Positive Bias Could Erode Public Trust In Science
ananyo writes "Evidence is mounting that research is riddled with positive bias. Left unchecked, the problem could erode public trust, argues Dan Sarewitz, a science policy expert, in a comment piece in Nature. The piece cites a number of findings, including a 2005 paper by John Ioannidis that was one of the first to bring the problem to light ('Why Most Published Research Findings Are False'). More recently, researchers at Amgen were able to confirm the results of only six of 53 'landmark studies' in preclinical cancer research (interesting comments on publishing methodology). While the problem has been most evident in biomedical research, Sarewitz argues that systematic error is now prevalent in 'any field that seeks to predict the behavior of complex systems — economics, ecology, environmental science, epidemiology and so on.' 'Nothing will corrode public trust more than a creeping awareness that scientists are unable to live up to the standards that they have set for themselves,' he adds. Do Slashdot readers perceive positive bias to be a problem? And if so, what practical steps can be taken to put things right?"
Right? isn't that what American schools and TV have been teaching for the last 30 years? Nerds aren't cool - facts are open to interpretation - everyone is special - you can eat more than you grow... When you have a society rewarding irrationality, what do you expect? Rigorous science?
I want to delete my account but Slashdot doesn't allow it.
Well you could have phrased that friendlier. Maybe positive bias only needs a little spin to leave the bad rep. behind?
Nuff' said
Positive Bias is another word for Group Think. I guess it could also mean deception
There are "studies", and then there is observation, modelling, prediction, model testing which is this thing called science. "Studies" are bullshit. Scientific research functions as it should. I believe the OP's article is just a chunck of sensationalist BS, or utterly ignorant of what science is (and is not).
'Nothing will corrode public trust more than a creeping awareness that scientists are unable to live up to the standards that they have set for themselves,' he adds.
No, the corrosion of public trust is the incessant idiocy coming from Fox and other Murdoch properties exclaiming "oh those silly scientists got it wrong again!" when the story is about a refinement of a model or something.
Scientists are losing the credibility war because scientists are not PR flacks and are unable to counteract the "we don't have to report actual news, we got a court order saying we don't" assholes at Fox.
There is a concerted effort to discredit scientific research no matter what it is.
--
BMO
I received my PhD in physics, and the thesis was measuring a number, in which I measured zero within the error bar. Not particularly interesting, but valid science. My wife was in a PhD program in Biology, she also did valid science, novel measurement technique, came up with an uninteresting result, therefore was not able to publish, therefore was unable to graduate. It would have been extremely simple to fudge the result to a 2-3 sigma result 'hinting' at an interesting answer, which would have gotten published. I think certain sciences have gotten to a point where they have forgotten that if you do valid work in a novel way, then that is science and you should not be punished for the conclusion of the measurement. Most measurements you do of the natural world should probably end up being unsurprising, and thus uninteresting, but you don't graduate or get tenure with those kinds of results. I think this is the mechanism for the positive bias. That is why I do not take results from certain branches of science at face value.
The solution lies in a reformation of research finance that is not focussed on how many papers X published compared to Y, but also takes into account whether they are consequential or not and if they actually comply with at least basic scientific attributes such as repeatibility, verifiablity, falsifiability, accessibility of all data and all conducted research, as well as actually conducted verification of research by independent third parties.
There should also be an outright condemnation of data mining, where data bases are checked only for the existence of attributes and correlations that happen to affirm the researchers opinion and leave all others untouched.
Fields like economics, medicine and climate have long since deteriorated to mere cargo cults due to those failings.
Some sort of redirection towards findings that can be verified by independent labs would seem to be an improvement on the current system. But that would require a focus non science as a system and less of the "great researcher" emphasis we see today.
The more specialised scientists become, the more difficult a proper and thorough peer review is to do. That's the 'innocent' side. And then, you have money and politics..
It also erodes science.
I thought positive bias was just one of those things part of the human brain that we just have to deal with. I mean, this isn't some kind of new thing. Look at all the miracles that have been attributed to God over the course of human history. I doubt that old research was any better. Cognitive science has just made us more aware of positive bias.
If what is reported by scientist is wrong, regardless of whether it is too optimistic or too pessimistic, then the public has to be losing faith. IMOO, what contributed the most to that trend is the growing pressure put on scientist to obtain results. Positive ones. Not in 1 or 10 years, but now, otherwise you might be looking for another job pretty quickly.
What is the more puzzling to me being that the said pressure has been put on the scientists mainly by the public itself, so well, I guess you reap what you sow.
They're overstating precision. Which rather then a forgivable error is an elementary mistake no trained scientist should ever make.
A VERY basic concept they teach at the lowest level of science education is the distinction between accuracy and precision. This is science 101.
Accuracy is whether or not a given conclusion is correct.
Precision is to the degree of specificity.
Typically you run into problems on complex subjects because they overstate the precision of their data or their ability analyze the data.
This can boil down to simple thinks like significant digits.
For example, I'm measuring volume to two significant digits in a giant data set with thousands of measurements. When and if I average those numbers the final average can't have more then two significant digits. That sounds elementary but you see this error made on some big studies. You'll have a situation where something is being measured in a crude sense by many sources and then in the analysis a much higher degree of specificity is implied.
Often that degree of specificity is required to make certain conclusions which is why they break the rule. This is lazy and a breach of scientific ethics. What they need to do is collect the data all over again this time to the level of specificity they need.
Simply saying its too hard to collect the data properly so they're going to make assumptions is not reasonable or ethical. I suppose you could do it so long as you kept an asterisk next to the data and the findings to make it very clear throughout that the conclusion is a guess and not in any way empirical science since at some point people were guesstimating results.
I've decided to stop wasting my time responding to AC trolls/sockpuppets... so if you want a response from me... login.
I used to be in academia, and it was no secret that researchers almost always found the results that they had planned to find from the beginning in their studies. I don't think I ever once saw a case where a researcher started out with a hypothesis, found it was completely wrong through the research, and then let it go. There are a million ways to cook the numbers to reach the conclusion that you want to (and the one that gets you the grant money and publication). If a certain position is popular (and well funded), expect everyone to jump on it and start producing paper after paper confirming it.
What political party do you join when you don't like Bible-thumpers *or* hippies?
When you have a hammer, everything looks like a nail.
Anything can become a religion, as a result. We're less critical of our data when that happens, and we "nudge" it into place.
