even more opportunities for figuring out the nuances of different parts of the brain.

      And - no surprise - we still have a lot to learn about it.

    25. Re:An odd approach... by DanTheStone · · Score: 2, Informative

      The eulogy, or at least some references to it (like the quote), are in The Salmon of Doubt. A worthwhile read if you haven't read it.

    26. Re:An odd approach... by fuzzyfuzzyfungus · · Score: 1

      It may not have been improvised in the field; but chain, grape, and canister shot were all(at least in naval contexts) widely used and available well before the civil war. I'm not terribly familiar with the conflict; but it would be totally unsurprising if some field guns being used in an anti-infantry role were firing assorted unpleasant payloads other than solid round shot.

      Of course, even aside from the cannons, your cotemporary 5.56 FMJ (while considerably lighter, higher velocity, and much easier to reload) is pretty much mom's kiss goodnight compared to a .58 or .68 Minié ball.

      Also, of course, without antibiotics available, a fair percentage of the more elegant tissue-conserving, never mind reconstructive, surgery was basically just a civilized method of getting Gangrene and dying horribly.

      As any chef or butcher going back to the era of flint knives could demonstrate, cutting tissue quite precisely is actually really doable for a skilled tradesman. Haemostasis and infection control, on the other hand, are what kept surgery at the "chop it off and dip what's left in hot tar" stage.

    27. Re:An odd approach... by operagost · · Score: 1

      Stir-fried with scallions, perhaps? But what side dish and wine selection?

      --

      Gamingmuseum.com: Give your 3D accelerator a rest.
    28. Re:An odd approach... by Muad'Dave · · Score: 1

      ...your co[n]temporary 5.56 FMJ ... is pretty much mom's kiss goodnight compared to a .58 or .68 Minié ball.

      Had you not said FMJ I would've disagreed with you. The amount of damage done by a modern expanding bullet is considerably worse than an old-school Minie ball. The expansion and fragmentation of a modern bullet in conjunction with the hydrostatic shock caused by its very high velocity makes for some pretty horrific wounds that are next to impossible to treat.

      I'd rather be shot with a Minie than with a 5.56 hollow point. It might break an arm or leg, but it won't make hamburger out of you. At least with the Minie you can plug the hole with a finger.

      Of course such horrific lethality is a plus when hunting. Humane kills are very important in that realm; not so in warfare, it seems. Hollow points are strictly forbidden by the Geneva Convention.

      --
      Tiller's Rule: Never use a word in written form that you've only heard and never read. You will end up looking foolish.
    29. Re:An odd approach... by Joe+Snipe · · Score: 1

      Unless future scientists are idiots, they'll likely realize that these are the best tools we have now.

      i'm sure they will be using the same tools as us: Undergrads.

      --
      Sometimes, life itself is sarcasm...
    30. Re:An odd approach... by mdielmann · · Score: 1

      So what? Gain as much knowledge as you can with the tools you have, and when new tools come out, you can look for more knowledge in the areas that provoked interest when you were looking with the old tools.

      Telescopes have been around for 600 years, and we still make better telescopes, and learn new things, up to finding planets around other stars. This doesn't demean Galileo for looking at Jupiter with his pitiful telescope and determining it wasn't a star.

      --
      Sure I'm paranoid, but am I paranoid enough?
    31. Re:An odd approach... by catmistake · · Score: 1

      that's what is done... with all the new imaging data... all the new techniques... most of what we know about brain comes from accidents

    32. Re:An odd approach... by Anonymous Coward · · Score: 0

      prey in secret – secret reward
      the great prophet Isaac
      (Third Law of Motion)

    33. Re:An odd approach... by drcheap · · Score: 1

      most of what we know about brain comes from accidents

      Tons of scientific "breakthroughs" and other 8th-wonder-of-the-world type inventions were accidents.

      The moral of this story?
      Scientists need to stop being so damn careful trying to delicately slice a brain into 2400 pieces and instead bust out a SlapChop!

    34. Re:An odd approach... by treeves · · Score: 1

      Hmm, I would have thought "with fava beans and a nice chianti".

      --
      ...the future crusty old bastards are already drinking the Kool-Aid.
    35. Re:An odd approach... by interkin3tic · · Score: 1

      I may have to steal that line in the future, just fyi.

    36. Re:An odd approach... by CrimsonAvenger · · Score: 1

      It may not have been improvised in the field; but chain, grape, and canister shot were all(at least in naval contexts) widely used and available well before the civil war. I'm not terribly familiar with the conflict; but it would be totally unsurprising if some field guns being used in an anti-infantry role were firing assorted unpleasant payloads other than solid round shot.

      Grapeshot and canister were certainly use in field artillery of the time. Chainshot was an anti-rigging shot, and thus pretty much useless on a conventional battlefield - amazing how seldom you found ships' masts to shoot down at Gettysburg, for instance.

      That said, the suggestion that grapeshot and canister were especially worse than roundshot shows a common misperception of the effect of roundshot, which was horribly damaging to anyone it hit. And if done right, any individual roundshot hit far more than one person.

      --

      "I do not agree with what you say, but I will defend to the death your right to say it"
    37. Re:An odd approach... by Joe+Snipe · · Score: 1

      Plagarism is the other tool. :)

      --
      Sometimes, life itself is sarcasm...
    38. Re:An odd approach... by Anonymous Coward · · Score: 0

      I just have to chuckle and think I can do this as an Anonymous Coward. :)))

  2. Clearly this is a front organization by Anonymous Coward · · Score: 3, Funny

    Clearly this a front organization--for zombies!

    1. Re:Clearly this is a front organization by Anonymous Coward · · Score: 1, Funny

      Halloween--and zombies--are certainly on-topic this month.

      Unlike you bringing up Christmas, for Christ's sake!

      Did you take time to consider that maybe Anonymous Coward is suffering from S.A.D. -- Seasonal Affective Disorder? Hmm?

      Of course not, you insensitive clod!

  3. Fat chance by oldhack · · Score: 1

    You will pry my brain off my cold dead...

    No you won't.

    --
    Fuck systemd. Fuck Redhat. Fuck Soylent, too. Wait, scratch the last one.
  4. This is simply misguided -- don't we know better? by metrix007 · · Score: 1, Interesting

    This is as misguided as studying Einstein's brain.

    It is very unlikely that a boost in intelligence or a unique way of thinking is due to a physical brain property.

    Brains are just brains, an organ, and most are not that different -- certainly the differences are not the cause of the vast personality and thinking differences and intelligence disparities we have.

    No, someone's intelligence or outlook on the world is a combination of upbringing, willpower and education. Anyone could be as intelligent and knowledgeable as they wanted to be, if they wanted to be.

    Think bog standard PC's, that can all run different OS's on the same hardware, each with different behaviors.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  5. Thanks. by Anonymous Coward · · Score: 0

    If I were HM, I'd have probably say "Don't give me that 'contribution to science' BS." If he were alive today though, I am sure I would thank him for his contributions anyway.

    1. Re:Thanks. by endymion.nz · · Score: 1

      No, because you're unable to form new memories, you would never know for more than about 10 - 15 seconds at a time.

      --
      mediocrity rules, man
  6. Things that matter by gmuslera · · Score: 1

    For once, Slashdot has been too fast publishing an article. This one should have been released in Halloween, telling that scientists are competing with zombies in the used brains market or something similar.

    1. Re:Things that matter by PatPending · · Score: 1

      For once, Slashdot has been too fast publishing an article.

      Sssssh! The /. editors don't want anyone to know they had a premature climax.

      --
      What one fool can do, another can. (Ancient Simian Proverb)
    2. Re:Things that matter by blair1q · · Score: 1

      I don't get why suddenly this Halloween has become the Zombie Festival.

      Maybe people didn't get enough of it last Easter and couldn't wait until next Easter.

      BTW, has anyone seen anyone selling a Sexy Zombie costume? It's, uh, not for me...

    3. Re:Things that matter by shougyin · · Score: 1

      SURE it isn't!!!

      But don't worry...it's not my place to pass judgment, and I won't do that....

      FREAK!!!!

      What? I can't lie now either?

    4. Re:Things that matter by SydShamino · · Score: 1

      You might try searching for Forsaken costumes. That's the best costume I could find on a quick search.

      --
      It doesn't hurt to be nice.
    5. Re:Things that matter by pinkushun · · Score: 1

      I don't get it either but I'm loving it! It just tickles my brains.

  7. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 3, Insightful

    No, someone's intelligence or outlook on the world is a combination of upbringing, willpower and education. Anyone could be as intelligent and knowledgeable as they wanted to be, if they wanted to be.

    How young are you?
    This is one of the most naive things I have ever heard. Some folks are never going to be rocket surgeons.That might not be ok with the current everyone is a genius and everyone gets a trophy crowd but it is the truth.

  8. Re:This is simply misguided -- don't we know bette by LoudMusic · · Score: 5, Insightful

    This is so unbelievably unintelligent that if it weren't so long I might think it was a joke.

    I often resort to extreme examples when explaining the ability for variations to people who deny variations exist. So with that in mind, an extreme example of a different kind of brain would be the autistic mind. Clearly it is different. It has little to nothing to do with the way the person was raised or educated over time. It is how their brain was created. If a brain can be created to that extreme of difference why not changed in more subtle ways that allow enhanced mathematical capabilities or greater empathy.

    Just because you can't see it doesn't mean it doesn't happen or exist.

    The whole point of science and these studies is to figure these things out. To learn about the things we can't see but effect our daily lives.

    --
    No sig for you. YOU GET NO SIG!
  9. Re:This is simply misguided -- don't we know bette by jelizondo · · Score: 5, Insightful

    Sorry to disagree with you, but clearly the physical properties of the brain matter.

    Which physical properties? Well, we need to find out.

    Think about it for a while. All my life I would have given a leg and an arm to learn to play any musical instrument (went to schools for years) and could never get beyond the really easy stuff; a seven year-old child could out-play me every time. But I have a gift for analisys and abstraction, thus I'm good at writing software.

    You say upbringing, education and will-power. Well I had all three: mom was a music director who wrote music and poetry, I went to very good music schools and I yearned to be able to play music; I simply don't have the right "hardware".

