Promising New Drug May Cure Malaria
Diggester writes "Researchers at the University of Cape Town in South Africa have developed a pill that can wipe out malaria with a single dose. It's a development that could save millions of lives in Africa alone, not to mention the rest of the world. But there's a teensy weensy little hurdle that must first be overcome: human testing. According to National Geographic, 'Clinical tests are scheduled for the end of 2013. If this tablet is approved in coming years, this achievement will surely usher in a new age for science in Africa. It will save millions upon millions of lives on the continent, helping avoid at least 24 percent of child deaths in sub-Saharan Africa.'"
... they'll all die of starvation anyway.
I do think this is a positive development, but it's going to have to be followed up with some pretty intense education and condom dispersal in order to actually help things.
An even greater step forward would be to stem the violence, ignorance about birth control, contraceptives and STDs/STIs. Saving lives is great, it would be even better if those lives are not condemned from the start. Well, I guess we'll sort out Africa one step at a time...for today, I'll drink to this cure and all the people it will help.
A 'singular oddity' is an event that cannot be explained and only happens when you are alone.
I here apple has a patent on round edible things.
Nah, I promise new drugs all the time without curing malaria. Must be something else that does it.
Seriously, can't we just ship a few pallets of tonic water over? It's an effective treatment, and as a bonus healthcare workers can take some beefeater and have a lovely after-work nightcap.
Now all those newly saved millions have left to do is to try to avoid dying of famine, AIDS, tribal wars, collateral damage in targeted attacks, etc, etc, etc.
There's one other "teensy weensy little hurdle": the cost. Or more precisely: the price. If this is something that WHO or other health agencies can purchase and dispense for a few cents per dose, it could revolutionize life in sub-Saharan Africa. If it's patent-protected and expensive... not so much.
http://alternatives.rzero.com/
The slashdot audience is sometimes incredibly cynical. "Oh, sure, cure Malaria, but I'll bet you all those people will just die of something else!"
Yes, true. If there's one thing we can probably all agree on is that in the long run, no one will be saved. Everyone will die. That's what happens to people.
The answer is either to give up and do nothing about it, or start doing something about it, knowing that even solving a part of the problem (Malaria) isn't solving the whole problem. Do you want to move the ball forward or sit back and snipe at those who do?
Personally -- speaking as someone who saw his father almost die of Malaria in the early 80's after returning from a trip to Kenya -- I can't see this as anything but a good thing.
What if it kills 90% of the people who take it?
Human trials find that drugs either work as expected, not at expected or there are serious complications from the drug that might even be worse than what it cures.
As certain folks on here will tell you, this is just a money grab by evil pharmaceutical companies. These poor souls in Africa will be forced to take these tablets simply so the evil companies can make a profit.
This could have been done a long time ago, and without companies making a profit, but it's been put off because of the conspiracy between government and evil corporations to keep the man down by making him pay for medications which can wipe out a disease/affliction/whatever.
As this is purely a profit-driven exercise, it must be shouted down and demonstrations made to prevent this tablet from being used.
Oh, and since this involves use of evolutionary doctrine, we need to get the Christian community in an uproar because this goes against the Almighty's will. If he didn't want malaria to exist, he wouldn't have created it to torment humans. Trying to find a way to prevent/cure malaria is an assault on religion and must be stopped.
Did I cover everything?
We will bankrupt ourselves in the vain search for absolute security. -- Dwight D. Eisenhower
These are the same morons who try to hinder nearly all human progress, they fail to realize "Perfect is the enemy of good".
In their other forms they claim electric cars will never get better, wind power kills birds, solar power takes land and that fracking can never be done. They never consider that perfection will never be reached, but each step towards a better answer is a worthwhile step.
This look great and all but...how much will it cost?
We can already cure Malaria but the best antibiotic cost a fortune and is the reason Africa still have the disease.
Of course, curing every form of Malaria with a single dose is good, but to be viable for Africa and other poor country, the real question is...how much does it cost?
Elok
Listen to all these comfortable, white, Western cynics. Any point you may have, any criticism you might bring to bear, should be measured against the litmus of millions dead, or millions more suffering irrevocable harm to their childhood development (disease plays a statistically larger role in this than any other, at least in sub-saharan Africa).
Yes: starvation remains a problem. Yes: tribal warfare and corrupt political systems remain a problem. Yes: someone will make money off all this.