The problem is not "science" per se but our social approach to it.
I would say that the bias is not so much positive as it is "get noticed and get more grant money" biased.
Unfortunately, you get noticed more and get more grant money if you find what you were looking for instead of disproving your initial hypothesis.
Also this article seems to imply that the problem that needs to be fixed is that of public trust, while I would argue that the public should distrust a community that gets it wrong so often (it is the skeptical, scientific thing to do). Unfortunately, far too many people have the opinion that science is absolute truth and always right; but science is not an "exact science" so to speak, scientists overlook variables all the time and prove what they want to prove just as readily as everyone else.
Troll is not a replacement for I disagree.
Academia is a Ponzi scheme built on fudged statistics, unreported failures and outright forged results.
Unfortunately, Publish or Perish and the overadmission of PhD candidates has resulted in a system where getting a paper out is more important than what goes into the paper.
Like just about everything else in this world, science is about money. And how do you get money in science? By finding and/or hyping the next leap forward. Being successful in science is all about getting grants. You don't get tenure without bringing in grant money, you don't get grant money without publishing in the best journals, you don't publish in the best journals without finding the next leap. Your typical PhD finishes school in their late 20's, probably with significant school loan debt. He or she then gets a postdoc where they can barely afford to live in the city with the prestigious school that they think they need to further their career. At the same, it's probably time to think about starting a family (especially if you are a woman). And as a postdoc, the pressure to publish is even greater in a more compressed time frame. There is so much pressure there financially, emotionally and mentally, that is it is no wonder that some people cave and take shortcuts and fudge results. And then, if you do make it to a tenure track position, you don't do much science any more. Instead you spend all your time writing grants and churning through postdocs, who may or may not be fudging their results to get a recommendation to get a better position...
In engineering research, there is definitely a positive bias; in fact, negative results are rarely published at all. This is both because negative results have less sex appeal than positive results and because peer reviewers are trained to outright reject publications without positive results. Although there is huge pressure to publish positive results, I'm not aware of systemic fraud in the literature. What does happen, however, is roughly this: 1) researcher gets great idea. 2) researcher tries idea. 3) idea fails to produce state-of-the-art results. 4) researcher adds hacks and kludges to marginally improve performance. 5) repeat steps 2-5. So, what you get in the end are journals filled with "positive results" that mean nothing and a bunch of "scientists" who make a living doing things that do not really resemble science at all.
What passes for science is not always science. You can't blame people for distrusting the conflicting and wrong headlines. Yes, the media deserves a lot of blame, but it's not all their fault. Watch this video from Tom Naughton and you'll learn how bad some areas of "science" can be: http://www.youtube.com/watch?v=y1RXvBveht0
I'm not sure if it's just me, but I've got the feeling that these days, most useful and ground breaking new research and technology comes from companies, not universities.
What do you think?
So what do you expect academics to do? Reinvestigating a previously reported research result is unlikely to get funded, it's unlikely to be published even if it is researched. They live and die by publications.
Unless and until the publication system makes it possible for academics to check each others' work without killing their own careers, we won't see it happen.
Lacking <sarcasm> tags,
And ignores the fact that once published, there's no reliable corrective mechanism to propagate those results down beyond a standard literature search. I'm posting as AC because quite a few years ago I published results that I believed at the time to be correct, but were shown to be wrong in a subsequent paper. Despite this, I'm *still* being cited in new papers while the paper that refuted mine is seldom cited. Science isn't some infallible field. We make mistakes; Sometimes those mistakes are accidental, sometimes they're sloppy, and yes, sometimes they're even intentional. That doesn't reduce the validity of science, but it requires us to be more vigilant.
The case of the green jelly beans.. http://xkcd.com/882/
Atlas stands on the earth and carries the celestial sphere on his shoulders.
Crap. I only thought I was posting as AC. Doh! :)
This article is about trying to convince religious nutjobs that science is valid? WTF is the point of that? People, in 2012, who don't understand the scientific method are hopeless. Ignore them and move on.
I don't respond to AC's.
I was gonna say, "Give it time before all the flat-Earthers showed up".
Slow news day on Drudge Report, huh?
LOL.
"First they ignore you, then they ridicule you, then they fight you, then you win." -- Mahatma Gandhi
This has always been the case. Science is not a uniform march to the Truth. There is a difference between well-verified and understood results (think engineering) and working at the margins with not much data and the usual human failings (the vast majority of publications). Scientists are humans, not gods. It takes a lot of effort and error to get to the well-verified and understood part.
This is pretty serious. I know that my own confidence in scientific research has been eroded quite a bit in recent years. I can only imagine how it vindicates those who despise science. As far as harming public perception, this is about the equivalent of Catholic priests diddling little boys.
Proverbs 21:19
When you consider what the US gives to it's science budget, the only thing eroding public trust is the paid-for blathering by bought-off scientists. Don't try and hide the real problem with "Positive Bias". That's what you get when you hire someone at a pharmaceutical company to write up a paper for Nature. You don't get independent viewpoints you get advertisement with a scientific undertone.
"A half a penny... The most powerful agency of the dreams of a nation is currently underfunded to do what it needs to be doing."
- Neil deGrasse Tyson
http://www.tor.com/blogs/2012/04/neil-degrasse-tyson-on-the-nasa-budget
Join the Slashcott! Feb 10 thru Feb 17!
You forgot to mention that it is yet another piece of published work that suffers from positive bias...
Nevermind that what about the inaccuracies? Economics is not a science and 'biomedical research' (where the article claims is where the biggest problems lie) and epidemiology are medicine. Perhaps the solution is to educate people as to what science is because it is not defined as any subject which publishes research papers containing numbers and/or long sounding names.
You are currently at step 2.
Most papers I've seen make magnificent speculative claims.
This novel material could usher in a new era in...
This novel method could become...
OMG this material has an IOR of 1.00000001 for gama rays - this will enable.... (yes this was a few days ago).
OMG jelly spread on glass can produce a voltage when exposed to sunlight - organic solar cells could change the world but more research will need to be done to get the efficiency above 0.3 percent.
Anything that isn't in a textbook is "novel" because that's an important word in patents and it's important to seem new. Then the grand claims are made either to make the research seem relevant or to line up funding for future work. Papers have become promotional material.