    Try running Deep Blue's software in your bog standard PC, see how far it gets.

    --
    Be very, very careful what you put into that head, because you will never, ever get it out. - Cardinal Wolsey
  10. Re:This is simply misguided -- don't we know bette by MithrandirAgain · · Score: 2, Insightful

    I've often found the people that never get fantastic jobs/lives, don't care about that anyway.
    Maybe that's the sour-grape syndrome though...

  11. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 3, Informative

    Affect

  12. Not sure how useful this is by WillAffleckUW · · Score: 2, Informative

    Here at the UW we harvest thousands of brains for various medical studies, and generally freeze half of the brain and slice up the other half and stain that half with various dyes, while taking electrical and other measurements within a few hours of death.

    While an approach like this described in the article might be useful for things like Pick's Disease, it would pretty much prove useless for Alzheimer's Disease, since that is an age-appropriate measurement of tangles and neurolytic fibers.

    Things like childhood diseases or other gross abnormalities might be interesting.

    But if you want to know if you'll get Alzheimer's it has a lot more to do with the exact APOE genes you carry and your general cardiovascular health and brain injury risk factors than it does other stuff. And by the time you harvest these brains it's way too late.

    And things like Parkinson's are more about mitochondrial failure to function correctly than about general brain health - it's not just your brain, it's the rest of your body too.

    --
    -- Tigger warning: This post may contain tiggers! --
    1. Re:Not sure how useful this is by tempest69 · · Score: 1

      I'm supposing that since the HM brain has a defect in forming long term memories that it makes for a nice contrast to a normal memory forming brain. Perhaps it may provide a new minimum (floor) for amount of brain trauma required to stop memory formation. If the damage is small and neat, it may provide some clues as how memories are written.

    2. Re:Not sure how useful this is by h4rr4r · · Score: 1

      Is there a way to sign up for this?
      Does it impact organ donor status or anything else?

      It is my hope to donate whatever parts are usable for reuse and have the rest used for science. No point in wasting perfectly good meat.

    3. Re:Not sure how useful this is by WillAffleckUW · · Score: 1

      Is there a way to sign up for this?
      Does it impact organ donor status or anything else?

      For most human brain studies, they tend to want to study health over a period of time. Recruitment normally is done by each study center, and generally takes a day a year and consent for emergency harvesting when you die (since the time windows are so short), since imaging only tells us some of what we gather when we actually have the (not working any longer) brain upon death.

      --
      -- Tigger warning: This post may contain tiggers! --
    4. Re:Not sure how useful this is by h4rr4r · · Score: 1

      What a bummer, as much as I love progress reuse comes before recycle :)

    5. Re:Not sure how useful this is by dogmatixpsych · · Score: 1

      I have to disagree. I research - in vivo MRI - the brains of people with Parkinson's and those with Alzheimer's disease. There are obvious gross (above cellular level) brain differences between them and "normals". It's not all genetic or mitochondria (besides that mitochondria & PD hypothesis/theory has not been verified; I'm not saying it's wrong, it's just too early to many definitive statements). My point is that none of this is useless with AD or PD or other things like that. Macrostructure of the brain is just as important as microstructure. With H.M.'s brain they can look at all of it. Plus they have years of cognitive test data for him to try and correlate with brain structures.

  13. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 0

    I'm not young enough that you should disregard the above. Yes, some folks won't be rocket scientists(I assume that's what you meant), because they don't care.

    Anyone with that aspiration can teach themselves what they need to, go to school or get training, and do it. Especially for that type of discipline(physics/math) where prerequisite knowledge is more important than original thinking.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  14. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 1, Informative

    No, someone's intelligence or outlook on the world is a combination of upbringing, willpower and education. Anyone could be as intelligent and knowledgeable as they wanted to be, if they wanted to be.

    It has been shown than intelligence is highly heritable. Identical twins raised in different environments will almost always have nearly the same IQ. Adopted siblings have vastly different IQs.

    On the other hand, it has been shown that the rich and powerful don't have better genetics or IQs than average people. The class system and inheriting wealth is what keeps them rich, not their willpower.

    This is the typical argument of why the poor deserve to be poor because they choose to be stupid and have no willpower while the rich deserve to be rich because they choose to be smart and have a lot of willpower. The only problem is that it is completely false.

  15. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 0

    Maybe you're tone deaf or something, either way it wouldn't relate to the point I made above.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  16. Re:This is simply misguided -- don't we know bette by MithrandirAgain · · Score: 1

    I live by the Hacker Ethic: do what you love to do in life, and be passionate about it.

  17. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 2, Insightful

    You're argument has so much more authority when you use insults...

    Anyway

    I am not denying variations in brain exist. I am saying teh variations in brains are about as meaningful as variations in livers, and are not the causes for different types and levels of intelligence in people.

    Your use of an autistic mind as an analogy is interesting, but flawed. An autistic mind is a defective brain. Using my PC analogy before, an autistic mind is the equivalent of only being able to boot in single user mode.

    Sorry, but I have read a lot on this and never found anything to meaningfully support that differences in the physical brain correspond to personality or intelligence. The differences in brains influence our personality or intelligence just as much as the differences in our livers or hair.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  18. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0
  19. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    My children are very good in school, i.e. 'smart.' This was a foregone conclusion. We knew, absent damage, they would be this way before they were born. All you have to do is look at the lineage.
    We could also predict they would be individualistic, egocentric and disrespectful of authority. All you had to do was look at me...
    These predictions came true because genetics, which determine the way the brain grows or can grow, matter hugely. Look at the studies of identical twins, separated at birth, who had the same hobbies and even married similar-looking spouses.
    What genetic properties determine this? Good question. But you can breed for intelligence the same way you breed for any other trait.
    If you don't have the physical properties to be intelligent, all the studying and willpower in the world won't help. The wiring has to be there.

    Brains are just brains, an organ, and most are not that different -- certainly the differences are not the cause of the vast personality and thinking differences and intelligence disparities we have.

    You are wrong. Worse, you a provably wrong.

  20. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    I know folks who never could do such a thing, no matter how bad they wanted it. I imagine you do as well.

    These folks vary from borderline disabled to just a little slow. These traits are clearly nature not nurture as they have perfectly functional siblings.

  21. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    So now you claim differences in brains can make them defective?

    Where exactly are you drawing this line you so suddenly found?

  22. Re:This is simply misguided -- don't we know bette by Trepidity · · Score: 1

    It's odd for you to have a pro-science polemic and be using quasi-religious terminology like "how their brain was created". It's currently a very open question when exactly brains are "created", with most scientists believing it isn't at any one time. Physical brain structure changes significantly over someone's life, especially in the earlier years; it doesn't spring from the womb fully preprogrammed. Experimental interventions on other mammals (can't do that research on humans) show that environmental and stimulus differences can even induce physically different brain structures.

  23. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 2, Insightful

    Tone deafness could be the result of brain structure for all we know at this point.

  24. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Are you a republican by any chance? This sounds like the beginning of an "anybody can be rich, but only those who worked hard actually achieve it" speech.

  25. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    I agree that determining what makes people different brain-wise may not be evident on a "macro" level, i.e. how heavy it is etc. But the idea that everyone is the same except for willpower and effort seems misguided.

    If someone applied such an argument to a physical activity, say hitting a baseball, running a 40 meter dash or vertical jump, it would immediately be seen an fallacious. Physically I could have been A-Rod or T.O. if I just tried? No, I think not.

    Mentally I could have been like Einstein or Tesla if I just thought hard enough? Been Mozart if I just applied myself to music? please.

    Sure, everyone has the potential to be better, no one is using all their talents perfectly, some are using them minimally, but that doesn't mean they can do anything they set their mind to.

  26. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    I fail to see how this applies to what I said. Please feel free to elaborate.

  27. Was it Hans Delbruck's? by PatPending · · Score: 1

    Dr. Frederick Frankenstein: [to Igor] Now that brain that you gave me. Was it Hans Delbruck's?

    Igor: [pause, then] No.

    Dr. Frederick Frankenstein: Ah! Very good. Would you mind telling me whose brain I DID put in?

    Igor: Then you won't be angry?

    Dr. Frederick Frankenstein: I will NOT be angry.

    Igor: Abby Someone.

    Dr. Frederick Frankenstein: [pause, then] Abby Someone. Abby who?

    Igor: Abby Normal.

    Dr. Frederick Frankenstein: [pause, then] Abby Normal?

    Igor: I'm almost sure that was the name.

    --
    What one fool can do, another can. (Ancient Simian Proverb)
    1. Re:Was it Hans Delbruck's? by Anonymous Coward · · Score: 0

      Not "Igor". "Egor".

  28. Re:We Have Our Priorities Straight by Anonymous Coward · · Score: 0

    Brutus! Stop playing with that knife, you're making me nervous.

  29. Re:This is simply misguided -- don't we know bette by fuzzyfuzzyfungus · · Score: 1

    What magical fairyland do you think "willpower" lives in?

    Also, just parenthetically, PCs compartmentalize their differences rather aggressively, for cost reasons; but it is actually relatively simple to observe the hardware differences between PCs running different OSes: just look at the arrangement of magnetic domains on the HDD platter surfaces. Hardly easier than just booting the sucker; but 100% physical and hardware based.

  30. Re:This is simply misguided -- don't we know bette by rthille · · Score: 1

    Of course intelligence or a unique way of thinking is due to a physical brain property. What other possibility is there? Fairy dust? A "soul"? Now I agree it may be that the physical properties which remain after death and dissection aren't enough to reconstruct the physical properties important to intelligence or unique thought, there are certainly enough properties there to make the study worthwhile.

    --
    Awesome furniture, accessories and cabinetry in Santa Rosa, CA: http://humanity-home.com/
  31. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    Why can we not do this research on humans at least in a observational manner?

    By that I mean using MRIs and other non-invasive techniques compare brain structure to lifestyle, education and important events in a group of peoples lives.

