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Promising New Drug May Cure Malaria

Posted by Soulskill on from the take-that-mosquitoes dept.

Diggester writes "Researchers at the University of Cape Town in South Africa have developed a pill that can wipe out malaria with a single dose. It's a development that could save millions of lives in Africa alone, not to mention the rest of the world. But there's a teensy weensy little hurdle that must first be overcome: human testing. According to National Geographic, 'Clinical tests are scheduled for the end of 2013. If this tablet is approved in coming years, this achievement will surely usher in a new age for science in Africa. It will save millions upon millions of lives on the continent, helping avoid at least 24 percent of child deaths in sub-Saharan Africa.'"

14 of 190 comments (clear)

  1. Unless you can give everyone birth control.... by Anonymous Coward · · Score: 4, Insightful

    ... they'll all die of starvation anyway.

    I do think this is a positive development, but it's going to have to be followed up with some pretty intense education and condom dispersal in order to actually help things.

    1. Re:Unless you can give everyone birth control.... by h4rr4r · · Score: 4, Insightful

      Western technology is what caused western birthrates.

      You have the whole thing backwards.

    2. Re:Unless you can give everyone birth control.... by higuita · · Score: 4, Insightful

      Not all African countries have food problems... not all have wars... not all have democratic problems... and finally, malaria isnt restricted to Africa, it exits in south and central america and asia as you can see here. And of course, there are countries where malaria is a higher danger than others.

      Reducing the death rate usually increase the stability of the regions in middle term (people have more to lose) and in a long term, birth rate is also decreased. Europe and North America showed this and right now, Asia is already in that way.

      Either way, this will help all and if sucess, will plug a huge unsolved problem (mostly because first world countries have no malaria, so almost no research is committed to find a cure for it)

      --
      Higuita
    3. Re:Unless you can give everyone birth control.... by silentcoder · · Score: 4, Insightful

      >Right, but the actual human toll, the suffering it will cause because Africa is so poor, is that suddenly made alright since tourists have one less deadly disease to worry about?

      In a round-about way, it actually might be. Tourism is one of the largest single sources of foreign capital in most African countries. Indeed for quite a few it's their single largest export- and creates a market that has among the lowest barriers of entry for some of it (anybody can set up a curio stall with relatively little start-up capital and no need to afford expensive business locales).

      So more tourists would mean less starvation.

      --
      Unicode killed the ASCII-art *
    4. Re:Unless you can give everyone birth control.... by i+kan+reed · · Score: 4, Insightful

      Birth control is made widely available in Africa, and population growth there is slowing at what can only be called a reasonable rate(i.e. current population kinda high, first derivative also kinda high, second derivative healthy negative). Your perspective is a common one towards Africa, and, in general, a kind of racist, imperialistic one.

    5. Re:Unless you can give everyone birth control.... by h4rr4r · · Score: 4, Insightful

      Yes, which is why adding in this treatment gets them closer no farther away from low birth rates.

      They need more western technology not less.

      They need roads, schools, air conditioning, etc. Much like those places we are fighting in now, making sure those places had comfortable folks working 9-5 would solve a lot of problems for everyone.

    6. Re:Unless you can give everyone birth control.... by h4rr4r · · Score: 4, Insightful

      Perfection is the enemy of good. We can do this, we cannot reasonably do what you suggest.

      Birth control is already widely available in Africa, most African nations have some form of public education and many are working towards sustainability. Within 50 years they will have negative population growth.

      Your entire set of comments sounds like "White Man's Burden" to me. I suggest you study the continent and the problems it faces before suggesting the world treat them like savages.

    7. Re:Unless you can give everyone birth control.... by dywolf · · Score: 5, Insightful

      "Here's a pill that can save your life Jonny...but first you have to promise to be good! Otherwise you can go die like all the rest."

      Seriously dude. WTF. Save the lives first. The rest comes naturally. The tighter you try to control it, the worse it will be. Just save the lives first. Then out of neccesity things start happening. So many of Africa's problems simply stem from lack of hope, lack of value of existence cause so many people simply expect to die by age 20. This is the first step to breaking that chain, and to place conditions upon it is unbelievably stupid, even evil.

      --
      The guy who said the election was rigged won the presidency with the second-most votes.
    8. Re:Unless you can give everyone birth control.... by PCM2 · · Score: 5, Insightful

      ... they'll all die of starvation anyway.

      People in this thread need to understand a few things about malaria. For starters, malaria isn't AIDS, so there's no reason to have the same prejudices about it. You don't get malaria because you're ignorant, or stupid, or religious, or poor, or you have bad morals, or you don't believe in medicine. You get it because one time, a mosquito landed on you and bit you. That's all it takes. It could happen when you're outside working in the fields or it could happen when you're indoors, in bed, asleep.