I remember a few days ago someone submitted a story about piracy for "The Avengers" being low compared to potential profits from them. A few high-ranked comments were like "This is yet another proof that [insert common /. parlance here]". I saw very few comments that stated the most plausible reason: a camcorded action film, with crappy audio and a shaking image, can't compete against the real thing. I thought the same thing: confirmation bias.
People do it all the time. If something can somehow support their views (specially if they don't RTFA) they'll use it as yet more confirmation. "I still don't get why this piece of evidence is discarded by everyone else! They must be delusional or have bad intentions". For example, I imagine this article will be used as evidence for: lack of funding, falling standards in the US, the demise of education, lack of scientific reasoning (maybe they'll even extend it to scientists themselves), and other common /. utterances. I wonder how many of them will actually say what I found out after RTFA...
So, everyone is playing the same game, and scientists are no exception. But hey, that study has numbers on it. At least you can try to replicate the findings, if only the entry barrier wasn't so high: these tests are *hugely* expensive. More collaboration may be a good idea. Shared laurels are better than none, right?
P.S., a nice article on confirmation bias (and other goodies) here.
I rarely respond to comments. Also, don't ask for clarifications: a brain and Google are faster, believe me!
Actually, science is stll working; the real trouble comes with the publicity of the science.
You should never believe the results of any single study. Every scientist knows this; or should know this. Science comes when results are confirmed, not when somebody publishes the first paper. The real work of science just starts when somebody publishes a study saying "we show that x has the effect y." That initial paper really is no more than "here's a place to start looking." However, newspapers want to publish news, and they need to publish whatever's hot and interesting and being done today, not "well, scientist z had his team take a look at the xy phenomenon to see if there was anything interesting there, and they couldn't really find anything there, although maybe some other research lab might have different results."
And, I suppose that somebody should post a link to the obligatory xkcd: http://xkcd.com/882/
http://www.geoffreylandis.com
In my early middle age, sometimes when looking back I wish I went into the natural sciences. My current business/tech career seams really meaningless most of the time and I think if I did something more "worthwhile" like research, then things would be better - you know that whole the grass is greener over the septic tank mind tricks.
When I see things like what you posted, I realize that things turned out OK. The World didn't lose a brilliant scientific mind, either - I honestly think I'd be a mediocre scientist at best. I had this dream briefly in college of being an experiemental physcist, limnologist or a botanist - I'm sooo glad I dodged that bullet.
It's just not your post either. I hear things from rank and file researchers about their own misgivings about their work, the profession, and the BS they have to deal with.
Get an independent lab to confirm your results if you want to be published. Ftfy
Materials: ...
You will need an inanimate entity or concept, an emotional situation, a forum of discourse, and a mind with approx 80 to 120 billion neurons.
Procedure:
0. Select commonly known, generally accepted concept or phrase.
1. Personify the inanimate subject.
2. Rephrase the concept or phrase including the situation designed to invoke an emotion, such as sympathy.
3. Await until an opportunity with sufficient relevance presents itself.
4. Present the phrase in the forum of discourse.
5. Cite a nebulous entity, so as to lend artificial credence.
6. Observe the Science!
7.
10. Prophet!
------
"If you torture the data long enough, it will confess to anything."
-- Unknown Econometrician.
...not just "scientists" who collaborate and challenge as a whole discipline.
They interact with the mass media at the level of individuals and very small groups. As such, most journalists won't pass up an opportunity to quote a researcher who says something like, "This changes everything!" and the spirit of such statements (if not the actual statements) are usually found throughout the articles written by "science" reporters. They play up the significance of individual studies and competition and downplay (or attempt to discredit) the consensus-built and collaborative aspects of science so that the stories fit in with the individualist and consumerist narratives favored by the corporate press.
That dynamic contributes greatly to the public's distorted notions of scientific pursuit. Thus, the popular American sentiment that scientists are mostly bozos "lacking in common sense", and that is when they feel charitible. You'll need to change the overall media culture before you can improve the situation.
Also, I keep thinking about the TV show "The Big Bang Theory". Is it me, or is the cast segregated into the engineers who manage a real social life, and the scientists who are not just eccentric but extreme (and extremely pitiful)?
Really.
With my five seconds of thought,
It seems to me that if scientific papers were published with a series of standard meta data they could be submitted to software based peer review that could go through the published literature and look for inconsistencies, missing references, misleading statistics and other things that need addressing.
Sort of a semantic web for scientific publishing.
It's know effect and why repeated testing is an important part of science.
The problem is the media keeps reporting single studies as if they're an answer, or written in stone.
The Kruger Dunning explains most post on
That's dumb. It's eroding *science* - turning science into religion. If the only problem you see with that is the erosion of public trust then there is something wrong on your end.
That said, the observations in the article are spot-on, and it's good to see others finally noticing this. And as the article notes, it's not limited to medical research. Not by any means. Climateology in recent years has been another area where this problem is quite severe.
=-=-=-=-=-=-=-=-=-=-=-=-=-=-
Friends don't let friends enable ecmascript.
Okay, it may not be exactly a myth. We can't tell. I strongly suspect there is actually a negative publication bias.
What most people think are "negative" results are actually inconclusive. A non-significant p-value is NOT a negative result. That misunderstanding is very widespread, and leads to lots of high level mistakes. Half of the neuroscience papers published in top journals including Nature the last two years that could make a mistake based on that fallacy, did. And neuroscience didn't seem to be particularly worse than most other fields.
A non-significant p-value is just that - not significant. Inconclusive. Getting an actual negative result is considerably more work than getting a positive one. You need to figure out what the minimum effect size you're interested in is (you should do that for positive results too, but almost everyone just uses zero for that) and show that your confidence intervals do not include it. As Ionnadis points out, you really should consider the power of your study as well (also for positive results), and take a stab at estimating the priors too.
If you go and do all that, and also do a quality experiment, in my experience you actually have a pretty good chance of getting published, because a) it's clear to the reviewers you've done a really thorough job (any idiot can run some data through a t-test and get a p-value, negative results are harder) and to show a negative result your study is probably much higher powered than a positive result one, meaning an impressively big p-value.
The problem is not that there's a positive publication bias, it's that most scientists don't know how to show negative results so there are very few negative papers around.
Increasingly people have been taught to trust only certainty. Science is anything but a certain process and people take that uncertainty as false or, worse, a wasted investment.
Until people are more scientifically literate with the process and the value of failure scientists will be driven towards only success and, ultimately, the positivity bias.
Also
"First they ignore you, then they ridicule you, then they fight you, then you die." -- Hitler
Mahatma Gandhi was an ass.