  32. Re:This is simply misguided -- don't we know bette by Naturalis+Philosopho · · Score: 3, Insightful

    I was going to mod you troll, but I'll give you the benefit of the doubt that you really do believe that all brains are created equal- but in that case, and by your own argument, you must not be very motivated or lack the discipline to learn the truth of the matter. I wonder what could account for that?

  33. Re:This is simply misguided -- don't we know bette by Raenex · · Score: 0, Offtopic

    Well there are differences in people's organs. Some people can drink more than others. Some are better athletes, etc. People have different hair -- mine happens to be thin and fly-away, which annoys me.

    This idea that all people are of equal capability intellectually is just really silly. You think geniuses like Newton or Einstein didn't have something different going on in their brains besides just upbringing or education?

    Anyways, this particular brain is interesting for it's known impairments. An unfortunate slice that causes memory failure teaches us about how the brain functions. We've actually learned a lot by doing tests on people for brain surgery. More detailed information of physiology can only help.

  34. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    What?

    Let me clarify for you, since the simple is not obvious

    Brains are all physically the same, with the significance of variations being negligible.

    Sometimes brains have an error that is reproducible, and that has the same symptoms.

    There. Now, what don't you get?

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  35. Re:This is simply misguided -- don't we know bette by RockoTDF · · Score: 1

    You are a brain. Even if that brain is very influenced by the world around it, you are still a brain.

    And as a neuroscientist let me tell you, brains ARE different.

    --
    There is more to science than physics!

    www.iomalfunction.blogspot.com
  36. Re:This is simply misguided -- don't we know bette by MichaelKristopeit+10 · · Score: 0, Troll
    you have absolutely no understanding of how brains develop.

    brains are not stamped out of the same die like computer processors... THEY GROW.

    you're an idiot.

  37. Re:This is simply misguided -- don't we know bette by MithrandirAgain · · Score: 1

    I fail to understand what you fail to understand.
    Let me try that again: Some people don't really give a shit about how much money, power, knowledge or fame they get. If someone finds physics interesting, that doesn't mean they're going to become a rocket scientist, or have any desire to do so.

  38. Re:This is simply misguided -- don't we know bette by RockoTDF · · Score: 2, Insightful

    Well, if I made a few changes to some genes your brain would be about as useful as a liver. Are you trolling? Because you are basically arguing against half a century of research in the cognitive and neural sciences with no evidence.

    --
    There is more to science than physics!

    www.iomalfunction.blogspot.com
  39. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    I think you are the one who does not get it. Your two statements are contradictory.

    If variations are negligible, and an error is a variation.....

  40. Re:This is simply misguided -- don't we know bette by EdIII · · Score: 2, Funny

    But I have a gift for analisys and abstraction, thus I'm good at writing software.

    You should put those programming skills to use creating a spell checker :)

  41. Re:This is simply misguided -- don't we know bette by Bruce+Perens · · Score: 3, Informative

    This illness for which H.M. is studied is one with gross pathology that should be very visible with the method used. The study of Einstein's brain did the most important thing that a scientific experiment can do: it falsified a hypothesis. Nobody really knew that Einstein did not have gross pathology until they looked. This is not to say that the person who kept Einstein's brain in a jar on his desk for his whole life had any right to do that, but preserving the brain for the imaging tools of a later generation was a good idea.

  42. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 2, Insightful

    I made no claim that they would.

    My only claim was that some people lack the capacity to do so and that may be and most likely is a result of differences in the brain.

  43. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    It seems to be due to a part of the brain missing.

    What the people above don't seem to get is the prevalence of many types of defects is not evidence of radical possible differences in a working brain.

    A particular car will be shipped out and most will work. The ones that work all work the same. The ones with defects may be grouped into the different defects. Yet if you fix that defect, it will be just like all the other working cars.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  44. A tad overrated by RockoTDF · · Score: 2, Insightful

    HM was certainly a very important brain, but not *the* most important. There are plenty of patients out there with very similar injuries that have yielded equally (if not more) important discoveries. It is frustrating to see someone present research on medial temporal lobe damage that contradicts studies with HM and see other people be like "But HM!." They have to be reminded that six patients tested with superior methodologies to those around 30-50 years ago should come out on top. He made valuable contributions, but as a field I'd like to see memory research move on from HM.

    --
    There is more to science than physics!

    www.iomalfunction.blogspot.com
    1. Re:A tad overrated by h4rr4r · · Score: 1

      Surely this can be tested on rats.

      Make them learn stuff, damage their brains and try teaching them new stuff. Seems pretty open and shut.

    2. Re:A tad overrated by RockoTDF · · Score: 2, Interesting

      Except there are LOTS of things rats can't learn, or that we can't ask them (...which is everything since they don't speak!). Not at all open and shut.

      --
      There is more to science than physics!

      www.iomalfunction.blogspot.com
    3. Re:A tad overrated by gmuslera · · Score: 1

      Wonder how important would have been Abby's brain. All the others in the Normal family were pretty average, but he was truly special, according to his doctor Frederick F.

    4. Re:A tad overrated by Waffle+Iron · · Score: 2, Funny

      Make them learn stuff, damage their brains and try teaching them new stuff.

      My friends and I survived that very experiment back in my college days. We used the "weekly drink special" methodology.

    5. Re:A tad overrated by Anonymous Coward · · Score: 0

      Damn, it's a shame we got all civilised and enlightened; else we could use negroes, jews, and/or aborigines as test subjects....

    6. Re:A tad overrated by E+IS+mC(Square) · · Score: 1

      Other than HM, the other patient coming to my mind is Clive Wearing - here is a very insightful article by The New Yorker back in 2007 - http://www.newyorker.com/reporting/2007/09/24/070924fa_fact_sacks?currentPage=all

      Though I am not sure how much he contributed, but his case is every bit as (or more?) interesting as HM.

    7. Re:A tad overrated by geekoid · · Score: 1

      Yes, but his suggest can be, and ahs been done on rats. Also cool, is medications you can give rats to make the forget, or make them remember something that has never happened.

      Cool stuff

      --
      The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
    8. Re:A tad overrated by Sardaukar86 · · Score: 1

      Damn, it's a shame we got all civilised and enlightened; else we could use negroes, jews, and/or aborigines as test subjects....

      A crying shame for sure. Happily for you, the rest of the 'civilised and enlightened world' also dismisses the idea of using bigoted Anonymous Cowards for these experiments instead.

      --
      ..Mullah or Pope, Preacher or Poet, who was it wrote: "Give any one species too much rope and they'll fuck it up"?
  45. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    Can you provide a source showing why you believe intelligence is highly heritable? My research indicates quite the opposite....inheritance can play a part, but nurture plays more of a role than nature.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  46. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 0, Troll

    We could also predict they would be individualistic, egocentric and disrespectful of authority. All you had to do was look at me...

    And with this, you have demonstrated your complete ignorance of genetics. Well done.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  47. Re:This is simply misguided -- don't we know bette by MithrandirAgain · · Score: 1

    I made no claim that they would.

    I never said that you did. :|

    My only claim was that some people lack the capacity to do so and that may be and most likely is a result of differences in the brain.

    Yes, I agree.

  48. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    Why couldn't you be like Einstein or Telsa? Those guys were knowledgeable more than anything, and kept thinking and thinking until they found something that made sense. You will find the people who make new discoveries these days are the same, laboring away at it.

    The worst thing we did was put these guys on a pedestal of intelligence, when they were probably not that more intelligent than many people on /.

    For the record, what were the significantdifference found from studying Einsteins brain? Oh, right. None.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  49. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    So a variation that is a defect in a working brain does not indicate other traits could be the result of similar variations.

    That is some might fine hair splitting you are doing there.

  50. Re:This is simply misguided -- don't we know bette by jelizondo · · Score: 1

    I would never take the spelling nazis' fun away! I'm a civilized being -.__.-

    Now I'll know if you're English or American!

    Analysis is a word I always have trouble with, in my native language is "analisis" and I always get confused as to where the "y" goes.

    --
    Be very, very careful what you put into that head, because you will never, ever get it out. - Cardinal Wolsey
  51. SCARE TACTICS is RIGGED !! by Anonymous Coward · · Score: 0

    It's fake. Saw the mic pack on the belt-back of a "victim", the same that was on her "accomplice" mother.

    FAKE !!

  52. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    Please list your research. It seems to contradict the majority of the literature out there and would be interesting to read.

  53. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    My statements are not contradictory. You're extrapolation that the presence of defects means the presence of meaningful variations of a working model is false. That's all.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  54. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    So where do you think they got that drive/willpower if not from some physical difference or chemical one?

  55. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    Jesus Christ dude.

    How many times do you have to try and understand?

    The presence of various defects of a working model do not imply the presence of meaningful non defecting variations of a working model.

    You seem to be convinced that's the case. Care to back it up?

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  56. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 2, Interesting

    Wait, a simpler analogy.

    If you buy a new car and there is a problem with cruise control, does that mean it is correct to infer that there may be cars of the same model that have significantly better cruise control?

    That is the leap you are making, and it is not supported, either logically or with our observations.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  57. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    Agreed, completely.

    As you say though, it falsified a hypothesis -- yet people still continue down the same road. Why?

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  58. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    Do you believe that nothing causes physical changes in the brain?

    No matter the cause nature or nuture, physical changes on some level must occur. How else does memory work?

  59. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    The "the arrangement of magnetic domains on the HDD platter surfaces" is something done by the software to standard hardware, so it still goes with what I said above.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  60. Re:This is simply misguided -- don't we know bette by sznupi · · Score: 1

    Funny how that terminology, and seemingly pro-science polemic with one extremely simplistic example thrown around (how one can even think it's sensible to use "the PC" for this?), appears to be mostly just a slightly stronger than usual manifestation of certain universal "errors" in...physical structure of the brain / the workings its neural network. Things like just-world phenomenon, correspondence bias or illusory superiority (which indeed partly disappear in some disorders...or indeed even if somebody "simply doesn't care")

    --
    One that hath name thou can not otter
  61. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    nurture. not nature.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  62. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    You've been making claims this whole thread, yet have not provided a single source.

    You seem to be arguing from what you personally believe, none of which is backed by current understanding.