If these are the criteria by which you spoiled children support or oppose change in Africa, replete with all the indignant and self-righteous offense that only such children can summon, then you are in fact supporting some asinine Zeno's paradox in which Africa is stuck in misery and never able to leap out it in the 'one fell swoop' you seem to require. Change come at a pace, and it comes at a price.
I doubt any of you are affecting the former, or even paying the latter. You should be ashamed of your willingness to reduce the suffering of strangers to a non-issue.
Note that there has been *zero* human testing yet, not even phase 1 tests on healthy human subjects. From among the compounds that make it to that stage, maybe one in 50 or 100 (!) really makes it to market.
Aminopyridines (the class this new compound is from) have known pharmaceutical uses - and some compounds of this class have severe side effects, such as causing epileptic seizures that are difficult to reproduce in animals. .And its pretty reactive amino group is a general red flag.
But of course I wish the researchers luck with their tests.
The continent that birthed all human life cannot support any?
Low population growth rates are a function of being comfortable. If infant mortality is high humans will have far more offspring.
Just being realistic here, slashmydots, you might want to think before typing.
Let's just leave them to die of unpleasant diseases. Oh good. What a super human being you are. Did it ever occur to you that there are links between these things? Like, you know, that healthier people are richer and thus have less children? Not that that's really the point. Also, that climate is where your ancestors evolved, so your first world superiority is perhaps a little misplaced. Just being realistic here.
[FUCK BETA]
When they "cure" 95% of the Malaria. It does leave room for the drug resistant strain to thrive. Not that it is a problem as the 95% is killing the poor people regardless. I hope BIll get to spend his Billions buying up the world supply and giving out if it works. Good legacy to go out with.
Submitted for your serious consideration: For years I've been harping on this. How many lives will be lost delaying this drug 1 year, much less 3-5?
How many would be lost introducing a bad drug prematurely?
Of course, the former millions a year don't show up in front of the cameras as well as a politician with the latter and some (admittedly) horriffic sob stories.
There are gigatons of snake oil fraud to root out. Still, nobody runs the relative numbers of fraud deaths vs. deaths due to delays proving things work to government agencies.
(-1: Post disagrees with my already-settled worldview) is not a valid mod option.
It works a lot better than Lariam/Mefloquine.
http://www.cbsnews.com/2100-500164_162-538144.html
"The average reporter we talk to is 27 years old......They literally know nothing." - Ben Rhodes
Actually it used to be quite common in parts of the US as well. It used to be called ague. I'm not sure of it's original range, but I think it was even as far north as Ohio. There are variants like avian malaria which have been a barrier to reintroducing eagles and other species.
Beta is broken and the link to classic doesn't work. Stop wasting our time or there won't be anybody left here.
like they did in TFA: No, No, DDT isn't banned when used to combat malaria.
Ooh, moderator points! Five more idjits go to Minus One Hell!
Delendae sunt RIAA, MPAA et Windoze
The drug testing regime we have was built incrementally to deal with flaws that existed in the previous setup. Remember Thalidomide?
[FUCK BETA]
I remember reading about clinical trials for some lifesaving drug a while ago. As they were going through the trials, they realized that the drug group was experiencing a very high survival rate, something like 90%+ cured, while the control group continued to experience mortality at the expected rates. They suspended the trials early, and provided the control group with the actual drug, citing humanitarian reasons.
It's possible that they could do the same for this drug. More likely, really, as South Africa probably doesn't have the same requirements as the US FDA for approving new drugs.
John
How many lives will be lost due to distrust of western medical science if they push forward prematurely and find serious side effects?
Give me Classic Slashdot or give me death!
He wants population control, and here we are working to eliminate a major natural population control mechanism.
Millions of dead kids = good for the environment.
...I hope they also figured out how to increase the food supply by 25%, if we're going to cut the mortality rate.
" Everyone will die. "
every one who is dead, has died. That's all you can really say.
The Kruger Dunning explains most post on
Can we give it to the mosquitos?
There are such pills but you won't survive taking one.
Please make some sort of effort to understand science.
They need to determine if it work. The statistics of who dies isn't really a constant number. Maybe you give the pill to 1000 people in the field, and 75% die. IS it because of the pill? IS it just a statistical dip? If it does drop, and it turns out to be a statistical dip then what? What about the money they wasted? what about people who don't understand statistics think that's proof it does work when ti doesn't? What if the pill does harm, but it's hidden inside of a statistical dip?