The Kruger Dunning explains most post on
If you have a personal web site or something similar, it may be a good idea on your part to make that clear and link to the refuting paper. It would take some guts on your part, of course, because it could negatively affect your career, but it would probably be the right thing to do.
Do Slashdot readers perceive positive bias to be a problem?
It doesn't matter what I perceive, it's a problem regardless. I can perceive any damned delusional thing I want, and that changes the laws of the universe not one whit. It might make me happier in the short term, until one of those laws I chose not to perceive happens to bite me in the ass.
Perception IS the problem here. Scientists engaging in this behavior are almost certainly doing it knowingly; they're aware they're not practicing the Method. They desire to be perceived as successful, inventive, and ground-breaking, and they're willing to cheat, in essence, and forego inconvenient parts of the Method to achieve that perception. Their own personal success is more important to them than the science.
1) This is all part of the process, and shouldn't be too much cause for concern. Interesting results will be re-tested for confirmation. If these results can't be replicated, it casts doubt on the original study and the reputation of the authors. Negative results are rarely published except when they challenge a prior paper with a positive result. 2) The citation index is another way that bad data gets ignored. The average citation for a paper is less than 1. This means that most papers are never cited and a few good ones are cited heavily. It is true that if wrong ideas become generally accepted, they may remain in the literature unchallenged for some time and can be hard to root out. 3) I suspect that research in biomedical and other highly profitable fields bias these results, since whenever there is huge money to be made, there is pressure for a positive finding. Many of these studies are even bankrolled by the drug companies who want to show that they have the next promising cure or, better yet, treatment--since if you cure someone, you lose your market ;) It's always good to look at who's funding the work.
Skepticism actually strengthens science.
Sometimes when people hear about a study in the news about some vague statistical connection, and treat it like it's a newly discovered fact. If that 'trust' is starting to erode, then it's time for rational people to throw a party!
You must be american.
Global warming: Fraud with a leftist political agenda
Creationism: Fraud with a rightest political agenda
FTFY
=-=-=-=-=-=-=-=-=-=-=-=-=-=-
Friends don't let friends enable ecmascript.
The problem isn't the science. It is the publish or perish mentality. The science is just as valid if result "a" happens or not. However, it's a lot harder to get funding for research if your research keeps coming up negative. 75 years ago, research occurred for the sake of research -- to expand knowledge. Today, research is for the purpose of developing something that can be monetized. 75 years ago, a research paper that showed that x didn't happen under y circumstance was still considered valid.
Today, it is not. Look at the wording on many grants to day: To develop a ...... whereas yesterday it was: To determine the effects of ...... As more and more research got funding by the private sector, colleges and universities shifted their focus to apply research in areas that could be profitable as that is what the buyer (the one paying the grant) wanted. Put differently, as the private sector shifted more and more of its R&D to colleges and universities, the positive bias was introduced because you get what you pay for.
In many fields the problem gets hidden by statistical tests. Frequentist statistics _assumes_ that the hypothesis being tested is true. Even a totally bogus conclusion, provided it is sufficiently different than a non conclusion, will end up being statistically significant. Many people take statistical significance as confirmation of their hypothesis and neglect to consider alternative hypothesis.
The solution to this problem is to demand verification of predictions, and not just rely on a p value. If your research involves building a model then you should test the model against data that wasn't used to fit the model parameters. The measure of utility should be how much better the new model performs versus other models.
It really doesn't matter how bizarre a model looks as long as it works better than the alternatives. It's not as though quantum physics is exactly intuitive, but we accept it because it's currently the best predictor.
What the hell does 'Positive Bias' have to do with the latest AMD processor, Linux distro, or Apple product? Do you even know which site this is?
Evidence is mounting that research is riddled with positive bias.
Maybe that's just what the researchers wanted to find.
The difference is positive bias on Slashdot, as in the Avengers movie doesn't really have much impact on the world. Positive bias on the cancer trials mentioned in the article has serious ramifications. So while it may happen everywhere, some places are more critical and some occupations should be held to a higher standard.
I'm a scientist. It's a big problem.
Here's how you fix it:
The metric for success for both researchers and their government funding sources is published papers. It's hard to change the cultural view of the scientific community, but it's easy to change government metrics. Paper publishing as a metric is easy to track between programs, but has had a terrible impact on scientific culture. It's also led to a large bias in how the government decides what areas to fund. If your metric is paper publishing and you're looking at energy issues, do you fund a sub-field with a historic high paper publication rate, a moderate paper publication rate or a low publication rate? It's fine for us here to say we'd fund the best research, but a government program manager may lose his job for picking a field with the lower publishing rate.
Other metrics such as how many other researchers use some results or whether a practical implementation of some new technique is developed will be harder to judge and take a longer time to evaluate, but would at least give us an honest assessment of the quality of government funded research. Tie future funding to what our broader society is looking for out of science, and eventually the scientific culture will follow.
Discussing the public perspective on science is fine. It's waning, why? That's a good question. But that's not the point here.
Talking about how scientists get "good" data is also a great topic, statistics, error bars, how we come by those numbers. Great points. But also not what's important here.
What is being highlighted, and has been since Ioannidis' publication, is that the overall CONCLUSIONS of these works are just wrong. The data is good. We collect great data, we put it out there, it's within reasonable error and is a true and observed phenomenon. The major problem is that we tend to do the WRONG experiments, or we direct our research toward answering a specific question, instead of gathering data comprehensively and looking to that data exclusively to find appropriate questions.
This bad rigor is prevalent, at least in biological science publications. I can't speak with any authority to any other discipline. Data taken out of context, and worse still, ignoring "inconvenient" observations that debunk proposed models is where a lot of this "bad" science comes from. Scientists will proclaim until they are blue in the face that they'd "never do this" - but I see it happen every single day, from major researchers. I fight with myself every day to not act this way, and it's still very hard, because I'd like to move forward in my career - and some crappy piece of data that shoots holes in my hypothesis is staring me in the face. The easy route is to just ignore that. "Oh, yes, this is a caveat we don't want to get into as it muddies the publication. We'll approach this problem in the next article". That's crap. You can't observe something and then ignore it and publish to the contrary of what that data says just to have a neat little story.
What I've outlined above is the underlying problem. Most of what is published, the conclusions being made, are flat out WRONG. The data is right. But what researchers are saying that data means based on their myopic and "I need to publish this" drive causes tunnel vision and bad conclusions.