    I'd point you to the wiki page on the human brain, and when you have a better understanding I would be interested if you hold the same beliefs as you do currently.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  63. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    If I know that the problem is a defect with this model. Like say I sliced the cruise control wire. Like in this case.

    Do you think you could run faster than Usain Bolt if you just tried?

    Everything about you is physical you could no more want to be smarter and become smarter than you could want to be taller and become so.

  64. I wonder... by Anonymous Coward · · Score: 0

    I wonder what the brain looks like of the guy who came up with this idea......Hmmm.

  65. Re:This is simply misguided -- don't we know bette by shougyin · · Score: 1

    I agree with this (and many others from above about the same issue) that genetics play a HUGE role in defining a person’s brain and "wiring".

    I come from a H.R. Manager and a Salesman...so unfortunately I have a great ability to read people and define them into work ethics, habits, and can use that to get desired results. What does this mean? Nothing really important, only that the abilities and traits held by my parents were passed on genetically to me, and as I have passed them on to my daughter. I see qualities of me and her mother surface daily.

    I have even had instances of my father’s negative willpower come out of me for periods, so I would say that this could be passed on genetically as well. But I'm by no means any type of scientist or have any experience in this, but it's just what I've gathered.

  66. Re:This is simply misguided -- don't we know bette by mibe · · Score: 1

    You only think that because your brain is different from theirs.

  67. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Your ?????? "You're. ???????

  68. Re:This is simply misguided -- don't we know bette by mcgrew · · Score: 1

    It is very unlikely that a boost in intelligence or a unique way of thinking is due to a physical brain property.

    Huh? If not physical then what? Spiritual? Thought is just chemistry, chemistry is just physics.

    The brain is a physical object. Mine is, right now, affected by beer. Simple chemistry. Well, maybe not so simple but still chemistry.

  69. Re:This is simply misguided -- don't we know bette by the_humeister · · Score: 1

    A brain is a brain, huh? Tell that to the kid kid with trisomy 21, fragile X, or numerous other genetic disease that cause brain malformations.

  70. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1
  71. Re:We Have Our Priorities Straight by Anonymous Coward · · Score: 1, Funny

    Brutus! Stop playing with that knife, you're making me nervous.

    Fabulous technology news, Caesar! March have launched their own IDE!

  72. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    So is that a physical/structural change or chemical one?

    Humans do not operate on fairy dust and unicorn farts.

  73. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    No, it is something that is directly observable as a structural change. You could take the platter off and see it with an electron microscope. It would be about as much a structural change as you will see on a turned off PC.

  74. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    You've been making claims this whole thread, yet have not provided a single source.

    That's the pot calling the kettle a nigger.

  75. Re:This is simply misguided -- don't we know bette by mcgrew · · Score: 1

    Tell that to my oldest daughter, who had her umbilical cord wrapped around her neck when bein born and suffered brain damage as a result.

    Retardation is incurable, but ignorance is not.

  76. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Or practice at the right age. Why is there an abnormal number of "perfect pitch" incidences in Tonal Language speakers. (See the Science Monitor Article from a half decade ago.) Neural pathways are built because we create them. Grey matter is created cause our body pooped it out.

    Saying one is more important than the other is like saying a sculptor is more important than the stone they chiseled out on. Both were integral in creating a work of art, and both can be studied, but should not be taken independent of the other. (Unless you're just being foolish for the sake of argument.)

  77. Re:This is simply misguided -- don't we know bette by mcgrew · · Score: 1

    He's not a troll, just ignorant. Hopefully this thread educated him.

  78. It is being done for the heart by npuzzle · · Score: 3, Interesting

    The same applies to the dissection of other organs as well. For instance, any dissection of the heart is inherently biased towards the cutting planes defined by the dissector (source). The true arrangement of muscle fibers in the left ventricle of the heart (more precisely the existence of sheet structure) is still a subject of hot debate because of this. Obviously, one might think that by now, we should be able to just pick an organ and throw it into the best relevant imaging scanner (CT, MRI, PET, etc.). The truth is, there is still anatomical information that even state-of-the-art medical imaging modalities cannot reliably reveal.

    As an example, consider DT-MRI that measures the diffusion of water molecules along the tissue fibers in an organ. The discretization in the data is such that only the local average orientation of the diffusion of water is known at any given location. To obtain more useful anatomical information, the full fiber pathway in a region needs to be reconstructed, a task called fiber tractography. Different computational methods based on different anatomical assumptions lead to results that are often contradictory (as is the case in the heart models described in the article cited above) and since there is no ground truth (remember that the dissection is biased), we currently hit a dead-end.

    Hopefully, as more dissections (like this one) are performed and the data is made available publicly, we will eventually be able to faithfully reconcile pieces of what we observe in medical conditions, in medical scanners, and on the dissection table.

  79. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    Note the GP said gross pathology not itty bitty little difference.

    We continue down this road, because there must be something changing. How else are memories recorded?

  80. Re:This is simply misguided -- don't we know bette by cptdondo · · Score: 5, Insightful

    Anyone with that aspiration can teach themselves what they need to, go to school or get training, and do it. Especially for that type of discipline(physics/math) where prerequisite knowledge is more important than original thinking.

    You're not serious, are you?

    You mean I can train myself to have perfect pitch, like some musicians? Or to have perfect color sense, like artists? Or a deep understanding of multiple dimensions?

    That's like saying that we can all play basketball like Wilt Chamberlain, or ride a bike like Lance Armstrong.

    Each brain is drastically different, each is capable of different things. No amount of training will make my daughter an engineer like her brother in spite of her nearly perfect math skills. No amount of training will give my son the empathy to deal with animals like his sister has.

    Brains are as different as our bodies, and no amount of training will let me run a marathon; my body won't allow it. For some, no amount of training will let them keep up with me on a bicycle.

    No amount of training will let most people keep up with me in my field of intellectual expertise; I have great vision in that one area, and I'm a total doofus in others.

    Yeah, I can learn to flip burgers. But that won't let me compete with an accomplished chef, who has talent and vision.

  81. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    If I spent 10 years maintain a correct diet and exercise regime, then yes, I could quite likely run faster than Usain Bolt.

    Just like your diet and what you do to your body can determine how it looks/acts during your life, the way you treat your brain can result in differences

    Someone who studies most of their life and tries to come up with new ideas will have different "software" from someone who watched TV and parties most of their life. These difference are not in the "hardware" or structure of the brain, simply in the "software".

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  82. Re:This is simply misguided -- don't we know bette by mcgrew · · Score: 1

    My brain is not normal. Ask anybody who knows me. However, it works better than yours.

  83. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    I know that everything is phsyical, genius.

    Never once did I mention magic or a soul, so please don't try and put words in my mouth.

    What I am saying is that the personality of a person, or the "software" is a result of nurture.

    To clarify, all working non defective brains start off the same and have no meaningful variations. (point 1)

    The neural pathways that may be mapped as a result of upbringing and environment will not be observable upon death. (point 2)

    Thus, studying the brains of dead people is misguided.

    If you can show some evidence against point 1 or 2, I would appreciate it. Let me ask you again: What meaningful variations did we learn from studying Einstein's brain? Oh, that's right. None.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  84. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    You're not arguing a point that relates to the claim I made. You are arguing an adjacent point, essentially a strawman.

    Otherwise, show me where I stated anything that is even close to fairy dust/unicorn farts/souls etc.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  85. Re:This is simply misguided -- don't we know bette by angus77 · · Score: 1

    All brains don't have to be created equal. It's pretty clear that the vast majority of the population are not making the best of the capabilities they were born with.
    It was once believed that the serfs couldn't possibly learn to read, or to benefit from it even if they did learn. Now we live in a society with near-universal literacy.
    We have no idea what the limits of our brains are, and thus have no way of comparing brain capacity.
    If Einstein had been raised in a box, do you think his brain capacity alone would have given Relativity to the world?

  86. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    Even software is physical, it gets recorded on the disks, thus changing them.

    If I spent 10 years maintain a correct diet and exercise regime, then yes, I could quite likely run faster than Usain Bolt.

    Not going to happen, people try that and fail all the time. They just are not built for it.

  87. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    I guess if you want to be pedantic you could say that it is a structural change. The same way a two harddrives with the same files will store them in slightly different ways.

    However, this is hardly meaningful, and we would learn nothing new by studying it.

    A more apt comparison would be with RAM.

    We spend our lives patching and updating our brain OS, and while we are alive it is stored in the same way as RAM.

    When we die the power is off, and so is the BrainOS. Studying our brains will not show a persistent structural change, just as studying a RAM chip that has been without power for a day won't show anything significant.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  88. Re:This is simply misguided -- don't we know bette by KillAllNazis · · Score: 1

    That doesn't refute the OP's point. Are you saying someone who studied rocket surgery their entire life wouldn't be a competent rocket surgeon?

  89. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Dude I am totally stealing that... That is *THE* best spelling Nazi remark I have ever read.

  90. Re:This is simply misguided -- don't we know bette by shougyin · · Score: 1

    Just write everything in code from now on, and I'm sure people (like me) will be too confused and dumbfounded to understand what you're saying, but then all the debuggers come out and flame it anyways, so I guess you're still screwed.

    Funny enough that I'm from an English background and still don't understand spelling, but I do resort to spell check before every post so I don't get SLAMED by people telling me things wrong with my genetic code that I already know!

    *sigh* If only I could talk through circuitry!

  91. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    I'm not young enough that you should disregard the above.

    Apparently you are or you've led a very sheltered life (read: filled with idiots).

    Anyone with that aspiration can teach themselves what they need to, go to school or get training, and do it.

    They can't.

    Especially for that type of discipline(physics/math) where prerequisite knowledge is more important than original thinking.

    Quite clearly you've never done advanced math, prerequisite knowledge is a small part of it while a certain way of thinking is the vast majority of it.

    For example, I took the Calculus AP exam at 11 after 6 months of learning Calculus online in my free time. Generally wasn't that difficult. I learned algebra before that, of course, but I didn't even know as much or spend as much time on it as the average High School student going into a Calculus class. I'm lazy by the way so I really didn't study very hard.