I could go only but if you haven't gotten the point by now, your just too damn stupid to ever understand why.
The Kruger Dunning explains most post on
If you are concerned about population consider India, more people than Africa and 1/15 the area.
Yes, civilization has degraded to the point where people will ignore any and all data in an article and instead complain about its diction.
You are right. We shouldn't have invented antibiotics. Now we have all these people in the developed countries dying from old age. What a fucking tragedy.
Yes,they do run those numbers. Instead of ranting and displaying your ignorance, maybe you should research.
Maybe you should make an attempt to understand that ti's more complex then comparing lives lost, like determining effect?
Fuck, you people are short sighted, ignorant and have the ego to say you must know everything. twads.
The Kruger Dunning explains most post on
Beyond the savings in human lives, there should be a productivity boom. Malaria is contracted periodically in adulthood by people in an environment where it is prevalent, and it can wipe out an individual's productivity for a couple weeks at a time, several times a year. In some areas, it can be contracted with the same frequency with which westerners are used to the common cold. So, you're looking at perhaps a 10% increase in productivity just from keeping adults at work instead of in their sickbed or tending sick children.
It's hard to provide food and shelter when a significant part of the population is in bed with terrible pain and extreme fever and unable to work. Or their children are, which leads to the same result because they have to stay home to take care of them.
What makes you think you are in any way superior to others? What's about African climate that makes it unfit for human life? Are you really that stupid or you just get off on trolling?
... they'll all die of starvation anyway.
The thing is, Africa is an amazingly fertile country. If farmers could just farm, they would easily be able to feed Africa and the children therein.
The great thing about a malaria cure is it takes one huge load of population control, meaning that going forward there will be more and more people - until the countries to inept to let farmers farm are overthrown and Africa becomes the land of plenty it once was.
"There is more worth loving than we have strength to love." - Brian Jay Stanley
Malaria is so common in Africa that most Africans don't consider it to be that big of a deal. You get malaria, go to the doctor and take some medication and then get better. Over time, your immune system will be more resistant to malaria so you don't get as sick.
Malaria is a serious disease for those who don't have access to medicine and is left untreated for a period of time. A new medication is not going to help much if people don't have access to it.
Sounds like South Africa has their own version of the FDA. Millions will die while they wait for the bureaucrats, but at least they die safely!
Liberty in your lifetime
I remember seeing a program a long time ago on an experiment where they were inoculating cows in Queensland to produce antibodies to ticks. The tick would bite the cow and suck out a heap of blood and the antibodies would then weaken or kill the tick.
They had some example ticks, and they looked pretty sick, but I never heard any more about it, so I don't know if it went anywhere.
I'm not sure, but I think the antibody attacked chitin, which meant that there was no way the ticks could develop an immunity. If it was chitin, it probably wasn't too healthy for fleas and mozzies either.
I'm guessing that wasn't on their radar screen...
One of the more effective forms of birth control is lowering infant and child mortality - like, ya know from malaria.
But, don't let me stop your subtle dismissal of the behaviours of an entire continent. Have fun at the Klan rally.
It's in Tampa this year, isn't it?
Human trials find that drugs either work as expected, not at expected or there are serious complications from the drug that might even be worse than what it cures.
I would note that the complications would have to be pretty bad for it to be worse than malaria. In particularly severe malarial infections, the death rate can be as high as 20%, with intensive treatments. In the general population. Very few drugs work harmlessly on animals, but have a one-in-five death rate for humans. It seems there might well be a point to expediting the test process for a disease with such high fatality and incidence rates.
On the other hand, I wouldn't be surprised if the time were needed for setting up mass-production at any rate. In which case, you might as well know as much about the side effects, etc. as possible before deployment.
A cure. I forgot that sometimes happens when US drug companies that would rather treat are involved
True, but because this is a single dose drug it is quite a lot less complicated to test.
love is just extroverted narcissism
"A novel class of orally active antimalarial 3,5-diaryl-2-aminopyridines has been identified from phenotypic whole cell high-throughput screening of a commercially available SoftFocus kinase library."
.. and superior to chloroquine in the K1 strain .. Compound 15 completely cured Plasmodium berghei-infected mice with a single oral dose of 30 mg/kg." link
"One of these frontrunner compounds, 15, was equipotent across the two strains
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