I have no idea what the answer is, but I think it's important we recognize what the problem is and what the question is, if we have any hope of getting to an answer.
Evidence is mounting that research is riddled with positive bias.
I just knew it! This was exactly the result I was expecting!
Even if you had a group of responsible an fair enlightened people, there's no guarantee that those people would have friends and families that lived up to those standards. Why am I saying this? Because people want to take care of their friends and family and will eventually exercise their privileges in order to do so.
Eventually, their efforts to ensure the well-being of their circles will advance inadequate people into the ruling groups.
It happens regardless of the political system.
"Science can amuse and fascinate us all, but it is engineering that changes the world. " - Asimov.
One of my cousins has worked for a pharmaceutical company for a few decades as a statistician. Her job is to evaluate research and report on the validity of the analysis. She has told me often that she rejects a lot more than she accepts, and her bosses have always implored her to challenge the findings she's been given, to prevent what we are discussing as 'positive bias' (or as they put it, 'avoiding recalls, liability, and financial ruin'). She calls it 'lying' or 'wishful thinking', if she's feeling charitable. And her opinion of some researchers is that they are gifted, but blinded by their fervent wishes to be successful. And yes, delivering products to save lives and ease suffering is secondary to 'success' for many of them. They don't, as she puts it, 'get the concepts of liability or deceit'. All they want is a bigger lab, more assistants, and an unassailable position. That's all. And a nice hot cup of tea, I'm sure.
My favorite quote from her: "That's a statistical test they use to make data out of noise".
Positive bias is inevitable. Probably started before Galileo, and of course he struggled with that a lot. No less a problem today, though we punish heretics somewhat more humanely today. We either premote them to government jobs when we agree, or we fire them when we don't. Not many go to the stocks any more.
deleting the extra space after periods so i can stay relevant, yeah.
There's nothing wrong with science itself. But there are many barriers against doing science correctly. I can't say for sure if the barriers have gotten worse in recent decades. But I think yes, it has become harder to do good science. Why?
The Space Race and Bobby Fischer's day in the sun are long gone. They were good contests, and well-liked, with very positive outcomes, especially when compared to the alternative of nuclear war. In a way, it makes up for science having discovered The Bomb. It was possible that no one would make it to the moon. We were not going to suffer big losses if that had been the outcome. As for Fischer, he looked more and more unstable as the years passed.
But one thing about The Bomb: it demonstrated the power of science, even if very darkly. After that, the Space Race demonstrated the power of science again.
And now? It's really hard to top The Bomb and The Moon. But, by some measures we have. We have the Internet, which has been, among other things, a virtual nuke to the traditional business model of Big Media. Perhaps that's too subtle for the more cretinous among us.
That's what I think is a big factor in the current state of science. We're still in the letdown following the big high of the moon landing, and the awesomeness that is the Internet has not been appreciated enough.
Some of the stretching and outright fraud is a symptom of that letdown. We're straining to meet impossible expectations. It's as if we have to top the Moon to impress the public. One of the more crudely obvious ways to do that is to visit Mars. Send a human to Mars. Except it can't be a mere visit, it would have to be a prelude to colonization. Can we do that? Not presently.
Is there any other reason to suppose that fraud in science is any worse than in the past? Maybe. I think also that science has become more accessible, which on the whole is good. But a bad consequence is that it's easier for quacks, cranks, and cons to fake it.
Finally, there is motivation for the increased fraud: bias against bad news. Right now, one of the loudest message scientists are giving is AGW. The frauds have seized on public dislike of that negative message. They've been riding high ever since Big Tobacco showed them the way with "Doubt is our product", and they've corrupted and captured the social conservatives. The Republican Party has fallen a long way from the sober fiscal pragmatism of the 1950s. In those days, they were the sane, careful counterbalance to the misty and foolish idealism of the Democrats. The book "The Republican War on Science" would have been laughable in the 1960s. Most "squares" were Republicans, while many Democrats were dirty, drug addled, brain rotted, uneducated hippies. No one would have asked if a Republican president was our worst ever, as Rolling Stone did. Now, the Republicans are the crazies in denial.
Intellectual Property is a monopolistic, selfish, and defective concept. It is "tyranny over the mind of man"
I work in optics and computer vision, and investigate research papers on a regular basis. In the majority of the papers I read the methods proposed either only work for the specific example in the paper (some don't even do that), or only work under such "ideal" circumstances that they barely work under lab conditions, much less real world cases. There are a few gems, but you can tell that much of what is published is just written so someone gets that degree or that quota to reach tenure. Prior to working at this job, my trust in published research was much higher. Now my tendency is to treat it all as garbage until it proves itself otherwise.
I would believe it, but then I would be skeptical of this findings so know I think the meta-meta-data is wrong...
The publication process is probably in part to blame for the perception people have of science. The notion of peer review may make one more inclined to believe an issue is settled when in fact there may be problems raised by reviewers that, although addressed to suit publication, are still open. The public rarely sees the questions others in the field may have with respect to a paper so are willing to accept the published paper as conclusive fact rather than further evidence.
People who question evolution hear up and down, "Evolution and climate change are proven true, you're nuts to deny them". Then they hear "Scientific theory X has been changed". They see this as a disconnect in the logic -- science declares things as absolutely true when science has shown its own previous beliefs to be false. And thus, they no longer trust science.
No, we're currently at the transition between Steps 2 & 3. Fortunately, because this is a 'war' of ideas, the fighting is simply stepped up ridicule, and trumpeting of falsities to combat the truth.
... psst. Follow the money...
I think the real problem is the "all or nothing" approach the public tends to take.
"I found a study on climate change that is mistaken; therefor, every study on climate change is mistaken!" "I found a minor tenant of Darwinian Theory that has been modified; therefor, every theory of evolution must be a lie!"
Science has always been contentious. It's really hard to admit we're wrong.
To me it seems a perfect example of how NON SCIENTISTS have made the expectations that scientists are not able to live up to.
The report was basically "Hey, guys, this looks odd, but we've corrected for everything we could think of. You may want to see if you can replicate this".
Nobody else managed to replicate.
MEANWHILE the original posters were being told how they had it wrong. They changed their process to accord for this and retained some extra difference, despite this. Another attempt by another team showed no effect, so the original scientists CONTINUED to see what could be the cause if not FTL neutrinos.