    That is innate intelligence. Things make sense instantly that others spend days struggling with. They always did for me. Out of the blue with no practice or training. I almost never studied for standardized tests and did better than kids who spend hours a day for months studying for them. I can put in a tenth of the effort of an average person and do just as well in most technical classes.

    That said, innate intelligence is more of a threshold talent. To become great at something you need a certain amount of innate talent and then a shit ton of practice. But if you lack that innate talent then no amount of practice will help you.

    Feel free to delude yourself into thinking otherwise so as to keep your ego from imploding but that is reality.

  92. Re:This is simply misguided -- don't we know bette by Bruce+Perens · · Score: 1

    If we're pursuing good science, it's necessary for there to be another study to corroborate the first. But there are differences in brains that we can just barely see now, and for which we need more research. For example, the structure of neuronal connections matters, and it's even influenced by use.

  93. Re:This is simply misguided -- don't we know bette by Kittenman · · Score: 1
    I write software. I play a musical instrument (tenor sax) and I can spell analysis correctly.

    It's practice. But you're right - some people can, some people can't. I'll never get beyond 'average' as a sax player. And I've heard buskers play better than I do - and I always will. Luckily I play for fun. I program for money. If I played for money I'd spend more time on it, and less time programming.

    --
    "The greatest lesson in life is to know that even fools are right sometimes" - Winston Churchill
  94. Re:This is simply misguided -- don't we know bette by moortak · · Score: 1

    You do realize that variations in livers can cause huge differences tight?

    --
    Xavier Rabourdin for president 2012
  95. Oblig. "Youing Frankenstein" quote by Kittenman · · Score: 2, Funny
    Dr. Frankenstein: [To Igor] Igor, may I speak to you for a moment?

    Igor: Of course.

    Dr. Frankenstein: Sit down, won't you?

    Igor: Thank you. [sits on the floor]

    Dr. Frankenstein: No no, up here.

    Igor: Thank you. [sits on a chair]

    Dr. Frankenstein: Now... that brain that you gave me... was it Hans Delbruck's?

    Igor: [Crosses arms] No.

    Dr. Frankenstein: [Holds up hand] Ah. Good. Uh... would you mind telling me... whose brain... I did put in?

    Igor: And you won't be angry?

    Dr. Frankenstein: I will not be angry.

    Igor: [Shrugs] Abby someone.

    Dr. Frankenstein: Abby someone? Abby who?

    Igor: Abby Normal.

    Dr. Frankenstein: [Slightly angry] Abby Normal?

    Igor: I'm almost sure that was the name. [He and Dr. Frankenstein laugh]

    Dr. Frankenstein: Are you saying... [Stands] that I put an abnormal brain... [Puts hand on Igor's hump] into a 7 and a half foot long... 54- inch wide... [Grabs Igor by throat] GORILLA?!?!?! [Strangling Igor] IS THAT WHAT YOU'RE TELLING ME!?!

    --
    "The greatest lesson in life is to know that even fools are right sometimes" - Winston Churchill
  96. Re:This is simply misguided -- don't we know bette by z0idberg · · Score: 1

    But there IS a physical difference between two formerly identical PCs that have different OS's installed on them. You can't see it on the outside but its not magic and pixie dust. The magnetic properties of the IDE drive are changed in distinct and decodeable ways that dictate how the OS works and operates the rest of the hardware of the PC.

    Studying the brain in this way is to try and figure out what the equivalent is to the magnetic storage method of the hard drive and then to somehow decode that storage method.

    Even if every brain were physically identical (which it's quite obvious they aren't) the "combination of upbringing, willpower and education" that makes you you must be stored somewhere inside you in some way. It's a pretty fair assumption that it is in the brain somewhere and somehow.

  97. Ourselves? by Anonymous Coward · · Score: 2, Funny

    which means, of course, that it promises to revolutionize our understanding of ourselves.'"

    You might think you are nothing more than your brain, but I am really my soul.* The brain is just a channel to communicate the will to the body.

    ---

    * "Soul" in this context means "testicles."

  98. Re:This is simply misguided -- don't we know bette by moortak · · Score: 1

    So clearly all those other world class athletes are slacking.

    --
    Xavier Rabourdin for president 2012
  99. Still... by denzacar · · Score: 3, Insightful

    I can't escape a feeling that what they are doing is akin to slicing apples and then taking high grain black and white photos of those slices - in order to find out how they taste.

    --
    Mit der Dummheit kämpfen Götter selbst vergebens
    1. Re:Still... by fuzzyfuzzyfungus · · Score: 1

      In a sense, that analogy is apt; but in a sense, that would actually be a reasonably sensible start to determining how an apple tastes.

      If you want the subjective experience of tasting an apple you just bite one. Problem solved. If you want to know why the apple tastes as it does it isn't clear that a biting them strategy will ever get you closer to that.

      At some point, you are going to have to break down and do a sophisticated analysis of the chemistry and structure of the apple. However, the more fine-grained the analysis, the pricier per cubic mm and thus the more likely that you will miss an important spot, or fail entirely to see some aspect of the taste based on the experience of contrast between two or more distinct regions. Therefore, having a bunch of black and white slice photos is hardly the end of your job; but it might actually be pretty useful in planning what parts of the apple to hit in greater detail, and what you need to know about them.

  100. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    The wiki page? Really? You call citing the wiki page 'research'? Dear god man...

  101. Re:This is simply misguided -- don't we know bette by moortak · · Score: 1
    --
    Xavier Rabourdin for president 2012
  102. Re:This is simply misguided -- don't we know bette by TarPitt · · Score: 1

    Science refutes Calvinism and the attendant ideology of success by person effort and willpower.

    Not every person who is unsuccessful is willfully indolent - in fact most are doing the best with what they have.

    Not everyone who is poor deserves to suffer and die - many are, apart from their genetics, no different than you or I

    --
    If your children ever found out how lame you are, they'd murder you in your sleep
  103. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    In my view you are bascially arguing that all brains are equal, ignoring obvious medical issues (head injuries, severe oxygen deprivation, missing genes etc) there is no substantial variation. To me this is an argument for a form of perfection - all brains being made more or less identically. A perfect manufacturing process if you will.

    I hope I dont have to argue that nothing is perfect.

    Could many people do much better than they currently do with what they have? I have no disagreement with that, I just disagree that everyones upper limit is the same.

  104. Re:This is simply misguided -- don't we know bette by Torvaun · · Score: 1

    Increased size of the inferior parietal lobe, statistically significant increase in the level of glial cells, enlarged Sylvian fissure, vacant parietal operculum. That's what we discovered in Einstein's brain. Unfortunately, Einstein is only one statistical point. Without more genius brains, it's difficult to say what exactly caused his genius. Therefore, let's study -all- the brains of dead people. As many as we can get. The one thing we can say from that is that there are clearly physical differences in brains, although if you dismiss everything different as a defect and irrelevant, I guess that doesn't help much.

    Also, as far as the computer comparison goes, I think that's particularly apt. Especially if you consider the practice of binning. Not all CPUs are created equal, even in manufacturing processes as close to identical as we can manage. Some work better. The same thing used to be done with guns. Before leaving the factory, sharpshooters would put a number of rounds through them, and some rifles would be more accurate than others. Those that went past a certain threshold would be put aside and sold separately, as the Winchester "One of One Thousands." It happens with screws, there are various grades to define how close to spec the threads are manufactured.

    With the best precision manufacturing capability history has ever known, we still can't manufacture a screw to perfection every time. And you think that there won't be variations among brains?

    --
    I see your informative link, and raise you a pithy comment.
  105. Re:This is simply misguided -- don't we know bette by jelizondo · · Score: 4, Funny

    The Funny English Language

    No wonder the English language is so very difficult to learn.
    I sometimes wonder how we manage to communicate at all!
    We'll begin with a box and the plural is boxes.
    But the plural of ox should be oxen, not oxes.

    The one fowl is a goose but two are called geese
    , Yet the plural of moose should never be meese.
    You may found a lone mouse or a whole set of mice,
    Yet the plural of house is houses not hice.

    If the plural of man is always called men,
    Why shouldn't the plural of pan be called pen?

    If I speak of a foot and you show me your feet,
    And I give you a boot, would a pair be called beet?
    If one is a tooth and a whole set are teeth, Why should not the plural of booth be called beeth?

    Then one may be that and three would be those,
    Yet hat in the plural wouldn't be hose.
    And the plural of cat is cats and not cose.

    We speak of a brother and also of brethren,
    But though we say Mother, we never say Methren,

    Then the masculine pronouns are he, his and him,
    But imagine the feminine she, shis and shim, So English, I fancy you will all agree,
    Is the funniest language you ever did see.

    Why can’t people from all over the world speak English?

    --
    Be very, very careful what you put into that head, because you will never, ever get it out. - Cardinal Wolsey
  106. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    i get that you're completely wrong, and pathetically and childishly cowering behind a james-bond wanna-be account that you use to spout ignorant ideas with no responsibility.

    brains are not all physically the same.

    you're an idiot.

    Except... if I give you a small sample of brain, can you identify which area it came from? My limited understanding is that brain tissue is uniform in structure.

    I'm not trying to side with metrix007. Maybe he misunderstood what that actually means...

  107. Re:This is simply misguided -- don't we know bette by LurkerXXX · · Score: 1

    Patient H.M.'s brain was NOT physically the same as all other brains. There were known changes made to it, and effects from that change that helped us do extensive mapping of brain activity which would have been difficult to do otherwise. That's the whole point of why patient H.M. was so important.

    You don't appear to get anything.

  108. And then .... by Anonymous Coward · · Score: 0

    "The Brain Observatory promises to revolutionize our understanding of how these three-pound hunks of tissue inside our skulls do what they do, which means, of course, that it promises to revolutionize our understanding of ourselves."

    And to be exploited to the fullest extent to which human greed will allow.

    With the good, comes the bad. Expecting anything else is just delusional.

  109. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    Agreed, but that has nothing to do with a discussion on whether or not we can learn something from studying a dead brain.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  110. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    It is well known that when a brain suffers trauma or damagage, other parts of the brain can be "rewired" and refit for a different purpose.

