Slashdot Mirror
Promising New Drug May Cure Malaria
Diggester writes "Researchers at the University of Cape Town in South Africa have developed a pill that can wipe out malaria with a single dose. It's a development that could save millions of lives in Africa alone, not to mention the rest of the world. But there's a teensy weensy little hurdle that must first be overcome: human testing. According to National Geographic, 'Clinical tests are scheduled for the end of 2013. If this tablet is approved in coming years, this achievement will surely usher in a new age for science in Africa. It will save millions upon millions of lives on the continent, helping avoid at least 24 percent of child deaths in sub-Saharan Africa.'"
The slashdot audience is sometimes incredibly cynical. "Oh, sure, cure Malaria, but I'll bet you all those people will just die of something else!"
Yes, true. If there's one thing we can probably all agree on is that in the long run, no one will be saved. Everyone will die. That's what happens to people.
The answer is either to give up and do nothing about it, or start doing something about it, knowing that even solving a part of the problem (Malaria) isn't solving the whole problem. Do you want to move the ball forward or sit back and snipe at those who do?
Personally -- speaking as someone who saw his father almost die of Malaria in the early 80's after returning from a trip to Kenya -- I can't see this as anything but a good thing.
Note that there has been *zero* human testing yet, not even phase 1 tests on healthy human subjects. From among the compounds that make it to that stage, maybe one in 50 or 100 (!) really makes it to market.
Aminopyridines (the class this new compound is from) have known pharmaceutical uses - and some compounds of this class have severe side effects, such as causing epileptic seizures that are difficult to reproduce in animals. .And its pretty reactive amino group is a general red flag.
But of course I wish the researchers luck with their tests.
"Here's a pill that can save your life Jonny...but first you have to promise to be good! Otherwise you can go die like all the rest."
Seriously dude. WTF. Save the lives first. The rest comes naturally. The tighter you try to control it, the worse it will be. Just save the lives first. Then out of neccesity things start happening. So many of Africa's problems simply stem from lack of hope, lack of value of existence cause so many people simply expect to die by age 20. This is the first step to breaking that chain, and to place conditions upon it is unbelievably stupid, even evil.
The guy who said the election was rigged won the presidency with the second-most votes.
... they'll all die of starvation anyway.
People in this thread need to understand a few things about malaria. For starters, malaria isn't AIDS, so there's no reason to have the same prejudices about it. You don't get malaria because you're ignorant, or stupid, or religious, or poor, or you have bad morals, or you don't believe in medicine. You get it because one time, a mosquito landed on you and bit you. That's all it takes. It could happen when you're outside working in the fields or it could happen when you're indoors, in bed, asleep.
Second, unlike AIDS, malaria doesn't go around killing everybody who gets it. In fact, a lot of people who get malaria get better. The problem is, while you're suffering from it, you are very ill. It's not, "Hey Bob, you were looking pretty rough during that PowerPoint presentation, is everything OK at home?" "Aw, well you know I got this malaria, it's really kicking my ass..." No, you are at home, in bed, covered with sweat, feeling miserable.
Third, malaria is not chicken pox. When you get better from malaria, you don't now have immunity against malaria. There are also two forms of malaria. One form, you get better and you're fine. The other form, you only seem to be fine, but the malaria will actually come back, again and again. So people in high risk areas sometimes get sick with malaria for a two-digit percentage of their adult lives.
So what we're talking about when we talk about curing malaria in Africa is improving the overall productivity of an entire region, not just increasing the population. Imagine what happens when you're a subsistence farmer who feeds your family by growing crops on your own land, but every 18 months you fall ill with malaria. Simple: You and your whole family starve.
Now imagine your chances of completing a college education if you live in a malaria-stricken area. Or finishing the third grade. One Laptop Per Child won't help you if you can't get out of bed.
People being healthy and productive isn't what causes widespread poverty and starvation. People being alive, yet unable to do even the most low-level agricultural work, let alone some kind of entrepreneurial work that can advance their community, is what causes it.
And you know what else it causes? High birth rates. When whole communities have been reduced to poverty because of disease (among other factors), most families there will support themselves through pure physical labor. What do you need to do physical labor? Hands and strong backs. One hedge against your crops failing because you come down with malaria in harvest season is to have some children who can take over the work for you. Maybe the more the better, since children aren't adults. Also, children are more vulnerable to actually die of malaria, and it's always heartbreaking to be left childless, so more people might be disinclined to stop at one.
Given all this, I can't imagine a single argument that would justify prolonging the suffering of Africa from malaria, in an age when we know exactly what causes it and we have the technology to prevent it. That's like saying the buildings keep burning down, but starting a fire department would be too expensive.
Malaria was once highly prevalent in the southern United States. We mainly used civics projects to combat it -- draining swamps and the like -- and now it's all but eradicated here. Those same methods might be impractical in Africa -- medicine is probably necessary -- but the fact that no living American remembers a time when malaria was a commonplace disease in the U.S. proves that although malaria has been with mankind since the dawn of recorded history, it doesn't need to be. Like smallpox, it may be possible to eradicate it completely. Anybody who thinks that's a bad thing needs to have their head examined.
Breakfast served all day!