They then found that the 50ns difference can be accounted for if the connectors were not tight.
NOT, at that time, that this was the cause of the discrepancy, but that
a) the couplings were loose NOW, but they didn't check THEN, could have loosened since then
b) an effect of this is a slight delay, enough to remove the difference they'd seen
All absolutely fine and no "positive bias" AT ALL.
But what is the public saying about it? What were the press saying about it?
THAT debacle (and how it's ignored by the parties involved in it) is a perfect example of the problems science has with people who aren't scientists.
I was referring to his post.
3C+/- 5% and 4C +/- 7% has a difference of 0.97C.
20C+/- 15% and 40+/- 35% have a bigger difference (3C).
And the old global models had a climate sensitivity range of 1.5-6C per doubling. Now we get 2-4.5C per doubling.
I fail to see where your claim "every year a new estimation would come out that was completely incompatible with the previous one".
It's amazing to me how common bias is in the healthcare field.
After reading Gary Taubes' "Why We Get Fat" and another piece he wrote for Science on the politics of salt research (http://garytaubes.com/wp-content/uploads/2011/08/science-political-science-of-salt1.pdf) it seems clear to me that there are a lot of well-placed individuals, who in spite of a solid science background aren't willing to give up long-held beliefs, even when the scientific studies they championed don't prove their theories.
In fact, the more ambiguous the results the more they tend to push the results as if they were definitive in favor of the researcher's viewpoints.
While this is bad for science generally, in healthcare its particularly disturbing because you have people whose reputations and careers are tied to opinions that can't be scientifically validated or worse -- are invalidated -- and yet they continue to be voices for health policies which are at best ineffective and at worst dangerous.
Thanks for posting. This should have a slash dot story of its own. Would love to see more opinions on this.
Let's all try to be careful, here.
Medical research was a little late the science party, and they still have serious issues to work out. Some of these problems can't be helped (low sample sizes lead to higher p values, but higher sample sizes place more human beings at risk), others can (not being skeptical enough of research conducted by organizations with a financial stake in the outcomes).
Most of these problems are peculiar to medical research and should not be conflated with all of science. While we should hold the medical research community's feet to the fire over this, the reason we are hearing so much about this is that they themselves are talking about it and they themselves are conducting the meta-research that is producing all of these articles. Other branches of science have looked down on medical research for a long time, but at least they are now getting serious about addressing the problems.
My first epiphany on the subject of positive bias was dark mater and dark energy. Quite frankly, the properties of dark mater and dark energy are nothing short of fantastic, least of which, the the universe is almost entirely made of the stuff. It's far easier for me to believe some math wizard made a mistake than to believe the universe is made from pixie dust. Given the current state of science, I made it a personal mission to go all the way back to science of the Victorian period to present and review firsthand the important experiments forming my own conclusions. I my three years of review to date, I discovered a number of unexpected surprises. First, history was very kind to Mr. Einstein. Many of the ideas attributed to him in history books were discovered and discussed long before him. Let's take one example, the famous equation -- E=MC^2. The matter/energy equivalence was published by Gustav LeBon long before Einstein published his papers. In fact, let's let Mr. LeBon speak for himself on the energy locked up in matter,
“Certainly it would be quite different if radium or any other substance were dissociated rapidly instead of requiring centuries for the purpose. The scholar who discovers the way to dissociate instantaneously one gramme of any metal — radium, lead, or silver — will not witness the results of his experiment. The explosion produced would be so formidable that his laboratory and all the neighboring houses, with their inhabitants, would be instantaneously pulverized.”
Mr. LeBon's description is simply chilling and has great impact upon us and our politics today. He is, of course, describing nuclear reactions. LeBon is almost entirely forgotten today. Science is subject to all our human frailties. Science is supposed to be empirical but data must be collected, interpreted, and conclusions presented -- all of which can be influenced by those in positions of prominence. In some cases, many dollars and jobs are at stake when new science leading to disruptive change occurs. This is not a new phenomena, science has never embraced disruptive change. One only needs to look back to sciences greatest heros for evidence. Great men of science like Ohm (Ohm's Law) and Robert Meyer (Conservation of Energy) were almost completely disenfranchised from science for their radical (and correct) views. milton.smith.rr@gmail.com
Something that most scientists know, but that is not widely appreciated by the public, is that "landmark" studies are particularly subject to positive bias. For a study to be acclaimed as a "landmark," it is the first report of a novel phenomenon, which by definition means that it has not yet been confirmed by other investigators, and moreover that it is in some sense unexpected--which means that there is not even much "indirect" evidence from other sources that it is correct. It is also likely to be submitted to one of the high-profile "newsy" journals, like Science or Nature, where submissions are not evaluated solely on the basis of whether the science is high quality, but are first screened (and usually by an editor, before it even gets specialist peer reviewers) on the basis of whether it is of "broad interest." Because these journals are widely read and cited , they have high impact factors, so even getting published in one of these journals is a feather in a researcher's cap. In contrast, a publication in a middle-rank journal does not give a major immediate boost to a scientist's career, but may have a long-term benefit--but only if it turns out to be correct. Being "scooped" (by having somebody else publish research leading to the same conclusion) will not prevent you from being published in a middle-rank journal, but it will knock you out of the newsy journals. So the alluring prospect of publication in a newsy journal may lead a scientist to be a bit less cautious than normal, and the risk of being "scooped" means that he/she may not take usual precautions (like seeing if somebody else in the lab can reproduce the result independently). High profile journals are stringently reviewed, but peer reviewers even in these highly-regarded journals necessarily take the authors at their word, unless there are blatant errors--nobody visits the authors' labs to look over the shoulders of the researchers or to verify that negative results have not been discarded. On the other hand, if you are planning to publish a result in a middle-rank journal, you are more likely to take the time to make sure that your conclusions will hold up over the long haul.
Working scientists know this, so they take these "landmark" studies with a grain of salt until they are independently confirmed. But the public can easily confuse "high profile" with "most reliable."
And, I suppose that somebody should post a link to the obligatory xkcd: http://xkcd.com/882/
And the obligatory PHDcomics: http://www.phdcomics.com/comics/archive.php?comicid=1174
In addition of the media needing "the latest hottest news" and thus over blowing the latest new subject (which merely has 1 study using a sample of 10) instead of making a deep review of a well studied subject, there are also problems comming from within the scientific community too :
Lots of research groups are under "publish or die" pressure: they a under pressure to publish as many papers as possible, and thus will tend to publish whenever they got a small "bump" in the signal - "which may under some circumstance be interpreted as something unexpected" - specially when it was never seen before (= unknown, more chance to attract attention, than being study number #23 that confirms that the well studied substance "XyZ-wateverocetone" and disease "Somethingitis" have no interraction, no matter what a paper published 13 years ago). There's a preference for original research in the scientific media, conferences, and so on.