    This still has nothing to do with the claim I made above about "standard" brains.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  111. You should try teaching... anything. by denzacar · · Score: 1

    At about... oh... 100 random students (as in - didn't really pick to be there by themselves, not their favorite subject but they have to this subject anyway) you will start to notice those that simply... don't function properly.
    Not retarded or stupid even, their minds simply can't bend around certain concepts or tasks.
    The best they can do is just memorize - or cheat.
    Think bog standard PC's - where one has an integrated graphic card and another comes with a pluginable one with similar performances. Similar on paper.
    And let's not even go into what makes a "standard" PC. Even two "standard" Macs are not exactly the same, let alone two random home-built boxes.

    As for "Anyone with that aspiration can"... everyone MAY not be able to.
    Ramanujan was a mathematical genius who was cast aside by two other professors before Hardy decided to take a closer look at his "scribblings".
    And just as things were starting to pick up for him - he died.

    Invictus may be a nice poem - but it is full of shit.
    Particularly the last two lines.

    --
    Mit der Dummheit kämpfen Götter selbst vergebens
  112. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 1

    Some people do have a physical advantage, it's true. However given most people starting off equal, the person who puts in the most effort will be rewarded.

    Have you any example of someone who had an analogous physical advantage in their brains?

    Einstein didn't and Newton probably didn't.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  113. Re:This is simply misguided -- don't we know bette by metrix007 · · Score: 0, Troll

    I'm not ignorant.

    People are arguing a sandman, yourself included, saying that I am saying that no physical changes occur

    What I am saying is that all working non defective brains start off equal, and that changes made are not persistent.

    am saying that the biggest cause of intelligence or a way of thinking is upbringing and environment, and that studying a brain will not show anything special.

    There are exceptions where we may learn something from studying an exceptional brain, but people with exceptional brains are going to tend to be strange in some way. The people who seem smarter than most have a greater interest, or try harder or whatever.

    If you can show me any definitive research that shows that brains that are not defective can be significantly different, and those difference can lead to increases in intelligence, I would appreciate it.

    --
    If you ignore ACs because they are anonymous - you're an idiot.
  114. Re:This is simply misguided -- don't we know bette by mywhitewolf · · Score: 1

    i find personal interest in a subject has more to do with your perceived intelligence in that subject than any brain power, your right though, some people will never become rocket surgeons, but IMO that has very little to do with their brains ability and more to do with personal taste. if I'm not interested in becoming a surgical lawyer and studying it becomes boring for me I'm not going to retain the information and have no desire to understand the concepts. in much the same way I'll never be a good laborer, i have no desire to work my self to physical exhaustion so I'll never get proficient in it.

  115. Re:This is simply misguided -- don't we know bette by Pseudonym+Authority · · Score: 1

    We could also predict they would be individualistic, egocentric and disrespectful of authority. All you had to do was look at me...

    Wow, it sure is Lamarckian genetics in this thread.

  116. Re:We Have Our Priorities Straight by Anonymous Coward · · Score: 0

    March have launched their own IDE!

    What does machine architecture have to do with an IDE? What am I missing here???

  117. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Yes. By definition when you have a PROBLEM it means that the state of things is not what it should be, that it could be better.

  118. The most important thing is... by Lord_of_the_nerf · · Score: 2, Funny

    ...whether we can still put into a great white shark.

  119. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    You are a moron. Studying patients like H.M. is how we learn things and how they become well known.

  120. Re:This is simply misguided -- don't we know bette by RockoTDF · · Score: 1

    I wasn't going into the success/willpower thing at all.....I don't think anyone "deserves" better because they are smarter, even though that is generally what happens in reality.

    --
    There is more to science than physics!

    www.iomalfunction.blogspot.com
  121. Re:This is simply misguided -- don't we know bette by megaditto · · Score: 1

    My minivan is different from your eighteen wheeler. Which one is defective? How do their differences contribute to their respective abilities?

    The amygdala (a brain part) in males is much larger than in females. The reverse is true for Broca's area. Which gender's brain is defective? Do these differences matter? Which one would you fix? I guess these are the sort of questions these guys try to understand.

    --
    Obama likes poor people so much, he wants to make more of them.
  122. Re:This is simply misguided -- don't we know bette by LurkerXXX · · Score: 1

    Patient H.M. was never able to regain the ability to form new long term memories, so your argument of how well-known "rewiring" of the brain is, is directly counter to what H.M. showed us.

    In short, your arguments are nonsensical and uninformed. You should leave this to those who work in neurosciences.

  123. Re:This is simply misguided -- don't we know bette by mywhitewolf · · Score: 1

    i think you need to understand that to be the best or one of the best you need to have the perfect / really good hardware, but anyone can learn how to run and run well, it may take longer for people to achieve a percieved success, but its still possible... Think of it this way, because we are so similar in nearly everyway, even the slightest variations in function are accentuated. am i going to be able to become a world renowned long distance runner? probably not, am i going to be able to teach / train myself to do long distance running? without a doubt if i had the drive to. In my opinion given the right circumstances any non defective brain should be able to learn the requirements for almost any job. if you want to use your PC as an example, some PC's come with more ram or faster CPU, they are able to handle more tasks or deal with tasks quicker, it doesn't mean your standard computer cant run the same tasks.

  124. Re:This is simply misguided -- don't we know bette by shougyin · · Score: 1

    Funny enough I always remember as a child watching some of Gallaghers old skits and one in particular talking about the same topic...in reference to the words "good" and "food" and how they are pronounced. "Good" being pronounced [goo d] and "food" being [fu d]....so shouldn't it be [goo d] [foo d] or [gu d] [fu d]!

    Always makes me laugh to think of how we can take something so natural (communication) and completely screw it all up!

  125. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    And yet, as anyone with a bit of age and insight will tell you, we are most definitely more than just a brain. The grey matter is just a significant part of the vessel that aids in our perception of its dimensional space..

  126. Re:This is simply misguided -- don't we know bette by mywhitewolf · · Score: 1

    Who would have thought that identical twins brought up in a similar way would be... similar? i bet if you sold one of the twins to slavers you would have very appreciable differences in tastes and intelligence.

  127. Re:We Have Our Priorities Straight by Anonymous Coward · · Score: 0

    Sometimes, the 'parent' button would be best left hidden...

    ~ KingAlanI

  128. Re:This is simply misguided -- don't we know bette by rockNme2349 · · Score: 1

    All my life I would have given a leg and an arm to learn to play any musical instrument

    MONKEY PAW!!!

    --
    Sewage Treatment Facilities - "Our duty is clear."
  129. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    I think you just shot your own thesis in the foot, if not the head, and you came full circle.

    You are now claiming it is a physical/chemical difference and not just the ethereal "willpower." If that is part of the physical difference in brains, then there will be enough variation in brains that even "normal" people can not achieve what they want because now they lack the necessary physical/chemical characteristics to do just that.

  130. Not so misguided after all by CycleMan · · Score: 1

    GP is correct -- if there is a something which truly "effects our daily lives" it is very much worth learning about, and a marvelous field for science to explore.

  131. Re:This is simply misguided -- don't we know bette by fractoid · · Score: 2, Interesting

    Let me try that again: Some people don't really give a shit about how much money, power, knowledge or fame they get. If someone finds physics interesting, that doesn't mean they're going to become a rocket scientist, or have any desire to do so.

    The GGP was stating that there are distinct physiological differences between people, which result in profound differences in ability. You seem to be supporting the GP's assertion that a person's intellectual ability is purely a product of their environment, and also claiming that people who don't achieve much fail to do so because of lack of motivation, not because of lack of intelligence.

    If you've ever tried to teach a complex skill (programming, mathematics, music) to a group of people, you'll know that intrinsic human aptitude for a given task varies dramatically from person to person. Some people understand intricate systems effortlessly, while others will never 'get' systems above a certain level of complexity. All of us hit the wall somewhere, but that 'somewhere' ranges from 'ability to understand why maxing out your credit card is bad' to 'some of the finer points of quantum physics'.

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  132. Re:This is simply misguided -- don't we know bette by fractoid · · Score: 1

    Thoughts:
    1. I think you mean straw man. I presume a sand man argument is one that puts your opponents to sleep? ;)
    2. While education certainly plays a part, and learning to think is a part of that education, I can't see how you can support the statement "all working non defective brains start off equal".
    3. I'm curious as to your definition of 'defective'. You seem to think that there's some factory spec. for brains, and that most of them conform to this spec whereas some don't properly implement it.
    4. While not 'definitive research', consider that there's often less intellectual variation between siblings (who generally share both upbringings and genetic makeup) compared with friends of similar socioeconomic status (who share similar upbringing but are genetically unrelated).
    5. If 4. didn't convince you, try this paper and its references for information establishing "a significant and substantial genetic influence on cognition."

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  133. Re:This is simply misguided -- don't we know bette by fractoid · · Score: 2, Insightful

    Our society has near-universal reading and writing skills, true. For anything more advanced, though, I think we're starting to see the limits of 'the average' human's capability. Consider that despite decades of widespread attempts to teach scientific method and basic mathematics in schools, we still have almost universal scientific and mathematical illiteracy.

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  134. Re:This is simply misguided -- don't we know bette by fractoid · · Score: 1

    I really hope people actually read your post instead of simply responding superficially to your slightly superior tone.
    - signed, the guy who didn't understand why the other kids in primary school DIDN'T get 100%

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  135. Re:This is simply misguided -- don't we know bette by fractoid · · Score: 1

    Not if they don't have the innate capacity to be a rocket surgeon. And even if they could be a competent rocket surgeon, they'd never be a great rocket surgeon. It's like saying "take a guy who's absolutely hopeless at driving, and train him for his entire life to be a racing driver." He might eventually have some measure of success but he'll never be a Schumacher or a Loeb.

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  136. Re:This is simply misguided -- don't we know bette by fractoid · · Score: 1

    effect v. To make or bring about; to implement.

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  137. Seems a bit too easy to go wrong. by The_mad_linguist · · Score: 1

    About a year ago, we watched live as neuroanatomist Jacopo Annese sliced the brain of Memento-style patient Henry Molaison (aka H.M.) into 2,401 pieces.