      Second, unlike AIDS, malaria doesn't go around killing everybody who gets it. In fact, a lot of people who get malaria get better. The problem is, while you're suffering from it, you are very ill. It's not, "Hey Bob, you were looking pretty rough during that PowerPoint presentation, is everything OK at home?" "Aw, well you know I got this malaria, it's really kicking my ass..." No, you are at home, in bed, covered with sweat, feeling miserable.

      Third, malaria is not chicken pox. When you get better from malaria, you don't now have immunity against malaria. There are also two forms of malaria. One form, you get better and you're fine. The other form, you only seem to be fine, but the malaria will actually come back, again and again. So people in high risk areas sometimes get sick with malaria for a two-digit percentage of their adult lives.

      So what we're talking about when we talk about curing malaria in Africa is improving the overall productivity of an entire region, not just increasing the population. Imagine what happens when you're a subsistence farmer who feeds your family by growing crops on your own land, but every 18 months you fall ill with malaria. Simple: You and your whole family starve.

      Now imagine your chances of completing a college education if you live in a malaria-stricken area. Or finishing the third grade. One Laptop Per Child won't help you if you can't get out of bed.

      People being healthy and productive isn't what causes widespread poverty and starvation. People being alive, yet unable to do even the most low-level agricultural work, let alone some kind of entrepreneurial work that can advance their community, is what causes it.

      And you know what else it causes? High birth rates. When whole communities have been reduced to poverty because of disease (among other factors), most families there will support themselves through pure physical labor. What do you need to do physical labor? Hands and strong backs. One hedge against your crops failing because you come down with malaria in harvest season is to have some children who can take over the work for you. Maybe the more the better, since children aren't adults. Also, children are more vulnerable to actually die of malaria, and it's always heartbreaking to be left childless, so more people might be disinclined to stop at one.

      Given all this, I can't imagine a single argument that would justify prolonging the suffering of Africa from malaria, in an age when we know exactly what causes it and we have the technology to prevent it. That's like saying the buildings keep burning down, but starting a fire department would be too expensive.

      Malaria was once highly prevalent in the southern United States. We mainly used civics projects to combat it -- draining swamps and the like -- and now it's all but eradicated here. Those same methods might be impractical in Africa -- medicine is probably necessary -- but the fact that no living American remembers a time when malaria was a commonplace disease in the U.S. proves that although malaria has been with mankind since the dawn of recorded history, it doesn't need to be. Like smallpox, it may be possible to eradicate it completely. Anybody who thinks that's a bad thing needs to have their head examined.

      --
      Breakfast served all day!
  2. Re:Whack-a-mole by CrankyFool · · Score: 5, Insightful

    The slashdot audience is sometimes incredibly cynical. "Oh, sure, cure Malaria, but I'll bet you all those people will just die of something else!"

    Yes, true. If there's one thing we can probably all agree on is that in the long run, no one will be saved. Everyone will die. That's what happens to people.

    The answer is either to give up and do nothing about it, or start doing something about it, knowing that even solving a part of the problem (Malaria) isn't solving the whole problem. Do you want to move the ball forward or sit back and snipe at those who do?

    Personally -- speaking as someone who saw his father almost die of Malaria in the early 80's after returning from a trip to Kenya -- I can't see this as anything but a good thing.

  3. Re:So, millions will die without the drug by h4rr4r · · Score: 4, Insightful

    What if it kills 90% of the people who take it?

    Human trials find that drugs either work as expected, not at expected or there are serious complications from the drug that might even be worse than what it cures.

  4. Re:Whack-a-mole by h4rr4r · · Score: 4, Insightful

    These are the same morons who try to hinder nearly all human progress, they fail to realize "Perfect is the enemy of good".

    In their other forms they claim electric cars will never get better, wind power kills birds, solar power takes land and that fracking can never be done. They never consider that perfection will never be reached, but each step towards a better answer is a worthwhile step.

  5. Too early to rejoice by Wdi · · Score: 5, Informative

    Note that there has been *zero* human testing yet, not even phase 1 tests on healthy human subjects. From among the compounds that make it to that stage, maybe one in 50 or 100 (!) really makes it to market.

    Aminopyridines (the class this new compound is from) have known pharmaceutical uses - and some compounds of this class have severe side effects, such as causing epileptic seizures that are difficult to reproduce in animals. .And its pretty reactive amino group is a general red flag.

    But of course I wish the researchers luck with their tests.

  6. Re:ZOMBIES!!!!! by ciderbrew · · Score: 4, Insightful

    When they "cure" 95% of the Malaria. It does leave room for the drug resistant strain to thrive. Not that it is a problem as the 95% is killing the poor people regardless. I hope BIll get to spend his Billions buying up the world supply and giving out if it works. Good legacy to go out with.