Also, most research groups need funding, and thus whenever something has a slightly above average correlation factor, the paper will automatically jump to the conclusion "could one day be used to cure cancer" trying to whore some investments (this is the life sciences equivalent of putting "might also have some possible military applications" at the end of an engineering paper).
Also, pharmaceutical industries have the need to patent the crap out of anything remotely interesting, and think about actual uses later on, just to be sure to be able to secure potential revenue if the substance turns out to be successful. (This also leads to a patent minefield, where some substance aren't investigated much, because they are patent covered by company AbCorp, which doesn't study at all the diseases which might benefit from it).
All this has a rather negative result both on the scientific community :
- too much hype which ends up making a bad signal-to-noise ratio in the litterature, and difficult to mine the litterature for leads, inspiration or good data upon which to build.
and on the general population:
- because a lot of hype in the media turns out to be fluke or overrated or simply not further researched, they tend to think that most science is based on wrongs.
In practice, one might be right to be sceptic about a single paper making wild predictions out of 10 samples, but on the other hand, when there has been absolutely massive amount of research all bringing the same conclusions, there's no need in being sceptical (like evolution...)
"Sufficiently advanced satire is indistinguishable from reality." - [Tips: 1DrYakQDKCQ6y52z6QbnkxHXAocMZJE61o ]
The media (tv news AND journalists) have a large degree of fault in the public's distrust in science. False balance, equating correlation with causation (they love using the phrase "scientists have found a link between x and y), and basic lack of fact checking propagates incorrect information and sometimes outright lies. Also most scientist seem to horrible communicating skills when communicating to the media and the public.
"When pro-AGW folks scream that we are all going to be underwater in 20 years" HAS NEVER HAPPENED.
The only time is there when you proclaimed it to then make your hate filled ignorance valid.
I heard about a study finding it causes cancer.
And Feynman said as much in his famous "Cargo Cult Science" speech, which I encourage everyone to go read.
The problem is a lot of scientists DON'T do science that way these days. Bad science, "positive bias" as this article calls it, was rampant in the behavioural sciences when I was studying them. I basically never read a paper where they falsified their theory, or where they said things were inconclusive. They always found a way to hammer the results in to support of their theory, and none of them were ever willing to give me raw data (admittedly I only asked a few, but still).
So while journalists are part of the problem, some scientists are another. They can't ever have their theory be wrong, so they'll do whatever they can to "prove" it. Rather than trying to be the ultimate skeptic and work to find evidence to falsify it, they discard any of that and try to show how it might be true.
This is not a flaw in the system. This is a virtue of the system. Nobody wants to read 100s of papers about how bananas do not cause cancer. No scientist (at least no scientist that I know) believes that a paper proves anything. The paper is a finding worth sharing which must then be confirmed repeatedly by other scientists to be accepted as a fact.
Sadly, results shaping is an old problem in social fields : survey questions, selecting the sample, the size and the diversity of the sample, the preset study direction and ignoring factors not in line with that direction.
Newton was wrong!
where would be to day if we'd believed him !?
I interpreted it as eating more than you grow...as in growing plants/animals and harvesting them.
My problem with Fox is not that it reports from the right, but that it often reports a mindblowingly slanted and outright false version of the news. They've also been known to go out of their way to *create* news, and then cover it as though they had nothing to do with it.
For instance, they've had an "entertainment" show on the channel say something outrageous and inflammatory, and then what is supposedly a straight news show reported that "people are saying...." without mentioning that the only people saying it were other people on Fox.
I'm a transplant surgeon, and (sometimes) researcher. I can tell you that there is a strong positive bias in most clinical articles in medicine. Basically, it is much more noteworthy to read of a clinically significant advance of some sort than to read that a certain treatment doesn't work, or doesn't work better than previous treatments.
Essentially, academic clinicians tend to report good results. A clinical series with outstanding results lends prestige the researcher and his/her institution, and is also more likely to be accepted for presentation or publication. So, if there is a particular surgical technique being developed, it is much more likely to be published if the clinical series has good outcomes, even if the good outcomes were partly due to chance. There doesn't have to be any dishonesty or misrepresentation involved. Of course, there are also rewards of prestige and promotion that can come with "important advances", so plenty of basically decent researchers fall into the trap of trying to prove that something works, as opposed to impartially testing whether something works. Also, leaving self-promotion out of it, in medicine it is completely understandable to hope for a positive result, because a genuine advance may save lives or cure diseases.
I do computer security research for a living Because of the general lack of scientific rigor that accompanies this field, no one is interested in results which do not produce some newsworthy result. A well-designed study which shows the lack of a security problem, where there is a good reason to suspect there may be one, is not considered valuable by anyone other than the manufacturer of the product.
There is also a lack of interest in problems which are not 'interesting'. If an attack methodology is only successful in one in a thousand cases, it is not sufficiently interesting to get attention because it is not easy to show. If you can't craft an easy plugin for MetaSploit, it is as though the problem doesn't exist.
I'd quibble with your thermometer accuracy statement. The wikipedia thermometer page says, "According to British Standards, correctly calibrated, used and maintained liquid-in-glass thermometers can achieve a measurement uncertainty of...±0.05 C up to 200 or down to 40 C".
Also, you need to make a distinction between significant figures and decimal places. If I measure a temperature of 11 degrees accurate to 1 degree, that is two significant figures. If I need to divide the temperature by 10, I get a result of 1.1, which is still two significant figures. In any case, "significant figures out" == "significant figures in" is only an estimation. To be rigorous, proper calculus error estimation should be used to determine the error bounds on the output of a calculation
Statistics also comes into play. If I take a thousand samples and 998 of them are 11, one is 10, and one is 12, I can state a margin of error of much less than 1 degree at a 95% confidence level.
Belief in religion - specifically with respect to creationism, is a very good example of positive bias that exists in the scientific community. I am in a high ranking biological science graduate program and am astonished at the sheer number of my peers that do not believe in evolution. And this lack in belief is due to the fact that they are biased towards believing in creationism which has absolutely no quality scientific data to support it. When I discovered their bias, it made me wonder how objective they can truly be about the data they collect.