    Now, I'm not a neurosurgeon, but that strikes me as a somewhat risky procedure.

    Did they at least try medication first?

  138. Re:This is simply misguided -- don't we know bette by angus77 · · Score: 1

    Our society has near-universal reading and writing skills, true. For anything more advanced, though, I think we're starting to see the limits of 'the average' human's capability. Consider that despite decades of widespread attempts to teach scientific method and basic mathematics in schools, we still have almost universal scientific and mathematical illiteracy.

    "Mathematical illiteracy" is pretty hyperbolic considering a) how advanced mathematically the average person in our society's math skills are compared to, say, that of someone in a South American tribe whose society and language has no concept of any number beyond 'three', and b) how often your average person has the opportunity to make practical use of more advanced math skills.

    I mean, what would be the mathematical equivalent (for the average person) of reading the newspaper every day?

    Also, we see great differences in average math skills in different countries. Canada and the US are neighbours, yet Canada ranks consistently higher in math skills (and science). A couple of rankings I've found have placed Canada about 5th out of industrialized nations, and the US about 24th or 25th. Clearly the US hasn't come anywhere near its math skills potential (and, I would halfheartedly argue, neither have Canada or Hong Kong).

  139. Re:This is simply misguided -- don't we know bette by MithrandirAgain · · Score: 1

    Actually, what I wrote was not some sweeping blanket for all of mankind; variations in humans would not make this possible. What I wrote was actually an addition to the previous ideas, not a new separate one.
    *Some* people have no interest in astrophysics and consequently will never become astrophysicists. Others *want* to become astrophysicists, but lack the (brains, intelligence...) to do so.

  140. "accidentally slice open the H.M. skull"? by chrb · · Score: 2, Informative

    "whose grandfather happened to be the surgeon to accidentally slice open the H.M. skull in the first place"

    The surgery was no accident - it was a planned procedure that the doctors (correctly) thought would stop the epileptic seizures that H.M. was experiencing.

  141. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Memory seems to be the exception, but there are many cases of patients with brain damage having their brains rewire or reconfigure to restore functionality.

    http://books.google.com/books?id=0Cm0PoI-7RMC&pg=PA147&lpg=PA147&dq=brain+damage+restructure&source=bl&ots=JxsoyNs8Km&sig=Xcp755HRxj-RNOb_JirvU_q-cu4&hl=en&ei=UpfGTJ7wGYf2tgPgg53-DA&sa=X&oi=book_result&ct=result&resnum=1&ved=0CBIQ6AEwAA#v=onepage&q&f=false
    You sure as hell don't work in neuroscience, or you would know this.

  142. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Sorry, have to post AC. All those downmods decreased my limit.

    Hi,

    Thanks for a civil reply.

    1. Yes, definitely meant strawman.
    2. Given healthy humans, the brains are not going to have any significant variations. The differences sure as hell won't count for differences in intelligence. How they are raised and what they are exposed to will.
    3. Defective as per what I have said in the rest of the thread....tone deaf is missing a part of the brain that working brains otherwise have, autism or downs syndrome would be other examples.

    The factory spec is pretty spot on...it's called DNA. Unfortunately some people still have this idea that who we are is mapped out in our brains physically, which simply isn't the case. Brains are about as different as thumbs, i.e. not overly. It's what we put in them that matters (yes, there may be some physically changes, but whether or not it is persistent is a separate thing).

    4.Interesting, I've found the opposite in my research. Take twins and raise them in vastly different environments, and they will have different IQ's.
    5.That abstract was interesting, but it concludes that there can be a genetic influence, not that genetics are responsible. I still maintain that nurture plays a far more pivotal role than nature.

  143. Re:This is simply misguided -- don't we know bette by Have+Brain+Will+Rent · · Score: 1

    How young are you?

    I don't think it's really a matter of age. Even a young, but reasonably observant person, is capable of seeing that organic factors will have significant impact on intellectual capabilities. Nurture may have a tremendous impact on what you end up being able to do with what you were given to start with, but what you were given to start with is what is going to establish where the boundaries lay. My guess for second most important factor would be nutrition in the early years, followed by nurture in the early years.

    --
    The tyrant will always find a pretext for his tyranny - Aesop
  144. Re:This is simply misguided -- don't we know bette by imakemusic · · Score: 1

    What counts as a defect?
    What counts as a variation?

    --
    Brain surgery - it's not rocket science!
  145. Re:This is simply misguided -- don't we know bette by imakemusic · · Score: 1

    Then that's something you can agree on. Are you going to answer his question now?

    --
    Brain surgery - it's not rocket science!
  146. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    People in the nature/predetermination camp are just as stupid as those who believe only environmental factors matter.

    Nature/genetics determines the size of the cup, and nurture/environment determine how much it gets filled in a life.

    What people can achieve in their lives is a combination of ability and opportunity.

  147. Re:This is simply misguided -- don't we know bette by fuzzyfuzzyfungus · · Score: 1

    I suspect that classic Von Neumman computers, and their crazy-fast-but-not-wildly-different descendants are not a wildly good analogy for the brain. Adult neurogenesis is a well established phenomenon, with some demonstrated links to behavioral change. At the level of crude analogy, the brain exhibits at least FPGA levels of hardware plasticity, quite possibly greater.

    On the other hand, as you note, a brain never actually shuts down(with the limited exception of a few cases of people being frozen and surviving). Consciousness ceases about once a day, or under anesthesia, or certain types of trauma; but the brain is "in flight" 24/7/365 from when it starts to grow to when it dies. There may be some amount of important activity that is never hardcoded into cellular structures that are well preserved after death.

    However, even in that case, it doesn't mean that studying the structure teaches you nothing. Consider the computer analogy: by design, certain things, like secure-swap crypto keys, are deliberately kept in RAM only, and never flushed to disk. They are lost on shutdown. However, the kernel code that implements the secure swap is visible as a magnetic structural change, and the function of SRAM is clearly visible from studying its circuit diagrams, which can be inferred by imaging it silicon.

    A researcher given a computer and forced to study it without turning it on could(with considerable difficulty) read the HDD contents, determine the initialization vector for that architecture, read the BIOS code, etc. and infer that, were the system still running, there would be a crypto key stored in RAM for the secure swap. He wouldn't be able to tell you what the key was before the computer was shut down; but(with some seriously arduous work), his purely physical study could tell you a great deal about what to expect, and what areas to study, if you had a method for imaging the RAM contents of a running computer.

    You don't get to know everything about every computer; but a useful composite view can be assembled. Similarly, with the brain, there are probably certain activities about which you just can't say much based on a dead brain; but structural study should be able to shed a great deal of light about where to look in a living brain if you want to see different functions in action. "This structure, based on its neural anatomy, looks like a timing mechanism. Expect to see periodic waveforms on electrodes in a living organism." "This area has strong connections to the retina, it should light up like a christmas tree when visual stimuli are presented.", etc.

  148. Re:We Have Our Priorities Straight by DanTheStone · · Score: 1

    Google "Ides of March"

  149. Re:This is simply misguided -- don't we know bette by Phydaux · · Score: 1

    Yes, some folks won't be rocket scientists(I assume that's what you meant)

    No, I'm pretty sure he meant Rocket Surgeon

  150. First Place to Fall in a Zombie Apocolypse by TheFakeMcCoy · · Score: 1

    Or... we lure them to the observatory and Nuke it from space

  151. An ideal candidate? by RulerOf · · Score: 1

    simple solution - start with a live brain and work quickly

    Might I recommend this "Anonymous Coward" fellow? Get enough Slashdotters with scalpels and we'll do the job in record time!

    --
    Boot Windows, Linux, and ESX over the network for free.
  152. Please destroy my childhood more.. by RulerOf · · Score: 2, Funny

    I am really my soul.*

    ...

    * "Soul" in this context means "testicles."

    I really, really hope you appreciate how incredibly gay you just made Mortal Kombat.

    --
    Boot Windows, Linux, and ESX over the network for free.
  153. Re:This is simply misguided -- don't we know bette by TheLink · · Score: 1

    Genetics certainly play a significant role.

    I doubt my neighbour's dog is going to do that well in matters requiring significant intelligence no matter how hard he tries.

    Similarly I'm never going to beat Usain Bolt's record.

    --
  154. Re:This is simply misguided -- don't we know bette by hedpe2003 · · Score: 1

    I am so surprised to hear everyone here speaking so matter-of-fact about this. I believe the book is far from closed on these matters. While it is true that genetics has a large hand in the way the brain forms - it is also quite possible (and I would say probable - with the exception of certain mental disorders) that this is just our brains default configurations. The brain is extremely adaptable - and while certain tasks are naturally easier for some, it rarely makes them impossible for others.

    The climb may be uphill, and the speed bumps more often and difficult - but this does not exclude someone from an activity. Its not that I _can't_ learn to play the guitar, it's simply that the amount of work I'd spend mastering that skill is substantially larger than it would be for many other people - so large it may not be worth it to me. I find, when learning something new, the classic "ah-ha" moments seem to, for me personally, confirm this idea.

    The brain, however, seems to be much less adaptable the older we get. Can't teach an old dog new tricks I suppose :)

    --
    Comprehensive solutions via a competition of ideas like no other.
  155. Re:This is simply misguided -- don't we know bette by Dabido · · Score: 1

    I have to agree with the parent poster. The parent is proof that someone can be as dumb and ignorant as they chose to be, and they are doing a fine job too. :-)

    --
    Sure enough, the cow costume was hanging up next to the superhero outfit and sailors uniform. (S,Spud)
  156. Re:This is simply misguided -- don't we know bette by Tarsir · · Score: 1

    we still have almost universal scientific and mathematical illiteracy.

    What exactly do you mean by that? By analogy to actual illiteracy, I would assume that mathematical illiteracy denotes an inability to do any math, even addition and subtraction, which is clearly not the case. What level of mathematical knowledge do you think constitutes basic literacy?

  157. Re:This is simply misguided -- don't we know bette by geekoid · · Score: 1

    Those folks would be very rare. Most people, if they applied themselves, could be 'rocket surgeons.* What it takes is an active interest in the subject. It's all motivation and obsession.

    Einstein was obsessed with finding out about a certain aspect of the universe. He got a lot of help from working mathematicians and scientists.

    And no, I am not young, nor am I naive. The idea of IQ, in the public usages, has hurt us far more then it has helped us, regulating people and expectations on a test, not on motivation.

    *Nice reference.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  158. Re:This is simply misguided -- don't we know bette by geekoid · · Score: 1

    I disagree.

    Interesting, dedication, obsession.

    I would argue the serotonin levels are the real way to measure success and aptitude, not 'IQ'.

    Yeah, some people get it sooner, but that's more of an artifact of the individuals thinking pattern, not a general IQ. I know people who would be considered extremely smart that just don't get music. (I hate to break the Smart = good at music myth, but their you go.)

    I know people who get music automatically, but couldn't get OO programing to save their life.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  159. Re:This is simply misguided -- don't we know bette by geekoid · · Score: 1

    Sure, it's about interest, not a magical 'IQ'.

    BTW, I know obese people, blind people, and have met a man with one leg all who have ran a marathon. I suspect the on'y reason you think you can not is because you don't want to do it; Which is fine. At your age it may be too late to win the Boston marathon.

    And contrary to what TV may tell us, pretty much ayone who properly applies themselves can be a great chef. The work isn't really that hard.*

    *I was trained as a chef, but I found it a horrible job, surrounded by uneducated people. I was trained in 1983-4; did the gob in 85. I consider it 'Shit I did while waiting for the computer stuff to take off'~.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  160. Re:This is simply misguided -- don't we know bette by geekoid · · Score: 1

    gee, I wait for your definitive paper on autism. After which I'm sure you'll gt you noble prize.

    Before you write that paper, let me give you a hint: it's not an extreme difference.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  161. Re:This is simply misguided -- don't we know bette by geekoid · · Score: 1

    Wow, you can cut and paste as well, truly you are a genius~

    English is the easiest languagte on the planet to communicate in..it's also one of the ahrdest to elarn all the rules. It stsill doesn't axcuse you from misspelling 'analysis'.

    Also, you might need to look up 'Anecdote'.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  162. Re:This is simply misguided -- don't we know bette by geekoid · · Score: 1

    Naturally I fat fingered 'hardest' and 'learn'. Oddly, that butchery did not show get a hit with spell checker.

    Stupid blood pressure meds making my hands shaky, and stupid me for not proof reading backwards.

    --
    The Kruger Dunning explains most post on /. http://en.wikipedia.org/wiki/Dunning%E2%80%93Kruger_effect
  163. Re:This is simply misguided -- don't we know bette by cptdondo · · Score: 1

    Sure, it's about interest, not a magical 'IQ'.

    BTW, I know obese people, blind people, and have met a man with one leg all who have ran a marathon. I suspect the on'y reason you think you can not is because you don't want to do it

    I'm a personal trainer and a group fitness instructor, as well as an endurance cyclist. Nope, my body will not stand up to the pounding of a marathon. No way, no how. After 13 miles, my knees and hips are done.

    And contrary to what TV may tell us, pretty much ayone who properly applies themselves can be a great chef. The work isn't really that hard.*

    *I was trained as a chef, but I found it a horrible job, surrounded by uneducated people. I was trained in 1983-4; did the gob in 85. I consider it 'Shit I did while waiting for the computer stuff to take off'~.

    You might have been a good cook, but to be a great chef you need to have a love and a deep understanding of food. If you consider the job shit, your food will taste likewise. I am a fair cook; I've run kitchens before and still do on occasion. A friend of mine is a great chef, and nothing I can do will allow my meager talents to match his.

  164. Re:This is simply misguided -- don't we know bette by operagost · · Score: 1

    You missed a few more than that. I wondered if you were making an ironic joke!

    --

    Gamingmuseum.com: Give your 3D accelerator a rest.
  165. Re:This is simply misguided -- don't we know bette by h4rr4r · · Score: 1

    Considering a human can be powered off if sufficiently cooled and powered back on without a loss of OS I disagree.

  166. Re:This is simply misguided -- don't we know bette by mcgrew · · Score: 1

    Your intelligence, like everything else about you, is partly determined by genetics and partly by environment.

    There are people born with excellent eye-hand coordination, and some without. Some grow muscle mass easily, some do not.

    Some are genetically tall, some genetically short. Some are predisposed to being fat and some to being skinny.

    Why do you think brains are all alike, when none of the other organs are? Your premise is illogical and counterintuitive and as such, it's up to you to show research. I'm not sure any has been done.

  167. Re:This is simply misguided -- don't we know bette by Naturalis+Philosopho · · Score: 1

    Why'd you post the most insightful comment of this thread AC? I'll bet you know better, but the environment around here may have you skittish. ;)

  168. Re:This is simply misguided -- don't we know bette by cekander · · Score: 1

    Talent and vision can be gained. Physical height is different, which makes Wilt Chamberlain unique. Anybody can be Van Gogh. Only tall people can be Wilt Chamberlain. Got it?

  169. Re:This is simply misguided -- don't we know bette by cekander · · Score: 1

    Or you simply didn't have the right teachers or the right mindset. I found that I wasn't able to play music particularly well either, until I altered my mind and talked to various professional artists/creators.

    However, this brings up an interesting point. The whole point here is to scientifically study the human brain. So it doesn't surprise me that these concepts that can't be scientifically proven (yet) are being derided as liberal equality feel-good ideas that we all have the same brain capability.

    Brains may form different physical properties as a result of their evolution/development throughout life, but most functional components in the brain all work the same way, and many people are capable of things they are not aware of. Or put another way, very few people reach their full potential, which is why we don't see van goghs or mozarts everywhere. Actually, these people were obsessive about their craft. Mozart probably analyzed more scores and sheet music than any other musician before. He was extremely dedicated. It didn't just happen.

  170. Re:This is simply misguided -- don't we know bette by LurkerXXX · · Score: 1

    Actually I do. And you'd understand why Patient H.M. being such an exception was so important to research if you did.

  171. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    Sorry for posting AC...my post quota expired

    I am not saying they are all identical, I am saying they are all alike. Think of it this way....everyone's arms are very very similar, i.e. alike, but none are identical. Some arms may have defects which cause them to work in different ways. All arms that are not defective tend to work in pretty much the same way however.

    I just think that environment plays a far more significant role than genetics.

    My premise is logical and I have supported it logically, and it certainly can't be counter-intuitive if there is a lack of current understanding and research. Indeed, based on our observations....it is intuitive.

  172. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    You realize Einstein was not anything special right? He put in the work and came up with something that worked..., there were a lot of other original theories, they were just wrong.

    He was also wrong about an awful lot of stuff we know today is right, and his IQ was nothing special.

    We have to stop putting people who make discoveries on some sort of intelligence pedestal....it's baseless.

  173. Re:This is simply misguided -- don't we know bette by jelizondo · · Score: 1

    Bad example for your position. Mozart was playing by the time he was four years-old and composing a year later. How much sheet music could he have read from the time he was born?

    The truth is that we don't know. We might find out soon, perhaps never.

    But I don't suscribe to the idea that we all basically have the same brain potential, it is not true for other functions of the body, why should it be true for the brain?

    Examples abound: lactose intolerance, color blindness, alcohol metabolism difference by genre, etc.

    Again, no one knows if indeed we have the same brain potential or how and why it varies, if it does.

    --
    Be very, very careful what you put into that head, because you will never, ever get it out. - Cardinal Wolsey
  174. Re:This is simply misguided -- don't we know bette by Anonymous Coward · · Score: 0

    It is the difference between going to sleep and turning off. In sleep mode everything is still in ram, once it is turned off its gone forever.

  175. Not overrated by Anonymous Coward · · Score: 0

    The importance of H.M. is the extreme localization of the brain damage. (It was surgically induced, after all.) Due to ethical considerations, his case is unlikely ever to be reproduced. It's generally best to steer clear of absolute statements such as "the most important", because someone is bound to take exception, but it is difficult to overstate the importance of H.M.'s case.

    Your specific complaint about further studies contradicting things learned from H.M. do not detract from the importance of H.M. Are Newton's findings less important because of Einstein?

  176. Re:This is simply misguided -- don't we know bette by KillAllNazis · · Score: 1

    What innate capacity to be a rocket surgeon? The rocket surgeon gene?

  177. Re:This is simply misguided -- don't we know bette by fractoid · · Score: 1

    In a sense, yes. There may not be a single gene that makes you good at rocket surgery (or any other thing), and I'm not denying that environment also has a strong influence, but there's certainly a significant genetic component in aptitude. To perform any task exceptionally, and to perform some tasks at all, you must have both in some degree. Read up on twin studies if you're interested in learning more.

    --
    Rampant carbon sequestration destroyed the Dinosaurs' tropical paradise. I'm here to help repair the damage.
  178. Re:This is simply misguided -- don't we know bette by KillAllNazis · · Score: 1

    http://ajpregu.physiology.org/cgi/content/full/291/3/R768 Here's a study among others that show the ability of the environment to override genetic predispositions. I won't dispute the importance of genetics in governing behaviour, but given the range of cultural norms experienced by humans in time frames far too short to be explained by genetics I think it's clear that the environment is the overriding factor. What I will dispute is your claim of an on-or-off state, where a person either can or cannot be a rocket surgeon regardless of their environment.

  179. Re:This is simply misguided -- don't we know bette by Sardaukar86 · · Score: 1

    you're an ignorant hypocrite.

    also, you're wrong.... completely and pathetically wrong.

    you're an idiot.

    Where would Slashdot be without you, MichaelKristopeit? You're always there, adding so much to the discussion.

    --
    ..Mullah or Pope, Preacher or Poet, who was it wrote: "Give any one species too much rope and they'll fuck it up"?
  180. Re:This is simply misguided -- don't we know bette by MichaelKristopeit116 · · Score: 1

    a better question is where would slashdot be without all the ignorant, hypocritical, pathetic idiots.