I figure movie piracy is different from music piracy, since big theater screens provide a different experience (whereas an official CD isn't that much different from a downloaded copy)
I listen to both RIAA and non-RIAA stuff if I like the music, tangential business/politics nonwithstanding.
Wrong. http://en.wikipedia.org/wiki/Economics
Don't like wiki? http://dictionary.reference.com/browse/economics?s=t
So you're completely, irrefutably wrong on that one. You can dislike it all you want, it changes nothing. And medicine ISN'T science? What? http://en.wikipedia.org/wiki/Medicine
You're wrong. That you think your attempt at pedantry had merit doesn't make you any less obviously and irrefutably wrong.
As long as it's not you doing the educating, since you're completely wrong on what is and is not science. Educator, educate thymotherfuckingself.
Wrong. http://en.wikipedia.org/wiki/Economics [wikipedia.org]
Only if you take the original latin meaning of the word meaning "knowledge". Since you trust Wikipedia I'm surprised that you did not look up science itself, and I quote from the article:
In modern use, "science" more often refers to a way of pursuing knowledge, not only the knowledge itself. It is "often treated as synonymous with ‘natural and physical science’...
Clearly this is not economics or indeed any of the social sciences where social critique and symbolic interpretation are acceptable tools to use - something that is an anathema to what the vast majority of people would undersand when you say "science". Medicine is closer to but, in case you are unaware of what natural science is I quote again from the relevant Wikipedia article:
The natural sciences are branches of science that seek to elucidate the rules that govern the natural world by using scientific methods.
Medicine applies science, so yes technically using the ancient definition of the word it is a "science" but using the definition of the word that most people (though clearly not you) use it is not science. As an example: if a doctor studies the effects of Magic Pill A on patients with a disease and finds that it cures them then he is a huge success medically because the aim of medicine is to cure people. Scientifically he would be far less of a success because he does not know why Magic Pill A cures people.
The scientist is interested in understanding how and why things behave the way they do. Some medics are indeed scientists because in order to develop the best way to cure people they want to understand how something works but in many cases the focus is on the result rather than the understanding which is not science in the modern, natural science, meaning of the word.
That you think your attempt at pedantry
Who is the pedant? The person using the modern, generally accepted interpretation of the word or someone insisting on the ancient dictionary definition? My apologies if I inadvertently caused the modern world to intrude on you but I had not realized that Slashdot posts were available in ancient Greece....still perhaps you have managed to learn something!
Well... was it accidental, sloppy, or intentional? :)
Science journalists William Broad and Nicholas Wade were writing about this back in 1982. See their book, Betrayers of the Truth: Fraud and Deceit in the Halls of Science . Science is a human enterprise. We have always trusted it more than we should. Better that our romantic notions about the objective standards of science be exposed for what they are than to continue believing them.
is just code for we know most published studies are fraudulent, and when the general public realizes just how low we've stooped, there WILL be hell to pay.
Belief in things you do not understand IS superstition, and "science" is the new religion for most people who like to think of themselves as being so fucking brilliant without actually doing any work.
America science is religion and you berrer not question that or we'll fire you from your teaching position
Just because an experiment cannot be reproduced by one group does not mean the original experiment was wrong.
Many experimental techniques require years to get right and the subtleties are not going to make it into a scientific paper , even if the experimenters are aware that there is a subtlety. The experimental techniques are often derived from trial and error, so a subtlety may not even be known.
In many cases if you can't reproduce something in your own lab you will have to spend some time at another lab to learn from the horses mouth.
Unless the original article has addressed these issues it is not saying anything useful.
OK I experienced this as an undergrad at UCSD. Our prof (who shall remain nameless) "let it be known" that our undergrad experiments would be graded better if the results contradicted the null hypothesis (no effect). It's very subtle and informal, it's not like they stand in front of the class and say it, but someone gets told and by the time the papers are turned in, everyone knows and has complied.
Research universities are notoriously political and cutthroat; even not complying could send the inadvertent signal that you think you're morally better than your TA, who did the same thing as an undergrad and everyone knows you never want to offend your TA in any way shape form or size; they'll end your career, at least at UCSD.
There's a lot that's wrong with the university and the more competitive the university the truer that becomes. With a surfeit of very over-qualified candidates, careers are decided by who likes whom or more often who doesn't like whom. Everyone know this and the whole scene is despotic with the power to of life and death over careers being handed over to temperamental 23 year olds.
So now you're telling me this system is also corrupt? Oh my!
Well, don't despair, we can clean this sewer right up.
1) anonymous grading where the the grader doesn't know whose paper / test / etc they are grading.
2) Enough experiments randomly selected for rigorous anonymous, independent confirmation so as to make any cheater properly nervous with a three strikes and your out policy (or such like) by a body composed for just this task.
Rolling back of the excessive metricization of performance. They essentially "grade" you as a prof by how many times you're cited and how many grants you pull down for the university. In many cases, the university acts as your pimp, taking their cut or what you get. How do you pull down grants? By being a golden researcher- one who consistently makes new discoveries, and that has come to mean positive results even though a negative result can bear just as much new information as a positive one if the experiment is aimed in the right place.
Tenure and grant money are decided by who gets positive results, even though a negative result can bear just as much new information as a positive one if the experiment is aimed in the right place.
An institution's character can largely come to be dominated by how many sociopaths it let through its doors and into positions of power. The dishonesty of these personalities can have enormous influence over every aspect of everyone's else's life and survival strategy. Then that attitude becomes institutionalized, meaning people who came up through that system and won by playing it reanimate during their own careers. Right now, the university culture, at least where I went, is an open running sewer.
It' s almost not worth fixing since the university as we know it will be dead within 15 years thanks to super-inflationary tuition models, layers and layers of overpaid bureaucrats thrashing around looking for something to get busy with in order to seem indispensable, no bankruptcy stipulations on quarter million dollar student loans and the creation of low cost / no cost alternatives for the vast majority of majors.
It's really too bad since the collective efforts of research university system has essentially saved civilization a few times now and been the only source of truly independent knowledge free from mundane political pressures and as such effectively kept progress technological and civic progress going for a least a century now. Such a thing must continue to exist in some capacity and it must be funded through public measures (or it's not independent.) Either that or society is going to extinguish itself.